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  • Melanosomes
  • Melanosomes are unique lysosome-related organelles present only in cells that make melanin, the major synthesized pigment in mammals. (upenn.edu)
  • Melanosomes are among a number of tissue-specific lysosome-related organelles that are malformed and dysfunctional in a group of rare heritable disorders, including Hermansky-Pudlak and Chediak-Higashi syndromes, and pigment cell-specific proteins that localize to melanosomes are targets for the immune system in patients with melanoma. (upenn.edu)
  • To investigate the mechanism by which only PKC-β phosphorylates tyrosinase, we examined the expression of receptor for activated C-kinase-I (RACK-I), a receptor specific for activated PKC-β, on the surface of melanosomes, the specialized organelle in which melanogenesis occurs. (biologists.org)
  • protein
  • Autophagy is responsible for the degradation of damaged organelles and protein aggregates and therefore plays a significant role in cellular homeostasis. (mdpi.com)
  • Regulation and diseases of intracellular protein transport and organelle biogenesis. (upenn.edu)
  • Work in my laboratory is focused on understanding how integral membrane protein complexes are assembled and sorted to the appropriate compartments within the late secretory and endocytic pathways, how sorting and assembly contribute to the biogenesis of specific organelles in several cell types, how these processes impact biological function in the pigmentary, blood clotting, and immune systems, and how they are thwarted by generally rare genetic diseases. (upenn.edu)
  • Using these approaches, we are (1) outlining protein transport pathways that lead to the formation of these unusual organelles, (2) dissecting biochemical pathways that lead to their morphogenesis, and (3) defining how these processes are subverted by genetic disease. (upenn.edu)
  • cell
  • Because genetic diseases like Hermansky-Pudlak syndrome affect multiple organ systems, we study how similar sorting processes involved in melanosome biogenesis influence other organelles in different cell types. (upenn.edu)
  • peroxisomes
  • The organelles resemble the peroxisomes of other eukaryotic organisms in that they may contain the enzymes catalase and superoxide dismutase, Futhermore their enzymes are imported into the organelly with the help of at least two different types of import signals, a C-terminal tripeptide (SKL or similar) and a N-terminal signal peptide, that have also been identified for peroxisomal enzymes. (bio.net)
  • Bacterial
  • Polar organelle (German: Basalkörper-Membran, also referred to in some microbiological literature articles as "polar membrane" or "polar cap") is a specialized region of the lipid cell membrane in bacterial cells, usually located at or near the so-called poles (e.g. the ends of a cylindrical cell). (wikipedia.org)
  • It is also possible to isolate these polar organelles from the bacterial cells and study them in face view in negatively stained preparations. (wikipedia.org)
  • It may thus be inferred that the polar organelle could be of importance in the supply and transfer of energy to the bidirectional molecular rotational motor situated at the base of each individual bacterial flagellum (see also electrochemical gradient). (wikipedia.org)
  • cytoplasmic
  • The vault or vault cytoplasmic ribonucleoprotein is a eukaryotic organelle whose function is not fully understood. (wikipedia.org)
  • Discovered and isolated by cell biologist Nancy Kedersha and biochemist Leonard Rome in 1986, vaults are cytoplasmic organelles which when negative-stained and viewed under an electron microscope resemble the arches of a cathedral vaulted ceiling, with 39-fold (Or D39d) symmetry. (wikipedia.org)
  • Macroautophagy, often referred to as autophagy, is a catabolic process that results in the autophagosomic-lysosomal degradation of bulk cytoplasmic contents, abnormal protein aggregates, and excess or damaged organelles. (wikipedia.org)
  • protists
  • As you probably all know glycosomes are the membrane surrounded microbody-like organelles of trypanosomatid and bodonid flagellated protists that belong to the order of the Kinetoplastida. (bio.net)
  • membranes
  • In most cases, the organelle is separated from the rest of the cell by selectively permeable membranes. (encyclopedia.com)
  • There are also occasional exceptions to the number of membranes surrounding organelles, listed in the tables below (e.g., some that are listed as double-membrane are sometimes found with single or triple membranes). (wikipedia.org)
  • metabolism
  • Indeed four of them refer to organelles of glycogen metabolism, the first of which appeared in Russian in 1977, followed then by a few others. (bio.net)
  • possess
  • The polar organelle bears a fine array of attached particles in hexagonal close packing and these have been shown to possess ATPase activity. (wikipedia.org)
  • name
  • As such the glycosomes are bonafide organelles tha have established their name in the parasitological, biochemical, cell biological and molecular biological literature. (bio.net)