• sensitivity
  • Women with dry eye disease scored significantly lower on tests for heat pain sensitivity ( P =0.03) - a measure of overall pain sensitivity - and heat pain suprathreshold ( P =0.003) - a measure of pain tolerance - than women who did not have dry eyes, according to Jelle Vehof, PhD, of the University Medical Center Groningen in the Netherlands, and colleagues. (zennioptical.com)
  • FS patients display a multimodal change in pain sensitivity which is generalized rather than anatomically restricted. (prohealth.com)
  • To provide an example we apply these methods to data from the mechanical pain sensitivity test of the QST protocol. (peerj.com)
  • Adverse effects of opioids Common and short term Itch Nausea Vomiting Constipation Drowsiness dry mouth Other Opioid dependence Dizziness Decreased sex drive Loss of appetite impaired sexual function Decreased testosterone levels Depression Immunodeficiency opioid-induced abnormal pain sensitivity Irregular menstruation Increased risk of falls Slowed breathing Like loperamide and other opioids, morphine acts on the myenteric plexus in the intestinal tract, reducing gut motility, causing constipation. (wikipedia.org)
  • analgesia
  • The aim of this study was to investigate whether expression of γ-aminobutyric acid (GABA) and the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) in the primary sensory neurons of cervical dorsal root ganglia (DRG) are involved in electroacupuncture (EA)-induced analgesia in a rat model of incisional neck pain. (bmj.com)
  • It has also been demonstrated that electroacupuncture (EA) stimulation at LI18 ( Futu ), LI4 ( Hegu ) and PC6 ( Neiguan )-traditional acupuncture points that have been classically used for analgesia in thyroid surgery patients 9 -is effective, and that EA treatment may reduce the required dosages of remifentanil and acetaminophen, with a superior effect compared with acetaminophen administration alone in the reduction of postoperative pain. (bmj.com)
  • American College of R
  • Ten women (aged 25-64 years, median: 50 years) diagnosed with TMD associated with widespread pain, reported from at least three different anatomical sites apart from the jaw region and pain to palpation according to the American College of Rheumatology criteria 1990, were included in the study. (diva-portal.org)
  • Synchrony
  • A study entitled "Synchrony and exertion during dance independently raise pain threshold and encourage social bonding" concludes that group dancing, especially to energetic beats such as Gangnam Style , the international hit song released in 2012 by the South Korean rapper Psy. (painweek.org)
  • sensory
  • A decreased threshold to sensory stimuli (ie tender points) in areas of spinal dyskinesia has also been recognized. (chiro.org)
  • Conclusions EA at LI18/LI4-PC6 increases PT in rats with incisional neck pain, which is likely related to downregulation of pronociceptive mediators SP/CGRP and upregulation of the inhibitory transmitter GABA in the primary sensory neurons of cervical DRGs. (bmj.com)
  • Responses
  • Responses suggest that dance involving both exertive and synchronized movement "…demonstrated significant independent positive effects on pain threshold (a proxy for endorphin activation) and in-group bonding. (painweek.org)
  • This may be because experimental studies describe participants' responses exclusively in terms of thresholds that conflate several aspects of the response. (peerj.com)
  • After injury, the balance of central responses tips towards persistent pain as a result of substance P release and a reduction in nitrous oxide synthesis and also because the efficacy of inhibitory neurons is diminished by excitotoxicity. (bmj.com)
  • stimulus
  • The threshold of pain or pain threshold is the point along a curve of increasing perception of a stimulus at which pain begins to be felt. (wikipedia.org)
  • A distinction must be maintained between the stimulus (an external thing that can be directly measured, such as with a thermometer) and the person's or animal's resulting pain perception (an internal, subjective thing that can sometimes be measured indirectly, such as with a visual analog scale ). (wikipedia.org)
  • Traditionally the threshold has often been defined, as we defined it formerly, as the least stimulus intensity at which a subject perceives pain. (wikipedia.org)
  • The stimulus is not pain (q.v.) and cannot be a measure of pain. (wikipedia.org)
  • The intensity at which a stimulus begins to evoke pain varies from individual to individual and for a given individual over time. (wikipedia.org)
  • An illustration of how the transmembrane voltage response to a supra-threshold stimulus may differ, based upon the presence of a depolarizing pre-pulse, may be observed in the adjacent image. (wikipedia.org)
  • musculoskeletal
  • Low physical activity levels and prolonged sedentary work time/hours have also been emphasized as a risk factor for developing musculoskeletal (MS) pain [ 10 , 11 ], more specifically of the neck and shoulder [ 12 ]. (hindawi.com)
  • mechanical
  • In accordance with previous research, we also found a decrease in mechanical pain threshold over pre-designated tender points and at control sites as well as a significantly larger mechanically induced neurogenic flare response. (prohealth.com)
  • The results show that adolescents are more sensitive to mechanical pain and contradict the idea that younger children simply use more lenient criteria to report pain. (peerj.com)
  • The mechanism of delayed onset muscle soreness is not completely understood, but the pain is ultimately thought to be a result of microtrauma - mechanical damage at a very small scale - to the muscles being exercised. (wikipedia.org)
  • nociceptors
  • However, Mense 2 studied muscle nociceptors which in good health have too high a threshold to respond to physiological muscle movements or stretch. (bmj.com)
  • higher
  • One study showed that morning oriented people have higher pain threshold for heat as compared to evening oriented individuals. (wikipedia.org)
  • A study by Oxford University found that pain thresholds become "significantly higher" after laughter, compared to the control condition, and saw this as being due to laughter itself, rather than the mood of the subject. (wikipedia.org)
  • study
  • At least one study shows that pain thresholds drop following exercise for people with this condition. (verywell.com)
  • The DRD1 gene was more common among those with low pain perception, the study revealed. (drugs.com)
  • The aim for this study was to investigate the effect of topical anesthesia on PPT for jaw muscles in patients with widespread pain. (diva-portal.org)
  • In conclusion, the study showed that application of topical anesthesia had no significant effect on PPT in patients with widespread pain. (diva-portal.org)
  • Thirty years ago a question about the size of abnormally tender myofascial regions arose in the relief of myofascial pain workshop of the 1981 Edinburgh meeting of the International Association of the Study of Pain, where David Simons examined a deltoid muscle of a delegate with shoulder pain. (bmj.com)
  • Dr Geoffrey Woods, who led the study, said that finding a gene responsible for pain could greatly increase the ability to conquer and control it. (aarogya.com)
  • a 2011 study showed that attendees at a comedy club showed increased resistance to pain. (wikipedia.org)
  • genes
  • Researchers pinpointed four genes that could help explain why perceptions of pain differ from person to person. (drugs.com)
  • Identifying whether a person has these four genes could help doctors better understand a patient's perception of pain," Onojjighofia explained. (drugs.com)
  • For those with moderate pain, the COMT and OPRK genes were seen more. (drugs.com)
  • Finding genes that maybe play a role in pain perception could provide a target for developing new therapies and help physicians better understand their patients' perceptions of pain. (drugs.com)
  • painful
  • For someone with a low threshold, it may become quite painful. (verywell.com)
  • That's why things that aren't painful to most people can cause pain in those with this condition. (verywell.com)
  • So if someone else feels pain from something you think shouldn't be painful, try to understand that their experience may be very different from yours. (verywell.com)
  • The temperature at which heat becomes painful for a recipient is called the heat pain threshold for that person at that time. (wikipedia.org)
  • Understanding both acute as well as chronic pain relies, to a large extent, on our ability to measure and quantify the response to painful and non-painful stimuli. (peerj.com)
  • perception
  • COMT was 25 percent more common in those with moderate pain than those with high pain perception. (drugs.com)
  • Meanwhile, the DRD2 gene variant was 25 percent more common among those with a high pain perception than those with moderate pain. (drugs.com)
  • This build-up of lactic acid was thought to be a toxic metabolic waste product that caused the perception of pain at a delayed stage. (wikipedia.org)
  • found
  • The researchers found this gene variant was 33 percent more prevalent in the low-pain group than in the high-pain group. (drugs.com)
  • Scientists at Cambridge University have discovered the 'pain gene' known as SCN9A - which was found to make some people more sensitive to and thus less able to tolerate pain. (aarogya.com)
  • The scientists found the gene in patients with sciatica, phantom pain, back problems and pancreatitis. (aarogya.com)
  • The researchers found the protein made by the mutated version of the gene SCN9A stays open longer than the normal one and this, they believe, increases the activation of nerves that produce sensations of dull, aching pain. (aarogya.com)
  • Morphine is a pain medication of the opiate variety which is found naturally in a number of plants and animals. (wikipedia.org)
  • intensity
  • Establishing the effects of low intensity cycling (LC), moderate intensity cycling (MC), and standing at a simulated office workstation on pain modulation, work performance, and metabolic expenditure. (hindawi.com)
  • Properly defined, the threshold is really the experience of the patient, whereas the intensity measured is an external event. (wikipedia.org)
  • response
  • Endorphins are naturally produced in response to pain, but their production can also be triggered by various human activities. (wikipedia.org)
  • patients
  • After excluding those who reported their pain as zero, the researchers divided the remaining patients into three groups depending on their pain score. (drugs.com)
  • Meanwhile 46 percent of the patients were considered to have moderate pain. (drugs.com)
  • Postoperative pain control is an important concern for both patients and surgeons. (bmj.com)
  • research
  • To receive news and publication updates for Pain Research and Management, enter your email address in the box below. (hindawi.com)
  • muscles
  • Delayed onset muscle soreness (DOMS) is the pain and stiffness felt in muscles several hours to days after unaccustomed or strenuous exercise. (wikipedia.org)
  • different
  • As individuals appear to have differing genetic susceptibilities to pain, future studies should be directed toward understanding whether responsiveness to different classes of analgesics is also genetically determined", Woods said. (aarogya.com)
  • often
  • The soreness is perceived as a dull, aching pain in the affected muscle, often combined with tenderness and stiffness. (wikipedia.org)
  • effectively
  • A method of effectively treating pain in humans is achieved by administering buprenorphine in accordance with first order kinetics over an initial three-day. (patents.com)
  • several
  • 3 A systematic review and several recent clinical trials 4-8 suggest that perioperative acupuncture may be a useful adjunct to standard postoperative pain management. (bmj.com)
  • Therapy
  • 1 2 Acupuncture therapy has been lauded as a promising alternative approach for postoperative pain relief. (bmj.com)
  • nerves
  • If the duration of the DPP is relatively short, i.e. much less than 100 μs, then the threshold of excitation for the surrounding nerves will be decreased as opposed to increased. (wikipedia.org)
  • studies
  • Additionally, lactic acid is known from multiple studies to return to normal levels within one hour of exercise, and therefore cannot cause the pain that occurs much later. (wikipedia.org)