• mixed gonadal dy
  • Gonadoblastoma has been found in association with androgen insensitivity syndrome, mixed gonadal dysgenesis and Turner syndrome, especially in the presence of Y chromosome-bearing cells. (wikipedia.org)
  • rare tumour
  • citation needed] On magnetic resonance imaging, a fibroma may produce one of several imaging features that might be used in the future to identify this rare tumour prior to surgery. (wikipedia.org)
  • embryonal
  • It is believed to arise from the ectopic gonadal tissue along the embryonal route of the genital ridge. (urotoday.com)
  • Teratocarcinoma refers to a germ cell tumor that is a mixture of teratoma with embryonal carcinoma , or with choriocarcinoma , or with both. (omicsgroup.org)
  • [ 6 ] This kind of mixed germ cell tumor may be known simply as a teratoma with elements of embryonal carcinoma or choriocarcinoma, or simply by ignoring the teratoma component and referring only to its malignant component: embryonal carcinoma and/or choriocarcinoma. (omicsgroup.org)
  • chemotherapy
  • The role of chemotherapy or radiation therapy in the treatment of granulosa cell tumors remains uncertain because of the lack of prospective randomized trials supporting their roles as adjuvant agents. (appliedradiology.com)
  • The survival rate for germinomatous tumors is higher in part because these tumors are very sensitive to radiation, and they also respond well to chemotherapy. (omicsgroup.org)
  • Gonadoblastoma
  • Gonadoblastoma is most often associated with an abnormal chromosomal karyotype, gonadal dysgenesis, or the presence of a Y chromosome in over 90% of cases. (wikipedia.org)
  • marker
  • Most dysgerminomas are associated with elevated serum lactic dehydrogenase (LDH), which is sometimes used as a tumor marker . (wow.com)
  • ovaries
  • These tumors are believed to start in the cells covering the ovaries, though some may form at the Fallopian tubes. (wikipedia.org)
  • tend
  • these tumors tend to have late recurrencies ( even after 30 years ) Using next generation DNA sequencing, it was discovered that 97% of granulosa cell tumours contain an identical mutation in the FOXL2 gene . (wikipedia.org)
  • mutations
  • The rational is based on dysregulation that FOXL2 mutations present in almost all granulosa tumors result in the expression of CYP17 that appears to be key in the development and progression of the disease. (clinicaltrials.gov)
  • Mutations in this gene are a cause of blepharophimosis syndrome and premature ovarian failure 3. (cancerindex.org)