• Ox1r
  • Abbas MG, Shoji H, Soya S, Hondo M, Miyakawa T, Sakurai T. Comprehensive behavioral analysis of male Ox1r (−/−) mice showed implication of orexin receptor-1 in mood, anxiety, and social behavior. (springer.com)
  • Considering the differences between pharmacologic blockade of Ox1r and the OKO mice, animals with RNAi mediated knockdown of orexin were then generated and analyzed to eliminate possible developmental effects of missing orexin. (nih.gov)
  • Orexin gene knockdown in the lateral hypothalamus in C57BL/6J mice resulted in blunted performance under both the variable ratio and progressive ratio schedules, resembling data obtained following Ox1r antagonism. (nih.gov)
  • Orexin receptor type 1 (Ox1R or OX1), also known as hypocretin receptor type 1 (HcrtR1), is a protein that in humans is encoded by the HCRTR1 gene. (wikipedia.org)
  • neuronal
  • Although the activity of orexin neurons is thought to be influenced by various neuronal input as well as humoral factors, the direct consequences of changes in the activity of these neurons in an intact animal are largely unknown. (sigmaaldrich.com)
  • These findings clearly show that changes in the activity of orexin neurons can alter the behavioral state of animals and also validate this novel approach for manipulating neuronal activity in awake, freely-moving animals. (sigmaaldrich.com)
  • prepro-orexin
  • Prepro-orexin is 130 amino acid long peptide with a putative 33 AA secretory sequence, a hydrophobic core followed by residues with small polar side chains. (abcam.com)
  • peptide
  • They are excited by the peptide ( 8 ), implying that orexin acts as a neuromodulator at glucosensitive cells, stimulating them under conditions of hunger. (diabetesjournals.org)
  • orexin-B is a linear 28 amino acid residue peptide. (wikipedia.org)
  • Orexin-A is a peptide composed of 33 amino acids including an N-terminal pyroglutamyl residue and two intramolecular disulfide bridges between cysteine residues in 6 and 12 and 7 and 14 positions. (wikipedia.org)
  • arousal
  • Thus, the sleepiness of orexin deficiency may simply be a consequence of inadequate activation of these fundamental arousal regions. (jneurosci.org)
  • We critically tested these hypotheses by examining the sleep-wake behavior of orexin KO mice under conditions that assess endogenous circadian rhythms, the integrity of fundamental arousal systems, and the homeostatic control of sleep. (jneurosci.org)
  • nucleus
  • In addition to the histaminergic nucleus, the orexin system also projects onto the ventral tegmental area dopamine nucleus, locus ceruleus noradrenergic nucleus, the serotonergic raphe nuclei, and cholinergic pedunculopontine nucleus and laterodorsal tegmental nucleus. (wikipedia.org)
  • gene
  • Hypocretin" refers to the gene or genetic products and "orexin" refers to the protein, reflecting the differing approaches that resulted in its discovery. (wikipedia.org)
  • rats
  • Orexin/hypocretin-1 receptor antagonism selectively reduces cue-induced feeding in sated rats and recruits medial prefrontal cortex and thalamus. (springer.com)
  • Moorman DE, Aston-Jones G. Orexin-1 receptor antagonism decreases ethanol consumption and preference selectively in high-ethanol-preferring Sprague-Dawley rats. (springer.com)
  • obesity
  • Brain orexin promotes obesity resistance. (biomedsearch.com)
  • Obesity in orexin knockout mice is a result of inability of brown preadipocytes to differentiate into brown adipose tissue (BAT), which in turn reduces BAT thermogenesis. (wikipedia.org)
  • increases
  • After depriving mice of sleep for 2-8 hr, orexin KO mice recovered their NREM and rapid eye movement sleep deficits at comparable rates and to the same extent as WT mice, with similar increases in EEG delta power, suggesting that their homeostatic control of sleep is normal. (jneurosci.org)
  • Fasting increases plasma OXA, supporting the idea that orexin is released in response to hypoglycemia. (diabetesjournals.org)
  • mice
  • Compared with wild-type (WT) littermates, orexin KO mice had essentially normal amounts of sleep and wake, but wake and non-rapid eye movement (NREM) bouts were very brief, with many more transitions between all behavioral states. (jneurosci.org)
  • In constant darkness, orexin KO mice had normal amplitude and timing of sleep-wake rhythms, providing no evidence for disordered circadian control. (jneurosci.org)
  • Instead, the fragmented behavior of orexin KO mice may be best described as behavioral state instability, with apparently low thresholds to transition between states. (jneurosci.org)
  • Founder orexin KO mice were on a C57BL/6J-129/SvEV background, and their offspring were backcrossed with C57BL/6J mice for six to eight generations. (jneurosci.org)
  • endocannabinoid
  • There is substantial anatomical and functional overlap and systemic cross-talk between the endocannabinoid system and orexin system within the central nervous system. (wikipedia.org)