OrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and Equipment
StreptozocinDiabetes Mellitus, ExperimentalIslets of Langerhans TransplantationDiabetic NeuropathiesRats, Sprague-DawleyFluorouracilBlood GlucoseRats, WistarAntineoplastic Combined Chemotherapy ProtocolsInsulin
DiabetesZanosarRatsMiceChemotherapyPowderInjectionTreatmentSupervisionDrugSymptomsFoundCompleteTimeMakeClassTypeChemicalHealthcareFullPublisherZANOSARAntineoplastic agentCarboplatinDiabetesEXPERIMENTALIslet cellIsletsRenalSeverePatientsResultsDamageTherapySolutionTreatCurrentEffectsBetaListArticleReview
Diabetes2
  • The objective of this study is to induce experimental diabetes mellitus using Streptozocin -nicotinamide in normal Albino wistar rats and study the antidiabetic activity of polyherbal formulation by comparison of changes in body weight and levels of glucose between normal and diabetic rats. (ijpsr.com)
  • Recovery of Ang II and TNF-α in renal interstitial fluid (RIF) was measured in conscious rats before and weekly for 12 wk after induction of diabetes with streptozocin and in response to oral valsartan (10 mg/kg·d). (psu.edu)
Zanosar1
  • STZ may refer to: Snowbird Tectonic Zone, a geological boundary in the Canadian Shield Stalingrad Tractor Factory (Russian: Stalingradskiy traktornyy zavod), now known as Volgograd Tractor Factory Stanozolol (STZ), an anabolic steroid Streptozotocin (streptozocin, STZ, Zanosar) is a naturally occurring chemical STZ, NYSE ticker symbol for Constellation Brands STZ TV, a Brazilian TV station This disambiguation page lists articles associated with the title STZ. (wikipedia.org)
Rats2
  • The effect of alcoholic extract of poly herbal preparation containing leaves of Gymnema sylvestre , fruits of Momordica charantia , rhizomes of Curcuma longa , seeds of Eugenia jambolana and fruits of Embilica officinalis was investigated in normal, glucose load conditions and streptozocin -nicotinamide induced diabetic rats. (ijpsr.com)
  • View cart "Saponin Fraction of Gongronema latifolium Reverses Dyslipidemia and Catalyzes Glucokinase in Lowering Blood Glucose Sugar in Streptozocin-Induced Diabetic Rats by G. O. Igile(1), I. A. Iwara(1), O. O. Ekpe(1), B. I. A. Mgbeje(1) and M. U. Eteng(1)" has been added to your cart. (afrithings.net)
Mice1
  • In streptozocin-induced type I diabetic mice and genetically obese type II diabetic ob/ob mice, hyperglycemia increased histone acetylation status on the CYP7A1 gene promoter, leading to elevated basal Cyp7a1 expression and an enlarged bile acid pool with altered bile acid composition. (omeka.net)
Chemotherapy4
  • Streptozocin should be given only under the supervision of a doctor with experience in the use of chemotherapy medications. (medlineplus.gov)
  • Streptozocin-Based Chemotherapy in Patients with Advanced Neuroendocrine Neoplasms--Predictive and Prognostic Markers for Treatment Stratification. (cancerindex.org)
  • Chemotherapy with streptozocin (STZ) in combination with 5-FU or doxorubicin (Dox) represents a standard of care for patients with metastatic pancreatic neuroendocrine neoplasms (pNEN). (cancerindex.org)
  • Streptozocin chemotherapy for advanced/metastatic well-differentiated neuroendocrine tumors: an analysis of a multi-center survey in Japan. (cancerindex.org)
Powder2
  • Streptozocin comes as a powder to be mixed with liquid and given intravenously (into a vein) by a doctor or nurse in a medical facility. (medlineplus.gov)
  • Streptozocin sterile powder should be administered intravenously by rapid injection or short/prolonged infusion. (wikidoc.org)
Injection3
Treatment6
  • Tell your doctor and pharmacist about all the medications you are taking so they can check whether any of your medications may increase the risk that you will develop kidney problems during your treatment with streptozocin. (medlineplus.gov)
  • Your doctor will order certain tests before, during, and after your treatment to check your body's response to streptozocin. (medlineplus.gov)
  • The length of treatment depends on how well your body responds to treatment with streptozocin. (medlineplus.gov)
  • You should not become pregnant or breast-feed during your treatment with streptozocin. (medlineplus.gov)
  • The physician must judge the possible benefit to the patient against the known toxic effects of this drug in considering the advisability of therapy with Streptozocin The physician should be familiar with the following text before making a judgment and beginning treatment. (wikidoc.org)
  • Streptozocin is an alkylating agent , antineoplastic agent and nitrosourea that is FDA approved for the treatment of metastatic islet cell carcinoma of the pancreas . (wikidoc.org)
Supervision1
  • Streptozocin should be administered under the supervision of a physician experienced in the use of cancer chemotherapeutic agents. (wikidoc.org)
Drug2
  • The educational content on WikiDoc drug pages is based upon the FDA package insert, National Library of Medicine content and practice guidelines / consensus statements. (wikidoc.org)
  • Information about the drug weight is presented on page 13. (cdc.gov)
Symptoms1
  • Symptoms of pancreatic cancer include jaundice (yellowing of the eyes and skin), belly or back pain, unintended weight loss, poor appetite, nausea and vomiting, enlarged gallbladder or liver, deep vein thrombosis or DVT (blood clots in a large vein This page lists the symptoms of pancreatic cancer, and explains what to do if you are worried about any of these symptoms. (web.app)
Found2
Complete1
  • The Complete Research Material is averagely 52 pages long and it is in Ms Word Format , it has 1-5 Chapters . (codemint.net)
Time2
  • The total storage time for streptozocin after it has been placed in solution should not exceed 12 hours. (wikidoc.org)
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Make2
  • you should know that streptozocin may make you drowsy or confused. (medlineplus.gov)
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Class1
  • Streptozocin is in a class of medications called alkylating agents. (medlineplus.gov)
Type1
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Chemical1
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Healthcare1
  • Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. (drugs.com)
Full1
  • As a page, heptocytes were less line to foods and books in the sensitive men and errors and connected to methodology with site-wide leaders, wild as full energy and honey story. (sound-solutions-inc.com)
Publisher1
  • 1790) about women, pdf learning scikit learn machine learning and publisher - Page 7. (mmeade.com)
ZANOSAR2
  • Streptozocin is available as a powder for reconstitution in 1 gram vials under the brand name Zanosar. (nih.gov)
  • STZ may refer to: Snowbird Tectonic Zone, a geological boundary in the Canadian Shield Stalingrad Tractor Factory (Russian: Stalingradskiy traktornyy zavod), now known as Volgograd Tractor Factory Stanozolol (STZ), an anabolic steroid Streptozotocin (streptozocin, STZ, Zanosar) is a naturally occurring chemical STZ, NYSE ticker symbol for Constellation Brands STZ TV, a Brazilian TV station This disambiguation page lists articles associated with the title STZ. (wikipedia.org)
Antineoplastic agent2
  • Streptozocin is a unique antineoplastic agent used to treat metastatic pancreatic islet cell carcinoma. (nih.gov)
  • Streptozocin is an alkylating agent , antineoplastic agent and nitrosourea that is FDA approved for the treatment of metastatic islet cell carcinoma of the pancreas . (wikidoc.org)
Carboplatin1
  • When at its onset by increments of mg m daunorubicin doxorubicin liposomal doxorubicin floxuridine epirubicin oxaliplatin idarubicin topotecan mitomycin irritants mitoxantrone bortezomib chlormethine mustine viagra u do need prescription buy carboplatin streptozocin irinotecan treosulfan mesna undiluted vinblastine teniposide vincristine neutrals vindesine asparaginase vinorelbine bleomycin inammatory agents cladribine aldesleukin cyclophosphamide etoposide phosphate cytarabine fluorouracil fludarabine methotrexate gemcitabine pemetrexed ifosfamide raltitrexed interferons mesna diluted interleukin pentostatin thiotepa trastuzumab classication as vesicant or irritant. (familytreecounseling.com)
Diabetes4
  • In animal models, streptozocin caused loss of pancreatic islet cells, resulting in a decrease in serum insulin and diabetes. (nih.gov)
  • Used initially as a means of creating an animal model of type 1 diabetes, streptozocin was later used clinically to treat insulin-secreting islet cell tumors. (nih.gov)
  • We found that the development of streptozocin (STZ)-induced DR, but not the STZ-induced hyperglycemia/diabetes itself, was significantly attenuated in PrPc-KO mice, compared to control wildtype (WT) mice, evident by measurement of retinal vascular leakage, retinal neovascularization, a retinopathy score and visual acuity assessment. (deepdyve.com)
  • We will induce diabetes in mice using streptozocin STZ and then transplant islets under the renal capsule, which is a well-established technique for islet transplantation in small animal models. (mordomas.com)
EXPERIMENTAL1
Islet cell1
  • In contrast, there have been no individual published case reports of self-limited clinically apparent liver injury attributed to streptozocin, but it has had limited use, as pancreatic islet cell carcinoma and neuroendocrine tumors are rare. (nih.gov)
Islets1
  • Streptozocin has high affinity for the cell surface glucose transporter GLUT 2 which is highly expressed on beta cells of the islets of Langerhans. (nih.gov)
Renal2
  • Hepatotoxicity is more common with daily dosing and high doses of streptozocin, but with higher doses renal and hematologic toxicities usually overshadow hepatic injury. (nih.gov)
  • Like the renal and bone marrow toxicity, the hepatic injury from streptozocin is likely due to a direct effect of the alkylating agent and its limited uptake by hepatocytes. (nih.gov)
Severe3
  • Streptozocin may cause severe or life-threatening kidney problems. (medlineplus.gov)
  • Streptozocin can cause a severe decrease in the number of blood cells in your bone marrow. (medlineplus.gov)
  • Streptozocin has been associated with a high rate of serum enzyme elevation during therapy and to rare instances of severe, clinically apparent acute liver injury. (nih.gov)
Patients1
  • There have been two reports of rapidly progressive and fatal acute liver failure in patients treated with streptozocin. (nih.gov)
Results2
  • Why is DailyMed no longer displaying pill images on the Search Results and Drug Info pages? (nih.gov)
  • It believed selected not 1405 - 1410 by an good online BD Chaurasia's Human Anatomy, and writes able results of the Chinese information of streptozocin-induced decade economist with OK pull and experience. (sound-solutions-inc.com)
Damage1
  • Structurally, streptozocin is a methylnitrosourea attached to a single molecule of glucosamine and acts as an alkylating agent causing DNA damage and interfering with synthesis. (nih.gov)
Therapy2
  • Common side effects of streptozocin therapy are nausea, vomiting, diarrhea, abdominal discomfort and local infusion site reactions. (nih.gov)
  • The ideal duration of maintenance therapy with Streptozocin has not yet been clearly established for either of the above schedules. (wikidoc.org)
Solution2
  • The resulting pale-gold solution will contain 100 mg of streptozocin and 22 mg of citric acid per mL. (wikidoc.org)
  • The total storage time for streptozocin after it has been placed in solution should not exceed 12 hours. (wikidoc.org)
Treat1
  • Streptozocin is used to treat cancer of the pancreas that has gotten worse or spread to other parts of the body. (medlineplus.gov)
Current1
  • Much of the current information on this page has been automatically compiled from Pubmed. (wikigenes.org)
Effects1
  • Substance intoxication or withdrawal effects with reduced cortisol suppression using the following pages describe the organ responsible for designing the leaet should be noted. (familytreecounseling.com)
Beta1
List1
  • Many other medications may also interact with streptozocin, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. (medlineplus.gov)
Article1
Review1
  • There is no review for this product at the moment, but you can be the first to add or you can read more in Testimonials Page about related products. (supremegenerics.com)