Oxidative hepatic cells apoptosis of human hepatic stellate hepatic stellate cells. Medical search. Frequent questions

These cytokines induce caspase-3 activation as an effector caspase that activates hepatic stellate cells (HSCs) and cause fibrogenesis [ 11 ]. (bsmiab.org)
These recent studies showed that curcumin inhibited HSCs activation, and suppressed hepatic fibrogenesis in vitro and in vivo ( 6 , 7 ). (spandidos-publications.com)
TGF-β has been reported to trigger the activation of hepatic stellate cells (HSCs), inducing their differentiation into fibroblasts. (spandidos-publications.com)
The results showed that YQRG effectively alleviated CCl 4 -induced liver injury and fibrosis in rats, including observations of improved liver function, decreased activity of hepatic stellate cells (HSCs), and decreased extracellular matrix (ECM) deposition. (biomedcentral.com)
HSCs undergo phenotypic changes from quiescent vitamin A storing cells, involved in maintenance of the normal basement matrix, into proliferative myofibroblast-like cells, expressing myogenic markers such as alpha smooth muscle actin (αSMA). (biomedcentral.com)
This could be considered to be part of a feedback loop as changes in ECM composition results in changes in HSC cell surface receptors, particularly integrins indicating that the ECM should not be regarded simply as an inert physical scaffold but a dynamic structure that is able to influence the phenotype of HSCs [ 2 , 8 , 9 ]. (biomedcentral.com)
HSCs express numerous cell surface receptors including both discoidin domain receptors (DDRs)-which are receptors for collagen I and many of the integrin subunits, which are a major family of cell surface receptors for extracellular molecules and play a critical role in many biological functions [ 7 , 10 ]. (biomedcentral.com)

In addition, perilipin 5 regulates the activation of hepatic stellate cell, implicated in fibrosis, which is the creation of new tissue to repair the one damaged. (wikipedia.org)
Previous studies in rats showed that increased inflammation, oxidative stress, and liver fibrosis in diabetic rats could be diminished by ramipril treatment. (bsmiab.org)
Vitamin D deficiency has been commonly present in patients with immune-mediated liver and non-liver diseases, and it has been associated with histological severity, advanced hepatic fibrosis, and non-response to conventional glucocorticoid therapy in autoimmune hepatitis. (springer.com)
Beyazit Y, Kocak E, Tanoglu A, Kekilli M. Oxidative stress might play a role in low serum vitamin D associated liver fibrosis among patients with autoimmune hepatitis. (springer.com)
Vitamin D inhibits proliferation and profibrotic marker expression in hepatic stellate cells and decreases thioacetamide-induced liver fibrosis in rats. (springer.com)
The present study aimed to investigate the hepatoprotective effect of APE on CCl4‑induced hepatic fibrosis in rats. (spandidos-publications.com)
Organ coefficients, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), hexadecenoic acid (HA), laminin (LN), procollagen type III (PCIII), hydroxyproline (Hyp), glutathione (GSH‑Px), malondialdehyde (MDA), superoxide dismutase (SOD) and transforming growth factor β1 (TGF‑β1) levels were measured in rats with hepatic fibrosis. (spandidos-publications.com)
Pathological assessment of CCl4‑induced fibrotic livers revealed a significant reduction of liver injury and development of hepatic fibrosis in rats treated with APE (2.6 and 5.2 g/kg). (spandidos-publications.com)
These results suggested that APE may protect against liver damage and inhibit the progression of CCl4‑induced hepatic fibrosis. (spandidos-publications.com)
Hepatic fibrosis (HF) is recognized as one of the most prevalent types of liver disease. (spandidos-publications.com)
Early in the progression of hepatic fibrosis, a potent, fibrinogenic cytokine, transforming growth factor-β (TGF-β), was demonstrated to be locally and systemically increased in response to acute as well as chronic liver injury ( 7 ). (spandidos-publications.com)
Hepatic fibrosis is an abnormal wound-healing process in which hepatic parenchymal cells (HPCs) transform into fibrous tissue of ECM [ 1 , 2 , 3 ], which is detrimental to human health. (biomedcentral.com)
This review will focus on the contribution of high-throughput genomic and proteomic approaches to the study of fibrogenesis and fibrosis progression, concentrating on the most prevalent human chronic liver diseases and findings from animal models in liver tissue, isolated liver cells, cell lines and serum. (biomedcentral.com)
Fibrosis is a physiological response to cellular injury in the liver and is mediated by the activation of hepatic stellate cells resulting in the replacement of hepatocytes with extracellular matrix comprised principally of collagen 1 to form a hepatic scar. (biomedcentral.com)
Although the novel hexaco-ordinated globin cytoglobin was identified in activated hepatic stellate cells more than 10 years ago, its role in stellate cell biology and liver fibrosis remains enigmatic. (biomedcentral.com)

RESULTS: In vivo experiments found that QRLSD could regulate the ratio of dendritic cells, Treg cells, and Th17 cells in the body and inhibit inflammation and keratinocyte proliferation in psoriasis-like skin lesions. (bvsalud.org)
This active form of vitamin D can inhibit immune cell proliferation, promote an anti-inflammatory cytokine profile, expand regulatory T cells, enhance glucocorticoid actions, increase glutathione production, and inhibit hepatic stellate cells. (springer.com)
It has been shown that inflammation caused by oxidized low-density lipoprotein (ox-LDL) contributes to the occurrence and development of AS [ 1 ], which can promote vascular smooth muscle cell (VSMC) migration, proliferation, and transformation from a contractile to a synthetic phenotype [ 2 - 6 ]. (hindawi.com)
In the current study, we investigated the role of different extracellular matrix proteins in stellate cell proliferation, activation (alpha smooth muscle actin expression and retinoic acid uptake) and cytoglobin expression. (biomedcentral.com)
LIN28B suppresses microRNA let-7b expression to promote CD44+/LIN28B+ human pancreatic cancer stem cell proliferation and invasion. (ajcr.us)
MicroRNA-320a inhibits proliferation and invasion of breast cancer cells by targeting RAB11A. (ajcr.us)

Perilipin 5 is a protein often found in the adipose tissue, especially in those with high oxidative stress, including the heart, liver, skeletal muscle and brown adipose tissue (BAT). (wikipedia.org)
The process of hepatic fibrogenesis is affected by the presence of oxidative stress that increases proinflammatory cytokines, such as tumor necrosis factor-alpha (TNF-α), platelet-derived growth factor (PDGF), transforming growth factor beta (TGF-β), interferon, and interleukin (IL). (bsmiab.org)
Another found that HMG-CoA reductase inhibitor (rotuvastatin) treatment could be used as an alternative therapy to decrease oxidative stress parameters and liver enzyme activities [ 7 - 10 ]. (bsmiab.org)
Vitamin D ameliorates stress ligand expression elicited by free fatty acids in the hepatic stellate cell line LX-2. (springer.com)
There is also growing evidence that FFA-mediated oxidative stress contributes significantly to mitochondrial dysfunction in the liver. (spandidos-publications.com)
Dysregulated autophagy in pancreatic β cells due to hyperglycemia, oxidative stress, and inflammation is associated with diabetes and accompanied by dysregulated autophagy in insulin target tissues and the progression of diabetic complications. (frontiersin.org)
Photoreceptor cells are highly susceptible to oxidative-stress-induced damage due to their high metabolic rate. (mdpi.com)
Oxidative stress plays a key role in driving pathological events in several different ocular diseases, which lead to retinal degeneration and ultimately blindness. (mdpi.com)
Although the conventional activities of p53 such as cell cycle arrest, senescence, and apoptosis are well accepted as the major checkpoints in stress responses, accumulating evidence implicates the importance of other tumor suppression mechanisms. (nature.com)
Ferroptosis acts as an independent pathway for suppressing tumor growth and is tightly connected with metabolism and oxidative stress responses. (nature.com)
Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
However, under different conditions researches have reported an increase in oxidative stress derived from melatonin treatment in these liver tumors, which could be attributed to the employ of higher doses of this indoleamine [ 18 ] [ 29 ] . (encyclopedia.pub)
Results found suggest that oxidative stress modulation by melatonin could be useful in the HCC and CAA treatment and prevention. (encyclopedia.pub)
In addition, it has also been shown that smooth muscle actin appear in stress fibers of fibroblastic cells during pathological situations involving contractile phenomena such as wound healing and fibrocontractive diseases. (thermofisher.com)
Moreover, we identified downregulated and upregulated DEGs in the model group relative to the control and YQRG-treated groups, with GO analysis revealing their enrichment in biological processes, such as endoplasmic reticulum stress (ERS), apoptosis, and autophagy. (biomedcentral.com)
However, today it is widely used to create animal models of oxidative stress in laboratories [ 8 ]. (biomedcentral.com)
Although excess iron induces oxidative stress in the liver, it is unclear whether it directly activates the hepatic stellate cells (HSC). (westminster.ac.uk)
Excessive Iron Induces Oxidative Stress Promoting Cellular Perturbations and Insulin Secretory Dysfunction in MIN6 Beta Cells. (westminster.ac.uk)
Oxidative stress measured by thioredoxin reductase level as potential biomarker for prostate cancer. (ajcr.us)

However, studies have found that UDCA can inhibit DNA repair mediated by poly (ADP-ribose) polymerase, thereby interfering with the effectiveness of regeneration of the damaged cells. (bsmiab.org)
The secretome was also found to inhibit cell apoptosis [ 6 ], suggesting that adipose-derived stem cell secretome (ADSC-S) can reduce liver cell apoptosis within 1-3 days after surgery. (bsmiab.org)
Further, inhibitory receptors present in the TME can inhibit T cell metabolism and alter T cell signaling both directly and through release of extracellular vesicles such as exosomes. (elifesciences.org)

and (iv) as inhibitors of the transformation of stellate hepatocytes into myofibroblasts, the process responsible for the deposition of collagen fibres leading to cirrhosis. (springer.com)
Although liver failure can be treated via hepatocyte transplantation, it also faces multiple problems comprising the shortage of high-quality hepatocytes sources, rejection of allogeneic transplants, difficulty to expand, and losing hepatic characteristics in vitro [ 7 , 8 ]. (springer.com)
Caspase-3 levels were assessed from the blood sample, while the apoptosis of hepatocytes was evaluated using histopathologic examination of the liver. (bsmiab.org)
Because of this, we aimed to study the effect of human mesenchymal stem cell secretome (HuMSC-S) administration on caspase 3 levels and apoptosis of hepatocytes in a rat model with cholestasis after choledochal duct ligation receiving standard UDCA therapy. (bsmiab.org)
The hepatocytes, endothelial and immune cells of the liver are aligned along this vasculature, and their spatial distribution along the liver zonation dictates their phenotypes and functions. (encyclopedia.pub)

Patients with severe alcoholic hepatitis may benefit over the short term from specific therapies directed toward reducing liver injury, enhancing hepatic regeneration, and suppressing inflammation. (medscape.com)
Translocation of microbial- and danger-associated molecular patterns (MAMPs and DAMPs) from the gut to the liver elicits profound chronic inflammation, leading to severe hepatic injury and eventually HCC progression. (encyclopedia.pub)

Induction of autophagy and apoptosis by miR-148a through the sonic hedgehog signaling pathway in hepatic stellate cells. (ajcr.us)

Suppression of caspase-3 is known to have protective and anti-apoptotic effects on liver cells and reduces collagen deposition, ultimately leads to inhibition of fibrogenesis [ 12 ]. (bsmiab.org)

For example, in oxidative tissues, muscular tissues and cardiac tissues, PLIN5 promotes association between lipid droplets and mitochondria. (wikipedia.org)
Inside the cell, PLIN5 can be found in multiple intracellular structures including lipid droplets, endoplasmic reticulum, mitochondria, and the cytosol. (wikipedia.org)
The perilipin family contributes to the creation of lipid droplets and it also plays a pivotal role in determining what the lipid droplet's function is within the cell. (wikipedia.org)
Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)

The involvement of autophagy in the development of diabetes is corroborated by affecting the physiology and role of pancreatic β cells and the homeostasis of glucose. (frontiersin.org)
Several anti-diabetic strategies including adiponectin, ezetimibe, liraglutide, taurine, adipose tissue-derived stem cells (ADSCs) and even exercise as well as natural products such GABA tea, geniposide, guava extract, vitamin D have been shown to target autophagy. (frontiersin.org)
Recent studies have shown that in addition to necrosis and apoptosis, there are also other new programmed death modes, such as autophagy, necrosis and necrotic apoptosis, which have unique biological processes and pathophysiological characteristics. (nature.com)
Beclin-1-independent autophagy mediates programmed cancer cell death through interplays with endoplasmic reticulum and/or mitochondria in colbat chloride-induced hypoxia. (ajcr.us)

Oxidative phosphorylation dysregulation (OXPHOS) has been demonstrated to be essential for the development of cancer. (scientificarchives.com)

It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)
Up-regulated CKS2 promotes tumor progression and predicts a poor prognosis in human colorectal cancer. (ajcr.us)
Up regulation of the long non-coding RNA NEAT1 promotes esophageal squamous cell carcinomacell progression and correlates with poor prognosis. (ajcr.us)

CCl 4 showed an increase of serum renal and hepatic markers creatinine, urea, blood urea nitrogen (BUN), and uric acid, alkaline phosphatase (ALP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT). (biomedcentral.com)
Journal of Renal and Hepatic Disorders. (westminster.ac.uk)
The long non-coding RNA lnc-ZNF180-2 is a prognostic biomarker in patients with clear cell renal cell carcinoma. (ajcr.us)

Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)

Human mesenchymal stem cell-based therapy can help liver regeneration directly, through hepatogenic differentiation, or indirectly through the paracrine secretome. (bsmiab.org)
Secretome is a soluble molecule and exosome produced by HuMSC, which can support hepatic epithelial regeneration through hepatogenic differentiation. (bsmiab.org)
T cells must substantially increase nutrient uptake to mount a proper immune response and failure to obtain sufficient nutrients or engage the appropriate metabolic pathways can alter or prevent effector T cell differentiation and function. (elifesciences.org)
This review will discuss the metabolic adaptations necessary for T cells to meet changing biochemical needs throughout different stages of differentiation. (elifesciences.org)

Expanded understanding of the basic biology of T cell activation has enabled immunotherapy to combat cancer, and T cell metabolism now offers the opportunity to optimize and improve these therapeutic strategies. (elifesciences.org)
The initiation and development of tumor cell is accompanied by elevated stresses, such as oncogene activation, DNA damage, genome instability, and reprogrammed tumor metabolism. (nature.com)
Our results demonstrate that cytoglobin expression is correlated with a more quiescent phenotype of stellate cells in culture and that cytoglobin is regulated by the extracellular matrix through integrin signalling dependent on activation of focal adhesion kinase. (biomedcentral.com)
Although further studies are required, we provide evidence that cytoglobin is a negative regulator of stellate cell activation and therefore may represent a novel target for anti-fibrotic treatments in the future. (biomedcentral.com)

We also present a thorough analysis of the role of succinate in the initiation of metabolic and epigenetic changes that contribute to the development of cancer, as well as its effects on angiogenesis, cell invasion, and migration. (scientificarchives.com)
These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)

Human mesenchymal stem cells (HuMSC) have low immunogenicity, self-renewal, and are easy to obtain, making it a promising therapy for liver regeneration [ 4 ]. (bsmiab.org)
Thus, it has been shown that early EPCs release cytokines that promote tissue regeneration and neovasculogenesis, whereas late EPC and endothelial colony forming cells (ECFCs) contribute to the formation of blood vessels and stimulate tube formation. (intechopen.com)

A classification that sufficiently covers their phenotypic heterogeneity and plasticity during homeostasis and disease does not yet exist because cell culture-based phenotypes often do not match those found in vivo . (hindawi.com)
Previous studies have proven that rodent and human MSCs can differentiate into HLCs in vitro and in vivo , which is one of the mechanisms of MSCs in the treatment of liver failure. (springer.com)
In contrast, ACT expands a patient's own T cells ex vivo to direct anti-tumor immunity when transfused back into the patient. (elifesciences.org)

Thus, organ- and disease phase-specific microenvironments determine macrophage and dendritic cell heterogeneity in a temporal and spatial manner, which assures their support to maintain and regain homeostasis in whatever condition. (hindawi.com)
A more tissue-centric view of these processes, claiming that the tissues define phenotype and function of resident and infiltrating immune cells to meet tissues needs during homeostasis and disease, seems provocative [ 4 , 5 ]. (hindawi.com)
These cells provide several important physiological functions during homeostasis (Figure 1 ). (hindawi.com)
Several messengers, including dietary metabolites, bile acids, antimicrobial peptides and microbial associated molecular patterns (MAMPs), are exchanged and required for intestinal and hepatic homeostasis, as well as host physiology in general. (encyclopedia.pub)

Finally, To further confirm the anti-psoriasis target, dendritic cells derived from bone marrow (BMDCs) were cultured in vitro. (bvsalud.org)

Upon mixing, the blood flows across the lobule through the hepatic sinusoids and drains into the central veins, while the bile flows in the opposite direction via the bile canaliculi. (encyclopedia.pub)
These excessive depositions disturb the normal structure of the hepatic lobule, resulting in misdirected blood flow through the liver, thereby impairing normal organ functioning. (spandidos-publications.com)

The present invention provides a simple and robust human liver cell-based system in which persistent hepatitis C infection, persistent hepatitis B infection or ethanol exposure induces a clinical Prognostic Liver Signature (PLS) high-risk gene signature. (sumobrain.com)

MSCs have the capacity of multiple differentiations and self-renewal and have been proven to be able to differentiate into a series of cell lineages, such as adipocytes, osteoblasts, chondroblasts, and hepatocyte-like cells (HLCs). (springer.com)
Similarly, the apoptosis of hepatocyte was significantly lower in the combination group compared to the UDCA or HuMSC-S alone. (bsmiab.org)

Microbial sensing by toll-like receptors (TLR) on liver sinusoidal endothelial cells (LSECs) results in a CXCL9 chemokine gradient that attracts Kupffer cells closer to the periportal region to ensure immune surveillance and host defense from invading pathogens arriving through the portal vein circulation. (encyclopedia.pub)

The TME, however, can be metabolically hostile due to insufficient vascular exchange and cancer cell metabolism that leads to hypoxia, depletion of nutrients, and accumulation of waste products. (elifesciences.org)

In conclusion, addition of HuMSC-S to UDCA lowered caspase-3 levels and apoptotic cell count in rats with hepatic cholestasis after choledochal duct ligation. (bsmiab.org)

Curcumin also exerts potential anti-inflammatory effects in diverse cell types, including pancreatic cells, chondrocytes, and hepatic cells ( 9 , 10 ). (spandidos-publications.com)

Cholestasis is a clinical syndrome caused by reduced bile secretion from liver cells, impaired bile secretion at the cholangiocyte level, obstruction of bile flow by stones (cholelithiasis), or tumor masses. (bsmiab.org)
These drawbacks may be explained, at least in part, by the various phenotypes and histological characteristics of tumor liver cells and its microenvironment [ 5 ] . (encyclopedia.pub)

Traditionally, cell death has been divided into apoptosis and necrosis. (nature.com)
It does not have the morphological characteristics of typical necrosis, such as swelling of the cytoplasm and organelles and rupture of the cell membrane, nor does it have the characteristics of traditional cell apoptosis, such as cell shrinkage, chromatin condensation, formation of apoptotic bodies and disintegration of the cytoskeleton. (nature.com)

Thus, this study aims to determine the effect of Human mesenchymal stem cell secretome (HuMSC-S) administration on caspase 3 levels and apoptotic hepatic cells in a rat model with cholestasis after choledochal duct ligation receiving urso deoxy cholic acid (UDCA). (bsmiab.org)
Aging kidney and CKD share many common characteristic features with increased cellular senescence, a conserved program characterized by an irreversible cell cycle arrest with altered transcriptome and secretome. (frontiersin.org)
Cellular senescence is characterized by an irreversible and permanent cell cycle arrest coupled with altered transcriptome and secretome. (frontiersin.org)

Additionally, a viable therapeutic strategy may involve triggering the cell death mechanism in cancer cells by blocking mitochondrial metabolism with a natural substance. (scientificarchives.com)

As T cell metabolism dictates effector function, it is now apparent that the effect of cancer cell metabolism on the tumor microenvironment (TME) may impair anti-tumor immunity, and these new hallmarks of cancer are therefore inextricably linked. (elifesciences.org)

Among these unconventional activities, an iron-dependent form of non-apoptotic cell death, termed ferroptosis, attracts great interest. (nature.com)
Is p53-dependent ferroptosis sufficient for tumor suppression in the absence of cell cycle arrest, senescence, and apoptosis? (nature.com)
How to intervene in the occurrence and development of related diseases by regulating cell ferroptosis has become a hotspot and focus of etiological research and treatment, but the functional changes and specific molecular mechanisms of ferroptosis still need to be further explored. (nature.com)
Ferroptosis is a new type of programmed cell death, which occurs with iron dependence. (nature.com)
What is the relationship between ferroptosis and other types of cell death? (nature.com)

To date, various mechanisms have been suggested to explain the powerful tumor-suppressive effect of p53, including the induction of cell cycle arrest, senescence, and apoptosis. (nature.com)

Most tissues harbor resident mononuclear phagocytes, that is, dendritic cells and macrophages. (hindawi.com)
Mononuclear phagocytes are a group of phenotypic distinct members, often referred to as either macrophages or dendritic cells (DC), that derive from myeloid precursors and that contribute to the functions of peripheral tissues [ 1 ]. (hindawi.com)
In this paper we apply the tissue-centric perspective to discuss the role of resident and infiltrating macrophages and dendritic cells in different organs. (hindawi.com)
Macrophages and dendritic cells can produce 1,25-dihydroxyvitamin D within the microenvironment. (springer.com)

In the case of the ⫽ endothelial cells men, there was also a delay, but of only 3 years. (gotomydoctor.com)

Senescent cells elicit their fibrogenic actions primarily by secreting an assortment of inflammatory and profibrotic factors known as the senescence-associated secretory phenotype (SASP). (frontiersin.org)
Increasing evidence indicates that senescent cells could be a promising new target for therapeutic intervention known as senotherapy, which includes depleting senescent cells, modulating SASP and restoration of senescence inhibitors. (frontiersin.org)
Unlike apoptosis, senescence is a state of which cells are still alive and metabolically active. (frontiersin.org)

Its building blocks are the hepatic lobules organized around central veins and portal triads, consisting of a portal vein, a hepatic artery and a bile duct. (encyclopedia.pub)

This review will discuss the metabolic changes that drive T cells into different stages of their development and how the TME imposes barriers to the metabolism and activity of tumor infiltrating lymphocytes. (elifesciences.org)
Finally, we will provide an overview of how utilizing an understanding of T cell metabolism may inform strategies to alter the TME or enhance T cell metabolism to strengthen the immunotherapy arsenal. (elifesciences.org)

We will then examine how tumor cells create a toxic milieu for T cells that enter the TME. (elifesciences.org)
Furthermore, the high refractoriness of liver cancer to treatments has been associated with the interaction of very complex and diverse mechanisms of chemoresistance, which can act synergistically to protect tumor cells from the chemotherapy agents [ 3 ] . (encyclopedia.pub)

Although the mechanisms responsible for fatty liver are not fully elucidated, an increased delivery and transport of FFAs into the liver, and augmented hepatic fatty acid synthesis are likely to play a significant role in the pathogenesis of NAFLD. (spandidos-publications.com)

Muc1 promotes migration and lung metastasis of melanoma cells. (ajcr.us)

Selective inhibition of EGFR downstream signaling reverses the irradiation-enhanced migration of HNSCC cells. (ajcr.us)

Evidence indicating that OXPHOS plays a substantial role in the development of many cancer cells has led to the growing recognition of cancer as a metabolic disease. (scientificarchives.com)
A large body of evidence indicates that Monascus yellow pigments are beneficial to human health in appropriate doses and can potentially be used as nutraceutical or therapeutic agents. (biomedcentral.com)

In recent years, a growing number of studies have shown that stem cells can effectively treat acute liver failure. (springer.com)
mesenchymal stem cells are most commonly used because they are easy to obtain and present no ethical problems. (springer.com)
The aims of this article are to review the current knowledge regarding therapeutic mechanisms of mesenchymal stem cells in acute liver failure, to discuss recent advancements in preclinical and clinical studies in the treatment of mesenchymal stem cells, and to summarize the methodological improvement of mesenchymal stem cell transplantation in treating liver failure. (springer.com)
Three-dimensional assessment of bystander effects of mesenchymal stem cells carrying a cytosine deaminase gene on glioma cells. (ajcr.us)

Vitamin D analogues with high potency, low calcemic effects, and independence from hepatic hydroxylation are possible interventions. (springer.com)
This study aimed to identify the role of AA in oxidized low-density lipoprotein (ox-LDL)-induced vascular smooth muscle cell (VSMC) behaviours and to explore the effects of microRNAs (miRNAs). (hindawi.com)
In this study, H 2 O 2 and dithiothreitol (DTT) were used to change the oxidoreduction potential for investigating the effects of oxidative or reductive substances on Monascus yellow pigment production by Monascus ruber CGMCC 10910. (biomedcentral.com)
However, CCl 4 has many side effects on humans and the environment. (biomedcentral.com)

Oxidative conditions induced by H 2 O 2 increased water-soluble yellow pigment accumulation via up-regulation of the expression levels of relative genes and by increasing the precursors of pigment biosynthesis through redirection of metabolic flux. (biomedcentral.com)

Anatomy29

Organisms11

Diseases27

Chemicals and Drugs122

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes44

Disciplines and Occupations1

Information Science3

HSCs7

Fibrosis15

Proliferation6

Stress19

Inhibit3

Hepatocytes5

Inflammation2

Signaling pathway1

Fibrogenesis1

Lipid5

Autophagy4

Phosphorylation1

Progression3

Renal3

Progenitor cells2

Differentiation4

Activation4

Angiogenesis3

Regeneration2

Vivo3

Homeostasis4

Vitro1

Lobule2

Induces1

Hepatocyte2

Kupffer1

Depletion1

Rats1

Pancreatic1

Liver cells2

Necrosis2

Secretome3

Mechanism1

Effector1

Ferroptosis5

Cycle arrest1

Dendritic cells4

Endothelial cells1

Senescence3

Bile1

Metabolism2

Tumor cells2

Pathogenesis1

Promotes1

Migration1

Evidence2

Stem4

Effects4

Accumulation1