Oxidative chronic biological markers. Medical search. Frequent questions

A measurable marker in all these fluids is the heat shock protein (Hsp70), which is a signal that there is a defense reaction going on both by inflammation and oxidative stress. (medicomunicare.it)
E-cig users have increased levels of biomarkers of inflammation and oxidative stress, reduced pro-resolving anti-inflammatory mediators, and endothelial dysfunction (11). (researchsquare.com)
Cigarette smoke-induced oxidative stress leads to dyslipidemia and systemic inflammation. (hindawi.com)
Population-based studies have also revealed that markers of systemic inflammation, such as C-reactive protein (CRP), are also elevated in smokers as well as those exposed to second-hand smoke [ 13 , 14 ]. (hindawi.com)
Indeed, aging appears to be characterized by chronic, low-grade systemic inflammation, a condition indicated as inflammaging [ 1 - 2 ], that is believed to contribute to the onset and progression of the major age-related diseases, also including frailty [ 3 - 5 ] and for the most of deaths in elderly. (aging-us.com)
A large amount of data indicates that inflammation is strictly connected to oxidative stress. (aging-us.com)
Both inflammation and oxidative stress can deeply affect a number of metabolic processes and therefore is to be expected that many differences exist on metabolome of centenarians that can be helpful in shedding light on the mechanisms of successful aging. (aging-us.com)
NAFLD is part of a complex system of mental and non-communicable somatic disorders with a common pathogenesis, based on shared lifestyle and environmental risks, mediated by dysregulation of inflammation, oxidative stress pathways, and mitochondrial function. (biomedcentral.com)
These studies provide strong support that dysregulation of energy and inflammation may be a part of the underlying biological features of GWI. (stanford.edu)
Buildup and abnormal processing of harmful lipids can trigger oxidative stress followed by inflammation, but harmful lipids can also directly cause inflammation. (stanford.edu)
Nitrative and oxidative DNA damage plays an important role in inflammation-related carcinogenesis. (hindawi.com)
In conclusion, CD44v6 and ALDH1A1 are candidate stem cell markers for NPC, and the increased formation of DNA lesions by inflammation may result in the mutation of stem cells, leading to tumor development in NPC. (hindawi.com)
Chronic inflammation induced by infection has been postulated to be an important risk factor for various cancers [ 1 , 2 ]. (hindawi.com)
Epidemiological and experimental studies have provided evidence showing that chronic infection and inflammation contribute substantially to environmental carcinogenesis. (hindawi.com)
S100A12 might aggravate acute and chronic inflammation by up-regulation of adhesion molecules, CXCL and CCL chemokines. (adacyte.com)

Using biological markers of exposure, such as urinary oxidative stress biomarkers, as an indication of chronic exposure may also be useful for some ENMs and should be further researched. (cdc.gov)
Atherosclerosis is a chronic inflammatory process, in which oxidative stress is the key event. (medscimonit.com)
Therefore, the measurement of allantoin may be useful for the determination of oxidative stress in humans. (degruyter.com)
Significant higher levels of allantoin in both plasma and erythrocytes of patients with chronic renal failure indicate that allantoin may be used as a good marker of oxidative stress. (degruyter.com)
Allantoin as a marker of oxidative stress in human erythrocytes" Clinical Chemistry and Laboratory Medicine , vol. 46, no. 9, 2008, pp. 1270-1274. (degruyter.com)
Kand'ár, R. and Žáková, P. (2008) Allantoin as a marker of oxidative stress in human erythrocytes. (degruyter.com)
An ezio-pathogenetic theory, also in vogue because it is supported by enough laboratory demonstrations, indicates that oxidative stress could be a key mechanism of the disease. (medicomunicare.it)
Markers of oxidative stress are present in the serum, in the peritoneal fluid, in the follicular ovarian fluid and even in the ovaries of women suffering from endometriosis. (medicomunicare.it)
Oxidative stress affects fertility in women with endometriosis in natural or assisted conception. (medicomunicare.it)
The imbalance between ROS and antioxidant mechanisms leads to the state of oxidative stress in the peritoneal environment, in follicular flow and in the surrounding ovary, which can partly explain the infertility status associated with endometriosis. (medicomunicare.it)
E-cig use can cause oxidative stress and endothelial cell dysfunction (8, 9), and compromised innate immune response in lungs (10). (researchsquare.com)
Recent studies have shown that EMF affects cellular stress levels, resulting in the deterioration of various tissues and changes to the concentrations of antioxidant markers in the blood. (martindalesnutrition.com)
As research suggests, taking antioxidants and limiting 5G exposure and EMFs offer an effective defense against oxidative stress generated by these technologies. (martindalesnutrition.com)
Melatonin is a hormone that minimizes the effects of oxidative stress. (martindalesnutrition.com)
When exposed to mobile phone radiation, a group of rats experienced decreased adverse effects after being treated with vitamins C and E. These two vitamins worked together synergistically to reduce the oxidative stress caused by cell phone radiation. (martindalesnutrition.com)
Evaluation of serum biomarkers in mice at the end of spirulina intervention showed reduced the oxidative stress and the blood lipid levels and increased the level of appetite controlling hormone leptin in a dose-response manner, which exhibited the significant correlation with differentially abundant microbiota taxa in the cecum. (frontiersin.org)
Additionally, several markers of oxidative stress are elevated in cigarette smokers. (hindawi.com)
While the molecular mechanisms of tobacco smoke toxicity are still not fully understood, free radical-mediated oxidative stress is believed to play a central role [ 16 , 17 ]. (hindawi.com)
Oxidative stress, as measured by serum malondialdehyde concentration, is positively correlated to elevated triglyceride and cholesterol levels in smokers [ 18 ]. (hindawi.com)
Not only does cigarette smoke increase oxidative stress by increasing free radicals but also by weakening of antioxidant defenses, such as decreasing paraoxonase enzyme activity [ 19 ]. (hindawi.com)
In this review the use of in vitro models of cardiovascular disease and one of the contributory factors, oxidative stress, is discussed in the context of assessing the risk potential of both conventional and modified cigarettes. (yes4yes.com)
DMD is a fatal hereditary myopathy that is associated with chronic inflammatory reaction and oxidative stress. (medscape.com)
The iron produced in the fluid of endometriotic cysts promotes oxidative stress, which in turn may cause genetic mutations and malignant progression of ovarian cysts. (endometriosi.it)
This may result in the accumulation of harmful lipids that promote oxidative stress, which occurs due to an excessive increase in reactive oxygen molecules and a reduction of antioxidants in the body. (stanford.edu)
Tissue damage caused by CS exposure is mediated, at least in part, by oxidative stress induced by its toxic and pro-oxidant components. (izon.com)
Neurological studies have demonstrated that chronic stress exposure induces neurodegeneration of important neuronal structures and destabilization of the mesocortical dopaminergic pathway. (spandidos-publications.com)
Finally, the positive effects of individualized supplementation are discussed in the context of diminishing anxiety and oxidative stress, neuroprotection and in the reversal of neurodegeneration, and also in alleviating/reducing neuromuscular symptoms. (spandidos-publications.com)
Oxidative stress tration being greater than the centrilobular has been demonstrated to be implicated region [ 6 ]. (who.int)
However, the effects of L. japonica polysaccharides (LJP) on exercise endurance and oxidative stress have never been investigated. (biomedcentral.com)
Therefore, this study was conducted to investigate the effects of LJP on exercise endurance and oxidative stress in a forced swimming mouse model. (biomedcentral.com)
LJP enhanced exercise endurance and protected mice against exhaustive exercise-induced oxidative stress. (biomedcentral.com)
There were no significant effects on oxidative stress, antioxidant status and other CVD risk factors. (cambridge.org)
Specifically, O3 therapy induces moderate oxidative stress when interacting with lipids. (diegovitello.it)
Especially, activated neutrophils produce reactive oxygen and nitrogen species and myeloperoxidase within intestinal mucosa, which induce oxidative stress. (adacyte.com)
Measurement of these modified proteins may serve both as a quantitative index of oxidative stress and an important new biological marker of clinical relevance to IBD. (adacyte.com)
In this review, we discuss current advances in defining the role of neutrophil-dependent oxidative stress in IBD. (adacyte.com)
The primary such as hs-CRP, total homocysteine, as well enzymatic defences are intracellular, but as oxidative stress, have been proposed other antioxidant defences are largely ex- as risk factors for the development and tracellular, including antioxidative sub- progression of atherosclerosis and athero- strates such as uric acid and unconjugated thrombotic cardiovascular disease [10-13]. (who.int)
Trans-resveratrol is a polyphenol with great antioxidant action that reduces the oxidative stress. (bvsalud.org)
This study investigated the effect of the trans-resveratrol supplementation on the cardiac oxidative stress in rats exposed to cigarette smoke. (bvsalud.org)
The supplementation of Trans-resveratrol attenuated the cardiac oxidative stress and increased the activity of catalase. (bvsalud.org)

Cigarette smoke exposure causes various diseases involving changes in miRNA expressions in the pathogenesis of atherosclerosis, chronic obstructive pulmonary disease (COPD) and lung cancer (12-15). (researchsquare.com)
The clinical presentation of chronic obstructive pulmonary disease (COPD) is highly heterogeneous. (archbronconeumol.org)
Chronic obstructive pulmonary disease (COPD) is characterised by inflammatory and oxidative alterations in the lung and extrapulmonary compartments, through involvement of the immune system. (ucm.es)
Tens of millions of people around the world find it distressingly difficult to breathe owing to a combination of emphysema and chronic asthmatic bronchitis - a deadly duo known as chronic obstructive pulmonary disease (COPD). (yes4yes.com)

This article presents the scientific evidence on the use of biomarkers to assess secondhand smoke exposure (SHSe), analytical methods, biological matrices and their interpretation. (yes4yes.com)
Given the ease of access to blood and the minimally invasive nature of blood collection, biological markers (biomarkers) in blood are desirable for routine clinical use. (stanford.edu)
The article analyses and concludes current literary data on the justified use of biomarkers of exposure and effect of OPCs that are widespread in the environmental objects and are one of the reasons of acute and chronic poisoning in the population. (kiev.ua)

Glutathione is a powerful antioxidant that shields cells from oxidative damage. (martindalesnutrition.com)
Two randomised controlled cross-over intervention studies investigating the effects of chronic and acute consumption of commercially-available fruit- and vegetable-puree-based drinks (FVPD) on bioavailability, antioxidant status and CVD risk factors are described. (cambridge.org)

It's concerning that human exposure to electromagnetic fields (EMFs), and 5G has a wide range of biological effects. (martindalesnutrition.com)
Biological exposure indices. (cdc.gov)
Threshold limit values for chemical substances and physical agents and biological exposure indices. (cdc.gov)
Chronic lymphoid leukaemia and hairy cell leukaemia due to chronic exposure to benzene: Report of three cases. (cdc.gov)
Hematotoxicity, leukemogenicity, and carcinogenicity of chronic exposure to benzene. (cdc.gov)
Followup study on the mortality and the development of leukemia in 44 pancytopenic patients with chronic benzene exposure. (cdc.gov)
1976. Combination of genetic factors and chronic exposure to benzene in the aetiology of leukaemia. (cdc.gov)
As previously demonstrated in mouse studies, disruption of lipid processing and regulation in the brain after exposure to GW pesticides results in accumulation of harmful lipids and chronic damage to the brain. (stanford.edu)
Physiological effects of chronic silver exposure in Daphnia magna. (upv.es)
Rats were euthanized at 7, 12, and 24wk to evaluate local and systemic immune markers corresponding to the baseline, exposure, and recovery phases of the study, respectively. (cdc.gov)
In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. (cdc.gov)

Waterpipe tobacco smoking also causes various acute and chronic health effects including cardiopulmonary diseases. (researchsquare.com)
During the last two decades, organophosphorus pesticides are directly the main reason of acute and chronic poisoning with pesticides among the agricultural workers, among population following household use as insecticides, as well as following accidental or deliberate use that requires emergency medical care, precise diagnostics, effective treatment, and prediction of consequences of intoxication [4, 6, 8-11]. (kiev.ua)
Overall, there was a non-significant trend towards increased endothelium-dependent vasodilation following both acute and chronic FVPD consumption. (cambridge.org)
Despite suspicions, a multitude of O3 therapies have shown substantial benefits that span a large variety of acute and chronic ailments. (diegovitello.it)

A combination of antioxidants and phytochemicals found in fruit and vegetables might promote health by combating free radicals, which are linked with early phase development of some chronic diseases. (bmj.com)
Free radicals are known to cause oxidative damage by increasing polymorphonuclear leukocytes and by inducing lipid peroxidation [ 2 , 3 ]. (hindawi.com)
2011). Larger quantities of free radicals (reactive disease, diabetes, chronic respiratory diseases, and oxygen species [ROS]) present in the cigarette cancer (WHO, 2012). (bvsalud.org)

Blueberry anthocyanins have been reported to exhibit cardiovascular protective health effects by preventing cholesterol-induced atherosclerosis, and reduction of oxidative and inflammatory damages to the endothelium through several mechanisms. (biomedcentral.com)

This review describes, analyzes and compares the effects of different types of diets in reducing the onset of typical Western countries non-communicable diseases (NCDs) (cardiovascular diseases, tumors, chronic respiratory diseases, diabetes, etc.), thus increasing the average lifespan. (iospress.com)
At the beginning of this century, the World Health Organization (WHO) found that the so-called non-communicable diseases (NCDs), also known as chronic diseases, are responsible for the death of forty million people every year, equivalent to 70% of all deaths globally. (iospress.com)
Among the individuals aged 60 and over, NCDs account for more than 87% of the disease burden, with an higher age-related occurrence of chronic diseases, disabilities, morbidity and mortality [ 4-7 ]. (iospress.com)
Moreover, the simultaneous usage of different types of drugs for the treatment of various chronic diseases makes the patient health status even weaker [ 4 ]. (iospress.com)
The exact mechanisms by which fruit and vegetables reduce the risk of these chronic diseases are not precisely known. (bmj.com)
There is a dichotomy in both developed and developing countries as their populations are experiencing the phenomenon of being 'over fed and under nourished', i.e., caloric/energy excess and lack of essential nutrients, leading to health deficiencies, skyrocketing global obesity rates, excess chronic diseases, and premature mortality. (springer.com)
However, the rising prevalence of NAFLD makes its coexistence with other chronic liver diseases quite possible. (biomedcentral.com)
Although Western medicine is substituted for 80% of traditional medicine, in some countries, people rely on natural herbs as a remedy for the treatment of certain chronic diseases. (eurekaselect.com)
Furthermore, the information regarding the presence of oxidized proteins and the specific membrane features of CSE-related EVs can be useful to define the utilization of circulating EVs as marker for diagnosing of CS-induced lung damage and/or CS-related diseases. (izon.com)
The average UK adult consumes less than three portions of fruit and vegetables daily, despite evidence to suggest that consuming five portions daily could help prevent chronic diseases. (cambridge.org)
Increasing epidemiological evidence suggests inverse association between consumption of diets rich in fruits and vegetables and the incidence of cardiovascular diseases (CVD), metabolic syndrome disorders, certain types of cancer, neurodegenerative disorders, and other forms of human chronic diseases. (biomedcentral.com)

During this time, I investigated lipid oxidative products and lipid mediators in chronic kidney disease comorbid with chronic inflammatory periodontitis. (j-alz.com)

I use flow cytometry to investigate the effects of lipids on immune cell markers. (j-alz.com)

A biomarker (biologic marker) is a measurable indicator of a specific biological state, particularly one relevant to the risk for, presence of, or stage of a disease. (medscape.com)
A biomarker is a characteristic that is objectively measured and evaluated as an indicator of normal biological or pathogenic processes, or pharmacologic responses to a therapeutic intervention. (medscape.com)

[ 1 ] At present, serum creatinine, which is used to measure the glomerular filtration rate (GFR), is the most commonly used marker of renal function. (medscape.com)

We measured allantoin and uric acid in human plasma and erythrocytes obtained from patients with chronic renal failure before hemodialysis (n=30) and blood donors (n=30). (degruyter.com)
Age- and tion period and were excluded if symptoms sex-matched individuals without any cle- of infection or systemic illness were present arly evident chronic disease were recruited (acute or chronic liver disease, cancer, renal as control subjects. (who.int)

however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)

The results indicated impairment of immune functions in COPD patients, both in innate and adaptive immunity, and higher pro-inflammatory and oxidative states in peripheral leukocytes than controls. (ucm.es)
This study presents peripheral eosinophil counts as a potential laboratory marker to evaluate muscle strength and response to treatment and to predict prognosis. (medscape.com)

Moreover, they are known to interact with other physiological anti-oxidants such as ascorbate or tocopherol and to synergistically amplify their biological effects 13 . (scialert.net)

Cigarette smoke (CS) represents one of the most relevant environmental risk factors for several chronic pathologies. (izon.com)

Gene set enrichment analysis of microRNAs showed significant changes in the top six enriched functions that consisted of biological pathway, biological process, molecular function, cellular component, site of expression and transcription factor in all the groups. (researchsquare.com)
The focus of our work is to better understand the biological and clinical characteristics of these molecular groups of carcinoids. (who.int)
While progress has been made in recent years in the characterisation of pulmonary carcinoids, little is known about the underlying biology or developmental origins of these molecular groups, hampering efforts to identify predictive markers and suitable therapeutic options. (who.int)

Attempts have been made to define subpopulations of patients who share clinical characteristics (phenotypes and treatable traits) and/or biological characteristics (endotypes), in order to offer more personalized care. (archbronconeumol.org)
Assigning a patient to any of these groups requires the identification of both clinical and biological markers. (archbronconeumol.org)

Several leukocyte functions are health markers and good predictors of longevity, and high pro-inflammatory and oxidative states are related to more aged profiles. (ucm.es)
Interview with Dr. Stephen Hussey: Toxins to Avoid, Importance of Cholesterol, and Which Health Markers to Look For! (briangryn.com)

Professor Mortensen and a team of researchers enrolled 420 patients with moderate to severe chronic heart failure. (wikipedia.org)
Professor Mortensen and a team of researchers assigned 420 patients with moderate to severe chronic heart failure to Coenzyme Q10 100 milligrams three times daily or matching placebos in addition to the patients' standard heart failure therapies for two years. (wikipedia.org)

Still on the subject of the biological fluids discussed, as some markers have increased (Hsp70, MDA, LOOH, 8-ISOP), others have decreased. (medicomunicare.it)
I have interdisciplinary collaborations with both scientists and clinicians and particularly interested in defining lipidomic profiles of biological fluids and understanding the underlying mechanisms and prevention strategies of disease development and progression. (j-alz.com)

1971. Haematological effects of chronic benzene poisoning in 217 workers. (cdc.gov)

Specifically, it has been shown that strenuous physical exercise decreases antioxidants levels and increases lipid peroxidation markers in the blood and tissues [ 7 ]. (biomedcentral.com)
To investigate the involvement of stem cells in Epstein-Barr virus infection-related nasopharyngeal carcinoma (NPC), we used double immunofluorescence staining to examine several cancer stem/progenitor cell markers (CD44v6, CD24, and ALDH1A1) in NPC tissues and NPC cell lines. (hindawi.com)
The staining intensity of 8-nitroguanine was significantly higher in cancer cells and inflammatory cells in the stroma of NPC tissues than in chronic nasopharyngitis tissues. (hindawi.com)
Expression levels of CD44v6 and ALDH1A1 were significantly increased in cancer cells of primary NPC specimens in comparison to chronic nasopharyngitis tissues. (hindawi.com)
In the case of CD24 staining, there was no significant difference between NPC and chronic nasopharyngitis tissues. (hindawi.com)

These findings reveal phospho/sphingolipids as putative markers and biological modulators of healthy aging, in humans. (aging-us.com)

Several studies have shown that women with chronic endometriosis have levels of vitamin C , vitamin E and the scavenger enzyme SOD lower than normal women. (medicomunicare.it)
The electrokinetic signals show detection of these markers on sEVs, highlighting distinct interpatient differences, e.g., increased EGFR levels in sEVs from a patient with EGFR mutation as compared to an ALK-fusion one. (izon.com)
The impact of changes in acyl chain composition of CSE-EVs accounted for the increased saturation levels of phospholipids, a membrane parameter that might influence EV stability, uptake and, at least in part, EV-mediated biological effects. (izon.com)

Therefore, the current chapter serves as a bird's eye view of anti-diabetic flavonoids for further experimental studies and to develop potent markers of therapeutic agents. (eurekaselect.com)

In this concern, flavonoids are the prevalent group of natural bioactive molecules that have shown interesting biological activities, including antidiabetic properties. (eurekaselect.com)

Epidemiological studies indicate that fruits and vegetables may reduce free radical-induced oxidative damage and lipid peroxidation in cigarette smokers [ 23 ]. (hindawi.com)

The purpose of the study was to assess the effect of the adjuvant therapy drug Coenzyme Q10 on several short-term and long-term endpoints in a total of 420 chronic heart failure patients enrolled in 17 cardiology centers in Europe, Asia, and Australia from 2003 to 2010. (wikipedia.org)
The present in vitro study adds new information concerning the biochemical composition of CSE-related EVs, useful to predict their biological effects on target cells. (izon.com)
In the chronic intervention study FVPD consumption was found to significantly increase dietary carotenoids ( P =0·001) and vitamin C ( P =0·003). (cambridge.org)
This study evaluated 3 promising new unconjugated bilirubin, delta bilirubin or markers for cardiovascular risk: bilirubin, mono- or di-conjugated bilirubin. (who.int)

As an example, acute inhalation MRLs may not be protective for health effects that are delayed in development or are acquired following repeated acute insults, such as hypersensitivity reactions, asthma, or chronic bronchitis. (cdc.gov)

Since Epstein-Barr virus (EBV) infection is common and NPC is rare, it is a complex disease caused by the interaction of chronic EBV infection, environmental factors, and genetic and epigenetic changes, in a multistep process of carcinogenesis [ 7 , 10 - 13 ]. (hindawi.com)
These results illustrate the combined impact of genetic, lifestyle, and environmental factors in modulating immunological responsivity and emphasize the importance of the exposome in shaping biological responses. (cdc.gov)

The analysis of sEVs from a patient prior and post ALK-TKI crizotinib treatment reveals significant increases in the expressions of some markers (EGFR and PD-L1). (izon.com)

The lungNENomics project aims to address these important questions, and will continue to improve the biological understanding of this exceedingly rare and understudied disease. (who.int)

The patients were selected for the Q-SYMBIO trial if they had chronic heart failure in New York Heart Association functional classes III (marked limitation of physical activity) or IV (unable to carry out any physical activity without discomfort). (wikipedia.org)
Over the past decades, L. japonica has been the focus of attention of chemists and pharmacologists because of its abundant functional compound content and the associated biological properties. (biomedcentral.com)

Evaluar las actividades del cultivo de callos propagados in vitro y en el campo de la lechuga iceberg, que pueden actuar como una fuente alternativa de metabolitos secundarios bioactivos. (jppres.com)
Los extractos se hicieron con metanol, n-hexano, acetato de etilo y agua para plantas de lechuga Iceberg cultivadas in vitro y en el campo y se evaluaron para determinar su potencial medicinal tanto in vitro como in vivo en ratas. (jppres.com)

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