Cell SurvivalPancreasPancreas, ExocrineSurvival RatePancreatic NeoplasmsPancreatic DuctsIslets of LangerhansApoptosisInsulin-Secreting CellsDisease-Free SurvivalCell Line, TumorEndocrine CellsSignal TransductionCell DifferentiationAmylasesPancreatic Polypeptide-Secreting CellsAcinar CellsCarcinoma, Pancreatic DuctalSurvivalCell ProliferationChymotrypsinogenHomeodomain ProteinsSurvival AnalysisCells, CulturedGlucagon-Secreting CellsCell LineGraft SurvivalPancreatitisCeruletideTime FactorsImmunohistochemistryInsulinReverse Transcriptase Polymerase Chain ReactionRNA, MessengerTrans-ActivatorsTumor Cells, CulturedCell TransdifferentiationMice, TransgenicBlotting, WesternStem CellsCell LineageEndodermGlucagonCell DivisionGene Expression Regulation, DevelopmentalAdenocarcinomaRegenerationGene Expression RegulationIslets of Langerhans TransplantationBasic Helix-Loop-Helix Transcription FactorsTranscription FactorsTreatment OutcomeGene ExpressionTransfectionGene Expression Regulation, NeoplasticNerve Tissue ProteinsIslet Amyloid PolypeptideCell DeathMolecular Sequence DataCell Culture TechniquesKaplan-Meier EstimateSomatostatinDNA-Binding ProteinsMice, NudeEmbryo, MammalianPancreatitis, Acute NecrotizingNestinTransplantation, HeterologousMutationEpithelial CellsProto-Oncogene Proteins c-aktModels, BiologicalDose-Response Relationship, DrugRetrospective StudiesPhosphorylationDisease Models, AnimalBase SequenceGlucoseProto-Oncogene ProteinsCholecystokininPhosphatidylinositol 3-KinasesEmbryonic Stem CellsProtein-Serine-Threonine KinasesFetusAntineoplastic AgentsMicroscopy, ElectronNeoplasm StagingCytoplasmic GranulesRats, WistarPromoter Regions, GeneticDeoxycytidineAntimetabolites, AntineoplasticRNA, Small InterferingProportional Hazards ModelsLectinsMice, Inbred C57BLFollow-Up Studiesbcl-X ProteinMice, KnockoutMicroscopy, Confocal