• proteins
  • 2 Modified proteins and lipids can alter EC and SMC gene expression, leading to increased production of procoagulants, adhesion molecules, chemotactic factors, and cytokines. (ahajournals.org)
  • Disturbances in the normal redox state of cells can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA. (wikipedia.org)
  • enzymes
  • These enzymes catalyze the oxidation of hypoxanthine to xanthine and can further catalyze the oxidation of xanthine to uric acid. (wikipedia.org)
  • While CYP2E1 itself carries out a relatively low number of these reactions (~4% of known P450-mediated drug oxidations), it and related enzymes CYP1A2 and CYP3A4 are responsible for the breakdown of a large number of toxic environmental chemicals and carcinogens that enter the body, in addition to basic metabolic reactions such as fatty acid oxidations. (wikipedia.org)
  • Like other enzymes of this class, the active site of CYP2E1 contains an iron atom bound by a heme center which mediates the electron transfer steps necessary to carry out oxidation of its substrates. (wikipedia.org)
  • nitric
  • They are produced commercially, usually as the first step in the production of nitric acid, either by the direct oxidation of atmospheric nitrogen in the electric arc (Birkeland-Eyder Process) or by the catalytic oxidation of anhydrous ammonia (Oswald Process). (cdc.gov)
  • Antioxidant
  • There is evidence in literature supports the fact that impairments in seminal antioxidant and lipid per-oxidation status play important roles in the physiopathology of male infertility. (ijbs.com)
  • Atig F, Raffa M, Ali HB, Abdelhamid K, Saad A, Ajina M. Altered Antioxidant Status and Increased Lipid Per-Oxidation in Seminal Plasma of Tunisian Infertile Men. (ijbs.com)
  • Vitamin E has also found use as a commercial antioxidant and biocompatible modifier of biomaterials and medical devices, for example in ultra high molecular weight polyethylene (UHMWPE) used in hip and knee implants by resisting oxidation and in hollow-fiber membrane cartridges used in extracorporeal hemodialysis therapy. (wikipedia.org)
  • adducts
  • In recent years, development of immunochemical detection of HNE-histidine adducts opened more advanced methodological possibilities for qualitative and quantitative detection of lipid peroxidation in various human and animal tissues[full citation needed] as well as in body fluids, including human serum and plasma samples. (wikipedia.org)
  • compounds
  • Nitrogen oxides form naturally during the oxidation of nitrogen-containing compounds such as coal, diesel fuel, and silage. (cdc.gov)
  • cycle
  • In general, diatomic gases only bind to the reduced heme, as ferrous Fe(II) while most peroxidases cycle between Fe(III) and Fe(IV) and hemeproteins involved in mitochondrial redox, oxidation-reduction, cycle between Fe(II) and Fe(III). (wikipedia.org)
  • presence
  • The presence of a large lipid core, necrotic tissue, macrophages, and a thin fibrous cap predisposes to plaque rupture. (ahajournals.org)
  • 4 Conversely, a relative absence of lipid and macrophages and the presence of a thick fibrous cap renders a plaque stable. (ahajournals.org)
  • profile
  • Adebayo AH, Aliyu R, Gatsing D, Garba IH (2006) The effects of ethanolic leaf extract of Commiphora africana (Buseraceae) on lipid profile in rats. (springer.com)
  • certain
  • While these oxidations are often of benefit to the body, certain carcinogens and toxins are bioactivated by CYP2E1, implicating the enzyme in the onset of hepatotoxicity caused by certain classes of drugs (see disease relevance section below). (wikipedia.org)