Reduced oxidative stressReactiveAntioxidantCell BiochemProteinsMembraneRatsBiomarkersMarker of oxidativeMitochondrial1999InflammationPhospholipidsStress in vivo2002PharmacolMalondialdehydeMetabolismOxidation2001DamageProteinBiophysAntioxidantsMethodsVitroCarcinogenesisAssayVitaminPancreaticAlterationsErythrocyteClinicalDiabeticIntracellularMechanismsBiologicalMiceOrganismConsequenceBlood1970AssessmentChronicImmuneResultsDiseasesSubstancesSignificantly
Reduced oxidative stress2
- Besides, the study suggests that B 2 or B 6 vitamins restored the levels of DA and reduced oxidative stress in brain of rats. (biomedcentral.com)
- Diabetic neuropathy - In experimental diabetic neuropathy, alpha-lipoic acid provides increased nerve blood flow, reduced oxidative stress and improves distal nerve conduction (24). (peoplesrx.com)
Reactive13
- When administrated orally, Arnica 30cH protects against hepatic mitochondrial membrane permeabilization induced by Ca 2+ and/or Fe 2+ -citrate-mediated lipid peroxidation and fragmentation of proteins due to the attack by reactive oxygen species. (thieme-connect.de)
- Our Exocell™ TBARS Malondialdehyde Oxidative Stress assay measures thiobarbituric acid reactive substances in biological specimens. (ethosbiosciences.com)
- Reactive oxygen species are a consequence of oxidative metabolism, but are balanced by reducing capacity under normal conditions. (ethosbiosciences.com)
- Lipid peroxidation damage on pyrethroid exposure and alternations in antioxidant status in rat erythrocytes: A possible involvement of reactive Oxygen species. (scialert.net)
- Hyperglycemia contributes to glycosylation of proteins and lipids, increases the production of reactive oxygen species, stimulates the synthesis and secretion of pro-inflammatory cytokines and acute phase proteins in various tissues, promoting thus inflammation processes in the vascular wall [ 2 , 3 ]. (medsci.org)
- respiratory burst (the rapid release of Reactions of oxygen radicals with Mitochondrial oxidative phosphor- reactive oxygen species from cells) cel ular components can deplete an- ylation is a major source of oxy- that involves nicotinamide adenine tioxidants, can cause direct oxidative gen radicals of endogenous origin. (who.int)
- Oxidative stress, defined as an imbalance between reactive oxygen species (ROS) production and removal, results from the overproduction of ROS, decreased antioxidant defence or a combination of both. (iiarjournals.org)
- Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
- In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)
- It is known that the increased internal lipid damages proteins and cells as well as DNA by converting reactive oxygen species (ROS) such as superoxide anion, hydrogen peroxide, and hydroxyl radical into malondialdehyde (MDA) [ 2 ]. (e-pan.org)
- Highly elevated contents of thiobarbituric acid reactive substances reflected extensive lipid peroxidation processes throughout the experiment. (nih.gov)
- f. on the 2-thiobarbituric acid reactive substances (TBARS) as lipid peroxidation biomarker, aldehydic and ketonic derivatives of oxidatively modified proteins, and total antioxidant capacity (TAC) in the muscle tissue of the rainbow trout (Oncorhynchus mykiss Walbaum). (org.ua)
- In lung tissue, lipid peroxidation, reactive oxygen species, superoxide dismutase activity and reduced glutathione were all increased by WPS exposure. (who.int)
Antioxidant6
- The results suggest that oxidative damage of erythrocyte caused by phenyl hydrazine could be prevented by calcium channel antagonist, diltiazem, which may act as antioxidant also. (scirp.org)
- Hydrogen peroxide protects tobacco from oxidative stress by inducing a set of antioxidant enzymes. (degruyter.com)
- The effects of chronic ethanol intoxication on the open-field behavior, on antioxidant enzyme activities, and the degree of lipid peroxidation were investigated. (nih.gov)
- One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
- Conclusion: Antioxidant combination therapy does not alleviate oxidative damage in pancreatic tissue better than astaxanthin alone. (jsurgmed.com)
- To counteract the oxidative stress mammalian cells have antioxidant system which includes enzymatic activities such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSHPx), and non enzymatic antioxidants including vitamins A, E, C, melatonin, uric acid (UA) and glutathione 6,10 . (bvsalud.org)
Cell Biochem1
- Cell Biochem Funct. (jcimjournal.com)
Proteins3
- 15 Castilho R.F., Meinicke A.R., Alemida A.M., Hermes-Lima M., Vercesi A.E. Oxidative damage of mitochondria induced by Fe(II)citrate is potentiated by Ca 2+ and includes lipid peroxidation and alterations in membrane proteins. (thieme-connect.de)
- Therefore, the presence of FR may upset this regulatory function of NO. The structural proteins in the lipid bilayer are contiguous with brain plasma membrane phospholipids [ 13 ] and the ionic inflow and outflow through the lipid bilayer is maintained by Na + , K + ATPase enzyme which stimulates Na + and K + flows [ 14 ]. (biomedcentral.com)
- 1992). These oxygen free radicals can modify DNA, proteins and membrane lipids, leading to cellular degeneration (Olanow, 1992). (scialert.net)
Membrane5
- Such FR-induced damage particularly affects the plasma membrane lipids [ 11 ]. (biomedcentral.com)
- 2000). The high polyunsaturated fatty acid content of the erythrocyte membrane and the continuous exposure to high concentrations of oxygen and iron in heamoglobin are factors that make erythrocytes very sensitive to oxidative injury (Bernabucci et al . (scialert.net)
- Oxidative damage of membrane phospholipids is called lipid peroxidation with malondialdehyde (MDA), an end-product of lipid peroxidation, being a widely used marker of cell exposure to oxidative stress ( 2 - 6 ). (iiarjournals.org)
- This effect has been linked to lipid peroxidation and membrane disruption, but the specific mechanisms behind these phenomena remain unclear. (sdu.dk)
- It is concluded that weight loss improves the n-3 LCPUFA status of obese patients in association with significant amelioration in the biomarkers of oxidative stress, membrane FA insaturation, and n-3 LCPUFA biosynthesis capacity, thus representing a central therapeutic issue in the improvement of obesity-related metabolic alterations involved in the mechanism of hepatic steatosis. (arasysperfector.com)
Rats3
- In view of all the aforementioned, the objective of the present work was to make a comparative analysis of the protective effects derivable from riboflavin (B 2 ) and pyridoxine (B 6 ) on 5-HIAA and dopamine levels, as well as on selected markers of oxidative stress in rats' brain regions after an induction of Huntington's disease (HD). (biomedcentral.com)
- Microchromatographic analysis of lipids, protein, and occurrence of lipid peroxidation in various brain areas of vanadium exposed rats: a possible mechanism of vanadium neurotoxicity. (thieme-connect.com)
- 10. Derouiche S, Degachi O, Gharbi K. Phytochemistry analysis and modulatory activity of Portulacaeoleracea and Aquilariamalaccensis extracts against High-fructose and high-fat diet induced immune cells alteration and heart lipid peroxidation in Rats. (ajptonline.com)
Biomarkers4
- Oxidative stress biomarkers of exposure to deltamethrin in freshwater fish, Channa punctatus Bloch. (scialert.net)
- Assessment of oxidative stress biomarkers in the equine blood after in vitro incubation with leaf extract obtained from Dendrobium parishii F. Agrobiodiversity for Improving Nutrition, Health, and Life Quality , 3, 416-427. (org.ua)
- Consistently, both CdSO 4 and ANF caused significant oxidative stress , including decreases in the reduced glutathione (GSH) level, inhibition of superoxide dismutase (SOD) activity, as well as increases in malondialdehyde (MDA) content in zebrafish embryo s, but these mixtures produced much more significant alterations on the biomarkers. (zju.edu.cn)
- Initially reported by Roberts and Morrow as major products of radical mediated lipid oxidation in vivo, they are now widely recognized as reliable biomarkers for oxidative stress. (oxfordbiomed.com)
Marker of oxidative2
- NO is also involved in cell kil ing but often used as a marker of oxidative Hanahan and Weinberg (2011), i n can also react with superoxide at DNA damage, although other bas- their landmark review "Hallmarks diffusion-limited rates to form per- es are also susceptible to oxidation. (who.int)
- The aim of the study was to investigate the relationship between plasma levels of malondialdehyde (MDA), a routinely used marker of oxidative stress, and squamous cell carcinoma of the oral cavity and oropharynx (OSCC). (iiarjournals.org)
Mitochondrial5
- To analyze the effect of homeopathic Arnica on mitochondrial oxidative stress induced by Ca 2+ plus inorganic phosphate and/or Fe 2+ -citrate-mediated lipid peroxidation through changes in oxygen consumption rates. (thieme-connect.de)
- In the presence of antimycin-A, electron transport chain inhibitor, as evidenced by antimycin-A insensitive O 2 consumption, Arnica inhibited lipid peroxidation of mitochondrial membranes. (thieme-connect.de)
- In oxidative stress conditions, in the presence of Ca 2+ and inorganic phosphate, animals receiving Arnica 30cH had a significant decrease in mitochondrial O 2 consumption compared to control animals. (thieme-connect.de)
- Aging and chronic disease development are multifactorial processes involving the cumulative effects of metabolic distress, inflammation, oxidative stress and mitochondrial dynamics. (provivapharma.com)
- Both formulations also ameliorated elevations in inflammation, oxidative stress and the loss of mitochondrial complex integrity. (provivapharma.com)
19991
- Chowdhury, T.D., Das, N., Chattopadhyay, A. and Datta, A.G. (1999) Effect of oxidative stress and erythropoietin on cytoskeletal protein and lipid organization in human erythrocytes. (scirp.org)
Inflammation8
- Disturbed lipid and carbohydrate metabolism are manifested by enhanced inflammation and endothelial dysfunction in patients with simply obesity. (medsci.org)
- Curcumin protects the rat liver from chemically-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. (greenmedinfo.com)
- This review aims at identifying the role of oxidative stress and inflammation as factors associated with chronic kidney disease pathophysiology. (ajptonline.com)
- Heavy metals, Oxidative stress and Inflammation in Pathophysiology of Chronic Kidney disease - A Review. (ajptonline.com)
- We provide biomedical researchers with the best tools available for the analysis of Oxidative Stress and Chronic Inflammation - two of the most important risk factors that play key roles in the development of a wide range of human illness, including cancer, cardiovascular disease, diabetes and neurodegeneration. (oxfordbiomed.com)
- Recent experimental studies reported the occurrence of lung inflammation and oxidative stress following acute and subacute exposure to WPS. (who.int)
- Here, we wanted to verify the extent of inflammation and oxidative stress in mice chronically-exposed to WPS and to evaluate, for the first time, its effect on alveolar injury and DNA damage and their association with impairment of lung function. (who.int)
- CONCLUSION: We show the persistence of lung inflammation and oxidative stress in mice chronically-exposed to WPS and demonstrate, for the first time, the occurrence of DNA damage and enlargement of alveolar spaces and ducts associated with impairment of lung function. (who.int)
Phospholipids1
- Our aim was to study the influence of weight loss on the fatty acid (FA) composition of liver and erythrocyte phospholipids and oxidative stress status in obese, non-alcoholic, fatty liver disease (NAFLD) patients. (arasysperfector.com)
Stress in vivo2
- 7. Roberts II, L.J., Morrow, J.D., Measurement of F2-isoprostanes as an index of oxidative stress in vivo, Free Radic. (oxfordbiomed.com)
- Zurück zum Zitat Kumar RS, Narayan B, Sawada Y, Hosokawa M, Miyashita K. Combined effect of astaxanthin and squalene on oxidative stress in vivo. (springermedizin.at)
20021
- Lu, C., Chan, S.L., Fu, W. and Mattson, M.P. (2002) The lipid peroxidation product 4-Hydroxyneal facilitates op- ening of voltage dependent Ca2+ channels in neurons by increasing protein tyrosine phosphorylation. (scirp.org)
Pharmacol1
- Biochem Pharmacol. (springermedizin.at)
Malondialdehyde4
- Upon the metabolic breakdown of the altered lipids is the formation of "secondary messengers" including malondialdehyde (MDA), 4-hydroxynonenal and others. (ethosbiosciences.com)
- The TBARS Malondialdehyde Oxidative Stress Assay depends on the reaction of thiobarbituric acid and MDA under acidic conditions to form a colored (and fluorescent) adduct (2). (ethosbiosciences.com)
- Pancreatic oxidative damage was evaluated with an increase in the serum activity of lipase and amylase, tissue levels of myeloperoxidase activity (MPO), malondialdehyde (MDA), luminol and lucigenin and decrease of glutathione. (jsurgmed.com)
- Lipid peroxidation in the intestinal tissue was evaluated by measuring the level of malondialdehyde (MDA), which is the end product of lipid peroxidation. (springermedizin.at)
Metabolism1
- 2004). LCPUFA are known to regulate hepatic lipid metabolism by modulating related enzyme expression at the level of gene transcription, mRNA processing and decay, and post-translational protein modifications, directing FA away from TAG storage and into oxidation and secretion (Clarke, 2004). (arasysperfector.com)
Oxidation1
- Buege, J.A. and Aust, S.D. (1978) Microsomal lipid per- oxidation. (scirp.org)
20011
- Consumption of fruits and vegetables containing high amounts of antioxidative nutraceuticals have been associated with the balance of the free radicals/antioxidants status, which helps to minimize the oxidative stress in the body and to reduce the risk of diseases (Kaur and Kapoor, 2001). (scialert.net)
Damage5
- Lipid peroxidation is an example of this damage. (ethosbiosciences.com)
- Vitamin C is an important first line of defense in protecting biomolecules from oxidative damage, especially in circulation. (ironpinoy.com)
- Halder, J. and Bhaduri, A.N. (1998) Protective role of bla- ck tea against oxidative damage of human red blood cells. (scirp.org)
- Conclusion V exposure in vitro resulted in oxidative damage with significant regional variations in brain tissue homogenates. (thieme-connect.com)
- Along with oxidative stress, WPS exposure significantly increased lung DNA damage index. (who.int)
Protein1
- Oxidative stress and formation of cytotoxic oligomers by the natively unfolded protein α-synuclein (α-syn) are both connected to the development of Parkinson's disease. (sdu.dk)
Biophys3
- Indian J Biochem Biophys 40: 300-308. (ethosbiosciences.com)
- Biochem Biophys Res Commun. (jsurgmed.com)
- Arch Biochem Biophys 137:365-373. (cdc.gov)
Antioxidants2
- Oxidative stress associated with NAFLD in obese patients represents a nutritional type of phenomenon, resulting from prolonged excess oxidative load (carbohydrates, lipids) and inadequate nutrient supply (dietary antioxidants) favoring pro-oxidant reactions (Sies et al. (arasysperfector.com)
- Thirunavukkarasu C, Sakthisekaran D . Effect of selenium on N-nitrosodiethylamine-induced multistage hepatocar- cinogenesis with reference to lipid peroxidation and enzymic antioxidants. (jcimjournal.com)
Methods1
- Methods for estimating lipid peroxidation: an analysis of merits and demerits. (ethosbiosciences.com)
Vitro2
- VC is pro-oxidative in vitro reactions and DF chelates V-ion moiety. (thieme-connect.com)
- To address this, we have prepared α-syn oligomers (αSOs) in vitro in the presence of the lipid peroxidation product 4-oxo-2-nonenal and investigated their interaction with live cells using in-cell NMR as well as stimulated emission depletion (STED) super-resolution and confocal microscopy. (sdu.dk)
Carcinogenesis2
- There is substantial evidence that oxidative stress participates in carcinogenesis ( 1 - 4 ). (iiarjournals.org)
- Progression as the final stage of carcinogenesis involves irreversible changes from the benign to the malignant cell phenotype by the continuous accumulation of genetic alterations with oxidative stress probably playing a similar role as in the previous stages ( 9 ). (iiarjournals.org)
Assay1
- A simple fluorometric assay for lipid peroxide in blood plasma. (ethosbiosciences.com)
Vitamin2
- The lipid peroxidation increased in cortex, striatum, and cerebellum/medulla oblongata, of animals treated with B 2 vitamin alone. (biomedcentral.com)
- Bansal AK, Bansal M, Soni G, Bhatnagar D . Protective role of Vitamin E pre-treatment on N-nitrosodiethylamine induced oxidative stress in rat liver. (jcimjournal.com)
Pancreatic1
- This results in hyperglycemia and pancreatic beta-cell dysfunction, especially when repeatedly exposed to oxidative stress. (vitalitymagazine.com)
Alterations1
- These hepatic alterations are related to insulin resistance and oxidative stress as crucial pathogenic factors (Videla et al. (arasysperfector.com)
Erythrocyte1
- An increase in lipid peroxidation, hemolysis and thiol content was observed after phenylhydrazine treatment of erythrocyte. (scirp.org)
Clinical1
- Zuo, L. Oxidative stress in neurodegenerative diseases: from molecular mechanisms to clinical applications. (benthamscience.com)
Diabetic1
- In humans, it has been demonstrated that oral administration of 600mg/day of lipoic acid can prevent or improve diabetic neuropathy, which may be due to a lowering of lipid peroxidation (25). (peoplesrx.com)
Intracellular1
- Oxidative stress occurs when the intracellular concentration of free radicals increases over the physiologic value. (bvsalud.org)
Mechanisms1
- Many tumor promoters manifest inhibitory effectson antioxidative defence mechanisms, thus increasing the level of oxidative stress in the tumor cell. (iiarjournals.org)
Biological1
- Lipid peroxidation can affect biological membranes by altering structure, permeability and function. (ethosbiosciences.com)
Mice1
- Effects of deltamethrin on lipid peroxidation in mice. (scialert.net)
Organism1
- The results showed that although the sulfluramid may cause the production of ROS, its slow action in the organism does not lead to oxidative stress. (springer.com)
Consequence1
- Andersen, J.K. Oxidative stress in neurodegeneration: cause or consequence? (benthamscience.com)
Blood2
- High fat and high cholesterol diets increase weight, blood lipid and cholesterol concentration [ 1 ]. (e-pan.org)
- High levels of cholesterol or other fats ( lipids ) in the blood ( hyperlipidemia ). (webmd.com)
19701
- He was the first to demonstrate the existence of hydrogen peroxide as a normal attribute of aerobic life in 1970, and he introduced the concept of Oxidative stress in 1985. (wikipedia.org)
Assessment1
- Measurement of MDA allows an assessment of oxidative stress. (ethosbiosciences.com)
Chronic1
- 11. Atieh M, Mohsen N, Zahra S. Oxidative Stress in Chronic Kidney Disease. (ajptonline.com)
Immune1
- Also oxidative stress suppresses the immune system's ability to protect and restore affected cells 10,12 . (bvsalud.org)
Results1
- The results confirm the capacity of 3-NPA to generate oxidative stress. (biomedcentral.com)
Diseases2
- One of the problems arising from the misfolded Huntingtin is the increase in oxidative stress, which is common in many neurological diseases such as Alzheimer's, Parkinson's, Amyotrophic Lateral Sclerosis and Creutzfeldt-Jakob disease. (benthamscience.com)
- Filip, M. Oxidative stress in neurodegenerative diseases. (benthamscience.com)
Substances1
- Is iron necessary to promote the production of lipid peroxides, or can other substances take the place of iron in ferroptosis? (nature.com)
Significantly2
- There is a rise in oxidative stress in workers of leafcutter ants treated with fipronil because SOD significantly increased when compared to the control group. (springer.com)
- Extracellular Ca2+ potentiates the phenylhydrazine-induced lipid peroxidation and hemoly- sis of erythrocytes significantly. (scirp.org)