• The lack of proven screening tools for early detection and the high mortality of ovarian serous carcinoma (OSC), particularly high grade, have focused attention on identifying putative precursor lesions with distinct morphological and molecular characteristics. (hindawi.com)
  • He is currently funded by NIH to evaluate the potential use of Clostridium Perfringens Enterotoxin (CPE) as a novel therapy against chemotherapy resistant ovarian carcinoma. (yale.edu)
  • Formalin-fixed, paraffin-embedded human ovarian carcinoma stained with MUC16 Recombinant Rabbit Monoclonal Antibody (OCA125/4505R). (neobiotechnologies.com)
  • This antibody is a useful aid for classification of a variety of tumors, such as some adenocarcinomas of the colon, breast carcinomas, malignant mesothelioma, uterine adenomatoid tumor, lung bronchoalveolar carcinoma, and ovarian endometrioid and serous carcinomas. (neobiotechnologies.com)
  • lt;h3>Endometrial Cancer Molecular Risk Stratification is Equally Prognostic for Endometrioid Ovarian Carcinoma. (vchri.ca)
  • Ultrasonography helps differentiate between ovarian tumors and fibroids. (jpgo.org)
  • Uterine fibroid tumors are non cancerous growths in the uterus. (jpgo.org)
  • Grossly, both uterine tumors had a polypoid appearance. (bmj.com)
  • Uterine tumors which resembled sex cord tumors of the ovaries were reviewed by Clement and Scully in 1976 and divided in two groups. (surgpath4u.com)
  • Group 1 tumors were were endometrial stromal tumors with sex-cord like elements (ESTSCLE), and group 2 tumors were uterine tumor resembling ovarian sex cord tumor (UTROSCT). (surgpath4u.com)
  • This supports the prevailing opinion that UTROSCT are polyphenotypic uterine tumors with true sex cord differentiation, most likely arising from pluripotent mesechymal cells (Czernobilsky, Irving). (surgpath4u.com)
  • Czernobilsky B. Uterine tumors resembling ovarian sex cord tumors: an update. (surgpath4u.com)
  • Clinicopathologic features of 2 new cases of uterine tumors resembling ovarian sex cord tumors. (surgpath4u.com)
  • Irving JA, Carinelli S, Prat J. Uterine tumors resembling ovarian sex cord tumors are polyphenotypic neoplasms with true sex cord differentiation. (surgpath4u.com)
  • Uterine tumors resembling ovarian sex cord tumors (UTROSCT) lack the JAZF1-JJAZ1 translocation frequently seen in endometrial stromal tumors. (surgpath4u.com)
  • This step, which is viewed as a metaplastic change, would be necessary to explain the morphologic appearance of ovarian epithelial tumors which have a müllerian-type phenotype. (hindawi.com)
  • However, others believe it is unlikely that CICs are precursors and have instead proposed that ovarian epithelial tumors develop from müllerian-type epithelium lining paraovarian and paratubal cysts (the so-called secondary müllerian system) [ 6 ]. (hindawi.com)
  • Initial assessment of tumor-associated antigen CA-125 in patients with ovarian, cervical, and testicular tumors. (ox.ac.uk)
  • Endometrial stromal sarcoma (ESS) is a rare neoplasm accounting for only 0.2% of female genital tract tumors. (biomedcentral.com)
  • We present a case of a 64-year-old woman presenting with abdominopelvic and bilateral ovarian tumors with misleading clinical presentation and diagnostic challenge. (biomedcentral.com)
  • We report herein a case of a 64-year-old wowan presenting with abdominopelvic and bilateral ovarian tumors diagnosed histologically as low grade ESS arising from ovarian endometriosis. (biomedcentral.com)
  • In November 2017 a 64-year-old wowan presented to our hospital with abdominopelvic and bilateral ovarian tumors recently discovered on magnetic resonance imaging (MRI). (biomedcentral.com)
  • Five months later (November 2017), MRI was performed and revealed 2 latero-uterine (ovarian) solido-cystic tumors measuring 60 × 53 mm (left) and 47 × 40 mm (right), along with 2 pelvic masses (located in the recto-vaginal fascia and in the vicinity of the uterine cervix). (biomedcentral.com)
  • Macroscopic aspects of the ovarian tumors. (biomedcentral.com)
  • The aim of this study was to evaluate the prognostic factors of recurrence in uterine tumors resembling ovarian sex-cord tumors (UTROSCT) and to determine clinical-pathological characteristics, treatment options and outcome. (turkjpath.org)
  • Uterine tumors with sex-cord-like elements can be divided into two groups. (turkjpath.org)
  • UTROSCTs rarely recur and are thus considered uterine tumors with low malignant potential 4 . (turkjpath.org)
  • No reactivity has been shown for mucinous ovarian tumors or in germ cell or hematopoietic tumors. (neobiotechnologies.com)
  • CNS metastases from any gynecological neoplasia are a rare occurrence and amount to about 1% of all tumors of uterine, cervical, or ovarian origin. (clinsurgeryjournal.com)
  • A Med- enlargement of the ovary can be associated line search on PubMed since 1969 using the with interstitial oedema without neoplastic keywords [massive ovarian oedema case changes and is considered to be the result report] found around 117 cases reported. (who.int)
  • This can be easily mistaken for neoplasm, in which case the appropriate treatment will be removal of the Case report whole ovary. (who.int)
  • OBJECTIVES: I. Determine the efficacy of prolonged oral etoposide (VP-16) in patients with advanced ovarian epithelial or cervical cancer. (knowcancer.com)
  • Ovarian cancer is the most lethal gynecologic cancer, responsible for over 13,000 deaths in the US in 2009 ( http://www.cancer.org ). (hindawi.com)
  • A lack of effective screening tools for early detection of ovarian cancer in high-risk and general populations has led to increased interest in the identification of precursor lesions defined by both morphological and molecular changes that could be the target of not only early detection but prevention efforts. (hindawi.com)
  • Ovarian cancer is heterogeneous, like other cancers, comprising a collection of subtypes with different histologic and molecular characteristics that in turn inform prognosis [ 1 ]. (hindawi.com)
  • Accumulating evidence suggests that there are two general pathways in the molecular pathogenesis of what is known as ovarian cancer [ 2 , 3 ]. (hindawi.com)
  • A tubal origin for high-grade serous ovarian cancer is supported by gene expression profiles of OSC that reveal that they are more similar to normal müllerian epithelium than the ovarian surface epithelium [ 7 ]. (hindawi.com)
  • The KPWA/UW-led ovarian/uterine cancer phenotype has been validated at Mayo Clinic, the secondary phenotype development site. (phekb.org)
  • The Ovarian/Uterine Cancer phenotype is now ready for network-wide implementation. (phekb.org)
  • Serum CA-125, a glycoprotein antigen, has been measured in serum of patients with ovarian cancer, cervical cancer, or nonseminomatous germ-cell tumor of testis. (ox.ac.uk)
  • Increased concentrations were found in 21 of 27 patients with epithelial ovarian cancer and two of three patients with ovarian teratoma. (ox.ac.uk)
  • The ovarian stroma cancer, was 27.56 U/mL, beta-human showed extensive oedema. (who.int)
  • Dr. Santin's translational research program in ovarian cancer has been funded multiple times by federal agencies including the Department of Defense (DoD), the National Institute of Health (NIH) as well as private National and International Foundations. (yale.edu)
  • Methods: A panel of human ovarian, endometrial and cervical cancer cell lines were treated with platinum drugs or ionizing radiation (IR) along with small molecule pharmacological kinase inhibitors of Ataxia telangiectasia mutated (ATM) and ATM and Rad-3-related (ATR). (usuhs.edu)
  • Genetic epidemiology of ovarian cancer in the 22 Arab countries: A systematic review. (cdc.gov)
  • Women with breast and uterine cancer are more likely to harbor germline mutations than women with breast or uterine cancer alone: A case for expanded gene testing. (cdc.gov)
  • Title : Take action to lower your breast and ovarian cancer risk Corporate Authors(s) : National Center for Chronic Disease Prevention and Health Promotion (U.S.). Division of Cancer Prevention and Control. (cdc.gov)
  • It has conventionally been assumed that ovarian cancers arise from the ovarian surface epithelium (OSE), which is viewed as a modified type of mesothelium similar to that which lines the peritoneal cavity, by a process of invagination leading to the development of cortical inclusion cysts (CICs). (hindawi.com)
  • Functional ovarian cysts Benign ovarian masses include functional cysts (eg, corpus luteum cysts) and neoplasms (eg, benign teratomas). (msdmanuals.com)
  • Among healthy women, 1 in 5 have a retroverted uterus either as a normal variant of uterine position or as an acquired condition. (medscape.com)
  • Fixation of the uterus by adhesions is a risk factor for the rare pregnancy complications of uterine torsion, incarceration, or sacculation. (medscape.com)
  • This is an aneurysmal-like dilatation of the most superior portion of the uterine wall that permits the uterus to enlarge with the consequence of major anatomic distortion. (medscape.com)
  • When the uterine contour is distorted by a müllerian anomaly or a strategically placed leiomyoma, or an inflammatory process has occurred in the past (eg, endometriosis or salpingitis with pelvic adhesions), the uterus may become fixed in retroversion/retroflexion and lose its normal mobility. (medscape.com)
  • C54.0 is a billable ICD code used to specify a diagnosis of malignant neoplasm of isthmus uteri. (icd.codes)
  • Most uterine sarcomas fall into the category of leiomyosarcoma, endometrial stromal sarcoma, or undifferentiated sarcoma. (bmj.com)
  • At that time, the initial histopathological diagnosis was extra-uterine low grade endometrioid stromal sarcoma (EESS), and the performed endometrial biopsy showed atrophic endometrium with no evidence of tumor. (biomedcentral.com)
  • Based on compiled clinical reports and the author's experience, the diagnosis and management of the principal types of both benign and pathologic uterine malpositionings that occur during pregnancy are described in this review. (medscape.com)
  • Preoperative diagnosis based on history, clinical examination and imaging features was of a malignant ovarian neoplasm. (jpgo.org)
  • This uterine tumor was largely comprised of epithelial-like cells forming nests, cords and tubules -- garnering a diagnosis of UTROSCT. (surgpath4u.com)
  • The histopathological examination of the resected specimens disclosed the diagnosis of primary extra-uterine ESS arising from ovarian endometriosis. (biomedcentral.com)
  • The awareness of the potential extra-uterine location of ESS should lead to correct diagnosis as this tumor has histopathological features and clinical behavior similar to its uterine counterpart. (biomedcentral.com)
  • Uncommonly, obstetric complications result from acute or chronic changes in uterine shape or position prior to labor (retroversion or incarceration, prolapse, torsion, herniation or sacculation), during labor (pathologic retractions rings), or postpartum (acute or chronic inversion). (medscape.com)
  • The presence of an ovarian fibroma can cause ovarian torsion in some cases. (wikipedia.org)
  • A stepwise model of progression from cystadenomas to low-grade carcinomas has been proposed for these neoplasms. (hindawi.com)
  • It is estimated that 60% of sporadic ovarian carcinomas and the majority of those diagnosed in BRCA1 mutation carriers are of the high-grade serous type [ 4 , 5 ]. (hindawi.com)
  • lt;h3>Validated biomarker assays confirm that ARID1A loss is confounded with MMR deficiency, CD8{{sup}}+{{/sup}} TIL infiltration, and provides no independent prognostic value in endometriosis-associated ovarian carcinomas. (vchri.ca)
  • Data about sociodemographic characteristics, the type of neoplasm and the chemotherapy scheme proposed were collected. (bvsalud.org)
  • Leelavathi, Roy P, Triveni K, Impana S. Broad ligament fibroid mimicking as ovarian tumor. (jpgo.org)
  • Association of JAK2-V617F Mutations Detected by Solid Tumor Sequencing With Coexistent Myeloproliferative Neoplasms. (cdc.gov)
  • DRG Group #736-741 - Uterine and adnexa procedure for ovarian or adnexal malignancy with MCC. (icd.codes)
  • The serum externa, and some follicles showing an level of CA125, the marker for ovarian attenuated layer of cells. (who.int)
  • In table 4 of pseudocode you are referencing malignant neoplasms of female breast. (phekb.org)
  • Intermittent myometrial contractions and changes in uterine shape and position are normal during pregnancy . (medscape.com)
  • Uterine retroversion and incarceration progressing to sacculation as pregnancy advances. (medscape.com)
  • When uterine retroversion with incarceration develops for any reason during pregnancy, acute symptoms and serious complications are possible, and initial misdiagnosis is frequent. (medscape.com)
  • During early pregnancy, uterine retroversion is a normal positional variant. (medscape.com)
  • The resort to surgery for the correction of chronic uterine retroversion in the absence of distinct pathologic process (eg, endometriosis , other inflammatory condition) has fallen into appropriate disrepute. (medscape.com)
  • [ 7 ] In addition, teenage girls with obstructive uterine or vaginal anomalies show retrograde menstrual bleeding, and endometriosis is common in these patients. (medscape.com)
  • [ 7 ] This theory also is supported by development of endometriosis in women who lack normal endometrial tissue, such as those with Turner syndrome or uterine agenesis . (medscape.com)
  • We present a rare case of a large broad ligament leiomyoma with cystic degeneration masquerading as ovarian malignancy. (jpgo.org)
  • 3] Thus broad ligament fibroid and cystic degeneration of fibroids with internal septations can mimic an ovarian malignancy. (jpgo.org)
  • This is the first reported uterine case of the spindle cell variant of embryonal rhabdomyosarcoma. (bmj.com)
  • Pelvic ultrasound revealed uterine enlargement, multiple small leiomyomas, and a large mass in the myometrium. (ejgo.net)
  • Based on these cases and the published literature, rhabdomyosarcoma, especially the pleomorphic variant, appears to be a very aggressive neoplasm with an extremely poor prognosis. (bmj.com)
  • Since CA125 is highly glycosylated it creates a hydrophilic environment that acts as a lubricating barrier against foreign particles and infectious agents on the apical membrane of epithelial cells.CA125 reacts with both normal tissues and neoplasms of fallopian tube, endometrium, endocervix and mesothelioma. (neobiotechnologies.com)
  • Results of epidemiological studies indicated that there was a nonstatistically significant excess mortality for lymphatic and hematopoietic neoplasms, and leukemia. (cdc.gov)
  • It has been argued that changes in the microenvironment of the ovarian stroma surrounding the CICs leads to müllerian-type differentiation. (hindawi.com)
  • Biology of ovarian neoplasia / edited by E. D. Murphy and W. G. Beamer. (who.int)
  • Foram quimioterapia, mientras que en el grupo de control, no había pautas ni recetas coletados dados referentes às características sociodemográficas, à neoplasia previas. (bvsalud.org)
  • At presentation the pleomorphic rhabdomyosaroma was stage IV, exhibiting massive pelvic and abdominal dissemination that mimicked an ovarian neoplasm. (bmj.com)
  • Uterine retroversion in nonpregnant women is now recognized as a normal variant that, in most cases, does not result in symptoms. (medscape.com)