• Glucocorticosteroids, when administered in greater doses than physiological concentrations, interact indirectly and directly with important groups of bone cells involved in the bone turnover process (including osteoclasts, osteoblasts and osteocytes) by stimulating the process of bone resorption and inhibiting bone formation. (medscape.com)
  • This finding paralleled an increase in dying osteoblasts and osteocytes in patients with glucocorticoid-induced bone loss. (nih.gov)
  • If glucocorticoids act as a signal to osteoblasts and osteocytes to begin the dying process, and if the nature of that signal can be determined, it may be possible to design drugs to block the signal and spare many bone cells that might otherwise be lost. (nih.gov)
  • The team of scientists, led by Stavros Manolagas, M.D., Ph.D., has been able to show that mice treated with prednisolone, a commonly used glucocorticoid, have bone loss similar to that seen in human patients ( J Clin Invest 1998;102:274-282). (nih.gov)
  • It is also suggested that vitamin K2 may improve osteocyte density and lacunar occupancy by viable osteocytes in the cortical bone of glucocorticoid-treated or sciatic neurectomized rats [73, 74]. (city-made.com)
  • Doctors are more likely to prescribe prednisolone to patients who have severe liver diseases or cats as they lack the enzyme needed to break prednisone to prednisolone. (ecoairmask.com)
  • Increased Fractures and Mortality in Combination with Abiraterone plus Prednisone/Prednisolone: Xofigo is not recommended in combination with abiraterone acetate plus prednisone/prednisolone. (nih.gov)