• ADCs and CAR‑Ts could alter the therapeutic framework for refractory cancers, especially diffuse‑type gastric cancer, ovarian cancer and pancreatic cancer with peritoneal dissemination. (spandidos-publications.com)
  • Gastric cancer (GC) is a leading contributor to global cancer incidence and mortality. (frontiersin.org)
  • Due to the unobvious early symptoms and the influence of some adverse factors such as tumor heterogeneity and low immunogenicity, patients with advanced gastric cancer (AGC) cannot benefit significantly from treatments such as radical surgical resection, radiotherapy, chemotherapy, and targeted therapy. (frontiersin.org)
  • Gastric cancer (GC) is a common malignant tumor originating from gastric mucosa epithelial cells, and its onset is relatively insidious. (frontiersin.org)
  • ATTRACTION-5 was looking at the adjuvant role for nivolumab in gastric cancer, and unfortunately, it did not meet its prespecified endpoint. (medscape.com)
  • Abstract Gastroesophageal cancers comprising gastric cancer (GC), and cancers of the distal oesophagus and gastroesophageal junction (GEJ) are a global health threat. (docksci.com)
  • In July 2022, I-Mab announced that the first patient in China has been treated with TJ-CD4B (also known as ABL111), a novel Claudin 18.2 x 4-1BB bispecific antibody, in a Phase 1 international multi-center clinical trial (IMCT) for patients with solid tumors, including gastric cancer, gastroesophageal junction carcinoma, esophageal adenocarcinoma, and pancreatic ductal carcinoma. (lucknownewsflash.in)
  • In an immunohistochemistry study performed in patients with gastric cancer, a high expression of EMT traits, the infiltration of TAMs, and the expression of TGF-β1 were associated with a negative prognosis [ 3 ] . (encyclopedia.pub)
  • Gastric cancer (GC) is a malignant tumor that negatively impacts human health, which typically presents in the advanced stages of disease in the majority of patients. (sagepub.com)
  • Ectopic expression of CDX2 is associated with the development and progression of gastric cancer. (biomedcentral.com)
  • Previous studies showed that CDX2 may be an upstream regulator of Reg IV expression in gastric cancer, and our previous report showed that Reg IV upregulated SOX9 expression and enhanced cell migration and invasion in gastric cancer cells. (biomedcentral.com)
  • However, the regulatory roles of CDX2 have not been clarified in gastric cancer, and the correlation between CDX2 and Reg IV requires further study. (biomedcentral.com)
  • CDX2 and Reg IV were examined in gastric cancer specimens and paired adjacent tissues via real-time PCR and immunohistochemistry (IHC). (biomedcentral.com)
  • To verify their relationship, knockdown and exogenous expression of CDX2 or Reg IV were performed in AGS and MKN-45 gastric cancer cells, and their expression was subsequently analyzed via a real-time PCR and western blotting. (biomedcentral.com)
  • A positive correlation was observed between CDX2 and Reg IV expression at the mRNA and protein levels in gastric cancer tissues. (biomedcentral.com)
  • Our findings demonstrate that CDX2 expression was positively correlated with that of Reg IV in gastric cancer, and CDX2 promoted cell migration and invasion through upregulation of Reg IV expression in AGS and MKN-45 cells. (biomedcentral.com)
  • Gastric cancer is one of the most common cancers and the leading cause of cancer-related deaths worldwide. (biomedcentral.com)
  • In addition, CDX2 overexpression promoted the development of MDR in SGC-7901/DDP (cisplatin-resistant) and BGC-823/5-FU (5-fluorouracil-resistant) human gastric cancer cells in vitro and in vivo [ 18 ]. (biomedcentral.com)
  • Taken together, these conflicting results show that the regulatory roles of CDX2 in gastric cancer remain unclear. (biomedcentral.com)
  • gastric cancer, is a novel member of CLAUDIN gene family JOURNAL Int. J. Mol. (dbcls.jp)
  • An individual infected with CagA-negative strains is likely only to develop chronic gastritis and have only a small chance of developing peptic ulcer disease or gastric cancer. (medscape.com)
  • In contrast, infection with CagA-positive strains greatly increases the risk of peptic ulcer disease and gastric cancer. (medscape.com)
  • Individuals infected with East-Asian type cagA strains are reported to have higher risk of PUD or gastric cancer than those with Western-type cagA strains. (medscape.com)
  • The association between serum anti-CagA antibodies and gastric cancer in East Asian countries (Japan, Korea, and China) was clarified in a meta-analysis of case-control studies with age and sex-matched controls, in which 10 studies with a total of 4325 patients were identified. (medscape.com)
  • Phase III clinical trials of Rova‑T for patients with small‑cell lung cancer and a phase III clinical trial of nirogacestat for patients with desmoid tumors are ongoing. (spandidos-publications.com)
  • Unraveling how cancer cells stop the immune system from recognizing tumors as dangerous. (benaroyaresearch.org)
  • Accumulating studies have suggested that miRNAs are frequently dysregulated in tumors compared with normal tissues, resulting in aberrant expression of target genes or proteins and cancer progression 13 . (nature.com)
  • Similarly, a genomic and proteomic analysis based on a tumor cell EMT signature conducted across almost 2000 different tumors [ 5 ] revealed a strong association between EMT and markers of inhibited or exhausted immune responses. (encyclopedia.pub)
  • In oncology, we have presented encouraging data updates for our individualized mRNA cancer vaccine candidate BNT122 in pancreatic cancer and our novel CAR-T cell therapy candidate BNT211 in solid tumors, leading to our first PRIME designation by EMA. (yahoo.com)
  • These treatment options can cure early and part of the intermediate tumors in certain degrees, but are not ideal for most of cancer in middle and late stages [ 2 ]. (biomedcentral.com)
  • High GLI1 expression is a property of claudin-low cells and tumors and correlates with markers of epithelial to mesenchymal transition and breast cancer stem cells. (stemcellsciencenews.com)
  • The epidermal growth factor receptor critically regulates endometrial function during early pregnancy. (bnwax.com)
  • The most aggressive subtype is TNBC, lacking of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), accounting for 15-20% of all breast cancers 5 . (nature.com)
  • Gene expression clustering studies in ovarian cancer have shown that the mesenchymal subtype, enriched in an EMT-related gene signature, has a worse prognosis and survival compared to other subtypes [ 1 ] . (encyclopedia.pub)
  • The OnPrime study is a multi-center, randomized open-label phase 3 study evaluating the safety and efficacy of Olvi-Vec followed by platinum-doublet chemotherapy and bevacizumab compared to the Active Comparator Arm with platinum-doublet chemotherapy and bevacizumab in women diagnosed with platinum-resistant/refractory ovarian cancer (includes fallopian tube cancer and primary peritoneal cancer). (uci.edu)
  • GLORIOSA is a Phase 3 multicenter, open label study designed to evaluate the safety and efficacy of mirvetuximab Soravtansine as maintenance therapy in participants with platinum-sensitive ovarian, primary peritoneal or fallopian tube cancers with high folate receptor-alpha (FRα) expression. (uci.edu)
  • The main goals of this study are to: - Find the recommended dose(s) of BT5528 that can be given safely to participants alone and in combination with nivolumab - Learn more about the side effects of BT5528 - Learn about how effective BT5528 is for the treatment of ovarian cancer, urothelial/bladder cancer, lung cancer (NSCLC), triple-negative breast cancer, head and neck cancer (HNSCC), and gastric/upper gastrointestinal cancer. (uci.edu)
  • This study will evaluate the use of a mobile application in improving the patient-reported health outcome measures (PROMIS) for patients diagnosed with advanced stage ovarian, fallopian tube, and primary peritoneal cancer. (uci.edu)
  • The purpose of the study is to assess the safety, tolerability, and efficacy of farletuzumab ecteribulin (MORAb-202) and compare it to Investigator's choice (IC) chemotherapy in female participants with platinum-resistant HGS ovarian, primary peritoneal, or fallopian tube cancer. (uci.edu)
  • Investigators demonstrate that in a unique population of high-grade serous ovarian carcinoma cancer cells with cancer stem cell properties, p53 protein aggregation is associated with p53 inactivation and platinum resistance. (stemcellsciencenews.com)
  • On February 5, 2020, the company announced management changes effective from April 1, 2020. (wikipedia.org)
  • According to the GLOBOCAN 2020 estimates of incidence and mortality for 36 cancers in 185 countries produced by the International Agency for Research on Cancer (IARC), GC ranks fifth and fourth, respectively, and seriously threatens the survival and health of people all over the world. (frontiersin.org)
  • According to the GLOBOCAN 2020 estimates of incidence and mortality for 36 cancers in 185 countries produced by the International Agency for Research on Cancer (IARC), an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths occurred worldwide in 2020, and GC ranked fifth (5.6%) and fourth (7.7%), respectively ( 2 ). (frontiersin.org)
  • In December 2020, Cancerworld reported on developments in the use of oncolytic viruses to fight cancers. (cancerworld.net)
  • Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. (cusabio.com)
  • Binds to the USP28 promoter in colorectal cancer (CRC) cells. (cusabio.com)
  • Colorectal cancer (CRC) is the third most common cancer and a leading cause of cancer-related mortality. (oncotarget.com)
  • Scientists investigated the crosstalk between colorectal cancer cells with stromal fibroblasts and the anti-cancer effects of curcumin and 5-Fluorouracil, especially on cancer stem cell survival in a 3D-co-culture model that mimics in vivo tumor microenvironment. (stemcellsciencenews.com)
  • Metastatic castration-resistant prostate cancer reveals intrapatient similarity and interpatient heterogeneity of therapeutic kinase targets. (bnwax.com)
  • Lacking of both prognostic biomarkers and therapeutic targets, triple-negative breast cancer (TNBC) underscores pivotal needs to uncover novel biomarkers and viable therapies. (nature.com)
  • Culture media composition influences patient-derived organoid ability to predict therapeutic responses in gastrointestinal cancers. (mayo.edu)
  • We propose that the unique properties of OSMR, which hyperactivates MAPK signaling when compared with other IL6 family receptors, make it an attractive therapeutic target, and that disrupting the OSM-OSMR-MAPK feed-forward loop may be a novel way to therapeutically target the stem-like behaviors common to aggressive PDAC. (bvsalud.org)
  • Culler MD, Taylor JE, Moreau JP: Somatostatin receptor subtypes: targeting functional and therapeutic specificity. (thrombin-inhibitor.com)
  • The efficacy of a therapeutic antibody depends on the Fab fragment and its binding activity to the target antigen, but also depends on the Fc fragment and its interaction with key Fc receptors.Therefore, candidates must be tested against a panel of receptors during antibody engineering. (acrobiosystems.com)
  • Breast cancer cells condition lymphatic endothelial cells within pre-metastatic niches to promote metastasis. (bnwax.com)
  • Argani, P. Intraductal spread by metastatic islet cell tumor (well-differentiated pancreatic endocrine neoplasm) involving the breast of a child, mimicking a primary mammary carcinoma. (hopkinsmedicine.org)
  • Patients diagnosed with pancreatic ductal adenocarcinoma (PDAC) frequently present with advanced metastatic disease and exhibit a poor response to therapy, resulting in poor outcomes. (bvsalud.org)
  • The acquisition of metastatic abilities by breast cancer cells is the most deadly aspect of disease progression. (thrombin-inhibitor.com)
  • In vivo selection of parental cells resulted in the isolation of independent, aggressively liver metastatic breast cancer populations. (thrombin-inhibitor.com)
  • In addition, these proteins can also associate with claudin, occludin and F-actin, at tight junction stands, where they provide a linkage between the actin cytoskeleton and the tight junction. (thermofisher.com)
  • The discovery that the CTLA-4 and PD1 proteins act as checkpoints that protect cancer cells from immune attack, and the idea - pioneered by Jim Allison - that the immune system could be freed to target cancer by blocking such immune checkpoints, provided the key that has unlocked progress. (cancerworld.net)
  • The expression of genes encoding tight-junctional proteins were elevated (Claudin-2) or lost (Claudin-3, -4, -5 and -7) in highly liver aggressive in vivo selected cell populations. (thrombin-inhibitor.com)
  • I'm thinking immediately of a trial just presented yesterday at this meeting on the management of pancreatic cancer, specifically pancreatic adenocarcinoma. (medscape.com)
  • DelveInsight's, "Pancreatic Ductal Adenocarcinoma Pipeline Insight, 2022," report provides comprehensive insights about 80+ companies and 80+ pipeline drugs in the Pancreatic Ductal Adenocarcinoma pipeline landscape. (lucknownewsflash.in)
  • It covers the Pancreatic Ductal Adenocarcinoma pipeline drug profiles, including Pancreatic Ductal Adenocarcinoma clinical trials and nonclinical stage products. (lucknownewsflash.in)
  • It also covers the Pancreatic Ductal Adenocarcinoma pipeline therapeutics assessment by product type, stage, route of administration, and molecule type. (lucknownewsflash.in)
  • In the Pancreatic Ductal Adenocarcinoma Pipeline Report, detailed description of the drug is given which includes mechanism of action of the drug, Pancreatic Ductal Adenocarcinoma clinical trial studies, Pancreatic Ductal Adenocarcinoma NDA approvals (if any), and product development activities comprising the technology, Pancreatic Ductal Adenocarcinoma collaborations, licensing, mergers and acquisition, funding, designations and other product related details. (lucknownewsflash.in)
  • DelveInsight's Pancreatic Ductal Adenocarcinoma Pipeline report depicts a robust space with 80+ active players working to develop 80+ pipeline therapies for Pancreatic Ductal Adenocarcinoma. (lucknownewsflash.in)
  • The Pancreatic Ductal Adenocarcinoma Companies and academics are working to assess challenges and seek opportunities that could influence R&D Pancreatic Ductal Adenocarcinoma. (lucknownewsflash.in)
  • The Pancreatic Ductal Adenocarcinoma pipeline therapies under development are focused on novel approaches to treat/improve Pancreatic Ductal Adenocarcinoma. (lucknownewsflash.in)
  • In June 2022, BioNTech SE announced initial data from an ongoing investigator-initiated first-in-human Phase 1 study evaluating the safety and tolerability of the mRNA-based individualized neoantigen-specific immunotherapy (iNeST) autogene cevumeran (also known as BNT122, RO7198457) in combination with anti-PD-L1 immune checkpoint inhibitor atezolizumab and chemotherapy in patients with resected pancreatic ductal adenocarcinoma (PDAC). (lucknownewsflash.in)
  • As an emerging cancer immunotherapy, oncolytic virotherapies (OVTs) can not only selectively lyse cancer cells, but also induce a systemic antitumor immune response. (frontiersin.org)
  • Immunotherapy has burst onto the scene in upper GI cancer in the past 2-2.5 years. (medscape.com)
  • Adoptive T cell immunotherapy with cytokine‑induced killer cells (CIKs) has been demonstrated to prolong the survival of patients with advanced non‑small cell lung cancer (NSCLC). (sagepub.com)
  • Cancer immunotherapy by chimeric antigen receptor-modified T (CAR-T) cells has shown exhilarative clinical efficacy for hematological malignancies. (ijbs.com)
  • Also, nanovaccines can be very helpful for making cancer treatments that use immunotherapy. (researchgate.net)
  • Overexpression of CXCL5 is associated with poor survival in patients with pancreatic cancer. (bnwax.com)
  • Nelson, W.G. Retinoblastoma pathway dysregulation causes DNA methyltransferase 1 overexpression in cancer via MAD2-mediated inhibition of the anaphase-promoting complex. (hopkinsmedicine.org)
  • Furthermore, overexpression of Claudin-2 is sufficient to promote the ability of breast cancer cells to colonize and grow out in the liver. (thrombin-inhibitor.com)
  • Pseudouridimycin The ratio of ELR1-IN mRNA species to ELR1 mRNA was 12 approximately.5. (angiogenesis-blog.com)
  • Furthermore, the alterative splicing of mRNAs through the maturation of eukaryotic pro-mRNA is normally another system for the forming of soluble receptors. (angiogenesis-blog.com)
  • Homo sapiens claudin 25 (CLDN25), mRNA. (dbcls.jp)
  • linear PRI 27-JAN-2013 DEFINITION Homo sapiens claudin 25 (CLDN25), mRNA. (dbcls.jp)
  • Homo sapiens claudin 22 (CLDN22), mRNA. (dbcls.jp)
  • linear PRI 23-MAR-2013 DEFINITION Homo sapiens claudin 22 (CLDN22), mRNA. (dbcls.jp)
  • Homo sapiens claudin 9 (CLDN9), mRNA. (dbcls.jp)
  • linear PRI 24-MAR-2013 DEFINITION Homo sapiens claudin 9 (CLDN9), mRNA. (dbcls.jp)
  • Homo sapiens claudin 20 (CLDN20), mRNA. (dbcls.jp)
  • linear PRI 14-APR-2013 DEFINITION Homo sapiens claudin 20 (CLDN20), mRNA. (dbcls.jp)
  • Homo sapiens claudin 3 (CLDN3), mRNA. (dbcls.jp)
  • Homo sapiens claudin 17 (CLDN17), mRNA. (dbcls.jp)
  • linear PRI 17-APR-2013 DEFINITION Homo sapiens claudin 17 (CLDN17), mRNA. (dbcls.jp)
  • Homo sapiens claudin 18 (CLDN18), transcript variant 1, mRNA. (dbcls.jp)
  • linear PRI 17-APR-2013 DEFINITION Homo sapiens claudin 18 (CLDN18), transcript variant 1, mRNA. (dbcls.jp)
  • This optimism is built on recently published studies demonstrating the efficacy of mRNA vaccines in combatting several types of cancer and infectious pathogens where conventional vaccine platforms may fail to induce protective immune responses. (researchgate.net)
  • Additionally, the 5′ and 3′ UTRs flanking the coding region regulate mRNA translation, half-life, and subcellular localization [2]. (researchgate.net)
  • I am speaking at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting in Chicago, where we have seen some interesting new data in gastrointestinal (GI) cancers that I'd like to tell you about. (medscape.com)
  • According to the American Cancer Society (2019), different types of the disease can affect the human body and acute myelogenous leukaemia (AML) is one of them. (assignology.com)
  • AML is among a broader group of blood cancers that start in the bone marrow and affect the normal functioning of blood cells (American Cancer Society 2019). (assignology.com)
  • However, they may alsooriginate from other blood cells, such as red blood cells (American Cancer Society 2019). (assignology.com)
  • Based on this characteristic, experts attribute AML to a deformity of cells that would have otherwise turned into white blood cells (American Cancer Society 2019). (assignology.com)
  • Medical experts classify them based on whether they are acute (fast growing) or chronic (slow growing) (American Cancer Society 2019). (assignology.com)
  • Broadly, some of them start from myeloid cells, while others come from lymphoid cells (American Cancer Society 2019). (assignology.com)
  • Prognostic Role of Blood NETosis in the Progression of Head and Neck Cancer. (uni-due.de)
  • The tight junction (TJ) protein claudin-4 (CLDN4) is overexpressed in bladder urothelial carcinoma (BUC) and correlates with cancer progression. (mdpi.com)
  • Here, we analyzed 157 cases of BUC and investigated the hypomethylation of CpG island in the CLDN4 promoter DNA and its correlation with cancer progression. (mdpi.com)
  • Small‑molecule γ‑secretase inhibitors (AL101, MRK‑560, nirogacestat and others) and antibody‑based biologics targeting Notch ligands or receptors [ABT‑165, AMG 119, rovalpituzumab tesirine (Rova‑T) and others] have been developed as investigational drugs. (spandidos-publications.com)
  • Small-molecule inhibitors, antagonistic monoclonal antibodies (mAbs), antibody-drug conjugates (ADCs), bispecific antibodies or biologics (bsAbs) and chimeric antigen receptor-modified T cells (CAR-Ts) targeting Notch signaling components have been developed as investigational anti-cancer drugs ( 10 - 12 ). (spandidos-publications.com)
  • Prophylactic utilization of inhibitors of VEGF expression in sufferers with hepatic cirrhosis might protect against the development of cancer. (dehydrogenase-signal.com)
  • Analyses altered by sex, diabetes length of time, body mass index, usage of angiotensin changing enzyme angiotensin or inhibitors receptor blocker, HbA1c, urinary albumin excretion, and creatinine at the proper period of the urine collection. (tam-receptor.com)
  • This review summarizes recent progress in our understanding of glucose metabolism in chemo- and radio-resistance malignancy, and highlights potential molecular targets and their inhibitors for cancer treatment. (biomedcentral.com)
  • adjuvant treatment of patients with HER2-positive early breast cancer who have residual invasive disease after neoadjuvant taxane and trastuzumab-based treatment. (huatengsci.com)
  • Overcoming acquired resistance to cetuximab by dual targeting HER family receptors with antibody-based therapy. (bnwax.com)
  • 1. Introduction Cancers of the stomach (GC), the gastroesophageal junction (GEJ) and the distal oesophagus are the second ⇑ Corresponding author at: Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany. (docksci.com)
  • Clinical trials are studying cancer from a variety of angles, including prevention and treatment. (benaroyaresearch.org)
  • We have ongoing clinical research studies in several areas of cancer research. (benaroyaresearch.org)
  • Please email Cancer Clinical Research or call (206) 287-6270 for more information. (benaroyaresearch.org)
  • His area of clinical expertise is kidney cancer, particularly those arising in children. (hopkinsmedicine.org)
  • Despite the evidence that hepatic metastases are associated with poor clinical outcome in breast cancer patients, little is known about the molecular mechanisms governing the spread and growth of breast cancer cells in the liver. (thrombin-inhibitor.com)
  • Finally, examination of clinical samples revealed that Claudin-2 expression is evident in liver metastases from patients with breast cancer. (thrombin-inhibitor.com)
  • necrosis aspect receptor (TNFR) superfamily. (angiogenesis-blog.com)
  • Predicated on its series and structural features, ELR1 is one of the TNF receptor (TNFR) superfamily [4], [5], and several receptors of the superfamily, like the development factor receptor, leptin Fas and receptor, have soluble forms also. (angiogenesis-blog.com)
  • Integration of human intelligence, cognitive computing and explainable artificial intelligence is necessary to construct a Notch‑related knowledge‑base and optimize Notch‑targeted therapy for patients with cancer. (spandidos-publications.com)
  • Unfortunately, patients are already in the terminal stage at this time, and the cancer cells have already invaded the surrounding organs or metastasized far away, which leads to the loss of the curative chance for most patients ( 1 ). (frontiersin.org)
  • The trial that was discussed yesterday, the NORPACT trial , was looking at whether we should be giving chemotherapy before surgery or going straight to the operating room in patients whose cancers are clearly resectable. (medscape.com)
  • Pancreas cancer remains, unfortunately, a fearsome enemy for patients and oncologists alike. (medscape.com)
  • During the past decade perioperative chemotherapy, pre- or postoperative radio-chemotherapy, and, in Asian populations, adjuvant chemotherapy have been shown to improve the outcome of patients with advanced GC and GEJ cancers suited for surgery. (docksci.com)
  • Patient-derived organoids, creating a new window of opportunities for pancreatic cancer patients. (mayo.edu)
  • The impressive results shown by the first CTLA-4 and PD-1 blockade therapies, in achieving complete remission in certain cancer patients with previously incurable stage IV melanomas - fuelled great optimism that this strategy could be made to work in a wider group of patients and a wider range of cancer types. (cancerworld.net)
  • In the field of oncology, this approach was pioneered with CAR T cell therapy, which harvested T cells from patients and engineered them to recognise and attack their cancer cells. (cancerworld.net)
  • Over the past couple of years, Cancerworld has spoken to many researchers immersed in efforts to do just that ‒ to translate our expanding knowledge about cancer and the immune system, and make use of our powerful tools of bioengineering, to find new strategies to get better results for wider groups of patients. (cancerworld.net)
  • Targeted therapy, based on molecular typing of breast cancer, is the most precise form of treatment, and CXC chemokine. (sagepub.com)
  • Soluble forms have already been discovered for a few immunoglobulins and chemokine receptors [6]C[8] also. (angiogenesis-blog.com)
  • Notably, ziyuglycoside II and syringin decreased the transepithelial electrical resistance of the monolayer, and promoted the protein expression of Occludin, Claudin-1 and zonula occludens-1 (ZO-1) in Caco2 cells. (bvsalud.org)
  • In vivo, ziyuglycoside II and syringin improved the symptoms of UC mice, including body weight, disease activity score, shortening of colon length, damaging of acidic mucus layer, histopathological changes, and protein expression of Occludin, Claudin-1, and ZO-1. (bvsalud.org)
  • Notch signaling cascades crosstalk with fibroblast growth factor and WNT signaling cascades in the tumor microenvironment to maintain cancer stem cells and remodel the tumor microenvironment. (spandidos-publications.com)
  • Germline mutations in the NOTCH1 , NOTCH2 and NOTCH3 genes cause Adams-Oliver syndrome, Alagille syndrome and cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, respectively ( 4 ), and DLL4-NOTCH3 signaling in human vascular organoids induces basement membrane thickening and drives vasculopathy in the diabetic microenvironment ( 5 ). (spandidos-publications.com)
  • Ectopic expression of DOCK8 regulates lysosome-mediated pancreatic tumor cell invasion. (mayo.edu)
  • Notch signaling is aberrantly activated in breast cancer, non‑small‑cell lung cancer and hematological malignancies, such as T‑cell acute lymphoblastic leukemia and diffuse large B‑cell lymphoma. (spandidos-publications.com)
  • By contrast, somatic alterations in the genes encoding Notch signaling components drive various types of human cancer, such as breast cancer, small-cell lung cancer (SCLC) and T-cell acute lymphoblastic leukemia (T-ALL) ( 6 - 9 ). (spandidos-publications.com)
  • ZO-1 expression is significantly reduced in many breast cancer lines. (thermofisher.com)
  • Despite important advances in early detection and research development, breast cancer remains a major health problem affecting women. (nature.com)
  • Argani, P. LKB1 protein expression in human breast cancer. (hopkinsmedicine.org)
  • Helzlsouer, K.J. Polymorphisms in estrogen-metabolizing and estrogen receptor genes and the risk of developing breast cancer among a cohort of women with benign breast disease. (hopkinsmedicine.org)
  • Helzlsouer, K.J. Flame-broiled food, NAT2 acetylator phenotype, and breast cancer risk among women with benign breast disease. (hopkinsmedicine.org)
  • Sukumar, S. Epigenetic suppression of secreted frizzled related protein 1 (SFRP1) expression in human breast cancer. (hopkinsmedicine.org)
  • Sukumar, S. HOXB7, a Homeodomain Protein, Is Overexpressed in Breast Cancer and Confers Epithelial-Mesenchymal Transition. (hopkinsmedicine.org)
  • Breast cancer is the most common malignant neoplasm in women worldwide, and the treatment regimens currently available are far from optimal. (sagepub.com)
  • The liver represents the third most frequent site for breast cancer metastasis, following the bone and lung. (thrombin-inhibitor.com)
  • We have utilized 4 T1 breast cancer cells to identify genes that confer the ability of breast cancer cells to metastasize to the liver. (thrombin-inhibitor.com)
  • We demonstrate that loss of claudin expression, in conjunction with high levels of Claudin-2, is associated with migratory and invasive phenotypes of breast cancer cells. (thrombin-inhibitor.com)
  • Cancer is caused by changes to genes that control the way cells function, especially the way they grow and divide. (benaroyaresearch.org)
  • Despite many types of investigation that have been performed, the most critical genes and signaling pathways taking part in the etiology of the disease have not been fully demonstrated [ 5 ]. (genominfo.org)
  • Reprogramming of cancer metabolism is a newly recognized hallmark of malignancy. (biomedcentral.com)
  • When the glucose metabolism of cancer is rewiring, the characters of cancer will also occur corresponding changes to regulate the chemo- and radio-resistance of cancer. (biomedcentral.com)
  • Targeting altered metabolic pathways related with the glucose metabolism has become a promising anti-cancer strategy. (biomedcentral.com)
  • As the molecular mechanisms underlying chemo- and radio-resistance are still poorly understood, the alteration of glucose metabolism in cancer provides new ideas to explain chemo- and radio-resistance. (biomedcentral.com)
  • The energy metabolism of cancer cells. (biomedcentral.com)
  • Knockdown of GLI1 expression in claudin-low cell lines resulted in reduced cell viability, motility, clonogenicity, self-renewal, and reduced tumor growth of orthotopic xenografts. (stemcellsciencenews.com)
  • Targeted therapies in gastroesophageal cancer. (docksci.com)
  • Here we summarise the current status and future developments of molecularly targeted therapies in GC and GEJ cancer. (docksci.com)
  • Since its first approval in 2017, CAR T cell therapies have been approved for treatment of a variety of blood cancers. (cancerworld.net)
  • Cancer is an umbrella term for a variety of diseases in which abnormal cells divide uncontrollably. (benaroyaresearch.org)
  • In the case of cancer, the immune system fails to recognize the cancerous cells and they can grow uncontrolled within the body. (benaroyaresearch.org)
  • Understanding the cells and processes that allow cancer to advance. (benaroyaresearch.org)
  • A431 human epithelial carcinoma cells were either left untreated or treated with 200 ng/mL recombinant human (rh) EGF (Catalog # 236-EG) for 5 minutes. (bnwax.com)
  • GLI1 interaction with p300 modulates SDF1 expression in cancer-associated fibroblasts to promote pancreatic cancer cells migration. (mayo.edu)
  • RESULTS: Ziyuglycoside I, ziyuglycoside II, syringin, and pedunculoside in IR reduced phenol red transmission of the monolayer, and inhibited the protein expression of oncostatin M and oncostatin M receptor in Caco2 cells. (bvsalud.org)
  • potent anti-cancer drugs, combretastatin A-4 (CA-4) and docetaxel (DTX), against tumor cells and vasculature. (ajol.info)
  • Many strategies and approaches have been tried to overcome these obstacles, including arming CAR-T cells with knock-out of PD-1 expression or secretion of cytokines/chemokines and using CAR-T cells in combination with other treatments [ 3 - 5 ]. (ijbs.com)
  • As a result, viral receptors over the cell membrane offer binding sites for the trojan and so are also mixed up in structural modulation of viral envelopes, resulting in the fusion Pseudouridimycin from the viral and mobile membranes and virion entrance, the first step in viral an infection of focus on cells [2]. (angiogenesis-blog.com)
  • As opposed to almost every other lentiviruses, such as for example human immunodeficiency trojan (HIV)-1, simian immunodeficiency trojan (SIV) and feline immunodeficiency trojan (FIV), which need co-receptors for effective an infection, EIAV seems to depend just on an operating ELR1 for the invasion of focus on cells. (angiogenesis-blog.com)
  • The idea had a strong scientific rationale: over millions of years our immune systems have evolved intricate and multi-layered ways to protect our health - why should cancer cells be exempt from its attentions? (cancerworld.net)
  • Doudna and Charpentier's development of the CRISPR/cas9 technique, which started to be used around 10 years ago, opened up mind-boggling possibilities for intervening in the behaviour of both cancer cells and immune cells. (cancerworld.net)
  • Oncolytic viruses' ‒ viruses that preferentially infect and kill cancer cells ‒ have been known about for some time. (cancerworld.net)
  • Early hypotheses focused principally on the observation that certain viruses seem to prefer cancer cells, which is assumed to be linked to the changed metabolic status of cancer cells that makes viral replication favourable. (cancerworld.net)
  • Cancer often starts when normal cells grow out of control and affect other parts of the body. (assignology.com)
  • This makes it a high-risk factor for cancer growth because it allows AML cells to affect other parts of the body, such as the liver, spleen, lymph nodes and testicles (Andreeff 2014). (assignology.com)
  • Researchers identified and characterized an intrinsic autofluorescent phenotype in cancer stem cells of diverse epithelial cancers and used this marker to isolate and characterize these cells. (stemcellsciencenews.com)
  • Investigators induced cancer stem-like cells from hepatocellular carcinoma cell lines using a unique medium, and examined their potential for resistance to anti-cancer drugs. (stemcellsciencenews.com)
  • Molecular connections between N-terminally truncated p53 family isoforms and self-renewal have arisen, suggesting their potential function in the generation of cancer stem cells from bulk tumor cells. (stemcellsciencenews.com)
  • AKT inhibition relieves feedback suppression of receptor tyrosine kinase expression and activity. (bnwax.com)
  • BACKGROUND: Neuropilin-1 (NRP1) can be a non-tyrosine kinase receptor pertaining to general endothelial progress aspect (VEGF) recently implicated inside tumour capabilities. (azd8931inhibitor.com)
  • Laboratory scientists are investigating the connections between autoimmune diseases and the mechanisms that help cancer grow and spread without being detected by the immune system. (benaroyaresearch.org)
  • The goal of our research is to better understand mechanisms of sensing and repair during diseases like cancer, infections, and neurodegenerative disorders. (benaroyaresearch.org)
  • Key to making progress has been a better understanding of the mechanisms that link oncolytic viruses to cancer regression. (cancerworld.net)
  • NOTCH1, NOTCH2, NOTCH3 and NOTCH4 are transmembrane receptors that transduce juxtacrine signals of the delta‑like canonical Notch ligand (DLL)1, DLL3, DLL4, jagged canonical Notch ligand (JAG)1 and JAG2. (spandidos-publications.com)
  • Salivary gland carcinoma (SGC) is an uncommon neoplasm, which constitutes approximately 6 percent of cancers in the head and neck region [ 1 , 2 ]. (genominfo.org)
  • In 2006 the oncolytic H101 adenovirus was approved in China for the treatment of head and neck cancer, but that approval has not been extended to other regulatory bodies so far. (cancerworld.net)
  • 2009;107:785-96, Smith N, Stoddart L, Devine N, Jenkins L, Milligan G. The action and mode of binding of thiazolidinedione ligands at free fatty acid receptor 1. (bnwax.com)
  • The Notch signaling network exerts oncogenic and tumor‑suppressive effects in a cancer stage‑ or (sub)type‑dependent manner. (spandidos-publications.com)
  • Notch signaling dysregulation is involved in a variety of pathologies, including cancer and non-cancerous diseases. (spandidos-publications.com)
  • Prostate-specific membrane antigen cleavage of vitamin B9 stimulates oncogenic signaling through metabotropic glutamate receptors. (bnwax.com)
  • Researchers show that tumor-associated monocytes and macrophages create a cancer stem cell (CSC) niche through juxtacrine signaling with CSCs. (stemcellsciencenews.com)
  • Though several scientific studies have reported within the prognostic value of protein markers of liver cancer, there exists no consensus pertaining to the usage of these markers to predict prognosis. (dehydrogenase-signal.com)
  • Liver cancer is one of the most common cancer types globally. (sagepub.com)
  • Proteome Profiler Mouse Angiogenesis Array Kit (Catalog # ARY015) Desmoglein 3 promotes cancer cell migration and invasion by regulating activator protein 1 and protein kinase C-dependent-Ezrin activation. (bnwax.com)
  • Appropriately, Pseudouridimycin studies from the function of viral receptors in the invasion from the trojan are important towards the advancement of antiviral reagents and vaccines. (angiogenesis-blog.com)
  • Biomedical advances over the past 50 years have vastly improved the treatments and outcomes for people facing cancer. (benaroyaresearch.org)