MilbemycinAmine oximeCompoundsExposed to phosgene oximePhosgene oxime exposureBenzaldehyde oximeColorlessUrticant or nettle agentOdorHydroxylamineExposurePyridiniumReactivateAtropineHydroxylaminesVaporSynthesisReactivationInhibitionAChEPoorlySubstancesCommonlyHivesChloridePenetrateRR'CIntenseBasicsChemical warfareFunctionalSulfur mustardProductsSolelyDerivativesAnnuallySkinFoundPropertiesResultReportProductGroups
Milbemycin33
- Interceptor ® is a monthly medication for the prevention of heartworms in dogs and cats , containing the active ingredient milbemycin oxime. (petmd.com)
- Interceptor ® Plus contains two active ingredients, milbemycin oxime and praziquantel. (petmd.com)
- The main active ingredient in both Interceptor ® and Interceptor ® Plus is milbemycin oxime. (petmd.com)
- Panoramis (Spinosad/Milbemycin Oxime) functions as both a worm treatment for dogs and a flea control medicine. (unitedpharmacies.com)
- Milbemycin oxime exhibits anthelmintic properties. (unitedpharmacies.com)
- Panoramis (Spinosad/Milbemycin Oxime) chewable tablets are available in 4 different strengths. (unitedpharmacies.com)
- One variety contains 270mg of spinosad and 4.5mg of milbemycin oxime, and is used to treat dogs in the 4.6kg to 9kg weight range. (unitedpharmacies.com)
- Panoramis (Spinosad/Milbemycin Oxime) tablets are only to be given to animals. (unitedpharmacies.com)
- Interceptor Spectrum Tasty Brown (Milbemycin Oxime/Praziquantel) is a chewable medication used to control and prevent heartworm and intestinal worm infections in small dogs weighing less than four kilograms. (4nrx.md)
- Follow the instructions of your veterinarian while using Interceptor Spectrum Tasty Brown (Milbemycin Oxime/Praziquantel) to get the most effective results. (4nrx.md)
- What are the side effects of Interceptor Spectrum Tasty Brown (Milbemycin Oxime/Praziquantel)? (4nrx.md)
- Interceptor Spectrum Tasty Brown (Milbemycin Oxime/Praziquantel) will not typically cause any side effects when used correctly. (4nrx.md)
- Strictly follow all instructions provided to you by your veterinarian while using Interceptor Spectrum Tasty Brown (Milbemycin Oxime/Praziquantel). (4nrx.md)
- Each plastic tube contains 0.25 mL of Milbemite Otic Solution as a 0.1% solution of milbemycin oxime. (expressvet.pharmacy)
- Milbemycin oxime is a medication commonly used in veterinary medicine to prevent and treat various parasitic infections in dogs and cats. (79pets.com)
- In this blog post, we will explore the benefits of using milbemycin oxime in pet medicine and how it can help keep your furry friend healthy and happy. (79pets.com)
- How is Milbemycin Oxime given? (79pets.com)
- Milbemycin oxime is typically given to dogs and cats as an oral medication, either in the form of a chewable tablet or a liquid suspension. (79pets.com)
- Your veterinarian will give the correct milbemycin oxime dosage based on your pet's weight and the condition being treated. (79pets.com)
- Milbemycin oxime is generally considered safe when used as directed, but like any medication, it can have potential side effects and interactions. (79pets.com)
- Certain breeds of dogs may be more susceptible to side effects from milbemycin oxime, such as collies and other herding breeds. (79pets.com)
- These breeds are known to have a genetic mutation that affects the metabolism of certain medications, including milbemycin oxime. (79pets.com)
- If you have a collie or a herding breed, it's important to inform your veterinarian before giving your pet milbemycin oxime. (79pets.com)
- It's important to also inform your veterinarian of any other medications your pet is taking, as milbemycin oxime may interact with other drugs. (79pets.com)
- It's also important to note that pregnant, nursing or breeding animals should not be treated with milbemycin oxime, as it may cause harm to developing fetuses or newborns. (79pets.com)
- Is there anything that needs to monitor with Milbemycin Oxime? (79pets.com)
- There are a few things to keep in mind when monitoring your pet's use of milbemycin oxime. (79pets.com)
- Third, it's important to keep track of your pet's weight, as the dosage of milbemycin oxime is based on weight. (79pets.com)
- Fourth, it's essential to keep your pet on a monthly heartworm preventative, even if you are giving milbemycin oxime, as it may not protect against all types of worms. (79pets.com)
- Lastly, it's essential to have your pet tested for heartworm disease before starting treatment with milbemycin oxime and to have them tested annually to ensure that the medication works effectively. (79pets.com)
- The anthelmintic activity (destroying parasitic worms) of the active ingredient milbemycin oxime is believed to be a result of interfering with the invertebrates' neurotransmission. (1800petmeds.com)
- Credelio Plus (lotilaner and milbemycin oxime) is a medication prescribed by a licensed veterinarian to treat ticks and fleas PLUS worms (gastrointestinal and lung) PLUS prevent heartworm disease in dogs. (canadapharmacy.com)
- Lotilaner and milbemycin oxime are the active ingredients contained in Credelio Plus. (canadapharmacy.com)
Amine oxime2
- To evaluate the diagnostic value of technetium-99m d, l-hexamethylpropylene amine oxime (HMPAO) labelled leucocytes in combination with a 99mTc-methylene diphosphonate (MDP) bone scan in the detection of chronic osteomyelitis, we retrospectively reviewed 55 patients. (nih.gov)
- Two 99mTc-labeled single photon emission computed tomography (SPECT) cerebral blood flow tracers-ethylcysteinate dimer (ECD) and hexamethylpropylene amine oxime (HMPAO)-are commonly used in human medicine and have been used previously in dogs but intrasubject comparison of both tracers in dogs is lacking. (avmi.net)
Compounds4
- O-substituted oximes form a closely related family of compounds. (wikipedia.org)
- Oximes can also be obtained from reaction of nitrites such as isoamyl nitrite with compounds containing an acidic hydrogen atom. (wikipedia.org)
- Oxime compounds are used as antidotes for nerve agents. (wikipedia.org)
- Phosgene oxime in the air may also react with moisture in clouds or rain and be broken down into other compounds. (cdc.gov)
Exposed to phosgene oxime9
- How might I be exposed to phosgene oxime? (cdc.gov)
- There are no studies on the health effects of children exposed to phosgene oxime. (cdc.gov)
- It is likely that the health effects seen in children exposed to phosgene oxime would be similar to the effects seen in adults. (cdc.gov)
- Most families will not be exposed to phosgene oxime. (cdc.gov)
- Is there a medical test to show whether I've been exposed to phosgene oxime? (cdc.gov)
- There are no tests to positively determine whether you have been exposed to phosgene oxime. (cdc.gov)
- If you suspect that you may have been exposed to phosgene oxime, a chest X-ray may be the quickest way to determine if your lungs have been damaged. (cdc.gov)
- been exposed to phosgene oxime. (cdc.gov)
- Showing these signs or symptoms does not necessarily mean that a person has been exposed to phosgene oxime. (cdc.gov)
Phosgene oxime exposure1
Benzaldehyde oxime1
- Oxime extractants 3- tert -butyl-2-hydroxy-5-methyl benzaldehyde oxime ( HL 1 ) and 3- tert -butyl-2-hydroxy-5-methoxy benzaldehyde oxime ( HL 2 ) were synthesized and characterized by conventional spectroscopic methods. (analchemres.org)
Colorless2
- In general, oximes exist as colorless crystals or as thick liquids and are poorly soluble in water. (wikipedia.org)
- Phosgene oxime is colorless in its solid form and yellowish-brown when it is a liquid. (cdc.gov)
Urticant or nettle agent2
- Phosgene oxime is a type of agent called an urticant or nettle agent. (cdc.gov)
- Phosgene oxime (CX) is an urticant or nettle agent that causes a corrosive type of skin and tissue injury and may produce systemic effects. (medscape.com)
Odor2
- Phosgene oxime has a disagreeable, irritating odor. (cdc.gov)
- Lewisite may have a geranium-like odor, and phosgene oxime has been described simply as irritating. (msdmanuals.com)
Hydroxylamine3
- Oximes are usually generated by the reaction of hydroxylamine with aldehydes (R−CH=O) or ketones (RR'C=O). The term oxime dates back to the 19th century, a combination of the words oxygen and imine. (wikipedia.org)
- Oximes can be synthesized by condensation of an aldehyde or a ketone with hydroxylamine. (wikipedia.org)
- A series of eleven hydroxy and methoxy substituted new chalcone oximes ( 2a-2k ) were synthesized by the condensation of chalcone ( 1a-1k ) with hydroxylamine hydrochloride in pyridine. (acgpubs.org)
Exposure13
- Exposure to high levels of phosgene oxime vapors may cause severe lung damage, and even death. (cdc.gov)
- The effects of long-term exposure to phosgene oxime in humans are not known. (cdc.gov)
- We do not know if exposure to phosgene oxime might cause reproductive effects in humans. (cdc.gov)
- There is no information to determine whether exposure to phosgene oxime might cause cancer. (cdc.gov)
- We do not know if exposure to phosgene oxime would result in birth defects or other developmental effects in people and no information exist from animal studies. (cdc.gov)
- How can families reduce the risk of exposure to phosgene oxime? (cdc.gov)
- Inhaling or directly contacting significant amounts of We do not know if exposure to phosgene oxime would result phosgene oxime can result in death. (cdc.gov)
- People's risk for exposure depends on how close they are to the place where the phosgene oxime was released. (cdc.gov)
- The extent of poisoning that phosgene oxime causes depends on the amount of phosgene oxime to which a person is exposed, how the person is exposed, and the length of time of the exposure. (cdc.gov)
- Quickly moving to an area where fresh air is available is highly effective in reducing exposure to phosgene oxime. (cdc.gov)
- Dermal Exposure to Vesicating Nettle Agent Phosgene Oxime: Clinically Relevant Biomarkers and Skin Injury Progression in Murine Models. (medscape.com)
- Cutaneous exposure to vesicant phosgene oxime: Acute effects on the skin and systemic toxicity. (medscape.com)
- Pain occurring at or shortly after exposure suggests to first responders that Lewisite or phosgene oxime is the chemical agent involved. (msdmanuals.com)
Pyridinium3
- Our laboratory has developed novel substituted phenoxyalkyl pyridinium oximes (US Patent 9,227,937) designed to more effectively penetrate the central nervous system. (msstate.edu)
- These data indicate that the novel pyridinium oximes are equally efficacious reactivators in adult and juvenile rats of both sexes and enhance survivability against lethal-level OP toxicity as compared to 2-PAM in adult female rats. (msstate.edu)
- Garcia, Jason Michael, "Efficacy of Novel Pyridinium Oximes against Two Organophosphates in Female Sprague Dawley Rats" (2019). (msstate.edu)
Reactivate1
- Treatment against acute OP toxicity includes oximes which reactivate phosphorylated acetylcholinesterase (AChE) restoring enzymatic activity. (msstate.edu)
Atropine1
- After development of seizure-like behavior, atropine and one of four oximes, 2-PAM, novel oxime 15, 20, or 55 or Multisol vehicle was administered. (msstate.edu)
Hydroxylamines1
- The hydrolysis of oximes proceeds easily by heating in the presence of various inorganic acids, and the oximes decompose into the corresponding ketones or aldehydes, and hydroxylamines. (wikipedia.org)
Vapor1
- Phosgene oxime vapor is heavier than air, so it will settle in low-lying areas. (cdc.gov)
Synthesis1
- Proper functionalization of α-haloketoximes and a change of conditions also allowed the chemoselective synthesis of chromenone-oximes as well as rearranged isoxazoles. (organic-chemistry.org)
Reactivation6
- Present study evaluates reactivation potency of two newly developed oximes, K456 and K733, against paraoxon (POX)-inhibited human-RBC-AChE and human-plasma-BChE in comparison to reported reactivator, pralidoxime (2-PAM). (simulations-plus.com)
- This research investigated any differences in oxime reactivation among four age/sex groups and also survivability in adult female Sprague Dawley rats challenged with a lethal dose of OP. Initially in in vitro experiments, paraoxon (PXN) and a nerve agent (sarin) surrogate, 4-nitrophenyl isopropyl methylphosphonate (NIMP), were incubated with pooled rat brain homogenate from four sex/age groups: adult male or female, and 12-day old male or female rats. (msstate.edu)
- Reactivation was performed utilizing 2-PAM or one of three novel oximes (15, 20, or 55), alone or in combination, and AChE activity was measured in a spectrophotometric assay. (msstate.edu)
- Out of all the oximes tested, 2-PAM showed the greatest reactivation percentages. (msstate.edu)
- Of the novel oximes, 15 and 20 displayed the highest reactivation against PXN and NIMP, respectively. (msstate.edu)
- No statistical difference was detected in reactivation for any oxime among the age/sex groups. (msstate.edu)
Inhibition1
- Overall, the oximes were more effective reactivating inhibition from PXN than from NIMP. (msstate.edu)
AChE2
- In vitro studies showed higher intrinsic toxicities of both oximes than 2-PAM for AChE. (simulations-plus.com)
- However, the detailed interaction study revealed inability of oximes to interact with catalytic anionic site of AChE and hBChE in contrast to 2-PAM. (simulations-plus.com)
Substances1
- Phosgene oxime vapors are broken down in the atmosphere by reacting with substances commonly found in the air, but this is a very slow process. (cdc.gov)
Commonly1
- In the presence of sulfuric acid catalyst, the oxime undergoes the Beckmann rearrangement to give the cyclic amide caprolactam: Oximes are commonly used as ligands and sequestering agents for metal ions. (wikipedia.org)
Hives1
Chloride3
- Certain amidoximes react with benzenesulfonyl chloride to make substituted ureas in the Tiemann rearrangement: In their largest application, an oxime is an intermediate in the industrial production of caprolactam, a precursor to Nylon 6. (wikipedia.org)
- [ 11 ] Possible mechanisms of toxicity include necrotizing effects of the chloride component or a direct effect of the oxime or carbonyl groups. (medscape.com)
- A series of oxime ethers were prepared from (E, E)-cinnamaldoxime, crotonaldoxime, (syn)- benzaldoxime and p-methoxybenzaldoxime by reaction with methyl iodide, ethyl bromide and benzyl chloride with silver oxide as base and catalyst. (scholarsresearchlibrary.com)
Penetrate1
- Phosgene oxime can penetrate clothing and rubber faster than other chemical warfare agents. (cdc.gov)
RR'C1
- In organic chemistry, an oxime is an organic compound belonging to the imines, with the general formula RR'C=N−OH, where R is an organic side-chain and R' may be hydrogen, forming an aldoxime, or another organic group, forming a ketoxime. (wikipedia.org)
Intense2
- We felt the chemistry of the OXIME brand so intense that we developed the original One Page website into a company website with several tabs, an offer basket for easy inquiries and a CMS panel for adding news and products. (dotred.pl)
- Skin contact with phosgene oxime causes intense, stinging ("nettling") pain and whitening within 5 to 20 seconds. (msdmanuals.com)
Basics1
- Available at https://emergency.cdc.gov/agent/phosgene-oxime/basics/facts.asp . (medscape.com)
Chemical warfare5
- Phosgene oxime was developed as a chemical warfare agent. (cdc.gov)
- Phosgene oxime is a manufactured chemical that was developed as a potential chemical warfare agent, but its use on the battlefield has never been documented. (cdc.gov)
- Most of the phosgene oxime in developed as a potential chemical warfare agent, but its use soil will be broken down upon contact with moisture or be on the battlefield has never been documented. (cdc.gov)
- Phosgene oxime is a manufactured chemical warfare agent. (cdc.gov)
- Although phosgene oxime has been produced only as a chemical warfare agent, it has never been used during wartime. (cdc.gov)
Functional2
- Therefore, oxime formation can be used for the identification of ketone or aldehyde functional groups. (wikipedia.org)
- Identification of benzothiazinones containing an oxime functional moiety as new anti-tuberculosis agents. (bvsalud.org)
Sulfur mustard1
- Goswami DG, Agarwal R, Tewari-Singh N. Phosgene oxime: Injury and associated mechanisms compared to vesicating agents sulfur mustard and lewisite. (medscape.com)
Products2
Derivatives1
- In general, oximes can be changed to the corresponding amide derivatives by treatment with various acids. (wikipedia.org)
Annually1
- About half of the world's supply of cyclohexanone, more than a million tonnes annually, is converted to the oxime. (wikipedia.org)
Skin5
- Contact with gaseous, liquid, or solid phosgene oxime may result in severe skin or eye damage. (cdc.gov)
- Phosgene oxime is also referred to as a corrosive agent because of the type of skin and tissue damage it causes. (cdc.gov)
- If phosgene oxime gas is released into the air, people can be exposed through skin contact or eye contact. (cdc.gov)
- Phosgene oxime produces instant and almost unbearable pain on exposed skin and exposed eyes. (cdc.gov)
- Absorbing phosgene oxime through the skin or inhaling it may result in fluid in the lungs (pulmonary edema) with symptoms of shortness of breath and cough. (cdc.gov)
Found3
- Phosgene oxime has been found in at least 1 of the 1,585 National Priorities List sites identified by the Environmental Protection Agency (EPA). (cdc.gov)
- Phosgene oxime is not found naturally in the environment. (cdc.gov)
- OXIME Industries online store - chemical raw materials, detergents, disinfectants have found their place on the virtual shelves of oxime.pl/sklep! (dotred.pl)
Properties1
- Indirubin-3′-oxime (IOX) is known to possess anticancer properties by inhibiting cell proliferation of various human cancer cell lines. (phytojournal.com)
Result2
- The Ponzio reaction (1906) concerning the conversion of m-nitrobenzaldoxime to m-nitrophenyldinitromethane using dinitrogen tetroxide was the result of research into TNT analogues: In the Neber rearrangement certain oximes are converted to the corresponding alpha-amino ketones. (wikipedia.org)
- Inhaling or directly contacting significant amounts of phosgene oxime can result in death. (cdc.gov)
Report1
- Glyoxylic Acid Oxime Report by Material, Application, and Geography - Global Forecast to 2021 is a professional and in-depth research report on the world's major regional market conditions, focusing on the main regions (North America, Europe and Asia-Pacific) and the main countries (United States, Germany, united Kingdom, Japan, South Korea and China). (researchbeam.com)
Product1
- For the OXIME online store, we have also prepared product visualizations, product photos, product labels and full copywriting. (dotred.pl)
Groups1
- If the two side-chains on the central carbon are different from each other-either an aldoxime, or a ketoxime with two different "R" groups-the oxime can often have two different geometric stereoisomeric forms according to the E/Z configuration. (wikipedia.org)