• We found that 7 of 48 (14.7%) of the analyzed cases harbored mutations in the JAK1 and JAK3 genes that mainly affected the pseudokinase domain of the corresponding proteins. (nih.gov)
  • We also studied global changes in gene expression in cells with mutated JAK1 and JAK3 proteins treated with INCB018424 and identified multiple genes that were differentially regulated by JAK/STAT signaling, such as FGF20 (upregulated) and EGR1 (downregulated). (nih.gov)
  • Gene expression refers to the process of making proteins using the instructions from genes. (cdc.gov)
  • There is a strong emphasis on the structure of molecules, particularly proteins, which are the nanoscale machines that carry out most processes in living organisms. (bbk.ac.uk)
  • His specific focus is functional characterization of the telomere proteins in the model organism Tetrahymena thermophila . (indwes.edu)
  • Confocal micrograph showing the expression of different fluorescent proteins in the stem of a thale cress seedling (Arabidopsis thaliana) used to study in vivo gene expression. (cellimagelibrary.org)
  • These organisms digest proteins and several fetid substances arise, leading to bad breath. (medscape.com)
  • These organisms usually enjoy proteins, and as they digest proteins several fetid substances arise. (medscape.com)
  • The course comprises molecular biology of genes, proteins, multicomponent protein complexes, and other biomolecules that provide structure and perform the organism's functions. (lu.se)
  • Immune system is a complex machinery, which is based on the highly coordinated expression of a wide array of genes and proteins. (lu.se)
  • These observations suggest genetic variants can decrease mRNA expression levels by increasing usage of intronic PAS. (elifesciences.org)
  • Thus, our work demonstrates that APA links genetic variation to variation in gene expression, protein expression, and disease risk, and reveals uncharted modes of genetic regulation. (elifesciences.org)
  • On the same line of thought, another important contribution was expressed by Denis Noble noble2006, showing that organisms are much more than simple machines built from genetic information, and the relationship between parts is fundamental as they affect gene expression. (nature.com)
  • Notably, a large number of stress-related elements present in the promoter regions of some ZmCAMTA genes, indicating a genetic basis of stress expression regulation of these genes. (frontiersin.org)
  • Examples of 2-omics analyses include expression quantitative trait locus eQTL (Franke & Jansen, 2009) and methylation quantitative trait locus meQTL (Smith, Kilaru, Kocak, Almli, & Mercer, 2014) that, respectively, assess the influence of genetic and epigenetic markers on gene expression. (researchgate.net)
  • These evidences are often based on the derivation of standard measures of association, linking (epi-)genetic markers to gene expression combined with gene expression analysis (Wagner, Busche, Ge, Kwan, & Pastinen, 2014). (researchgate.net)
  • Genomics refers to the study of all of the genetic material in an organism. (cdc.gov)
  • Funding Information: The research was supported by US National Institutes of Health grant to JHW (1R24GM084917 ?Genetic and Genomic Tools for the Emerging Model Organism, Nasonia? (lu.se)
  • Gene technology: basic and applied molecular genetic methods. (lu.se)
  • Genetic model organisms. (lu.se)
  • The genetic components of a approximately 24-hour clock are found in all organisms so far studied, from cyanobacteria to human beings, with few exceptions. (cdc.gov)
  • The student will evaluate gene expression in relation to measures of genetic diversity, differentiation, and neutrality across the genome to evaluate whether the sequences or the flanking regions of genes with stage-specific expression demonstrate signs of selection. (lu.se)
  • A genetic process by which the adult organism is realized via mechanisms that lead to the restriction in the possible fates of cells, eventually leading to their differentiated state. (bvsalud.org)
  • Here, we investigated, in females of both D. melanogaster and D. nigrosparsa , the gene expression between animals uninfected and infected with w Mel, using RNA sequencing to see if the two Drosophila species respond to the infection in the same or different ways. (nature.com)
  • The scientists used the Drosophila wing because it is an excellent model to describe how cells behave when a certain gene is mutated and to determine and test how this mutation affects adjacent cells. (sciencedaily.com)
  • Here, we identify and characterize the single Drosophila ortholog of the HB9/MNR2 gene family. (jneurosci.org)
  • Drosophila genes expressed specifically in all motoneurons have not been described, although a growing number of genes are known to be expressed in subsets of motoneurons. (jneurosci.org)
  • In Expression Atlas, users can query genes or gene-sets of interest and explore their expression across or within species, tissues, developmental stages in a constitutive or differential context, representing the effects of diseases, conditions or experimental interventions. (oregonstate.edu)
  • Novel features and visualizations include the on-the-fly analysis of gene set overlaps and the option to view gene co-expression in experiments investigating constitutive gene expression across tissues or other conditions. (oregonstate.edu)
  • RNA sequencing is a powerful method to study differential gene expression because it can detect a whole gene expression across particular tissues 1 . (nature.com)
  • Amy Radunz, a nutritionist from the department of animal sciences at the University of Wisconsin in River Falls, has partnered with molecular biologist Hasan Khatib, an associate professor at University of Wisconsin-Madison, to ask how differences in maternal diet during pregnancy induce gene expression and DNA methylation changes in fetal tissues in sheep. (genengnews.com)
  • The study also looked at the impact of paternally expressed genes: IGF2, PEG1, PEG3, DLK1, and DIO3 for transcriptomic and epigenomic alterations of the imprinted genes in fetal tissues. (genengnews.com)
  • Notch activity is required for the correct development of organisms and for the maintenance of tissues in adults. (sciencedaily.com)
  • There may be scope for future work comparing miRNA expression in different tissues between hybrids and parental species. (lu.se)
  • Professor Linger's primary research interest is the functional analysis of telomeres, protective complexes at the ends of linear chromosomes in eukaryotic organisms. (indwes.edu)
  • Mechanisms that regulate development from single cell to multicellular organisms. (lu.se)
  • The microbiome is the community of bacteria and fungi that are associated with different environments, including the surface, digestive tract, or other organs of multicellular organisms. (lu.se)
  • Developing targeted therapy for cutaneous T cell lymphoma (CTCL) patients still requires actionable mutated genes and deregulated pathways to be identified. (nih.gov)
  • Resistance arises by mutation (influencing the target or efflux of the antimicrobial agent) or by the acquisition of resistance genes (encoding antimicrobial or target alter- ation, or alternate pathways) (2,3). (cdc.gov)
  • The same pathways responsible for the development and growth of organisms are involved in the transformation of healthy cells into cancerous ones," says Marco Milán, so "all new data on the modulation of Notch activity, the first step in the chain, may be relevant for the design of effective therapies. (sciencedaily.com)
  • This RNA-Seq analysis presents a detailed picture of the candidate detoxification genes and other pathways that are potentially associated with pyrethroid and organophosphate resistance in Ae. (cdc.gov)
  • Our findings bring new insight into the role of lncRNAs in P. falciparum 's capacity to cause malaria, gene regulation, and sexual differentiation,' said Le Roch, who directs UCR's Center for Infectious Disease and Vector Research. (news-medical.net)
  • CAMTAs participate in gene expression regulation by binding to the cis -elements in the promoter regions of numerous target genes. (frontiersin.org)
  • In bacteria, gene regulation is mediated by either an activator or a repressor which binds DNA to turn a gene on or off, respectively. (findaphd.com)
  • Sexual dimorphism requires regulation of gene expression in developing organisms. (lu.se)
  • Unlike the decision systems, the circadian clocks show strong cooperative binding and negative regulation, which achieves tight temporal control of gene expression. (lu.se)
  • Molecular mechanisms for regulation of gene expression at different levels: remodeling of chromatin, initiation of transcription, nuclear transport and signalling, and RNA interference. (lu.se)
  • Principles for regulation of gene expression through intercellular signalling. (lu.se)
  • Gene regulation in developmental biology and the cell cycle. (lu.se)
  • Moreover, since zebrafish larvae and juveniles are small (less than 3 mm), they are ideal test subjects for potential 3D whole-organism imaging techniques ( Figure 1A ). (elifesciences.org)
  • For the first time, scientists have now demonstrated that the hourglass motif arises in organisms as diverse as the fruit fly and zebrafish, not only at morphological level but also at molecular level - a finding that suggests that parallels do, indeed, exist between ontogeny and phylogeny. (news-medical.net)
  • Meanwhile, Tomislav Domazet-Lošo and Diethard Tautz, researchers at the Max Planck Institute for Evolutionary Biology in Plön, demonstrated with zebrafish ( Danio rerio ) that the phylogenetically oldest genes are active during the phylotypic stage and that, before and after this stage, the most active genes are those that arose later in evolutionary history. (news-medical.net)
  • The Plön-based evolutionary biologists also made another astonishing discovery: they observed that in adult zebrafish progressively older genes are also activated with the increasing age of the animals. (news-medical.net)
  • For their study on zebrafish, another model organism widely used in evolutionary biology, the researchers from Plön also developed a new method: the transcriptome age index (TAI). (news-medical.net)
  • Confocal micrograph of a transgenic zebrafish embryo at 24 hours post-fertilization, showing expression of the fusion protein PARD3_GFP. (cellimagelibrary.org)
  • Functioning and Gene Expression of Adenosine A 1 Receptor During Zebrafish ( Danio rerio ) Development. (bvsalud.org)
  • Zebrafish is an established model organism for studies on health and disease . (bvsalud.org)
  • In this study, we evaluated the functionality of A1 adenosine receptor through development of zebrafish (6-7-day-, 3-, 8-, and 24-month-old), assessing (I) the effects of the agonist N6-cyclopenthyladenosine (CPA) over locomotor parameters , (II) the anticonvulsant properties of CPA and adenosine per se in the pentylenetetrazol -induced seizure, and (III) the gene expression of adora1b through development. (bvsalud.org)
  • Microarray expression analysis was used to determine whether global biological differences underlie common pathological features of prostate cancer and to identify genes that might anticipate the clinical behavior of this disease. (nih.gov)
  • Methods for analysis of gene expression: microarray, hybridisation, promoter analyses. (lu.se)
  • In his pioneering work, Jacques Loeb 3 considered that physicochemical biology completely and correctly explained the development of organisms and all participating processes. (nature.com)
  • Gene coexpression analysis refers to the en masse discovery of coexpressed genes from a large variety of transcriptomic experiments. (mdpi.com)
  • Scientists are keen to understand the mechanisms that regulate gene expression through the different stages of P. falciparum 's lifecycle because such knowledge can help in the discovery of novel antimalarial therapies. (news-medical.net)
  • There is increasing evidence that activating mutations in JAK genes and deregulated JAK/STAT signaling are important mechanisms involved in multiple B and T cell malignancies, including CTCL. (nih.gov)
  • The identification of causal or predictive variants/genes/mechanisms for disease-associated traits is characterized by 'complex' networks of molecular phenotypes. (researchgate.net)
  • Fruit flies are one of the most thoroughly researched model organisms and offer unique possibilities for the study of the molecular mechanisms that underlie embryonic development. (news-medical.net)
  • 2007). Meanwhile, new research in the field of genetics has shown that there may be other relevant mechanisms, besides melatonin production, which are also controlled by the genes involved in maintaining the circadian rhythm (Stevens et al. (cdc.gov)
  • Model organism databases (MODs) are biological databases, or knowledgebases, dedicated to the provision of in-depth biological data for intensively studied model organisms. (wikipedia.org)
  • Services provided to biological research communities include: Genome sequence annotations Location of genes and regulatory regions in the genome Functional curation of gene products Discern functions fulfilled by the gene product by looking at a variety of data including Gene Ontology (GO) annotations, phenotypes, gene expression, pathway information Protein/RNA sequence annotations Anatomical information Stock centres Orthology Oliver SG, Lock A, Harris MA, Nurse P, Wood V (June 2016). (wikipedia.org)
  • For years, anyone trying to assess biological variation has had to choose between measuring whole organisms at low resolution or studying only parts of them at high (cellular) resolution. (elifesciences.org)
  • In-depth biological analysis of connected genes in ANDnet and XORnet revealed genes that are related to energy metabolism, cell cycle control (AATF), immune system response, and several cancer types. (researchgate.net)
  • The type of biological networks that studies gene coexpression, known as Gene Coexpression Networks, consist of an undirected graph depicting genes and their coexpression relationships. (mdpi.com)
  • Thermal profiles reveal stark contrasts in properties of biological membranes from heart among Antarctic notothenioid fishes which vary in expression of hemoglobin and myoglobin. (organismnames.com)
  • During the second half of the 20th century, barley ( Hordeum vulgare ) has been widely used as a model organism for studying biological processes such as photosynthesis and chloroplast development. (mdpi.com)
  • By identifying disruptions in the biological systems we can make better predictions about resulting effects for both natural organisms and humans on both short and long term scales. (lu.se)
  • For example, all MODs use the Gene Ontology (GO) to describe functions, processes and cellular locations of specific gene products. (wikipedia.org)
  • Significant changes shared by the fly species belong to the expression of genes involved in processes such as oxidation-reduction process, iron-ion binding, and voltage-gated potassium-channel activity. (nature.com)
  • Molecular modeling calculations previously carried out in our laboratory revealed that both homo and hetero-dimers of histones from two euryarchaeal organisms are equally plausible. (pittstate.edu)
  • Hosted data range from genome assemblies with annotated gene features, transcript and protein expression data to population genetics including variation and insecticide-resistance phenotypes. (nih.gov)
  • Cytochrome P450s were the most overexpressed detoxification genes across all resistant phenotypes. (cdc.gov)
  • Model organism databases generate, source and collate species-specific information integratively by combining expert knowledge with literature curation and bioinformatics. (wikipedia.org)
  • Moreover, a model using gene expression data alone accurately predicted patient outcome following prostatectomy. (nih.gov)
  • Once they had working designs, the researchers used one of the circuits to create logic gates that would modify the expression of a specific developmental gene in a precisely defined type of root cell of Arabidopsis thaliana , a small, weedy plant that is often used as a model organism. (scienceblog.com)
  • Now that they've demonstrated that they can change the growth structure of a model organism, the researchers intend to apply these same tools to commercial crops. (scienceblog.com)
  • Xenbase: The Xenopus Model Organism Knowledgebase. (xenbase.org)
  • Moreover, the scientists also observed that the expression pattern of key genes reflects the hourglass model most faithfully. (news-medical.net)
  • We compare the dynamics of differential expression, isoform switching and functional interactions in the sexual development of the model parasitoid wasp Nasonia vitripennis, a system that permits genome wide analysis of sex bias from early embryos to adults. (lu.se)
  • Several of the commonly used tools for identifying targets of various miRNAs perform poorly for non-model organisms (e.g., anything that is not a human, mouse, fly or worm). (lu.se)
  • The experimental part focus on the model organisms, Bacillus subtilis , Escherichia coli and Streptomyces coelicolor . (lu.se)
  • Expression Atlas ( http://www.ebi.ac.uk/gxa ) is an added value database that provides information about gene and protein expression in different species and contexts, such as tissue, developmental stage, disease or cell type. (oregonstate.edu)
  • These developmental differences are caused by differential expression of genes and isoforms. (lu.se)
  • We find relatively little sex-bias in embryos and larvae at the gene level, but several sub-networks show sex-biased functional interactions in early developmental stages. (lu.se)
  • A cluster and humans coming into contact with the animals (farm that includes three genes, vanH , vanA , and vanX , is required for high-level resistance to glycopeptides. (cdc.gov)
  • Some researchers have proposed that the vanH , vanA , and vanX genes of hospital enterococci may have been acquired en bloc from the actinomycetes ( 8 ). (cdc.gov)
  • These results support the notion that the clinical behavior of prostate cancer is linked to underlying gene expression differences that are detectable at the time of diagnosis. (nih.gov)
  • The discovery of the hourglass pattern in different species makes it possible for evolutionary biologists to travel back in time to the earliest days of evolution when the differences between organisms arose. (news-medical.net)
  • We want to understand differences in life stage-specific gene expression in the peacock fly and relate these patterns to signatures of selection across the genome. (lu.se)
  • Here, we applied Illumina RNA-Seq to study the gene expression patterns associated with resistance to three widely used insecticides (malathion, alphacypermethrin, and lambda-cyhalothrin) in Ae. (cdc.gov)
  • As of August 2017, Expression Atlas holds data from 3,126 studies across 33 different species, including 731 from plants. (oregonstate.edu)
  • Basically, if miRNA repression is evolutionarily important for a gene, we expect the miRNA binding sites to be shared across closely related species. (lu.se)
  • Gene ontology: tool for the unification of biology. (wikipedia.org)
  • Gene Ontology Consortium (January 2015). (wikipedia.org)
  • The gene ontology (GO) terms associated with monooxygenase, iron binding, and passive transmembrane transporter activities were significantly enriched in four out of six resistant vs. susceptible comparisons while serine protease activity was elevated in all insecticide-resistant groups relative to the susceptible strain. (cdc.gov)
  • We then surveyed the distribution of stress-related cis -regulatory elements in the −1.5 kb promoter regions of ZmCAMTA genes. (frontiersin.org)
  • Evolution of chaperome gene expression and regulatory elements in the antarctic notothenioid fishes. (organismnames.com)
  • miRNAs are small noncoding RNAs that have broad regulatory functions on gene expression. (lu.se)
  • This will include co-expression network analyses to identify groups of genes that are expressed similarly and might belong to the same or linked gene regulatory networks. (lu.se)
  • Their mutagenic potential and gene regulatory effect have shaped the evolution of transcriptional networks involved in development, pluripotency, and inflammation. (lu.se)
  • Different gene expression patterns, shown by tools such as quantitative PCR, microarrays, and high-throughput RNA sequencing, reveal how organisms respond to different environments. (nature.com)
  • Quantitative real-time PCR was used to test the expression of ZmCAMTA genes under several abiotic stresses (drought, salt, and cold), various stress-related hormones [abscisic acid, auxin, salicylic acid (SA), and jasmonic acid] and biotic stress [rice black-streaked dwarf virus (RBSDV) infection]. (frontiersin.org)
  • Expression Atlas: gene and protein expression across multiple studies and organisms. (oregonstate.edu)
  • Since expression of both genes is under the control of the LacI repressor increased protein expression should not be significant enough to account for cell death. (pittstate.edu)
  • We observe sex-biased isoform switching consistently across development, but mostly in genes that are already differentially expressed. (lu.se)
  • Now in its 11th year, VectorBase currently hosts the genomes of 35 organisms including a number of non-vectors for comparative analysis. (nih.gov)
  • Strategies for gene therapy and production of medicines via genetically-modified organisms (expression vectors and viral vectors). (lu.se)
  • Two groups of scientists, including researchers at the Max Planck Institute of Molecular Genetics in Dresden and the Max Planck Institute for Evolutionary Biology in Plön, have now succeeded in demonstrating, for the first time, that parallels exist between individual development and phylogeny on the level of gene expression. (news-medical.net)
  • MODs allow researchers to easily find background information on large sets of genes, plan experiments efficiently, combine their data with existing knowledge, and construct novel hypotheses. (wikipedia.org)
  • In a developing wing and through a technique called Clonal Analysis, the researchers manipulated groups of cells, among groups of normal cells, to remove Notch receptor expression. (sciencedaily.com)
  • The availability of such a theory represents a fundamental progress in explaining both normal and pathological organism development. (nature.com)
  • Furthermore, nucleotide sequences related to the cluster vanHAX are present in this DNA, suggesting that the prolonged use of avoparcin in agriculture led to the uptake of glycopeptide resistance genes by animal commensal bacteria, which were subsequently transferred to humans. (cdc.gov)
  • Other bacteria, other micro-organisms and debris become incorporated in the biofilm. (thepigsite.com)
  • Bacteria within a biofilm communicate by quorum sensing leading to phenotypic modifications and changes in gene expression. (thepigsite.com)
  • Good" bacteria such as L. acidophilus can help break down food, absorb nutrients, and fight off "bad" organisms that might cause diseases. (medlineplus.gov)
  • The realization of the vastness of bacterial diversity and the development of novel experimental techniques have propelled molecular microbiology into a new era of investigation This course provides insights into how genes are organized and regulated in bacteria and in their viruses. (lu.se)
  • The third gene, vanA , Francisco, CA). encodes an ATP-dependent D-Ala-D-Lac ligase. (cdc.gov)
  • In this case, they used those logic gates to specify which types of cells were expressing certain genes, allowing them to adjust the number of branches in the root system without changing the rest of the plant. (scienceblog.com)
  • Use of Agrobacterium and baculoviruses for gene expression in plant and insect cells respectively. (up.ac.za)
  • This suggests that not only does feeding on the wrong host plant have large fitness costs for these flies, but the genes that are expressed during this life stage are under strong selection. (lu.se)
  • In contrast, selectively isolating microorganisms that accumulate desirable intracellular compounds, such as high-valued organic chemicals or environmental pollutants (such as heavy metals), can be challenging, as these organisms may not grow rapidly or may not grow in a unique environment that can be utilized as a selection parameter or selective pressure. (frontiersin.org)
  • In this study, we propose a strategy for the isolation of polyphosphate-accumulating organisms (PAOs) by coupling (i) specific staining of an intracellular accumulate without compromising cell viability, and (ii) rapid detection and sorting of target cells by using fluorescence-activated cell sorting (FACS), for which wastewater sludge samples were utilized. (frontiersin.org)
  • When the ligand and receptor come into contact, the Notch receptor is processed and the intracellular part moves to the nucleus to activate gene expression. (sciencedaily.com)
  • Activated macrophages kill intracellular organisms and secrete cytokines (eg, tumor necrosis factor-alpha [TNF-alpha], IL-10). (msdmanuals.com)
  • Conversely, ectopic HB9 expression causes an expansion of ventral motoneuron projections and repression of Even-skipped. (jneurosci.org)
  • and heterochromatization which result in selective gene expression or repression. (bvsalud.org)
  • DNA mutations in a gene can change what protein is made. (cdc.gov)
  • Large-scale mutations such as gene duplications and deletions add and remove network components, whereas smaller mutations alter the connections between them. (lu.se)
  • Accumulating evidence shows that tRNA expression and mutations are associated with various diseases such as neurological pathologies and cancer development3,4. (cdc.gov)
  • While no expression correlates of age, serum prostate specific antigen (PSA), and measures of local invasion were found, a set of genes was identified that strongly correlated with the state of tumor differentiation as measured by Gleason score. (nih.gov)
  • Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)
  • The actual origins of acquired resistance genes are unknown, but environmental microbes, including the strains producing antimicrobial agents, are believed to be important sources (4,5). (cdc.gov)
  • The polyP positive cells were recovered by FACS, purified by colony isolation and phylogenetically identified by 16S rRNA gene sequencing. (frontiersin.org)
  • We find relatively little sex-bias in embryos and larvae at the gene level, but several sub-networks. (lu.se)
  • He is also interested in the development of molecular tools to study protein function and gene expression in T. thermophila . (indwes.edu)
  • These results could inform development of novel molecular tools for detection of resistance-associated gene expression in this important arbovirus vector and guide the design and implementation of resistance management strategies. (cdc.gov)
  • Life sciences need a theory of organisms to test different hypothesis and consequences of its fundamental premises. (nature.com)
  • Such observations prompted the hypothesis that the individual development of an organism reflects its evolutionary history or phylogeny. (news-medical.net)
  • The present work introduces a computational implementation of some principles of a theory of organism development, namely that the default state of cells is proliferation and motility, and includes the principle of variation and organization by closure of constraints. (nature.com)
  • This is a computational task where genes act as logic gates that connect to form transcriptional networks, which are shaped at all scales by evolution. (lu.se)
  • Improved access to bioinformatics tools enables scientists to process, manage, and store raw data, annotate sequences to define genes, and quantitate RNA sequence data to get insight into gene expression patterns. (genengnews.com)
  • The vanH gene encodes a D‑lactate dehydrogenase that provides the requisite D‑lactate. (cdc.gov)
  • They are key regulators of gene expression in plants and other organisms. (ncbs.res.in)
  • Finally, we discover that sex-biased networks are enriched by genes specific to the Nasonia clade, and that those genes possess the topological properties of key regulators. (lu.se)
  • This separation into positive and negative regulators requires gene duplications, which highlights the interplay between mutation and selection in shaping the transcriptional networks. (lu.se)
  • Strong selection pressures experienced during one stage of development may differ from those experienced in other stages, and with consequences for the underlying patterns of gene expression. (lu.se)
  • The effect of expressing a gene is also influenced by which other genes are simultaneously expressed (functional interactions). (lu.se)
  • Interestingly, cuticular-related protein genes (chinase and chitin) were predominantly downregulated, which was also confirmed in the functional enrichment analysis. (cdc.gov)
  • The level of gene expression of adora1b was stable in brain from adult animals (8- and 24-month-old animals ). (bvsalud.org)
  • The student will analyze gene expression in a reference-based pipeline using existing RNA sequencing data from larvae, pupae, and adult flies from each of the two host forms. (lu.se)
  • The hyperthermophilic abilities of T. maritima , along with its deep lineage, suggests that it is potentially a very ancient organism. (eol.org)
  • This theory would deal with the way an organism spontaneously grows from a single cell to a complete and complex organism, introducing organization at the different development stages and homeostasis for a mature organism. (nature.com)
  • The student will be responsible for improving the annotations, especially for the untranslated regions that lie up and downstream of protein coding genes. (lu.se)
  • In this study, we developed a strategy for the isolation of polyphosphate-accumulating organisms (PAOs) by combining (i) nontoxic fluorescence staining of polyphosphate granules in viable microbial cells and (ii) fluorescence-activated cell sorting (FACS) for the rapid detection and collection of target cells. (frontiersin.org)
  • Therefore, in this study we focused on studying the mutational status of JAK1, JAK2 and JAK3 genes in a series of human CTCL lesions and cell lines using next-generation sequencing (NGS). (nih.gov)
  • This study investigated gene expression changes in whole blood samples obtained from donors diagnosed with major depressive disorder (MDD) compared to healthy controls. (nih.gov)