ArteriesInflammation and oxidative stressMicrovascular oxidative stressEndothelialParenchymal arteriolesInflammatoryDysfunctionCerebralNitricOcclusionCutaneousMitochondrialPathwaysChronicEndotheliumMechanismNrf2NeurovascularActivationPathologyMiceCardiovascularRenalExposureResponsesDamageProliferationProgressionDeficiencyHarmDiseasesResultsResponseBrainConditionsWallBloodHighPatients
Arteries7
- A feature of endothelial dysfunction is the inability of arteries and arterioles to dilate fully in response to an appropriate stimulus, such as exogenous nitroglycerine, that stimulates release of vasodilators from the endothelium like NO. Endothelial dysfunction is commonly associated with decreased NO bioavailability, which is due to impaired NO production by the endothelium or inactivation of NO by reactive oxygen species. (wikipedia.org)
- Some of these have been implicated in perivascular adipose tissue-mediated, endothelial cell dysfunction in arteries and arterioles [12, 13]. (iah2010.org)
- Raynaud phenomenon (RP) was first described by Maurice Raynaud in 1862 and refers to a transient vasospasm of peripheral arteries and arterioles that classically results in triphasic color changes in the affected region. (medscape.com)
- The arteries and arterioles then dilate, causing rapid return of blood flow (red, reactive hyperemia). (medscape.com)
- the vasospasm that occurs in the digital arteries, precapillary arterioles, and cutaneous arteriovenous shunts involves both central and peripheral mechanisms. (medscape.com)
- Common characteristics of IHD are the obstruction or narrowing of arteries and arterioles resulted in inadequate supply of oxygenated blood for the myocardium [ 1 ]. (hindawi.com)
- Aging Exacerbates Pressure-Induced Mitochondrial Oxidative Stress in Mouse Cerebral Arteries. (ouhsc.edu)
Inflammation and oxidative stress4
- SM can trigger several molecular pathways involved in inflammation and oxidative stress, which cause cell necrosis and apoptosis, and loss of cells integrity and function. (ac.ir)
- Recent experimental studies reported the occurrence of lung inflammation and oxidative stress following acute and subacute exposure to WPS. (who.int)
- Here, we wanted to verify the extent of inflammation and oxidative stress in mice chronically-exposed to WPS and to evaluate, for the first time, its effect on alveolar injury and DNA damage and their association with impairment of lung function. (who.int)
- CONCLUSION: We show the persistence of lung inflammation and oxidative stress in mice chronically-exposed to WPS and demonstrate, for the first time, the occurrence of DNA damage and enlargement of alveolar spaces and ducts associated with impairment of lung function. (who.int)
Microvascular oxidative stress3
- Nanoparticle inhalation increases microvascular oxidative stress and compromises nitric oxide bioavailability. (cdc.gov)
- Nanoparticle exposure also increased microvascular oxidative stress by approximately 60%, and decreased NO production. (cdc.gov)
- In Aim 1, we will determine the effect of microvascular oxidative stress on neurovascular function in WT and 5xFAD mice. (uky.edu)
Endothelial5
- Evidence has been provided that activation of the vascular endothelial cells in the presence of the risk factors promotes oxidative stress and vascular inflammatory responses, leading to acceleration of atherosclerotic vascular disease. (frontiersin.org)
- Atherosclerosis Endothelial activation Nitric oxide endothelial nitric oxide synthase Prostacyclin Endothelium-derived relaxing factor Endothelin Integrin network Endothelial shear stress Sitia, S. (wikipedia.org)
- Caspase 3 subunits remained unchanged in all groups, and HSP70 was increased approximately twofold in endothelial layer of arterioles (p = 0.01).This study shows that taurine could reduce myocardial apoptotic nuclei and thus confer myocardial cytoprotection via stimulating myocardial HSP70 via HSF-1 and caspase 3-independent mechanisms. (austin.org.au)
- Hypoxia and ischemia are linked to oxidative stress, which can activate the oxidant-sensitive transient receptor potential ankyrin 1 (TRPA1) channel in cerebral artery endothelial cells, leading to vasodilation. (elifesciences.org)
- El-Remessy et al [ 10 ] recently reported that CBD prevented inflammatory and oxidative damage and preserved endothelial integrity in an experimental model of diabetic retinopathy. (biomedcentral.com)
Parenchymal arterioles3
- Parenchymal arterioles were monitored using videomicroscopy. (silverchair.com)
- Acetylcholine concentration-dependently dilated rat parenchymal arterioles, while S-methyl-L-thiocitrulline as well as N-nitro-L-arginine methyl ester completely abolished this response. (silverchair.com)
- Donepezil produces acute vasodilation induced by a selective activation of neuronal nitric oxide synthase in the cerebral parenchymal arterioles. (silverchair.com)
Inflammatory3
- Recent research provides emerging evidence supporting an essential role of increased activity of arginases including arginase-I and arginase-II in causing eNOS-uncoupling, which results in vascular oxidative stress and inflammatory responses, and ultimately leading to vascular diseases. (frontiersin.org)
- IB2 Type 2 diabetic patients also exhibit a range of vascular, oxidative stress and inflammatory changes [20] that may affect skin and neurovascular quality [21, 22]. (iah2010.org)
- One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
Dysfunction5
- These results indicate that in conjunction with microvascular dysfunction, nanoparticle exposure also increases local oxidative stress and decreases NO bioavailability. (cdc.gov)
- Here, we propose to use cutting edge physiology approaches combined with human postmortem brain specimens from our world class brain bank at the Sanders-Brown Center on Aging, to test the hypothesis that oxidative stress-indicated by NT incorporation into fibronectin- exacerbates cerebrovascular and synaptic dysfunction in the context of AD. (uky.edu)
- Age-associated vascular oxidative stress, Nrf2 dysfunction, and NF-{kappa}B activation in the nonhuman primate Macaca mulatta. (ouhsc.edu)
- Oxidative stress, mitochondrial dysfunction and, inflammation common events in skin of patients with Fibromyalgia. (fibromyalgiapodcast.com)
- The three finite responses that can cause the body to be dysfunctional are inflammation , oxidative stress , and vascular immune dysfunction. (pushasrx.com)
Cerebral1
- Photothrombosis of small cerebral arterioles revealed accumulation of fibronectin/NT colocalization at intravascular and nearby perivascular regions, similar to what we observe in human AD brain tissue. (uky.edu)
Nitric3
- Along with acting as a semi-permeable membrane, the endothelium is responsible for maintaining vascular tone and regulating oxidative stress by releasing mediators, such as nitric oxide, prostacyclin and endothelin, and controlling local angiotensin-II activity. (wikipedia.org)
- Nitric oxide (NO) suppresses platelet aggregation, inflammation, oxidative stress, vascular smooth muscle cell migration and proliferation, and leukocyte adhesion. (wikipedia.org)
- The purpose of this study was to identify alterations in the production of oxidative stress and endogenous nitric oxide (NO) after nanoparticle exposure, and determine the relative contribution of hemoproteins and oxidative enzymes in this process. (cdc.gov)
Occlusion3
- It leads to occlusion of distal pulmonary arterioles, with accompanying increase in pulmonary vascular resistance. (cincinnatichildrens.org)
- The major advantage of this novel vascular oxidative stress model is that vessel stalls, occlusion, and microhemorrhage can be followed in single capillaries in living mice, in real time, using multiphoton imaging. (uky.edu)
- Moreover, compared with the control group, adenine induced a significant increase in the number of circulating platelet and shortened the thrombotic occlusion time in pial arterioles and venules in vivo, and induced a significant reduction in the prothrombin time and activated partial thromboplastin time. (uaeu.ac.ae)
Cutaneous1
- Excessive peptidergic sensory innervation of cutaneous arteriole-venule shunts (AVS) in the palmar glabrous skin of fibromyalgia patients: Implications for widespread deep tissue pain and fatigue. (fibromyalgiapodcast.com)
Mitochondrial1
- Sirtuin-3 (SIRT3) performs a vital role in regulating metabolism, mitochondrial function, and oxidative stress. (mdpi.com)
Pathways1
- Oxidative stress is one of the predominant pathways underlying cardiovascular diseases due to air pollutants. (fourthfrontier.com)
Chronic3
- Mechanisms of pathogenesis of atherosclerosis are complex interplay between bloodstream cells and arterial wall components that leads to a chronic state of vascular oxidative stress and inflammation ( Hansson and Hermansson, 2011 ). (frontiersin.org)
- Chronic kidney disease (CKD) progression is associated with persisting oxidative stress, which impairs the NO-sGC-cGMP signaling cascade through the formation of oxidized and heme-free apo-sGC that cannot be activated by NO. Runcaciguat (BAY 1101042) is a novel, potent, and selective sGC activator that binds and activates oxidized and heme-free sGC and thereby restores NO-sGC-cGMP signaling under oxidative stress. (bvsalud.org)
- 19. Repine JE BA, Lankhorst I. Oxidative stress in chronic obstructive pulmonary disease. (ac.ir)
Endothelium1
- We have shown that pulmonary nanoparticle exposure impairs endothelium dependent dilation in systemic arterioles. (cdc.gov)
Mechanism1
- An alternative mechanism of these effects is metal chelation, which may reduce amyloid aggregation or oxidative neurotoxicity. (iospress.com)
Nrf21
- In conclusion, the administration of adenine in mice induced CKD-associated cardiac inflammation, oxidative stress, Nrf2 expression, and DNA damage. (uaeu.ac.ae)
Neurovascular1
- Using loss-of-function pericyte-deficient mice, here we show that pericyte degeneration diminishes global and individual capillary CBF responses to neuronal stimuli, resulting in neurovascular uncoupling, reduced oxygen supply to the brain and metabolic stress. (nature.com)
Activation1
- Four mechanisms associated with it are described, Glucotoxicity, non-enzymatic glycosylation, polyol pathway activation and oxidative stress, all may contribute to development of nephropathy in patients with diabetes. (czytelniamedyczna.pl)
Pathology1
- In Aim2, we will test the hypothesis that oxidative stress-induced microvascular pathology in 5xFAD mice leads to the global exacerbation of cognition and synaptic function in the context of AD-like pathology. (uky.edu)
Mice3
- In this R21, we aim to apply this technique to 5xFAD mice to generate and characterize a novel AD/VCID mouse model en route to determining whether fibronectin- a matrix protein that supports vascular structure and integrity-serves as a major point of confluence for the oxidative stress that arises from both cerebrovascular disease and AD. (uky.edu)
- Here, we evaluated cardiac inflammation, oxidative stress, DNA damage, and coagulation events in mice with adenine (0.2% w/w in feed for 4 weeks)-induced CKD. (uaeu.ac.ae)
- 17. Pant SC, Vijayaraghavan R, Kannan GM, Ganesan K. Sulphur mustard induced oxidative stress and its prevention by sodium 2,3-dimercapto propane sulphonic acid (DMPS) in mice. (ac.ir)
Cardiovascular3
- Therefore, elucidation of mechanisms underlying oxidative stress and inflammations in the vascular wall will have important impact in understanding atherosclerosis and vascular diseases associated with cardiovascular risk factors and will eventually lead to novel and effective therapeutic modalities. (frontiersin.org)
- Oxidative stress and inflammation are important pathophysiological mechanisms of various cardiovascular diseases. (hindawi.com)
- 1,22 Even the most current medical literature stresses that people with documented hypertension should receive intensive nonpharmacologic therapies to improve control of their condition and reduce the risk of developing further cardiovascular disease. (massagetoday.com)
Renal2
- In various mouse and rat models of obesity and type 1 and 2 diabetes mellitus, eCBs generated in various renal cells activate CB 1 receptors and contribute to the development of oxidative stress, inflammation, and renal fibrosis. (degruyter.com)
- These supplements can help to ameliorate oxidative stress, inflammation, proteinuria and progressive renal damage. (drprincetta.com)
Exposure1
- Along with oxidative stress, WPS exposure significantly increased lung DNA damage index. (who.int)
Responses2
- Some homeostatic responses need changes in blood vessel tone, especially arterioles. (fourthfrontier.com)
- My accepted me to test up this Deficiency and bias a small-volume, oxidative heart information to identify some closely coronary exploring maintenance responses. (augenta.net)
Damage2
- Vascular remodeling is promoted by the survival and proliferation of pulmonary arterial vascular cells under conditions of oxidative stress and in the presence of DNA damage. (cincinnatichildrens.org)
- It also helps protect against oxidative damage and inflammation. (tinobosconsultancy.nl)
Proliferation1
- We use a combination of animal models, single-cell transcriptomics, mechanistic biochemistry and structure-aided drug design to elucidate mechanisms that promote, and interventions that prevent, the proliferation of cells under conditions of oxidative stress. (cincinnatichildrens.org)
Progression2
- In the past decades, unambiguous evidence has been provided that heightened oxidative stress and vascular wall inflammation are the key mechanisms for initiation and progression of atherosclerosis and vascular diseases associated with the risk factors ( Hansson and Hermansson, 2011 ). (frontiersin.org)
- The role of increased oxidative stress is associated with both the incidence and the progression of AMD and is reviewed by Jarrett and Boulton (2012) . (frontiersin.org)
Deficiency1
- Age-related focal loss of contractile vascular smooth muscle cells in retinal arterioles is accelerated by caveolin-1 deficiency. (ouhsc.edu)
Harm2
- True to the tenets of do no harm, treat the whole patient, and stress preventative medicine, I am looking for ways to improve kidney function in my patients. (drprincetta.com)
- Oxidative stress can lower your methylation status too - is there anything oxidative stress doesn't harm? (resyncproducts.com)
Diseases2
- Oxidative stress and inflammation in the vascular wall are essential mechanisms of atherosclerosis and vascular dysfunctions associated with risk factors such as metabolic diseases, aging, hypertension, etc. (frontiersin.org)
- This review article will summarize the most recent findings on the functional roles of arginases in vascular diseases and/or dysfunctions and the underlying mechanisms in relation to oxidative stress and inflammations. (frontiersin.org)
Results1
- Blood pressure and haemodynamics in the glomeruli are under control of and results from an interplay of contracting or dilating afferent and efferent arterioles. (czytelniamedyczna.pl)
Response3
- These distinct molecular signatures correlate with differential sensitivity to drugs targeting the replication stress response ad IGF1R kinase activity. (cincinnatichildrens.org)
- Raynaud phenomenon can be thought of as an exaggerated normal response to cold and emotional stress. (medscape.com)
- 3, 5-diiodothyropropionic acid (DITPA) have evidences of improving effects on I/R in heart through modulation of cellular signaling in response to ischemic stress. (biomedcentral.com)
Brain1
- Our ongoing work on postmortem human brain specimens has revealed that astrocyte- derived fibronectin strongly colocalizes with the oxidative stress marker, nitrotyrosine (NT) especially around cerebrovessels and Aβ deposits. (uky.edu)
Conditions2
- In summary, the sGC activator runcaciguat significantly prevented a decline in kidney function in a DKD rat model that mimics common comorbidities and conditions of oxidative stress of CKD patients. (bvsalud.org)
- Radical-induced oxidative stress and inflammation can be modulated by Tempol (TP)-based nitroxide drugs to prevent or treat vascular, ocular, and other pathological conditions and aging associated disease. (frontiersin.org)
Wall1
- Oxidative stress in the microvascular wall was quantified via dihydroethidium fluorescence (O2 - probe). (cdc.gov)
Blood1
- Many studies ( ref. link ) have demonstrated that individuals exposed to different types of air pollution have higher levels of biomarkers of oxidative stress in their blood and in urine samples. (fourthfrontier.com)
High1
- In recent work we have shown that Ewing sarcoma tumors can be classified into two groups - one in which replication stress levels are high and IGF1R is membrane-associated, and another in which replication stress levels are low and IGF1R is nuclear. (cincinnatichildrens.org)
Patients1
- Furthermore, oxidative stress was compared in the ZSF1 rat kidney with kidney samples from DKD patients. (bvsalud.org)