AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesHealth Care
Fetal HypoxiaElasmobranchiiCardiotocographyAnoxiaRespiratory TransportCell HypoxiaPregnancyFetal Growth RetardationOxygenFetusAltitudeMedulloblastomaCerebellar NeoplasmsBrain NeoplasmsGlioblastomaGlioma
Explaining hypoxia-inducedHemoglobinAcuteIschemiaTumorMaternalVasaGestationalSaturationObstructive pulmonary diseaseNeovascularizationDemiseSevereFetusesMarkedlyUltrasoundPlacentalOccursMetabolicHemolytic anemiaIntravenousMolecularInducesPulmonaryIncreased oxygen deliveryVascularLungTissuesInitiallyAnemiaHypoxic conditionsInfantsTranscription factorsComplicationsMechanismCardiovascularCarbonGrowthPediatricTissuePartial pressure of oxygenOccurBloodDeprivationChemotherapyAdverseAdaptationCommonlyPatients with chronicTensionCellularNeonatesAdultGenesProliferationSupplementation
Explaining hypoxia-induced1
  • Together our results demonstrate a new mechanism explaining hypoxia-induced resistance involving the alteration of the response to DSB in D283-MED cells, but also highlight the cell type to cell type diversity and the necessity to take into account the differing tumour genetic make-up when considering re-sensitisation therapeutic protocols. (biomedcentral.com)
Hemoglobin9
  • The protein hemoglobin, found in red blood cells, is responsible for oxygen delivery. (medscape.com)
  • Anemia, decreased hemoglobin oxygen saturation, decreased oxygen release from hemoglobin, and reduced oxygen delivery can all be sensed in the kidney and lead to the increased production of Epo. (medscape.com)
  • Aniline converts the Fe+2 in hemoglobin to Fe+3 which impairs its oxygen transport capacity. (cdc.gov)
  • However, the major stimulus for EPO production is decreased oxygen delivery due to decreased RBC mass or decreased oxygen saturation of hemoglobin. (medscape.com)
  • Carbon monoxide binds to hemoglobin, which has a 210-fold greater affinity for carbon monoxide than for oxygen. (medscape.com)
  • [ 7 ] This binding results in a left-shift of the oxygen-hemoglobin dissociation curve, leading to tissue hypoxia. (medscape.com)
  • The decrease in the total amount of healthy red blood cells causes lower oxygen levels in your blood than usual, as hemoglobin, the protein inside RBCs, is responsible for carrying oxygen throughout your body. (nuvovivo.com)
  • Your body requires iron to produce enough hemoglobin, the protein in red blood cells that transports oxygen from lungs to organs. (nuvovivo.com)
  • Hydroxyurea is used to help increase the level of fetal hemoglobin (HbF) which results in decreased pain and other complications. (academicfinest.com)
Acute7
  • Aniline has a characteristic aromatic or fishy odor which provides adequate warning of acute exposure. (cdc.gov)
  • [ 3 ] According to the Centers for Disease Control and Prevention (CDC), excessive alcohol consumption contributed to over 87,000 adult deaths in the United States from 2006 to 2010, with 44% due to chronic conditions and 56% due to acute conditions. (medscape.com)
  • We applied a range of molecular and cellular techniques to measure cell survival, cell cycle progression, protein expression and DNA damage combined with a transcriptomic micro-array approach in D283-MED cells, for global gene expression analysis in acute and chronic hypoxic conditions. (biomedcentral.com)
  • In D283-MED and U87MG, chronic hypoxia (5 days), but not acute hypoxia (24 h) induced resistance to chemotherapy and X-ray irradiation. (biomedcentral.com)
  • This report describes the role of neuroprotection in acute disorders such as stroke and injuries of the nervous system as well as in chronic diseases such as neurodegenerative disorders because many of the underlying mechanisms of damage to neural tissues are similar in all these conditions and several products are used in more than one disorder. (researchandmarkets.com)
  • Renal inflammatory diseases range from mild to severe, acute to chronic and may be associated with predisposing risk factors like diabetes mellitus, human immunodeficiency virus (HIV), leukemia, vesico- ureteric reflux and staghorn calculi. (egyptianjournal.xyz)
  • T he 1986 National Research Council (NRC) report on commercial airliner cabin air quality notes that information regarding the environmental characteristics (e.g., relative humidity and air pressure) and contaminants identified in surveys of airline cabin air "suggests a diverse set of adverse health effects that could arise from exposure to the cabin environment-from acute effects…to long-term effects. (nationalacademies.org)
Ischemia3
  • Insufficient delivery of oxygen and destruction of red blood cells may cause cardiopulmonary complaints with the development of ischemia, arrhythmia and shock. (cdc.gov)
  • In the early stage of ischemia and hypoxia, cells will increase the energy supply to the ischemic area, especially the functional area of the ischemic penumbra, by regulating glycolysis. (ijpsonline.com)
  • Autophagy is a process that relies on lysosomal pathways for the degradation of cytoplasmic proteins and organelles and plays an important role in the pathology of brain injury such as hypoxia ischemia[ 3 ]. (ijpsonline.com)
Tumor2
  • Hypoxia is an important micro-environmental factor in promoting tumor progression. (spandidos-publications.com)
  • Although aerobic glycolysis and anaerobic glycolysis are similar in that lactic acid is produced under both situations, aerobic glycolysis can arise in tumor cells from damaged respiration whereas anaerobic glycolysis arises from the absence of oxygen. (plantbasedacademy.com)
Maternal4
  • Diabetes mellitus Maternal age less than 20 years or over the age of 35 Multiple pregnancies Chronic high blood pressure Being underweight or obese Also, chronic renal disease, collagen vascular disease, thrombophilia, and cardiovascular disease increase the risk of developing placental disease. (wikipedia.org)
  • This leads to decrease oxygen carried past the maternal villi into the intervillus space. (wikipedia.org)
  • In turn, chronic fetal hypoxaemia promotes oxidative stress, and maternal antioxidant therapy in animal models of hypoxic pregnancy has proven to be protective with regards to fetal growth and cardiovascula. (researchgate.net)
  • In this respect, several animal research indicated that prenatal exposure to maternal beneath nutrition leads to the development of diet-induced obesity, hyperleptinemia, hyperinsulinism, and hypertension inside the rat offspring [41]. (esiservizi.com)
Vasa2
  • Abruptio placentae Placenta accreta Placenta increta Placenta percreta Placentitis Villitis of unknown etiology TORCH infections Circumvallate placenta Placental villous immaturity Placenta previa Vasa previa Fetal thrombotic vasculopathy Hypertrophic decidual vasculopathy Chorangiosis Chorangioma Placental infarction Trophoblastic neoplasms derive from trophoblastic tissue. (wikipedia.org)
  • These can be loosely defined as peripartum in nature, such as placental abruption, vasa praevia (a condition where fetal blood vessels cross the external orifice of the uterus and often rupture), or a hypoxic-ischemic event at birth ( 2 , 3 ). (frontiersin.org)
Gestational2
  • Gestational hypoxia is a major contributor to fetal growth restriction (FGR) and perinatal morbidity and mortality and has been closely linked to the activation of the unfolded protein response (UPR) in the placenta. (researchgate.net)
  • The severity of ROP was associated with earlier gestational age, lower birth weight, and oxygen supplementation. (hindawi.com)
Saturation1
  • Preductal and postductal oxygen saturation measurements via pulse oximetry will often show a 10% or higher gradient difference, which is dependent on the magnitude of left-to-right shunting at the foramen ovale (with preductual saturations being higher). (medscape.com)
Obstructive pulmonary disease1
  • I believe understanding nutritional interventions to attenuate loss of lean body mass at altitude may have future application to muscle wasting associated with subcaloric diets and disease states such as chronic obstructive pulmonary disease and cancer cachexia. (utah.edu)
Neovascularization1
  • In this study, we investigated the role of hypoxia induced SIRT1 in choroidal neovascularization in relation to age-related macular degeneration. (molvis.org)
Demise1
  • However, porcine reproductive and respiratory syndrome virus, an animal virus related to coronaviruses, is commonly associated with early fetal demise in pigs ( 7 ). (cdc.gov)
Severe3
  • EPO production has been observed to increase as much as 1000-fold in severe hypoxia. (medscape.com)
  • Treatment with SPRYCEL is associated with severe (NCI CTCAE Grade 3/4) thrombocytopenia, neutropenia, and anemia, which occur earlier and more frequently in patients with advanced phase CML or Ph+ ALL than in patients with chronic phase CML. (sprycel-hcp.com)
  • While the genetic factor influences the severity of the disease, there are also important environmental factors that patients and families should be mindful of such as weather, air quality and pollutants, severe cold or high temperatures, high altitudes and low oxygen levels all can contribute to exacerbation of SCD (Eckdahl, 2017). (academicfinest.com)
Fetuses4
  • Leptin gene the truth is is very sensitive to oxygen abundance and IUGR fetuses, exhibiting extreme distress and having considerably greater leptin concentrations per kilogram of weight [46, 48, 49]. (esiservizi.com)
  • Some investigators documented a reduced fetal IL-6 and TNF levels in growth restricted fetuses [51, 52], possibly resulting from impaired placental insufficiency. (esiservizi.com)
  • Alternatively, an upregulation of IL-6 and TNF in IUGR fetuses may be secondary to hypoxia and to survival mechanism, by inducing muscle insulin resistance and enabling glucose to be spared for brain metabolism [10, 53]. (esiservizi.com)
  • In IUGR mothers this finding may well reflect the state of inflammation and chronic tension, expressed also by high levels of CRP, not found amongst IUGR, SGA, and AGA fetuses. (esiservizi.com)
Markedly2
  • Our understanding of fetal cardiovascular physiology has markedly increased in the last 50 years, with the introduction of suitable animal models. (researchgate.net)
  • This compound markedly decreased the hypoxia-induced accumulation of HIF-1α protein dose-dependently, whereas it did not affect the expressions of HIF-1β and topoisomerase-I (topo‑I). Furthermore, celastrol prevented hypoxia-induced expression of HIF-1 target genes for vascular endothelial growth factor (VEGF) and erythropoietin (EPO). (spandidos-publications.com)
Ultrasound2
  • Placental Disease can be diagnosed through technologies such as, Prenatal ultrasound evaluation and invasive foetal testing. (wikipedia.org)
  • A fetal ultrasound performed at this time was reportedly normal. (cdc.gov)
Placental3
  • Risk factors such as diabetes, chronic blood pressure and multiple pregnancies can increase the risk of developing placental disease. (wikipedia.org)
  • Also, exposure to sudden trauma can increase the risk of placental abruption which coincides with placental disease. (wikipedia.org)
  • The abnormal spiral arteries lead decreased level of oxygen diffusion through the placental villus, which cause chronic hypoxia. (wikipedia.org)
Occurs3
  • This process initially occurs in fetal liver cells and subsequently takes place in the bone marrow of children and adults. (medscape.com)
  • Erythropoiesis initially occurs in fetal hepatocytes, subsequently occurring in the bone marrow of children and adults. (medscape.com)
  • Exposure to carbon monoxide commonly occurs through inadequate ventilation of heating sources, including house/building fires, grilling indoors, motor vehicle exhausts, as well as through occupational hazards, including mining. (medscape.com)
Metabolic1
  • Among these transcription factors, hypoxia-inducible factor-1 (HIF-1) is one of the most important factors that play a critical role in controlling oxygen delivery and metabolic adaptation to hypoxic conditions. (spandidos-publications.com)
Hemolytic anemia2
  • Sickle cell disease is an inherited autosomal recessive disorder and chronic hemolytic anemia and that causes spleen dysfunction, heart issues, vision impairment, and most commonly intense pain and swelling to the extremities (Mkombachepa et al. (academicfinest.com)
  • SCD is suggested by the typical clinical picture of chronic hemolytic anemia and vaso-occlusive crisis. (medscape.com)
Intravenous2
  • and alanine aminotransferase of 42 U/L (normal range 10-40 U/L). She was given supplemental oxygen for hypoxia and intravenous azithromycin and ampicillin to treat typical and atypical respiratory pathogens associated with community-acquired pneumonia. (cdc.gov)
  • Should a patient need to be hospitalized, usual treatment includes oxygen therapy, intravenous fluids and opioids such as morphine or dilaudid to relieve pain (Eckdahl, 2017). (academicfinest.com)
Molecular1
  • In this review, we discuss the consequences of hypoxia, as well as the molecular and physiological processes that occur in subjects exposed to HBOT. (mdpi.com)
Induces2
  • Aniline induces methemoglobinemia, which impairs the delivery of oxygen to tissues. (cdc.gov)
  • Our study results demonstrate that hypoxia mimetic cobalt chloride induces SIRT1 and augments HIF-2α, which activates and releases VEGF. (molvis.org)
Pulmonary1
  • Ventilation/perfusion studies have shown no clinically significant effects on pulmonary gas exchange or arterial oxygen tension. (theodora.com)
Increased oxygen delivery1
  • Erythropoiesis is carefully regulated with negative feedback inhibition from increased oxygen delivery, which down-regulates Epo production. (medscape.com)
Vascular1
  • Activated SIRT1 signals hypoxia inducible factor (HIF)-2α, which transactivates vascular endothelial growth factor (VEGF) and erythropoietin. (molvis.org)
Lung2
  • Antenatal glucocorticoids accelerate fetal lung maturation and reduce mortality in preterm babies but can trigger adverse effects on the cardiovascular system. (researchgate.net)
  • and (v) the role of hypoxia-inducible factor-1 in lung development. (stanford.edu)
Tissues1
  • The human body physiology changes in low oxygen pressure environments so that the blood can deliver enough oxygen to body tissues to maintain life. (visionlearning.com)
Initially1
  • ROP was initially associated with premature birth and shortly after with oxygen treatment. (hindawi.com)
Anemia2
  • This below-normal blood oxygen level is the major cause of many of the debilitating symptoms of anemia. (nuvovivo.com)
  • In October 2022 , Akebia submitted a Formal Dispute Resolution Request (FDRR) with the U.S. Food & Drug Administration (FDA) regarding the Complete Response Letter (CRL) received in March 2022 for vadadustat, which was under review as a treatment for anemia due to chronic kidney disease (CKD). (akebia.com)
Hypoxic conditions2
  • Whilst U87MG shared the same dampened p53 activity, upon chemotherapeutic drug treatment in chronic hypoxic conditions, these cells used a different mechanism, independent of the DNA damage pathway. (biomedcentral.com)
  • Exposure to a variety of growth factors has also been shown to increase HIF-1 activity in normoxic and hypoxic conditions. (spandidos-publications.com)
Infants1
  • Chronic fetal hypoxaemia is a common pregnancy complication that increases the risk of infants experiencing respiratory complications at birth. (researchgate.net)
Transcription factors1
Complications1
  • The unpredictable nature of the many obstetric complications that contribute to intrapartum asphyxia, in addition to the multi-organ damage associated with intrapartum oxygen deprivation ( 11 ), presents a unique set of challenges to clinical and research professionals in their endeavor to implement effective treatments for intrapartum asphyxia. (frontiersin.org)
Mechanism1
  • The goal of this study was to explore the regulatory mechanism of trehalose on the autophagy death of SHSY5Y cells induced by oxygen and sugar deprivation from the aspect of glycolysis. (ijpsonline.com)
Cardiovascular1
  • Developmental hypoxia has profound and persistent effects on the vertebrate cardiovascular system, but the nature, magnitude and long-term outcome of the hypoxic consequences are species-specific. (researchgate.net)
Carbon2
  • [ 2 ] No data were reported for carbon disulfide and N-hexane exposures. (medscape.com)
  • Arterial blood gas levels (through an indwelling line [eg, umbilical arterial catheter or preductal peripheral arterial line]): To assess the pH, partial pressure of carbon dioxide (PaCO 2 ) and the partial pressure of oxygen (PaO 2 ) which might be higher in the preductal arterial line. (medscape.com)
Growth1
  • The former include hypoxia, high lactate levels or the abundance of growth factors within the cellular microenvironment. (springer.com)
Pediatric2
  • [ 3 ] In dentistry, it is commonly used as a single agent (with oxygen) for partial sedation, most commonly in pediatric dental populations. (medscape.com)
  • In pediatric patients with chronic phase CML, cases of Grade 1 or 2 fluid retention were reported in 10.3% of patients. (sprycel-hcp.com)
Tissue2
  • This treatment is used to hasten tissue recovery and improve its physiological aspects, by providing an increased supply of oxygen to the damaged tissue. (mdpi.com)
  • The inversely correlation between fetal AL ratio and aIMT might represents a hyperlink between endocrine function of adipose tissue and endothelial damage. (esiservizi.com)
Partial pressure of oxygen1
  • Among the many plausible explanations of the complaints are the flight environment (e.g., partial pressure of oxygen (PO 2 ) and relative humidity), chemical or biological contaminants, psychological and physiological stressors, and exacerbation of pre-existing medical conditions. (nationalacademies.org)
Occur2
  • Rather, all the topics tie into one particular medical condition: chronic mountain sickness (CMS), which can occur in people spending long periods of time at altitudes higher than 2,500 meters, and affects more than 15 percent of people who live higher than 3,200 meters. (visionlearning.com)
  • Hypoxia (low oxygen availability) can occur in physiologica. (uc.edu)
Blood2
  • IUGR ovine models showed that leptin levels are inversely associated with uterine blood flow and fetalplacental weight, suggesting that fetal leptin may be involved in an adaptive response [47]. (esiservizi.com)
  • Increased parasympathetic stimulation leading to hypoxia, this may require blood transfusions. (elastizell.com)
Deprivation3
  • This transient but potentially catastrophic deprivation of oxygen in the intrapartum period is thought to be directly responsible for 691,000 deaths and 1.02 million stillbirths each year, making it the fifth most common cause of childhood deaths under 5 years ( 5 - 7 ). (frontiersin.org)
  • Human SH-SY5Y cells were divided into three groups includes control group (control), model group (oxygen and sugar deprivation) and experimental group (oxygen and sugar deprivation+trehalose). (ijpsonline.com)
  • Trehalose can reduce the damage of SH-SY5Y cells caused by oxygen and sugar deprivation. (ijpsonline.com)
Chemotherapy1
  • This is called tumour hypoxia and leads to resistance to radiotherapy and chemotherapy. (biomedcentral.com)
Adverse1
  • The CDC Surveillance Coordination Group has established a steering committee that is charged with the development of a broad range of case definitions for noninfectious conditions (e.g., environmental or occupational conditions, chronic diseases, adverse reproductive health events, and injuries). (cdc.gov)
Adaptation1
  • 1. Role of ion channels in T cell response and adaptation to hypoxia. (uc.edu)
Commonly2
  • It is commonly delivered by a nasal mask in combination with oxygen. (medscape.com)
  • Less commonly, self-administered nitrous oxide is reported for chronic pain from terminal illness and pain associated with cancer treatment. (medscape.com)
Patients with chronic1
  • Adult patients with Chronic Lymphocytic Leukemia (CLL) ( 1.2 ). (drugs.com)
Tension1
Cellular2
  • Hypoxia-inducible factor-1 (HIF-1) is the central mediator of cellular responses to low oxygen and vital to many aspects of cancer biology. (spandidos-publications.com)
  • Hypoxia changes the cellular redox state and activates class III histone deacetylase sirtuin1 (SIRT1). (molvis.org)
Neonates1
  • Each year approximately four million neonates become seriously deprived of oxygen (O 2 ) during birth ( 1 ). (frontiersin.org)
Adult2
  • In adult patients with newly diagnosed or imatinib-resistant or -intolerant chronic phase CML, grade 3/4 fluid retention occurred in 6% of patients treated with SPRYCEL at the recommended dose (n=548). (sprycel-hcp.com)
  • To investigate whether exposure to atomic bomb radiation altered the prevalence of hepatitis C virus (HCV) infection or accelerated the progress toward chronic hepatitis after HCV infection, the seropositivity of antibody to hepatitis C virus (anti-HCV) was determined for 6,121 participants in the Adult Health Study of atomic bomb survivors in Hiroshima and Nagasaki. (bioone.org)
Genes1
  • Using transcriptomic analysis in D283-MED cells, we found a large transcriptional remodelling upon long term hypoxia, in particular the expression of a number of genes involved in detection and repair of double strand breaks (DSB) was altered. (biomedcentral.com)
Proliferation1
  • Hypoxia and genetic defects that chronically drive proliferation leave such tumors dependent on a steady supply of nutrients, especially glucose. (springer.com)
Supplementation1
  • 2013) Effect of leucine supplementation on fat free mass with prolonged hypoxic exposure during a 13-day trek to Everest Base Camp: A double-blind randomized study. (utah.edu)