• morphologic
  • This extensively folded or ruffled border facilitates bone removal by dramatically increasing the cell surface for secretion and uptake of the resorption compartment contents and is a morphologic characteristic of an osteoclast that is actively resorbing bone. (wikipedia.org)
  • mice
  • Osteoclast-specific ARKO (ocl-ARKO) mice showed no changes neither in osteoclast surface nor in bone microarchitecture nor in the response to orchidectomy and androgen replacement, indicating that the AR in osteoclasts is not critical for bone maintenance. (sigmaaldrich.com)
  • Since tibiae of ubiquitous ARKO mice displayed increased osteoclast counts, the role of AR was further explored using cell cultures from these animals. (sigmaaldrich.com)
  • In knockout studies, TRAP−/− mice exhibit mild osteopetrosis, associated with reduced osteoclast activity. (wikipedia.org)
  • transmembrane
  • M-CSF acts through its receptor on the osteoclast, c-fms (colony-stimulating factor 1 receptor), a transmembrane tyrosine kinase-receptor, leading to secondary messenger activation of tyrosine kinase Src. (wikipedia.org)
  • Osteoclast stimulatory transmembrane protein is a protein that in humans is encoded by the OCSTAMP gene. (wikipedia.org)
  • activity
  • In addition, the distribution and frequency of osteoclasts in the various bones of this frog were examined to relate their occurrence with the state of activity of the parathyroid glands. (rice.edu)
  • In addition to its effects on kidney and intestine, PTH increases the number and activity of osteoclasts. (wikipedia.org)
  • The increase in activity of already existing osteoclasts is the initial effect of PTH, and begins in minutes and increases over a few hours. (wikipedia.org)
  • Bone health is reliant on maintaining physiologically needed levels of calcium, where the body constantly maintains this calcium homeostasis through osteoblast and osteoclast activity. (wikipedia.org)
  • RANK
  • Signaling from RANK changes gene expression patterns through transcription factors like NFATc1 and characterizes the active osteoclast. (genome.jp)
  • myeloid
  • This observation suggests that TREM-2 may function in myeloid cells other than DCs, most probably osteoclasts (OCs) and microglial cells, which are involved in bone modeling and brain function. (rupress.org)
  • This observation suggests that the TREM-2-DAP12 complex may regulate the function of an unexpectedly vast array of myeloid cells, including not only DCs, but also osteoclasts (OCs) and microglial cells, which are critical for bone modeling and brain function, respectively. (rupress.org)
  • cells
  • However, the effect of bisphosphonates on their target cells remains enigmatic, since in patients benefiting from therapy, little change, if any, has been observed in the number of osteoclasts, which are the cells responsible for bone resorption. (natap.org)
  • These findings suggest that OCPs may serve as a source for both osteoclasts and other effector cells and participate actively in the pathogenesis of diseases. (wiley.com)
  • These may have dozens of nuclei, and typically express major osteoclast proteins but have significant differences from cells in living bone because of the not-natural substrate. (wikipedia.org)
  • The osteoclasts are multi-nucleated cells that contain numerous mitochondria and lysosomes. (wikipedia.org)
  • CT works by activating the G-proteins Gs and Gq often found on osteoclasts, on cells in the kidney, and on cells in a number of regions of the brain. (wikipedia.org)
  • hydrogen
  • The osteoclast releases hydrogen ions through the action of carbonic anhydrase (H2O + CO2 → HCO3− + H+) through the ruffled border into the resorptive cavity, acidifying and aiding dissolution of the mineralized bone matrix into Ca2+, H3PO4, H2CO3, water and other substances. (wikipedia.org)
  • increase
  • Conclusions- Long-term alendronate treatment is associated with an increase in the number of osteoclasts, which include distinctive giant, hypernucleated, detached osteoclasts that are undergoing protracted apoptosis. (natap.org)
  • In early postmenopausal women, treatment with alendronate for 3 years decreased biochemical markers and histomorphometric indexes of bone turnover and simultaneously increased bone mineral density.3 Our study indicates that these changes were accompanied by a dose-dependent increase in the number of osteoclasts. (natap.org)