Osteoarthritis functional cartilage on scaffolds tissue engineering. Medical search. Frequent questions

Final considerations: Current treatments for articular cartilage repair have major limitations. (bvsalud.org)
He has written a report on articular cartilage repair entitled "Articular Cartilage Repair: Tissue Engineering's Killer Application? (medscape.com)
Tissue-regeneration engineering has become an important method for articular cartilage repair. (singaporeherald.com)

This structure, called an extracellular matrix, allows cartilage to flex and absorb shock. (nih.gov)
A team led by Drs. Farshid Guilak and Charles Gersbach at Duke University set out to create an artificial scaffold that could direct stem cells within to differentiate and form extracellular matrix. (nih.gov)
Without any extra prompting, the cells created a cartilage-like extracellular matrix within 4 weeks. (nih.gov)
Collagen: Collagen is a structural protein present in the extracellular matrix of cartilage. (wikipedia.org)
Different scaffolding techniques are used for tissue engineering applications, including the use of decellularized extracellular matrix (ECM) and sheets of cells on ECM. (tissueandcells.com)
Assays of the tissue constructs indicate that intermittent compression at 500 and 1000 psi (3.44 and 6.87 MPa, respectively) stimulated the production of extracellular matrix, enhancing the rate of de novo chondrogenesis. (lievers.net)
Constructs derived from juvenile cells contained concentrations of extracellular matrix components at levels more like that of native tissue than did constructs derived from adult cells. (lievers.net)
To create smart and functional 3D matrices, RESTORE will develop (i) nanobiomaterial-based nanocarriers to modulate inflammatory, cartilage extracellular matrix degradation and infection threats, (ii) stimuli-responsive nanobiomaterials tuned via external physical stimulus using radiofrequency and electromagnetic fields, and (iii) non-invasive wearable and wireless device for remote stimulus and regeneration monitoring. (forskningsradet.no)
The mechanical environment of the chondrocyte is an important factor that influences the maintenance of the articular cartilage extracellular matrix. (lievers.net)

ACS Biomaterials Science & Engineering. (westminster.ac.uk)
Professor Michael V. Sefton, PhD of the Institute of Biomaterials and Biomedical Engineering at the University of Toronto in Canada, gave a presentation on The Life Initiative, a multicenter collaboration to address the vital organ shortage. (medscape.com)
The new paradigm of regenerative medicine and tissue engineering requires biomaterials with high specificity, where physical and chemical properties are duly tailored and combined with appropriate mechanical and degradation features in order to trigger specific cell events and functions involved in the regenerative process. (ibecbarcelona.eu)
Grant applications that are involved in the development of biomaterials and biomimetic scaffolds for tissue engineering, as well as the design of orthopaedic implants may be assigned to MTE. (nih.gov)
Applications that are involved with the application of biomaterials to enhance the intrinsic capacity of the regeneration of bone, tendon/ligaments and cartilage, gene therapy, as well as the mechanisms of orthopaedic implant loosening, may be assigned to SBSR. (nih.gov)
By engineering structural proteins and functional peptides, BDG is able to introduce new properties and functions to biomaterials. (uhasselt.be)

A survey conducted by Curl and colleagues of 31,516 knee arthroscopies revealed that chondral lesions were present in 63%, with an average of 2.7 hyaline cartilage lesions per knee. (medscape.com)
Techvest's estimate is that 427,800 arthroscopies are performed on people with hyaline cartilage lesions present. (medscape.com)
The nanobiomaterials will be integrated into cutting-edge 3D matrices that meet the needs of severe and mild chondral lesions: 1) the COPLA Scaffold commercialised since 2017 for animal health use and 2) 3D cartilage microtissues engineered via 3D bioprinting of iPS cells in a nanocellulose and alginate bioink. (forskningsradet.no)
Cartilage lesions are debrided sharply back to a circumferentially stable articular cartilage. (medscape.com)
These defects can range in size and depth, from small lesions to larger areas of cartilage damage. (singaporeherald.com)
Study data published in Arthritis Rheumatology suggest that destabilizing meniscal tears, large bone marrow lesions, and cartilage loss may predict the development of accelerated knee osteoarthritis (OA). (braceworks.ca)

Each type of cartilage has varying concentrations of components such as proteoglycans, collagen and water which determine its functional properties and location in the body. (wikipedia.org)
Collagen is composed of a triple helix structure of polypeptide chains and offers shear and tensile properties to the cartilage. (wikipedia.org)
Type II collagen is the most common type of collagen present in cartilage though types IX, X, XI, and XIV are also present. (wikipedia.org)
Cells: Chondrocytes are an obvious choice to use in the regeneration of cartilage due to their ability to secrete collagen and other ECM components necessary for the functional properties of cartilage. (wikipedia.org)
Recent animal studies in rat and rabbit models have provided strong evidence suggesting that the use of MSCs with engineered scaffolds in conjunction with surgical repair improve the tendon to bone interface healing, collagen fiber alignment, increased rate of healing, and overall improved strength of the repaired tendon . (stemcellcarolina.com)
Efficacy of supraspinatus tendon repair using mesenchymal stem cells along with a collagen I scaffold. (stemcellcarolina.com)
Development of a silk and collagen fiber scaffold for anterior cruciate ligament reconstruction. (uoanj.com)

Collagens are fibrous proteins that serve as the building blocks of skin, tendon, bone, and other connective tissues. (nih.gov)
This technique has shown promising results in conditions such as osteoarthritis, tendon injuries, and cartilage defects. (suzyfavorhamilton.com)
This therapy has shown great potential in the treatment of tendon injuries, ligament sprains, and osteoarthritis. (suzyfavorhamilton.com)
Molecular and cell biology of bone, cartilage, meniscus, tendon and ligament injury and repair. (nih.gov)
The role of microvesicles derived from mesenchymal stem cells in tissue regeneration, a dream for tendon repair? (unicyte.ch)
4-9 Tendon engineering therapies focus on Mesenchymal stem cells (MSC) due to their ability to differentiate into connective tissue. (stemcellcarolina.com)
6-9 Growth factors are involved in the activation and regulation of the cellular environmental response in tendon healing, and literature suggests that a 3D scaffold with sustained release of growth factors such as platelet-derived growth factor, transforming growth factor beta, vascular endothelial growth factor, insulin-like growth factor, and basic fibroblastic growth factor can provide the microenvironmental control needed to influence cell phenotype. (stemcellcarolina.com)
6-9,11 The literature offers compelling evidence to suggest that the placement of scaffolds seeded with MSCs into the tendon repair site during surgical repair of RC tears may provide improved overall recovery and a reduction in reinjury for patients . (stemcellcarolina.com)
Engineered stem cell niche matrices for rotator cuff tendon regenerative engineering. (stemcellcarolina.com)
Mesenchymal Stem Cell Secretome Improves Tendon Cell Viability In Vitro and Tendon-Bone Healing In Vivo When a Tissue Engineering Strategy Is Used in a Rat Model of Chronic Massive Rotator Cuff Tear. (stemcellcarolina.com)
The 2017 Fusion Conference on "Musculoskeletal Development and Regeneration", a premier scientific forum for the scientific investigation of the musculoskeletal system, will cover a wide range of topics to encompass basic to translational aspects of the biology and pathology of musculoskeletal tissues, including cartilage, bone, tendon, ligament, and muscle. (fusion-conferences.com)
Radioprotection provides functional mechanics but delays healing of irradiated tendon allografts after ACL reconstruction in sheep. (uoanj.com)

Creating replacements for musculoskeletal tissues is challenging. (nih.gov)
In orthopedic care, tissue engineering offers exciting possibilities for regenerating damaged bone, cartilage, and other musculoskeletal tissues. (suzyfavorhamilton.com)
Characterization of the intrinsic capacity of musculoskeletal tissues and joints to repair and regenerate. (nih.gov)
Gene expression, gene regulation, and gene therapy in injury and repair of musculoskeletal tissues. (nih.gov)
There are shared interests with Musculoskeletal Tissue Engineering (MTE) in the development of strategies to enhance repair of bone, cartilage and joints. (nih.gov)
Special emphasis will be on the application of contemporary approaches to address epigenetic, molecular, cellular, and tissue biology of musculoskeletal tissues, including a session featuring new directions and technologies, and challenges and opportunities in musculoskeletal research. (fusion-conferences.com)

Chondrocytes, cells found throughout cartilage, produce and maintain the structure. (nih.gov)
Cells within the artificial scaffold successfully differentiated into chondrocytes within 2 weeks. (nih.gov)
Chondrocytes vary in size, shape and concentration depending on their location in articular cartilage. (wikipedia.org)
Additionally, aging chondrocytes show less metabolic activity and may not produce functional proteins or not enough functional proteins to create a desired ECM. (wikipedia.org)
Mesenchymal stem cells can also be used to create chondrocytes and make cartilage regeneration possible. (wikipedia.org)
Isolated equine chondrocytes, from juveniles and adults, were cultured in resorbable polyglycolic acid meshes for up to 5 weeks with semicontinuous feeding using a custom-made system to intermittently compress the regenerating tissue. (lievers.net)
Effects of cyclic hydrostatic pressure on proteoglycan synthesis in cultured chondrocytes and articular cartilage explants. (lievers.net)
for example, present interest in treating defective joints is aimed solely towards chondrocytes or mesenchymal cells, which are found in healthy articular cartilage. (omicsonline.org)
To investigate the role of interleukin-6 (IL-6) and transforming growth factor beta 1 (TGF beta 1) in the regulation of tissue inhibitor of metalloproteinases-1 (TIMP-1) synthesis in human articular chondrocytes. (uni-bielefeld.de)
Previous studies have utilized theoretical models of chondrocytes within articular cartilage to predict the stress-strain and fluid flow environments around the cell, but little is currently known regarding the cellular properties which are required for implementation of these models. (lievers.net)
The objectives of this study were to characterize the mechanical behavior of primary human chondrocytes and to determine the Young's modulus of chondrocytes from non-osteoarthritic ('normal') and osteoarthritic cartilage. (lievers.net)
This finding suggests that chondrocytes from osteoarthritic cartilage may have altered volume regulation capabilities in response to mechanical deformation. (lievers.net)

However, the landscape of orthopedics has been transformed by regenerative medicine, which aims to restore, regenerate, and rejuvenate tissues and organs in the body. (suzyfavorhamilton.com)
Stem cells, which are undifferentiated cells capable of differentiating into various cell types, have the unique ability to regenerate damaged tissues. (suzyfavorhamilton.com)
To combat this issue, NIBIB-funded researchers are developing an implantable, biodegradable film that helps to regenerate the native cartilage at the site of damage. (nih.gov)
Some of these studies have demonstrated that bioengineered cartilage tissue can regenerate when implanted in patients with cartilage injuries. (medscape.com)
Mesenchymal stem cells (MSCs) have shown promising potential to regenerate periodontal tissue in various preclinical and clinical studies. (biomedcentral.com)
It turns out that humans can regenerate certain tissues faster than others too. (braceworks.ca)

2 Connecticut Convergence Institute for Translation in Regenerative Engineering, University of Connecticut Health Center, Farmington, CT 06030, USA. (nih.gov)
Direct orthopedic care has taken a significant leap forward with regenerative techniques that stimulate the body's natural healing processes, facilitating tissue repair and regeneration. (suzyfavorhamilton.com)
With continually evolving tissue engineering and stem cell technologies, the application of regenerative strategies has gained momentum among many research groups worldwide. (tissueandcells.com)
Regenerative medicine is a broad term encompassing all efforts to reach the ultimate goal of tissue replacement clinically. (tissueandcells.com)
The use of drug molecules for tissue engineering and regenerative procedures has also been reported to be a logical and successful regenerative mechanism. (tissueandcells.com)
Lung biofabrication is a new tissue engineering and regenerative development aimed at providing organs for potential use in transplantation. (ibecbarcelona.eu)
In recent years, regenerative medicine has emerged as an attractive field for new cellular and non- cellular approaches to tissue repair. (unicyte.ch)
Ensuing specialists later determined that this multifunctional organ contained a number of valuable resident cells, other worthy non-indigenous cellular populations and a quantity of distinct structural elements, which possessed the potential to optimize fat graft survival and eventually further tissue engineering applications in regenerative medicine. (scirp.org)
Focal chondral defects can be challenging to manage as articular cartilage has limited regenerative capacity. (singaporeherald.com)
MSC culture conditioned medium (CM) contains secretomes that had shown immunomodulatory and tissue regenerative potential in pre-clinical and clinical studies. (biomedcentral.com)

There are three types of cartilage in the human body: fibrocartilage, hyaline cartilage and elastic cartilage. (wikipedia.org)
Fibrocartilage is most often found in the intervertebral discs, elastic cartilage is found in the external ear and hyaline cartilage is found on many joint surfaces in the body. (wikipedia.org)
Replacement of hyaline cartilage (articular cartilage) is the most common application of synthetic cartilage. (wikipedia.org)
Based on these estimates, a technology superior to microfracture or mosaicplasty in achieving hyaline cartilage repair has a potential market of $300 million to $1 billion in the US alone. (medscape.com)
The goal is to resurface defects with hyaline cartilage in a one-step procedure. (medscape.com)

BACKGROUND: Knee osteoarthritis (OA) is a progressive and degenerative condition. (bvsalud.org)
Knee Osteoarthritis (OA) is a leading cause of premature disability in Veterans who develop knee OA at higher rates and younger ages than the population in general. (stanford.edu)
People at high risk for knee osteoarthritis (OA) may be reluctant to participate in strenuous physical activities such as jogging, cycling, singles tennis, and skiing. (braceworks.ca)
This study is a head-to-head comparison of non-surgical treatment of knee osteoarthritis and total knee replacement surgery. (braceworks.ca)

Tissue engineering principles are used in order to create a non-degradable and biocompatible material that can replace cartilage. (wikipedia.org)
Researchers are developing innovative strategies to seed cells onto biocompatible scaffolds and provide them with the necessary signals to grow and differentiate into fully functional tissues. (suzyfavorhamilton.com)
Engineered scaffolds are composed of biocompatible materials that support cell adhesion, cellular growth, the formation of three-dimensional tissue, and provide mechanical strength. (stemcellcarolina.com)

Reconstruction of such defects has conventionally been approached using autologous, allogenic, or xenogeneic grafts to restore the missing tissue with the hope for long-term functional rehabilitation. (tissueandcells.com)
Focal chondral defects of the knee joint refers to localized areas of damage or loss of articular cartilage in the knee. (singaporeherald.com)
If left untreated, these defects can progress, leading to further cartilage degeneration, joint instability, and the development of osteoarthritis (OA). (singaporeherald.com)
The treatment of focal chondral defects aims to promote cartilage repair and restoration of joint function. (singaporeherald.com)

Accordingly, tissue engineering could overcome these limitations by producing in vitro cartilage substitutes. (bvsalud.org)
Tissue engineering advancements and the application in the craniofacial region are quickly gaining momentum, although most research is still at early in vitro/in vivo stages. (tissueandcells.com)
Schneiderman R, Keret D, Maroudas A. Effects of mechanical and osmotic pressure on the rate of glycosaminoglycan synthesis in the human adult femoral head cartilage: an in vitro study. (lievers.net)
Effects of static and cyclic compressive loading on articular cartilage plugs in vitro. (lievers.net)
These highly controllable in vitro model systems would closely mimic functions of human tissues or organs. (nih.gov)

Proteoglycans: Proteoglycans are the second most abundant macromolecule in the ECM of cartilage. (wikipedia.org)
Changes in the metabolism of the proteoglycans from sheep articular cartilage in response to mechanical stress. (lievers.net)
The key components of articular cartilage are proteoglycans, which are large molecules composed of a core protein and attached glycosaminoglycan (GAGs) chains. (singaporeherald.com)
However, when articular cartilage degeneration sets in, the structure and composition of proteoglycans break down, leading to a range of issues. (singaporeherald.com)
Age, trauma, genetics, and inflammatory conditions can all contribute to this degeneration, which highlights the essential role proteoglycans play in maintaining articular cartilage health and function. (singaporeherald.com)

Researchers developed a 3-D scaffold that guides the development of stem cells into specialized cartilage-producing cells. (nih.gov)

Tissue Eng Part A. 2017;23(15-16):811-822. (stemcellcarolina.com)

Planning panels were convened in September and October 2004 in the areas of research on arthritis and other rheumatic diseases, orthopaedics, bone biology and bone diseases, muscle biology and muscle diseases, skin biology and skin diseases, and cartilage and connective tissue biology and diseases. (nih.gov)

Since the main cause of arthritis is degeneration of cartilage [ 4 ], along with scientific findings showing a significant depletion of levels of mesenchymal cells in osteoarthritis [ 5 ], attention has been directed towards harnessing these cells to prolong the life of an implant. (omicsonline.org)
This intervention may prevent chronic degeneration of cartilage tissue, an irreversible degenerative process that eventually develops into osteoarthritis (OA). (singaporeherald.com)

RESTORE, built upon the consortium's proofs-of-concept and discussions between orthopaedic surgeons, tissue engineers, material scientists, cell biologists and SMEs, will realize a new generation of smart nanoenabled 3D matrices able to fit into complex lesion geometry, modulate undesirable biological events, and remotely control, stimulate and monitor cartilage repair. (forskningsradet.no)
This bioactive molecules may inhibit fibrosis and apoptosis, enhance angiogenesis, stimulate mitosis and/or differentiation of tissue-intrinsic progenitor/stem cells5 and modulate the immune response6. (unicyte.ch)
The combination of tissue engineering with surgical repair has been suggested to stimulate stronger and more complete healing when compared to traditional methods. (stemcellcarolina.com)
Hedgehog signalling does not stimulate cartilage catabolism and is inhibited by Interleukin-1β. (medscape.com)

10. Klimczak A, Kozlowska U. Mesenchymal Stromal Cells and Tissue-Specific Progenitor Cells: Their Role in Tissue Homeostasis. (jcorth.com)

The purpose of this study is to determine changes to knee joint loading, biological markers, and cartilage structure following a novel active feedback gait retraining program in anterior cruciate ligament reconstructed patients. (stanford.edu)

Artistic rendering of human stem cells on the polymer scaffold. (nih.gov)
The technique could also be applied to other kinds of tissues using other stem cells-or even a patient's own cells. (nih.gov)
Once in place, stem cells promote tissue repair by differentiating into specific cell types and releasing bioactive molecules that facilitate healing. (suzyfavorhamilton.com)
However, the triad components - stem cells, morphogenic agents, and scaffolds - need further improvement before clinical application. (bvsalud.org)
More than one-and-a-half years after implantation, researchers report that human neural stem cells (NSCs) grafted into spinal cord injuries in laboratory rats displayed continued growth and maturity, with functional recovery beginning one year after grafting. (nih.gov)
To avoid immune recipient's rejection of the transplanted bioengineered lung, autologous bone marrow/adipose tissue-derived mesenchymal stem cells, lung progenitor cells or induced pluripotent stem cells are used for biofabricating the bioengineered lung. (ibecbarcelona.eu)
Stem cells have evoked considerable excitement in vet- erinary medicine because of the promise that stem cell technology could deliver tissue regeneration for injuries for which natural repair mechanisms do not deliver func- tional recovery and for which current therapeutic strate- gies have minimal effectiveness. (unicyte.ch)
Emerging technologies - Advances in tissue engineering using mesenchymal stem cells and scaffolds in rotator cuff repair. (stemcellcarolina.com)
An Engineered Multiphase Three-Dimensional Microenvironment to Ensure the Controlled Delivery of Cyclic Strain and Human Growth Differentiation Factor 5 for the Tenogenic Commitment of Human Bone Marrow Mesenchymal Stem Cells. (stemcellcarolina.com)
Cell-biology-related research on preadipocyte (adiposal-mesenchymal cell) differentiation laid the foundation for discoveries of adipose-derived cells (both in stromal vascular fraction, or SVF, and adipose-derived stromal/stem cells, or ASCs), which had become an increasing interest to both stem cell biologists and clinicians because of their potential for angiogenesis and suppression of inflammation for tissue engineering and treatments. (scirp.org)
Dental pulp mesenchymal stem cells (DP-MSCs) and umbilical cord mesenchymal stem cells (UBC-MSCs) were more proliferative than bone marrow mesenchymal stem cells (BM-MSCs) and adipose tissue mesenchymal stem cells(AT-MSCs). (vitalityhccs.com)
Therefore, umbilical cord mesenchymal stem cells (UC-MSCs) are more favorable choice than bone marrow mesenchymal stem cells (BM-MSCs) for neovascularization (the natural formation of new blood vessels) of engineered tissues. (vitalityhccs.com)

Osteoarthritis - a painful condition that results from the deterioration of the cartilage in our joints - affects millions of people worldwide. (nih.gov)
Mow VC, Ratcliffe A, Robin Poole A. Cartilage and diarthrodial joints as paradigms for hierarchical materials and structures. (lievers.net)
Mechanobiology and biomechanics of bone and joints at the molecular, cellular and tissue level. (nih.gov)
In osteoarthritis, the cartilage in the joints breaks down. (nih.gov)
Articular cartilage was obtained from human knee joints 24 hours after death. (uni-bielefeld.de)
OBJECTIVES: The lubrication of articulating cartilage surfaces in joints occurs through several distinct modes. (bio-goods.com)

The approach could allow for the creation of orthopedic implants to replace cartilage, bone, and other tissues. (nih.gov)

Relazione: "PRP intra-articular injection as treatments for early osteoarthritis. (elizavetakon.it)
In vivo optical imaging of early osteoarthritis using an antibody specific to damaged arthritic cartilage. (medscape.com)

Grant applications that focus on modeling and rehabilitative therapeutic interventions to improve spine and joint function, and biomechanics may be assigned to MRS. Applications that focus on animal models to evaluate the efficacy and functional outcomes of cell- and molecular-based therapies on joint movement and to identify biological markers for bone and joint diseases are assigned to [SBSR]. (nih.gov)
Applications that focus on biomechanics, osteoarthritis and cartilage biology of temporomandibular joint may be assigned to SBSR. (nih.gov)

This is performed even though the surface will be resurfaced to encourage the interstices between the grafts to form a fibrocartilage grout or seal between the native cartilage and the grafts. (medscape.com)

More specifically, we will devote attention to the current use of MSCs that have been used experimentally and in limited numbers of clinical cases for the surgical treatment of subchondral-bone cysts, bone-fracture repair and cartilage repair. (unicyte.ch)
Sup- port for the hypothesis of paracrine action of MSCs de- rives from in vivo studies indicating that, although MSCs exhibit multilineage differentiation potential and can mi- grate to injured sites after systemic administration, the dif- ferentiation of MSCs in cells of injured tissues contributed little to their therapeutic benefits. (unicyte.ch)
The poor survival rate of MSCs during in vivo transplantation and host immunogenic reaction towards MSCs are the main drawbacks of direct use of MSCs in periodontal tissue regeneration. (biomedcentral.com)
MSC-CM-based indirect treatment has the potential to eliminate the drawbacks of direct use of MSCs for periodontal tissue regeneration. (biomedcentral.com)

Torzilli PA, Grigiene R, Huang C, Friedman SM, Doty SB, Boskey AL, Lust G. Characterization of cartilage metabolic response to static and dynamic stress using a mechanical explant test system. (lievers.net)

The use of a biomimetic scaffold and a meniscal substitute. (elizavetakon.it)

Perfusion abnormalities in subchondral bone association with marrow edema, osteoarthritis and avascular necrosis. (universityorthopedics.com)
Mechanosensitive Control of Articular Cartilage and Subchondral Bone Homeostasis Requires Osteocytic TGFß Signaling. (ucsf.edu)

Moreover, one should consider the application of mechanical stimuli and surface properties to produce an articular cartilage with satisfactory characteristics for in vivo application. (bvsalud.org)
Most primary cells in 2-D cultures quickly lose in vivo properties such as tissue-specific gene expression, cell polarity, and cell-cell and cell-matrix contacts. (nih.gov)

Alternatively, expanded cells may be loaded into a bioactive scaffold. (tissueandcells.com)
Sequential release of bioactive IGF-I and TGF-?1 from PLGA microsphere-based scaffolds. (universityorthopedics.com)

Thus, trauma and certain inflammatory diseases that affect the articular cartilage may severely compromise quality of life, causing pain and disability. (bvsalud.org)
Interfaces 2021 Oct 13;13(40):47313-47326, Dual-Functional Dendrimer Micelles with Glycyrrhizic Acid for Anti-Inflammatory Therapy of Acute Lung Injury. (bioimagingsystem.com)
Pro-inflammatory IL-1beta and/or TNF-alpha up-regulate matrix metalloproteases-1 and -3 mRNA in chondrocyte subpopulations potentially pathogenic in osteoarthritis: in situ hybridization studies on a single cell level. (uni-bielefeld.de)
Periodontitis is a chronic inflammatory disease that leads to the destruction of both soft and hard periodontal tissues. (biomedcentral.com)

The technique used in this preclinical study could aid tissue regeneration following severe accidents, surgical resections, or progressive muscle loss due to age or genetic disease. (nih.gov)
The sad buy professionals handbook of financial risk management of such rechten in using knowledge company and tissue with preclinical being tissue. (a-e-markt.de)

Interspecies comparisons of in situ intrinsic mechanical properties of distal femoral cartilage. (lievers.net)

The scientists coated a 3-D woven scaffold with a compound that can secure viruses to a surface but still allow them to transfer genes into target cells. (nih.gov)
Tissue engineering principles include the use of cells, growth factors, and synthetic scaffolds in order to do this. (wikipedia.org)
These cells can be harvested from various sources, such as bone marrow, adipose tissue, or umbilical cord blood, and then introduced into the affected area. (suzyfavorhamilton.com)
Objective: To review the literature regarding sources of cells, scaffolds, and morphogenic agents currently used to produce articular cartilage. (bvsalud.org)
In this context, tissue engineering is an emerging and multidisciplinary field, which three main components are responsive cells, scaffolds, and morphogenic agents. (bvsalud.org)
Bioengineers print 3D implants with layered cells destined to become distinct combinations of tissue, like bone and cartilage. (nih.gov)
NIBIB-funded engineers have developed nanoparticles that lure immune cells away from the spinal cord, allowing regeneration that restored spinal cord function in mice. (nih.gov)
The most common pillars of the tissue engineering process are cells, scaffolds, growth factors, and gene modification to guide cellular differentiation and proliferation. (tissueandcells.com)
The first one is cell technology, which includes cell sourcing and the manipulation of cells in order to obtain the desired functional characteristics. (medscape.com)
The second is construct technology, where the cells are organized into three-dimensional structures that mimic native tissue in both architecture and function. (medscape.com)
One approach would be to grow human heart muscle cells outside the body, in a scaffold made of degradable material in the shape of the heart. (medscape.com)
Lung biofabrication is based on seeding cells into an acellular organ scaffold and on culturing them in an especial purpose bioreactor. (ibecbarcelona.eu)
By manipulating the biological machinery of living cells, our group focusses on the development of functional protein-based materials. (uhasselt.be)
2021 Sep 14;10(9):2420, PTX-3 Secreted by Intra-Articular-Injected SMUP-Cells Reduces Pain in an Osteoarthritis Rat Model. (bioimagingsystem.com)
They also identified several aspects of the cell transplantation procedure that could have a significant impact on the size of the therapeutic effect, including: the time-point of application, the use of surgical micro-dissection to "refresh" the scar tissue, the localization of transplanted cells, the number of injections, the injected volume, and the dose of cells administered. (vetscite.org)
Within 3D tissues, cells must coordinate remodeling in response to stress or growth signals, and this communication may occur by direct contact or by secreted signaling molecules. (pharmaceuticalintelligence.com)
Retraction Note: Mast cells are the main interleukin 17-positive cells in anticitrullinated protein antibody-positive and -negative rheumatoid arthritis and osteoarthritis synovium. (medscape.com)

Following cellular adhesion and proliferation, the engineered tissue is then implanted into the defect. (tissueandcells.com)
Michael J. Lysaght, PhD, Associate Professor in the Department of Molecular Pharmacology, Physiology and Biotechnology at Brown University, and President of the Rhode Island Center for Cellular Medicine, gave a talk on the business of tissue engineering and cellular medicine. (medscape.com)
Grant applications that address the development and fundamental cellular and molecular mechanisms of bone and cartilage may be assigned to SBDD. (nih.gov)
Functional loss is influenced by changes at the cellular and molecular physiology level. (cdc.gov)

The conference will be interdisciplinary and multidisciplinary, merging concepts and approaches from the sciences, engineering, medicine and more. (fusion-conferences.com)

A Researcher reasons that a main component of cartilage may contribute to this degenerative process. (singaporeherald.com)
Our research focuses on the molecular pathways controlling mesenchymal stem cell differentiation, how these pathways coordinate with physical cues to influence mechanical integrity of normal skeletal tissue, and how they can be harnessed to repair tissue damaged in degenerative skeletal disease. (ucsf.edu)

Tissue engineering involves creating functional, three-dimensional tissues and organs in the laboratory for transplantation or as models for research. (suzyfavorhamilton.com)
The future attention of the tissue-engineering community will turn to the vital organs with the potential of confronting the crisis in transplantation. (medscape.com)
The Life Initiative began in Toronto on June 2, 1998 with the goal of using tissue engineering to create an essentially unlimited supply of vital organs for transplantation. (medscape.com)
Through the program, researchers will develop 3-D human tissue chips that accurately model the structure and function of human organs. (nih.gov)

Lastly, in the case of creating synthetic cartilage to be used in joint spaces, high mechanical strength under compression needs to be an intrinsic property of the material. (wikipedia.org)
In addition, to address the main challenges for the production of functional cartilage: mechanical and lubricant properties. (bvsalud.org)
Literature review: The articular cartilage is a highly specialized tissue that reduces joint friction and distributes forces related to high mechanical loads between bone ends. (bvsalud.org)
The scaffolds developed in this work provide mechanical support, adequate 3D surface roughness, bioactivity and controlled drug delivery function, and are thus interesting candidates for bone tissue engineering applications. (westminster.ac.uk)
And because they grow quickly by leveraging simple mechanical processes, anole lungs provide new inspiration for engineers designing advanced biotechnologies. (nih.gov)
These aggregates are what give articular cartilage its unique properties, allowing it to absorb and distribute mechanical loads and offer resistance to compression. (singaporeherald.com)

First, cartilage is an avascular structure in the body and therefore does not repair itself. (wikipedia.org)

Soluble biglycan: a potential mediator of cartilage degradation in osteoarthritis. (medscape.com)

Tissue Repair Techniques of the Future: Options for Articular. (medscape.com)
Techvest, LLC's first annual conference on Tissue Repair, Replacement and Regeneration was held October 27-28, 1999 in New York, NY, and featured 50 presenting companies and eight lectures by leading figures in tissue engineering and medical practice. (medscape.com)
The process of bone remodeling is to repair bone damage and restore aging bone tissue [ 7 ]. (hindawi.com)
This makes cartilage repair difficult. (singaporeherald.com)
Does Gender Influence Outcome in Cartilage Repair Surgery? (uni-regensburg.de)

Cartilage is the slippery tissue that covers the ends of bones in a joint. (nih.gov)
Articular cartilage is the smooth, protective covering that lines the ends of bones within the joint. (singaporeherald.com)

In osteoarthritis (the most common type of arthritis), cartilage breaks down and wears away. (nih.gov)
Arthritis is a condition in which the cartilage surfaces between bones wears away resulting in bone rubbing on bone. (cdc.gov)

31 Medical Innovations in Tissue Engineering: Aiding Individuals with Meniscus Tears. (uoanj.com)
Patel JM, Merriam AR, Culp BM, Gatt CJ , Dunn MG (2016) One-year Outcomes of Total Meniscus Reconstruction Using a Novel Fiber-Reinforced Scaffold in an Ovine Model. (uoanj.com)
Successful Total Meniscus Reconstruction Using a Novel Fiber-Reinforced Scaffold: A 16- and 32-Week Study in an Ovine Model. (uoanj.com)

The development of cell interactive hydrogels is mainly responsible for the progress in tissue engineering over the past decades Today, the ideal hydrogel is considered to be a dynamic environment that answers the need of the developing tissue. (uhasselt.be)
Self-assembled rosette nanotube/hydrogel composites for cartilage tissue engineering. (universityorthopedics.com)

The scaffolds degrade over time to leave the natural tissues in place. (nih.gov)
With this in mind, it would be favourable to design hydrogels that remain stable during tissue development but fully degrade once the material has fulfilled its purpose. (uhasselt.be)

This approach could allow for implants that restore function to a joint immediately and drive development of a mature, viable tissue replacement. (nih.gov)
Specifically, lubricin helps to create a lubricating surface on the cartilage for easier joint mobility. (wikipedia.org)
Articular cartilage plays a vital role in joint health and its function, providing a smooth surface for frictionless movement and cushioning the joint during weight-bearing activities. (singaporeherald.com)
For instance, obesity has been shown to be a predictor of osteoarthritis (MMWR, 2010), suggesting a transference of benefits from obesity prevention to the prevention of joint pain. (cdc.gov)
There are various types of joint disorders and Osteoarthritis is the most common of the lot. (think3d.in)

Traditionally, orthopedic treatments focused on alleviating symptoms and repairing damaged tissues using surgical interventions or conservative approaches. (suzyfavorhamilton.com)
Diagrammatic representation of the different scaffold approaches used in tissue engineering. (tissueandcells.com)
Tissue engineering is used to denote the production of the target tissue using one of many approaches, which all follow similar principles. (tissueandcells.com)

Artificial cartilage is a synthetic material made of hydrogels or polymers that aims to mimic the functional properties of natural cartilage in the human body. (wikipedia.org)
While creating a useful synthetic cartilage material, certain challenges need to be overcome. (wikipedia.org)
Synthetic cartilage also needs to be stably attached to its underlying surface i.e. the bone. (wikipedia.org)
Synthetic cartilage can be composed of many different materials that mimic its functional properties. (wikipedia.org)

A total knee arthroplasty performed as a revision unicondylar knee arthroplasty is thought by some authors to have equivalent functional outcomes to a primary total knee replacement. (openorthopaedicsjournal.com)

Chondroitin sulfate is a chemical found in human and animal cartilage. (nih.gov)
Chondroitin sulfate is one of the building blocks of cartilage. (nih.gov)
Chondroitin sulfate is used for osteoarthritis and cataracts. (nih.gov)
Taking chondroitin sulfate by mouth seems to provide some relief from osteoarthritis pain and improve function. (nih.gov)
Chondroitin sulfate is the most predominant glycosaminoglycan found in articular cartilage, and it binds to the core protein to form proteoglycan aggregates. (singaporeherald.com)

This provides cartilage with its intrinsic ability to resist compression. (wikipedia.org)

Chondrocyte deformation and local tissue strain in articular cartilage: a confocal microscopy study. (lievers.net)

By delivering therapeutic genes directly to the affected tissues, gene therapy can potentially promote tissue regeneration and restore normal function. (suzyfavorhamilton.com)
Eukaryotic expression system complemented with expressivity of Semliki Forest Virus's RdRp and invasiveness of engineered Salmonella demonstrate promising potential for bacteria mediated gene therapy. (bioimagingsystem.com)

1,2 Partial and full thickness tears to the RC are associated with pain and instability and if left untreated often result in osteoarthritis and/or a complete loss of function. (stemcellcarolina.com)

There are shared interests with Skeletal Biology Development and Disease (SBDD) in the investigation related to bone and cartilage. (nih.gov)
Increasing knowledge about cell biology, materials science, and microfabrication technologies is enabling scientists to engineer functional units of human tissues (i.e., 3-D human tissue models). (nih.gov)

Being the most common and important models in trauma research, this review focuses on hemorrhagic shock, blunt chest trauma, bone fracture, skin and soft-tissue trauma, burns, traumatic brain injury and polytrauma. (biomedcentral.com)

There are on the other hand still many challenges that clearly require further research in order to catch up with the engineering of other parts of the human body. (tissueandcells.com)
Current biomedical research is frequently carried out in a 2-dimensional (2-D) tissue culture environment, despite the fact that human tissues are 3-dimensional (3-D) structures that require the interactions of multiple cell types with one another and with the environment to maintain their shape and function. (nih.gov)
What specific NIAMS questions can be best answered by 3-D human tissue models? (nih.gov)
Bone-cartilage crosstalk informed by aging mouse bone transcriptomics and human osteoarthritis genome-wide association studies. (ucsf.edu)

Anatomy60

Organisms6

Diseases22

Chemicals and Drugs65

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Psychiatry and Psychology2

Phenomena and Processes34

Disciplines and Occupations8

Technology, Industry, Agriculture30

Information Science3

Health Care3

Articular cartilage repair3

Extracellular9

Biomaterials6

Lesions6

Collagen7

Tendon12

Musculoskeletal6

Chondrocytes12

Regenerate6

Regenerative10

Hyaline cartilage5

Knee Osteoarthritis4

Biocompatible3

Defects4

Vitro5

Proteoglycans5

Specialized cartilage-produ1

20171

Connective tissue1

Degeneration of cartilage2

Stimulate4

Mesenchymal stromal cells1

Ligament1

Stem cells12

Joints6

Replace cartilage1

Early osteoarthritis2

Biomechanics2

Native cartilage1

MSCs4

Characterization1

Biomimetic1

Subchondral bone2

Vivo2

Bioactive2

Inflammatory4

Preclinical2

Situ1

Cells17

Cellular4

Multidisciplinary1

Degenerative2

Organs4

Mechanical6

Avascular structure1

Degradation1

Repair5

Ends of bones2

Arthritis2

Meniscus3

Hydrogel2

Degrade2

Joint5

Approaches3

Synthetic4

Arthroplasty1

Chondroitin5

Intrinsic1

Chondrocyte1

Gene therapy2

Left untreated1

Biology2

Bone fracture1

Human4