See Linezolid#Pharmacodynamics) Some of the most important oxazolidinones are antibiotics. (wikipedia.org)
Examples of antibiotic oxazolidinones include: Linezolid (Zyvox), which is available for intravenous administration and also has the advantage of having excellent oral bioavailability. (wikipedia.org)
The first commercially available 1,3-oxazolidinone antibiotic was linezolid, discovered and developed by Pharmacia & Upjohn. (wikipedia.org)
Based on the finding that oxazolidinone compounds have antibacterial activity, Upjohn succeeded in developing antibiotic compounds U-100766 (Linezolid) and U-100562 (Eperezolid) in 1996. (justia.com)
Linezolid is the first antibacterial drug in a new class of human-made antibiotics called oxazolidinones. (adam.com)
Linezolid is in a class of antibacterials called oxazolidinones. (medlineplus.gov)
Lincosamides, Oxazolidinones, and Streptogramins Lincosamides ( clindamycin), oxazolidinones ( linezolid, tedizolid), and streptogramins ( dalfopristin [streptogramin A] and quinupristin [streptogramin B]) are structurally different but are. (merckmanuals.com)
Antibiotics5
Oxazolidinone antibiotics are active against many Gram-positive bacteria, but are only weakly active against Gram-negative pathogens. (rsc.org)
We describe the synthesis of conjugates between a catechol moiety and oxazolidinone antibiotics. (rsc.org)
Particularly, novel oxazolidinone antibiotics are imperatively needed to circumvent the problem of resistant strains. (justia.com)
Culminating in the present invention, with the goal of overcoming the problems encountered in the prior art, intensive and thorough research was conducted by the present inventors into novel oxazolidinone class antibiotics with more potent anti-bacterial activity, which resulted in the finding that oxazolidinone derivatives with difluorophenyl moieties are highly inhibitory of resistant strains including Gram-positive bacteria and VRE. (justia.com)
Tedizolid is in a class of medications called oxazolidinone antibiotics. (medlineplus.gov)
Tedizolid2
AZD5847 and tedizolid also increased the bactericidal activity of BDQ+PMD, but they were less effective than the other oxazolidinones. (tbdrugaccelerator.org)
Sivextro (tedizolid phosphate) is an antibacterial agent of the oxazolidinone class. (centerwatch.com)
Derivative1
An oxazolidinone derivative used for other purposes is rivaroxaban, which is approved by the FDA for venous thromboembolism prophylaxis. (wikipedia.org)
Zyvox1
Oxazolidinone susceptibility patterns for 2005: International report from the Zyvox® Annual Appraisal of Potency and Spectrum Study. (jmilabs.com)
Compounds4
Oxazolidinones are a class of compounds containing 2-oxazolidone in the structure. (wikipedia.org)
Note that cycloserine, while technically an oxazolidone, has a different mechanism of action and substantially different properties from the aforementioned compounds. (wikipedia.org)
A series of novel teraryl oxazolidinone compounds was designed, synthesized, and evaluated for their antimicrobial activity and toxicities. (figshare.com)
The antibiotic activity of the oxazolidinone class compounds was first discovered by researchers at E.I. DuPont. (justia.com)
Synthesis3
The antibacterial effect of oxazolidinones is by working as protein synthesis inhibitors, targeting an early step involving the binding of N-formylmethionyl-tRNA to the ribosome. (wikipedia.org)
Background: MiBIECT is a new oxadiazolyl-oxazolidinone that has been developed by means of chemoinformatic tools, synthesis and biological evaluation. (unimib.it)
Synthesis and evaluation of pretomanid (PA-824) oxazolidinone hybrids. (stjude.org)
Antimicrobials1
citation needed] Oxazolidinones are mainly used as antimicrobials. (wikipedia.org)
Organic1
2-Oxazolidone is a heterocyclic organic compound containing both nitrogen and oxygen in a 5-membered ring. (wikipedia.org)
Activity1
The present experiments compared the activity of different oxazolidinones in combination with BDQ+PMD with or without PZA in the same model. (tbdrugaccelerator.org)
Work1
Oxazolidinones work by preventing bacteria from producing proteins they need to grow and multiply. (msdmanuals.com)
Conditions1
Enantioselective hydroxylation of other fatty acids including elaidic acid, petroselinic acid, vaccenic acid, and linoleic acid were evaluated under the similar conditions using (4R,5S)-(+)-4-methyl-5- phenyl-2-oxazolidinone as a chiral auxiliary to give 98% ee values for all cases. (usda.gov)
Novel oxazolidinone1
The funding will be used to conduct preclinical testing on a novel oxazolidinone inhibitor that was identified by researchers with the TB Alliance and Johns Hopkins University in 2020 as having the potential to treat two types of NTM, Mycobacterium abscessus and Mycobacterium avium complex. (umn.edu)
Chiral2
Base induced C-5 epimerisation of 4-methyl-5-phenyl oxazolidinones: Chiral auxiliaries derived from norephedrine and norpseudoephedrine. (ox.ac.uk)
Chiral oxazolidinones auxiliaries were found to be effective for completely controlling the stereochemistry of the products. (ttu.edu)
Mechanism of act1
Note that cycloserine, while technically an oxazolidone, has a different mechanism of action and substantially different properties from the aforementioned compounds. (wikipedia.org)
AZD25631
Validation of commercial dry-form panels (Sensititre) for the susceptibility testing of AZD2563, a new long-acting oxazolidinone. (jmilabs.com)
Macrolides1
Rifamycins, Oxazolidinones and Macrolides act on DNA. (nih.gov)
Stereochemistry1
effect of anomeric stereochemistry on the removal of the oxazolidinone group. (uchicago.edu)
Descriptor1
Oxazolidinones" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (uchicago.edu)
Class2
Oxazolidinones are a class of compounds containing 2-oxazolidone in the structure. (wikipedia.org)
Oxazolidinones--a new class of broad-spectrum chemotherapeutics. (nih.gov)
Acid2
Usually, the acid chloride substrate reacts with the oxazolidinone to form an imide. (wikipedia.org)
This was coupled with (S)-4-isopropyl-2-oxazolidinone to give a mixture of diastereomeric coronafacyl oxazolidinones, which were readily separable by silica-gel column chromatography to give 630 mg of optically pure (+)-coronafacic acid. (elsevierpure.com)
Drug1
The first ever used oxazolidinone was cycloserine (4-amino-1,2-oxazolidin-3-one), a second line drug against tuberculosis since 1956. (wikipedia.org)
Group2
Oxazolidinone protection of N-acetylglucosamine confers high reactivity on the 4-hydroxy group in glycosylation. (uchicago.edu)
Variations in the oxazolidinone, protecting group, and imine components show this to be a quite general reaction. (ttu.edu)
TOPIC1
This graph shows the total number of publications written about "Oxazolidinones" by people in this website by year, and whether "Oxazolidinones" was a major or minor topic of these publications. (uchicago.edu)