• scanning electron m
  • By scanning electron microscopy, OPGL-treated osteoclasts generate more clusters of lacunae on bone suggesting that multiple, spatially associated cycles of resorption have occurred. (rupress.org)
  • The use of scanning electron microscopy, real-time cell monitoring and confocal microscopy indicated that osteoclasts responded in a time and dose-dependent manner to osteoprotegerin treatments with retraction of peripheral adhesive structures and detachment from the extracellular substrate. (sigmaaldrich.com)
  • morphologic
  • This extensively folded or ruffled border facilitates bone removal by dramatically increasing the cell surface for secretion and uptake of the resorption compartment contents and is a morphologic characteristic of an osteoclast that is actively resorbing bone. (wikipedia.org)
  • vitro
  • I have done a literature search (1966-present) and the seminal article seems to be Boyde & Jones (1984) Resorption of dentine by isolated osteoclasts in vitro. (histosearch.com)
  • calcitriol
  • It is believed that the increased levels of serum calcium resulting from calcitriol-stimulated intestinal uptake causes bone to take up more calcium than it loses by hormonal stimulation of osteoclasts. (wikipedia.org)
  • TRAP
  • In osteoclasts, TRAP is localized within the ruffled border area, the lysosomes, the Golgi cisternae and vesicles. (wikipedia.org)
  • In knockout studies, TRAP−/− mice exhibit mild osteopetrosis, associated with reduced osteoclast activity. (wikipedia.org)
  • apoptosis
  • Conclusions- Long-term alendronate treatment is associated with an increase in the number of osteoclasts, which include distinctive giant, hypernucleated, detached osteoclasts that are undergoing protracted apoptosis. (natap.org)
  • transmembrane
  • M-CSF acts through its receptor on the osteoclast, c-fms (colony-stimulating factor 1 receptor), a transmembrane tyrosine kinase-receptor, leading to secondary messenger activation of tyrosine kinase Src. (wikipedia.org)
  • Osteoclast stimulatory transmembrane protein is a protein that in humans is encoded by the OCSTAMP gene. (wikipedia.org)
  • histomorphometric
  • In early postmenopausal women, treatment with alendronate for 3 years decreased biochemical markers and histomorphometric indexes of bone turnover and simultaneously increased bone mineral density.3 Our study indicates that these changes were accompanied by a dose-dependent increase in the number of osteoclasts. (natap.org)
  • bones
  • In addition, the distribution and frequency of osteoclasts in the various bones of this frog were examined to relate their occurrence with the state of activity of the parathyroid glands. (rice.edu)
  • cells
  • This observation suggests that TREM-2 may function in myeloid cells other than DCs, most probably osteoclasts (OCs) and microglial cells, which are involved in bone modeling and brain function. (rupress.org)
  • This observation suggests that the TREM-2-DAP12 complex may regulate the function of an unexpectedly vast array of myeloid cells, including not only DCs, but also osteoclasts (OCs) and microglial cells, which are critical for bone modeling and brain function, respectively. (rupress.org)
  • These findings suggest that OCPs may serve as a source for both osteoclasts and other effector cells and participate actively in the pathogenesis of diseases. (wiley.com)
  • These may have dozens of nuclei, and typically express major osteoclast proteins but have significant differences from cells in living bone because of the not-natural substrate. (wikipedia.org)
  • The osteoclasts are multi-nucleated cells that contain numerous mitochondria and lysosomes. (wikipedia.org)
  • CT works by activating the G-proteins Gs and Gq often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain. (wikipedia.org)
  • hydrogen
  • The osteoclast releases hydrogen ions through the action of carbonic anhydrase (H2O + CO2 → HCO3− + H+) through the ruffled border into the resorptive cavity, acidifying and aiding dissolution of the mineralized bone matrix into Ca2+, H3PO4, H2CO3, water and other substances. (wikipedia.org)