Oxidation gene encodes alcohol aldehyde dehydrogenase. Medical search. Frequent questions

LuxAB was used to screen the substrate scopes of three prokaryotic oxidoreductases: an alcohol dehydrogenase (Pseudomonas putida), a choline oxidase variant (Arthrobacter chlorophenolicus) and a carboxylic acid reductase (Mycobacterium marinum). (tuni.fi)
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. (cancerindex.org)
A transcriptome analysis of isoamyl alcohol-induced filamentation in yeast reveals a novel role for Gre2p as isovaleraldehyde reductase. (rhea-db.org)
The biochemical activities ascribed to these two genes (d-lactate dehydrogenase and methylglyoxal reductase, respectively) displayed similarly timed increases to those of their respective mRNAs. (rhea-db.org)
These results indicate a previously unsuspected and novel role for the GRE2 gene product as a suppressor of filamentation by virtue of encoding isovaleraldehyde reductase activity. (rhea-db.org)

Alcohol dehydrogenases are a group of seven dehydrogenase enzymes that occur in many organisms and facilitate the interconversion between alcohols and aldehydes or ketones with the reduction of NAD+ to NADH. (biobool.com)
The application of genetically encoded biosensors enables the detection of small molecules in living cells and has facilitated the characterization of enzymes, their directed evolution and the engineering of (natural) metabolic pathways. (tuni.fi)
Aldehyde dehydrogenase are a superfamily enzymes which catalyze the oxidation of a large variety of aldehydes (Jo et al. (springeropen.com)
An analysis of the genome and its transcriptome revealed enzymes with biotechnological potential, such as two extracellular tannases (Atan1p and Atan2p) of the tannic-acid catabolic route, and a new pathway for the assimilation of n-butanol via butyric aldehyde and butyric acid. (biomedcentral.com)
These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. (cancerindex.org)
A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (lookformedical.com)
Enzymes that catalyze the cleavage of a carbon-carbon bond by means other than hydrolysis or oxidation. (lookformedical.com)
Metabolism of ethanol in the human body is a two-step process (Equation 1), mediated by the enzymes alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). (justia.com)
Hormetic pathways activated by phytochemicals may involve kinases and transcription factors that induce the expression of genes that encode antioxidant enzymes, protein chaperones, phase-2 enzymes, neurotrophic factors and other cytoprotective proteins. (psychosocialsomatic.com)

It catalyzes the oxidation of ethanol to acetaldehyde. (biobool.com)
An enzyme found primarily in BACTERIA and FUNGI that catalyzes the oxidation of ammonium hydroxide to nitrite. (lookformedical.com)
An enzyme that catalyzes the oxidation of nitrite to nitrate. (lookformedical.com)

In these experiments it was found that a glutathione-dependent formaldehyde dehydrogenase that oxidizes formaldehyde 6 was found to be encoded by a gene, which can be transferred between the microorganisms via plasmids, and the mechanisms of resistance can be transferred to unrelated strains of the same bacterial species, such as Escherichia coli. (basicmedicalkey.com)

Accumulation of long-chain fatty alcohols and modification of macromolecules by an excess of fatty aldehydes are thought to be the pathophysiologic mechanisms causing the manifestations of Sjögren-Larsson syndrome. (medscape.com)
Alcohol dehydrogenase is responsible for catalyzing oxidation of primary and secondary alcohols to aldehydes and ketones, respectively, and also can effect the reverse reaction. (biobool.com)
In this work, the LuxAB biosensor system from Photorhabdus luminescens was implemented in Escherichia coli to monitor the enzymatic production of aldehydes from primary alcohols and carboxylic acid substrates. (tuni.fi)
Whereas, microorganic synthesis of PAA is impeded by the formation of by-product phenethyl alcohol due to quick, endogenous, and superfluous conversion of aldehydes to their corresponding alcohols, which resulted in less conversation of PAA from aldehydes. (springeropen.com)

Sjögren-Larsson syndrome (SLS) is diagnosed by demonstrating the enzyme deficiency or by mutation analysis of the FALDH gene. (medscape.com)
Sjögren-Larsson syndrome (SLS) is due to deficient activity of fatty aldehyde dehydrogenase (FALDH), an enzyme required to oxidize fatty alcohol to fatty acid. (medscape.com)
Product Description specifical Introduction: Alcohol dehydrogenase (ADH) is an enzyme discovered in the mid-1960s in Drosophila melanogaster. (biobool.com)
One of those ions is crucial for the operation of the enzyme: it is located at the catalytic site and holds the hydroxyl group of the alcohol in place. (biobool.com)
Furthermore, the dual role of LuxAB as sensor and monooxygenase, emitting bioluminescence through the oxidation of aldehydes to the corresponding carboxylates, promises implementation in artificial enzyme cascades for the synthesis of carboxylic acids. (tuni.fi)
This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. (cancerindex.org)

Alcohol dehydrogenase is also involved in the toxicity of other types of alcohol: for instance, it oxidizes methanol to produce formaldehyde and ethylene glycol to ultimately yield glycolic and oxalic acids. (biobool.com)
Formaldehyde is the simplest of the aldehydes and is also known as methanal. (basicmedicalkey.com)
Some microorganisms have been found to have increased resistance to formaldehyde due to the expression of formaldehyde dehydrogenase. (basicmedicalkey.com)
5 Formaldehyde is oxidized by formaldehyde dehydrogenase. (basicmedicalkey.com)
7 , 8 However, Azachi et al 9 described that formaldehyde dehydrogenase was not the sole reason for increased resistance to formaldehyde in two gram-negative bacteria. (basicmedicalkey.com)

During alcohol consumption, acetaldehyde is formed in the digestive system by microbes in normal gut and flora. (who.int)
The engineered strain converts glucose to ethanol via acetate and acetaldehyde, catalyzed by the host-encoded aldehyde ferredoxin oxidoreductase AOR and heterologously expressed AdhA, in an energy-conserving, redox-balanced pathway. (brenda-enzymes.info)
Acetaldehyde has been implicated as a major factor in oral carcinogenesis associated with alcohol consumption. (hippokratia.gr)
Poor dental health status, infrequent oral hygiene habits and dental visits, smoking and presence of a dental prosthesis were significant parameters for increased levels of salivary acetaldehyde production from alcohol. (hippokratia.gr)
There is increasing evidence that a majorpart of the tumour-promoting action of alcohol might be mediatedvia its first, toxic and carcinogenic metabolite acetaldehyde. (hippokratia.gr)
Recent biochemical and epidemiological findings strongly suggest that acetaldehyde, the first metabolite of ethanol, plays an important role in alcohol-related carcinogenesis in the UADT consisting oral cavity, pharynx, larynx and esophagus 5-8 . (hippokratia.gr)
Intracellular formation of acetaldehyde from ethanol is produced in the epithelial cells by mucosalalcohol dehydrogenase (ADH), however much higher levels derive from microbialoxidation of ethanol by the oral microflora. (hippokratia.gr)
It is well established that acetaldehyde is the culprit in hangovers and in alcohol-induced facial flushing, and it is the principal suspect in alcohol-associated cancers as well vide infra. (justia.com)

In order for a cell to respond to changes in internal and external environmental factors, a broad range of protein co- and post-translational modifications have evolved to expand upon the relatively static properties encoded in protein side-chains. (biologists.com)
What does this gene/protein do? (cancerindex.org)
What pathways are this gene/protein implicaed in? (cancerindex.org)

We establish a microbial biosynthetic pathway for PAA production from the simple substrate phenylalanine in E. coli with heterologous coexpression of aminotransferase (ARO8), keto acid decarboxylase (KDC) and aldehyde dehydrogenase H (AldH) gene. (springeropen.com)
In this study, we establish a microbial biosynthetic pathway for PAA production from the simple substrate phenylalanine through overexpression of an aminotransferase gene ARO8, a keto acid decarboxylase gene KDC from S. cerevisiae and an aldehyde dehydrogenase H gene aldH from E. coli in E. coli (Fig. 1 ). (springeropen.com)
For example, acetaldehydemia-related facial flushing after light drinking, or upon administration of ethanol-containing pharmaceutical compositions, is experienced by individuals possessing inactive or inefficient aldehyde dehydrogenase (ALDH). (justia.com)

It binds and inactivates the 140 kDa subunit of RNA polymerase II, blocking all gene expression leading to proteins. (helmberg.at)
This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. (thermofisher.com)

Alda1 is used in treatment for the alcohol flush reaction experienced by people with genetically deficient ALDH2. (alda1agonist.com)

Virulence is controlled by a set of transcriptional regulators that directly bind to DNA promoter regions of toxin-encoding genes. (cipsm.de)

Ethanol oxidation also occurs, to a limited extent, in nearby tissues. (who.int)

In the online version, these sections contain links to more information about proteins encoded by over 17,000 known or predicted human genes. (cshlpress.com)

The AOR/AdhA pathway also converts exogenously added aliphatic and aromatic carboxylic acids to the corresponding alcohol using glucose, pyruvate, and/or hydrogen as the source of reductant. (brenda-enzymes.info)

Impaired fatty alcohol oxidation in cultured fibroblasts due to deficient fatty alcohol:nicotinamide adenine dinucleotide oxidoreductase activity. (medscape.com)
Deficient activity of the fatty aldehyde dehydrogenase component of fatty alcohol:NAD+ oxidoreductase in cultured fibroblasts. (medscape.com)

alpha-ketoisovalerate decarboxylase Kivd from Lactococcus lactis combined with alcohol dehydrogenase Adh3 from Zymomonas mobilis are the optimum candidates for 3-methyl-1-butanol production in Corynebacterium glutamicum. (brenda-enzymes.info)

A simple high-throughput assay utilized the bacterial luciferase-previously reported to only accept aliphatic long-chain aldehydes-to detect structurally diverse aldehydes, including aromatic and monoterpene aldehydes. (tuni.fi)
In this study, an Escherichia coli K-12 MG1655 strain with reduced aromatic aldehyde reduction (RARE) that does duty for a platform for aromatic aldehyde biosynthesis was used to prompt more PAA biosynthesis. (springeropen.com)

Ethanol serves this process by acting as a competitive inhibitor against methanol and ethylene glycol for alcohol dehydrogenase. (wikipedia.org)
It is obtained either in a polymeric form, paraformaldehyde (HO[CH 2 O] n H), or in a liquid aqueous suspension at ˜40% vol/vol stabilized with methanol (10%-15%) to prevent oxidation or polymerization generally referred to as formalin. (basicmedicalkey.com)

A transcriptome analysis was performed of Saccharomyces cerevisiae undergoing isoamyl alcohol-induced filament formation. (rhea-db.org)

for example, they provide structural stability to cells and tissues, give motility to individual cells, carry messages within and between cells, and regulate gene expression and metabolism. (biologists.com)
During general alcohol metabolism, hepatocytes generate mitochondria- and cytochrome P450 2E1 (CYP2E1)-mediated reactive oxygen species (ROS) whose accumulation elicits activation of the hepatic anti-oxidant system, including glutathione (GSH). (e-cmh.org)
In addition, we address different responses of alcohol metabolism that are specific to hepatic zones ( Fig. 1 ). (e-cmh.org)
The CcpA regulon comprises genes involved in sugar uptake, fermentation and amino acids metabolism, confirming the role of CcpA as a link between carbon and nitrogen pathways. (studyres.com)
In recent years, with the development of the next generation sequencing, molecular and genetic analysis methods, lots of genes which are involved in the chlorophyll, carotenoid, cell wall, central and secondary metabolism have been identified and confirmed to regulate pigment contents, fruit softening and other aspects of fruit flavor quality. (biomedcentral.com)
However, given that tomato specialized metabolism is highly complex, in order to identify the novel genes involved in aspects of fruit quality that are associated with these metabolites still requires considerable research effort. (biomedcentral.com)
Here, we focus on the recently obtained knowledge considering structural genes as well as transcriptional and post-translational regulators involved in the metabolic pathways underlying both appearance and internal quality such as those involved in chlorophyll, carotenoid, cell wall, central and secondary metabolism (Table 1 , Figure 1 ). (biomedcentral.com)

in yeast and many bacteria, some alcohol dehydrogenases catalyze the opposite reaction as part of fermentation. (biobool.com)
However, we previously demonstrated that the grisemycin (grm) cluster contained cryptic dehydratase and epimerase genes by heterologous expression of this biosynthetic gene cluster in Streptomyces lividans and proposed that two genes (grmH and grmL) with unknown functions catalyze dehydration and epimerization reactions. (hokudai.ac.jp)

Several studies have shown that the presence of ADH2*2 alleles, which encode hyper-active forms of alcohol dehydrogenase (W. F. Bosron, T. K. Li, Hepatology, 1986 6:502-510), also contributes to alcohol flushing and a predisposition to esophageal cancer (A. Shibuya et al. (justia.com)

Posttranscriptional regulation of adrenal TH gene expression contributes to the maladaptive responses triggered by insulin-induced recurrent hypoglycemia. (rochester.edu)
Nicotinic and muscarinic acetylcholine receptors are essential for the long-term response of tyrosine hydroxylase gene expression to chronic nicotine treatment in rat adrenal medulla. (rochester.edu)
Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
Because we showed that integration neither affects the levels of viral genes, nor those of virally disrupted human genes, a genome-wide screen was performed to identify human genes which expression is influenced by viral integration and have clinical relevance. (cancerindex.org)
There is significant overlap inside their gene expression patterns, as expected, but several notable dif ferences. (plasignaling.com)
The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. (thermofisher.com)

Presenting the genes of the human genome in their biological context, Guide to the Human Genome is an extensive online resource (also available in print) that provides easy access to information about human genes and their roles in specific processes. (cshlpress.com)

Furthermore, it's recognized that a genes transcriptional response supplies significant clues to its perform. (plasignaling.com)
A considerable amount of research has reported that fruit quality is affected by metabolic shifts which are under the coordinated regulation of both structural genes and transcriptional regulators. (biomedcentral.com)
2017 ). Recently, the high quality tomato genome and large scale transcriptomic datasets have significantly accelerated the illumination of the structural genes and transcriptional regulators underlying the formation of high quality fruit (The Tomato Genome Sequencing Consortium 2012 ). (biomedcentral.com)

In coenzyme A, the business end is the thiol group that becomes bound to the substrate, and in NAD + it is the nicotinamide moiety that undergoes reversible reduction and oxidation. (heresy.is)

With numerous illustrations and tables, each of the nearly 300 sections of the Guide describes genes involved in a specific pathway, process, or structure from the molecular and cellular levels to developmental and physiological processes. (cshlpress.com)
Recently there is an observation suggesting that transamination of phenylalanine, decarboxylation of phenylpyruvate, subsequent oxidation of phenylacetaldehyde would be the most likely pathway for PAA synthesis (Cook et al. (springeropen.com)
construction of a synthetic pathway for bioalcohol production at 70°C by insertion of the gene for alcohol dehydrogenase AdhA into the archaeon Pyrococcus furiosus. (brenda-enzymes.info)
However, chronic alcohol consumption decreases GSH generation through cysteine deficiency by suppressing the methionine cycle and trans-sulfuration system, whereas it turns on an alternative defense pathway, such as the xCT transporter, to compensate for GSH shortage. (e-cmh.org)

This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. (cancerindex.org)

There are five classes (I-V) of alcohol dehydrogenase, but the hepatic form that is primarily used in 3 humans is class 1. (biobool.com)

By whole transcriptome analyses, we characterized glucosedependent and CcpA-dependent gene regulation in Clostridium difficile. (studyres.com)
About 18% of all C. difficile genes are regulated by glucose, for which 50% depend on CcpA for regulation. (studyres.com)

The pathogenesis in the early stages of ALD, including alcoholic steatosis, also varies with oxidative stress, alcohol metabolite-mediated toxicity, and activation of diverse inflammatory signals. (e-cmh.org)

Hemeproteins whose characteristic mode of action involves transfer of reducing equivalents which are associated with a reversible change in oxidation state of the prosthetic group. (lookformedical.com)

The biosynthetic gene clusters of these linaridins lack obvious candidate genes for the dehydratase and epimerase required to introduce dehydrobutyrine and D-amino acid residues, respectively. (hokudai.ac.jp)

Ethanol (also called ethyl alcohol, grain alcohol, drinking alcohol, or simply alcohol) is an organic compound with the chemical formula CH3CH2OH. (wikipedia.org)

deletion of the hypoxanthine phosphoribosyltransferase gene in ethanol tolerant strain adhE*(EA), carrrying mutation P704L/H734R in the alcohol dehydrogenase gene, and deletion of lactate dehydrogenase (ldh) to redirect carbon flux towards ethanol reults in a strain producing 30% more ethanol than wild type on minimal medium. (brenda-enzymes.info)
We suggest that, while a known link from gene mutation to increased production of bisretinoids (as in ABCA4- and RDH12-associated diseases) causes primary elevation in fundus autofluorescence, a secondary autofluorescence elevation also exists, where an impairment and degeneration of photoreceptor cells by various causes leads to an increase in bisretinoid levels in RPE cells. (bvsalud.org)

Before the late 18th century the term "alcohol" generally referred to any sublimated substance. (wikipedia.org)

It was found that PAA transformation yield was up to ~94% from phenylalanine in E. coli and there was no by-product phenethyl alcohol was detected. (springeropen.com)
The pET-B3 plasmid harbouring the phaB gene derived from Ralstonia eutropha H16, was driven by the lac promoter in E. coli BL-21(DE3). (bvsalud.org)

The Guide will be useful to researchers looking to connect sequence data with functional information, and can be used in parallel with traditional texts in undergraduate and graduate courses to provide a genomics dimension and experience of identifying genes underpinning processes of interest. (cshlpress.com)
Using combination of chromatin immunoprecipitation and genome sequence analysis, we detected 55 CcpA binding sites corresponding to 140 genes directly controlled by CcpA. (studyres.com)

The compositions of the invention are expected to ameliorate some of the negative side effects associated with the consumption of alcohol, such as hangover and facial flushing. (justia.com)

Anatomy9

Organisms9

Diseases7

Chemicals and Drugs134

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Psychiatry and Psychology4

Phenomena and Processes37

Disciplines and Occupations1

Technology, Industry, Agriculture2

Information Science3

Health Care2

Reductase5

Enzymes9

Catalyzes the oxidation3

Glutathione-dependent formaldehyde dehydrogenase1

Alcohols4

Enzyme6

Formaldehyde5

Acetaldehyde8

Protein3

AldH3

Subunit2

ALDH21

Toxin-encod1

Ethanol oxidation1

Proteins1

Carboxylic1

Deficient2

ADH31

Aromatic2

Methanol2

Saccharomyces1

Metabolism7

Catalyze2

ADH21

Expression6

Human genes1

Transcriptional3

Reduction1

Pathway4

Chromosome1

Hepatic1

Regulation2

Metabolite1

Reversible1

Dehydratase1

Organic1

Mutation2

Generally referred1

Coli2

SEQUENCE2

Consumption of alcohol1