• tubules
  • The most typical is composed of tubules lined by Sertoli cells and interstitial clusters of Leydig cells. (wikipedia.org)
  • Translocation of germ cells from the base to the lumen of the seminiferous tubules occurs by conformational changes in the lateral margins of the Sertoli cells. (wikipedia.org)
  • inhibin and activins - secreted after puberty, and work together to regulate FSH secretion androgen binding protein (also called testosterone binding globulin) - increases testosterone concentration in the seminiferous tubules to stimulate spermatogenesis estradiol - aromatase from Sertoli cells convert testosterone to 17 beta estradiol to direct spermatogenesis glial cell line-derived neurotrophic factor (GDNF) - has been demonstrated to function in promoting undifferentiating spermatogonia, which ensures stem cell self-renewal during the perinatal period. (wikipedia.org)
  • transferrin - a blood plasma protein for iron ion delivery The occluding junctions of Sertoli cells form the blood-testis barrier, a structure that partitions the interstitial blood compartment of the testis from the adluminal compartment of the seminiferous tubules. (wikipedia.org)
  • Sertoli cells control the entry and exit of nutrients, hormones and other chemicals into the tubules of the testis as well as make the adluminal compartment an immune-privileged site. (wikipedia.org)
  • chemotherapy
  • GOG 205 (2005-2009) - Vulva - Phase II trial of radiation therapy and weekly cisplatin chemotherapy for the treatment of locally-advanced squamous cell carcinoma of the vulva. (wikibooks.org)
  • The role of chemotherapy or radiation therapy in the treatment of granulosa cell tumors remains uncertain because of the lack of prospective randomized trials supporting their roles as adjuvant agents. (appliedradiology.com)
  • Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. (utswmedicine.org)
  • Giving more than one drug (combination chemotherapy) may kill more tumor cells. (utswmedicine.org)
  • It is not yet known which chemotherapy regimen is more effective in treating sex cord-ovarian stromal tumors. (utswmedicine.org)
  • If the tumor is late stage and particularly aggressive (which is rare), radiation therapy , chemotherapy , or both, in addition to surgery, may be needed. (coliseumhealthsystem.com)
  • predisposition
  • For each tumour type, we detail the personal and family history features and the presenting characteristics of the ovarian tumour as well as the pathological features and molecular markers that point towards a cancer predisposition syndrome. (bmj.com)
  • recurrent
  • This randomized phase II trial studies paclitaxel and carboplatin to see how well they work compared with bleomycin sulfate, etoposide phosphate, and cisplatin in treating patients with sex cord-ovarian stromal tumors that have spread to other places in the body and usually cannot be cured or controlled with treatment (advanced) or has returned (recurrent). (utswmedicine.org)
  • I. To assess the activity of paclitaxel and carboplatin with respect to progression free survival (using bleomycin, etoposide, and cisplatin [BEP] as a reference) for newly diagnosed advanced or recurrent chemonaive ovarian sex cord-stromal tumors. (utswmedicine.org)
  • transitional cell carc
  • Transitional cell papilloma, NOS M8120/2 Transitional cell carcinoma in situ Urothelial carcinoma in situ M8120/3 Transitional cell carcinoma, NOS Urothelial carcinoma, NOS Transitional carcinoma M8121/0 Schneiderian papilloma, NOS (C30.0, C31. (wikipedia.org)
  • Papillary urothelial carcinoma, non-invasive M8130/3 Papillary transitional cell carcinoma (C67. (wikipedia.org)
  • Papillary urothelial carcinoma M8131/3 Transitional cell carcinoma, micropapillary ( C67. (wikipedia.org)
  • proliferation
  • Sertoli cell proliferation and differentiation is mainly activated by FGF9. (wikipedia.org)
  • Factors hypothesized to contribute to pituitary neoplasia initiation and proliferation include altered growth factors and cell-cycle regulators that are the result of epigenetic changes ( 6 ), abnormal hormonal milieu, abnormal intrapituitary microenvironment ( 7 ), and inherited or somatic mutations ( Fig. 1 ). (aacrjournals.org)
  • The primitive sex cords originate from the proliferation of the epithelium of the 2 genital ridges. (wikipedia.org)
  • Regardless of sex, though, WNT4 is needed for cell proliferation. (wikipedia.org)
  • carcinoma
  • There are five main subtypes of ovarian carcinoma, of which high-grade serous carcinoma is the most common. (wikipedia.org)
  • M8043/3 Small cell carcinoma, fusiform cell M8044/3 Small cell carcinoma, intermediate cell M8045/3 Combined small cell carcinoma Mixed small cell carcinoma Combined small cell-large cell carcinoma Combined small cell-adenocarcinoma Combined small cell-squamous cell carcinoma M8046/3 Non-small cell carcinoma (C34. (wikipedia.org)
  • Anal intraepithelial neoplasia, grade III (C21.1) AIN III (C21.1) M8078/3 Squamous cell carcinoma with horn formation M8080/2 Queyrat erythroplasia (C60. (wikipedia.org)
  • Intraepidermal squamous cell carcinoma, Bowen type (C44. (wikipedia.org)
  • M8082/3 Lymphoepithelial carcinoma Lymphoepithelioma Lymphoepithelioma-like carcinoma Schmincke tumor (C11. (wikipedia.org)
  • M8083/3 Basaloid squamous cell carcinoma M8084/3 Squamous cell carcinoma, clear cell type M8090/1 Basal cell tumor (C44. (wikipedia.org)
  • M8090/3) Basal cell carcinoma, NOS (C44. (wikipedia.org)
  • Basal cell epithelioma Rodent ulcer Pigmented basal cell carcinoma M8091/3 Multifocal superficial basal cell carcinoma (C44. (wikipedia.org)
  • Multicentric basal cell carcinoma M8092/3 Infriltrating basal cell carcinoma, NOS (C44. (wikipedia.org)
  • Infiltrating basal cell carcinoma, non-sclerosing Infiltrating basal cell carcinoma, sclerosing Basal cell carcinoma, morpheic Basal cell carcinoma, desmoplastic type M8093/3 Basal cell carcinoma, fibroepithelial (C44. (wikipedia.org)
  • Fibroepithelioma of Pinkus type Fibroepithelial basal cell carcinoma, Pinkus type Pinkus tumor Fibroepithelioma, NOS M8094/3 Basosquamous carcinoma (C44. (wikipedia.org)
  • Mixed basal-squamous cell carcinoma M8095/3 Metatypical carcinoma M8096/0 Intraepidermal epithelioma of Jadassohn (C44. (wikipedia.org)
  • M8097/3 Basal cell carcinoma, nodular (C44. (wikipedia.org)
  • Basal cell carcinoma, micronodular M8098/3 Adenoid basal carcinoma (C53. (wikipedia.org)
  • Trichilemmal carcinoma M8103/0 Pilar tumor (C44. (wikipedia.org)
  • Pilomatrixoma, malignant Pilomatricoma, malignant Matrical carcinoma M8120/0 Transitional cell papilloma, benign Transitional papilloma M8120/1 Urothelial papilloma, NOS Papilloma of baldder (C67. (wikipedia.org)
  • cancer
  • These cells are also found in a woman's ovaries, and in very rare cases lead to cancer. (floridahealthfinder.gov)
  • This is primarily because 80% of women with ovarian cancer present with advanced-stage disease. (appliedradiology.com)
  • Despite being a potent anti-cancer agent, the turmeric ingredient curcumin (C) has limited anti-tumor efficacy in vivo due to its low bioavailability. (readbyqxmd.com)
  • The study aims to determine the outcomes of systematic follow-up of patients diagnosed with ovarian or endometrial cancer from Gynaecologic-oncology multidisciplinary meetings who were deemed appropriate for genetics assessment. (readbyqxmd.com)
  • They can be benign or malignant (ovarian cancer). (wikipedia.org)
  • There are no known ways to prevent ovarian cancer of any kind, as the cause is unknown. (coliseumhealthsystem.com)
  • Less common types of ovarian cancer include germ cell tumors and sex cord stromal tumors. (wikipedia.org)
  • If caught and treated in an early stage, ovarian cancer is often curable. (wikipedia.org)
  • Death from ovarian cancer is more common in North America and Europe than in Africa and Asia. (wikipedia.org)
  • Play media Play media Early signs and symptoms of ovarian cancer may be absent or subtle. (wikipedia.org)
  • The early stages of ovarian cancer tend to be painless. (wikipedia.org)
  • If these symptoms start to occur more often or more severely than usual, especially after no significant history of such symptoms, ovarian cancer is considered. (wikipedia.org)
  • A biopsy should not be performed, as it raises the risk of spreading cancer cells into the scrotum. (wikipedia.org)
  • Inguinal orchiectomy is the preferred method because it lowers the risk of cancer cells escaping. (wikipedia.org)
  • This is because the lymphatic system of the scrotum, through which white blood cells (and, potentially, cancer cells) flow in and out, links to the lower extremities, while that of the testicle links to the back of the abdominal cavity (the retroperitoneum). (wikipedia.org)
  • A transscrotal biopsy or orchiectomy will potentially leave cancer cells in the scrotum and create two routes for cancer cells to spread, while in an inguinal orchiectomy only the retroperitoneal route exists. (wikipedia.org)
  • genes
  • An important gene associated with Sertoli Cell Tumor is SYP (Synaptophysin), and among its related pathways/superpathways is Ovarian Infertility Genes . (malacards.org)
  • To follow up on these findings, we are now studying the methylomes and transcriptomes of SCCOHT tumors and cell lines to identify critical SMARCA4 target genes/networks. (williamfoulkeslab.com)
  • There is mounting evidence to support the notion that, unlike the situation with oncogenes or classical tumor suppressor genes, DICER1-related tumor development relies on a delicate balance of germ-line and somatic lesions that compromise the microRNA processing function of the enzyme while in most cases avoiding its complete loss. (williamfoulkeslab.com)
  • familial
  • Pituitary adenomas with no other associated tumors have been described as familial isolated pituitary adenomas. (aacrjournals.org)
  • Sequencing of additional tumors, familial and sporadic in origin, revealed that all had loss of SMARCA4 expression resulting either from mutations or loss of heterozygosity, identifying SCCOHT as a monogenic disease. (williamfoulkeslab.com)
  • differentiation
  • The cell is also responsible for establishing and maintaining the spermatogonial stem cell niche, which ensures the renewal of stem cells and the differentiation of spermatogonia into mature germ cells that progress stepwise through the long process of spermatogenesis, ending in the release of spermatozoa in a process known as spermiation. (wikipedia.org)
  • After sexual differentiation, at day 49, the sex cords in males become the testis cords by the action of the testis-determining factor protein, which helps to develop and nourish the Sertoli cells. (wikipedia.org)
  • If deficient in XY mice, there is a delay in Sertoli cell differentiation. (wikipedia.org)
  • androgens
  • If it is secreting androgens the tumour is usually asymptomatic, but can cause precocious puberty in pre-pubertal boys. (wikipedia.org)