• and orbital diseases including thyroid eye disease and traumatic orbital "blowout" fractures. (bu.edu)
  • Graves' disease), orbital fractures from trauma, and idiopathic orbital inflammation. (colvardvision.com)
  • Dr. Lefebvre specializes in all forms of eyelid surgery, eyelid and periorbital trauma and cancer reconstruction, orbital fractures, endoscopic tear duct (DCR) surgery, and orbital diseases including thyroid eye disease. (va.gov)
  • A differential diagnosis includes lymphoproliferative lesions, thyroid ophthalmopathy, IgG4-related ophthalmic disease, sarcoidosis, granulomatosis with polyangiitis, orbital cellulitis and carotid-cavernous fistula. (wikipedia.org)
  • Thyroid eye disease is an autoimmune multisystem disorder that can lead to partial or total loss of vision. (b-ent.be)
  • The aim of the study was to evaluate the safety of orbital surgery and assess the scale of complications in patients with thyroid eye disease who underwent orbital decompression. (b-ent.be)
  • This was a retrospective study designed to review and analyze clinical data, different types of complications (e.g., sinonasal, orbital, cerebral, and general), and status of diplopia in patients with thyroid eye disease who underwent orbital decompression in the Otorhinolaryngology Department between 2011 and 2018. (b-ent.be)
  • Fifty-one patients with thyroid eye disease (34 females and 17 males, average age 56.37 years) underwent surgical decompression. (b-ent.be)
  • For patients with thyroid eye disease, surgical decompression seems to be a safe procedure with a low rate of marked complications. (b-ent.be)
  • Brożek-Mądry E, Jurek-Matusiak O, Krzeski A. Postsurgical complications in orbital decompression for thyroid eye disease. (b-ent.be)
  • Common orbital diseases include thyroid eye disease (i.e. (colvardvision.com)
  • He has special expertise in thyroid eye disease, and reconstructive surgery of the eyelids and upper face. (pennmedicine.org)
  • What Kind of Doctor Treats Thyroid Eye Disease? (medicinenet.com)
  • Thyroid eye disease, also known as Graves' orbitopathy or Graves' ophthalmopathy, is an eye condition that happens in a person with an overactive thyroid. (medicinenet.com)
  • Most eye surgeons (ophthalmologists) and hormone specialists (endocrinologists) will be in contact with an oculoplastic surgeon with experience in treating patients with thyroid eye disease. (medicinenet.com)
  • An oculoplastic surgeon is a plastic surgeon with extensive training in managing the cosmetic and eye complications of thyroid disease . (medicinenet.com)
  • What is thyroid eye disease? (medicinenet.com)
  • Thyroid eye disease is caused by Graves' disease, an autoimmune condition in which the body's immune cells cause the tissue around and behind the eyes to grow. (medicinenet.com)
  • This, along with the loss of facial fat, results in the typical appearance of bulging eyes, which is the typical appearance of a person affected with thyroid eye disease. (medicinenet.com)
  • In most patients, the same mechanism that causes thyroid eye disease can also affect the thyroid gland and result in an overactive thyroid. (medicinenet.com)
  • Thyroid eye disease may happen in a person months before the diagnosis of an overactive thyroid or after receiving treatment for Graves' disease affecting the thyroid. (medicinenet.com)
  • Receiving iodine therapy for Graves' disease increases the risk of thyroid eye disease. (medicinenet.com)
  • How is thyroid eye disease diagnosed? (medicinenet.com)
  • How is thyroid eye disease treated? (medicinenet.com)
  • Earlier, surgery was the only option for most patients with thyroid eye disease. (medicinenet.com)
  • This surgery is usually reserved for patients who are at a heightened risk of losing their eyesight due to thyroid eye disease. (medicinenet.com)
  • The main clinical differential diagnoses would be thyroid orbitopathy, sarcoidosis, Sjögren syndrome, lymphoma, Rosai-Dorfman disease or periocular xanthogranulomas. (aad.org)
  • Dr. Woeller's current research interest is understanding the key molecular and cellular pathways involved in eye disease, with a particular focus on Thyroid Eye Disease (TED). (rochester.edu)
  • The pathophysiology of thyroid eye disease. (thieme-connect.de)
  • The combination of absent thyroid peroxidase antibodies and high thyroid-stimulating immunoglobulin levels in Graves disease identifies a group at markedly increased risk of ophthalmopathy. (thieme-connect.de)
  • Evidence for an association between thyroid-stimulating hormone and insulin-like growth factor 1 receptors: a tale of two antigens implicated in Graves disease. (thieme-connect.de)
  • Orbital fibroblasts from thyroid eye disease patients differ in proliferative and adipogenic responses depending on disease subtype. (thieme-connect.de)
  • Her specialties include ptosis (droopy eyelid), thyroid eye disease, eyelid and eye tumors, tear outflow system disorders, and proptosis (bulging eyes). (stanford.edu)
  • Dr. Men's clinical research is focused on thyroid eye disease, orbital diseases and tumors, and improving surgical techniques. (stanford.edu)
  • Her fellowship research projects included the use of teprotumumab to treat thyroid eye disease and using artificial intelligence (AI) to analyze orbital imaging. (stanford.edu)
  • In addition, severe forms of GO can lead to and thyroid disease was first recognized sight-threatening complications. (who.int)
  • Introduction: Treatment of Graves´ disease (GD) with radioiodine increases the risk of developing Graves´ ophthalmopathy (GO), and the link between thyroid and orbital tissue may be the presence of TSH-receptors. (lu.se)
  • Aouidad et al reported the case of a 51-year-old woman presenting with orbital "pseudotumors" (I do not understand why these are not just "tumors" - large swellings of any cause that may be benign or malignant) that histologically demonstrated eosinophilic angiocentric sclerosis related to IgG4. (aad.org)
  • Transcranial approaches can be used for tumors involving the orbital-cranial regions. (medscape.com)
  • Graves disease, originally called Graves-Basedow disease, was first described as the triad of hyperthyroidism , goiter , and exophthalmos in 1835. (medscape.com)
  • Severe ophthalmopathy is an uncommon but problematic manifestation of Graves disease. (medscape.com)
  • Only 5-6% of patients with Graves disease develop problems severe enough to warrant surgical decompression on a functional basis. (medscape.com)
  • Orbitopathy associated with Graves disease may severely compromise a patient's vision. (medscape.com)
  • Some patients with Graves' disease require orbital decompression, either to protect the vision, improve comfort, or improve their appearance by letting the eyes go back into the orbit. (beautifuleyes.com)
  • The shortened eye muscle in Graves' disease can pull the ligaments and result in double vision. (medicinenet.com)
  • Thyrotropin receptor autoantibodies are independent risk factors for Graves ophthalmopathy and help to predict severity and outcome of the disease. (thieme-connect.de)
  • Graves disease mechanisms: the role of stimulating, blocking, and cleavage region TSH receptor antibodies. (thieme-connect.de)
  • Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves ophthalmopathy. (thieme-connect.de)
  • Bidirectional TSH and IGF-1 receptor cross talk mediates stimulation of hyaluronan secretion by Graves disease immunoglobins. (thieme-connect.de)
  • There have been few studies to evaluate with Graves disease will develop GO and the prevalence and severity of GO in Iranian severe forms affect 3% to 5% of patients. (who.int)
  • The onset of the ophthalmopathy is in aimed to investigate the prevalence and most cases concomitant with the onset severity of ophthalmopathy in Graves of hyperthyroidism, but eye disease may patients in our area (north-east of the precede or follow hyperthyroidism [ 3 ]. (who.int)
  • All patients with regarding the pathogenesis, pathophysio- confirmed diagnosis of Graves disease logy, and management of this disease attending the endocrine clinics of the [ 6,7 ]. (who.int)
  • It is a benign, nongranulomatous orbital inflammatory process characterized by extraocular orbital and adnexal inflammation with no known local or systemic cause. (wikipedia.org)
  • Idiopathic orbital inflammation has a varied clinical presentation depending on the involved tissue. (wikipedia.org)
  • It can range from a diffuse inflammatory process to a more localized inflammation of muscle, lacrimal gland or orbital fat. (wikipedia.org)
  • Pediatric IOI accounts for about 17% of cases idiopathic orbital inflammation. (wikipedia.org)
  • proposes that organisms resembling Mollicutes cause orbital inflammation by destroying the cytoplasmic organelles of parasitized cells. (wikipedia.org)
  • The histopathology of idiopathic orbital inflammation is described as nondiagnostic and diverse. (wikipedia.org)
  • They include inflammation of the extraocular muscles (myositis) with tendinous involvement, orbital fat stranding, lacrimal gland inflammation and enlargement (dacryoadenitis), involvement of the optic sheath complex, uvea, and sclera, a focal intraorbital mass or even diffuse orbital involvement. (wikipedia.org)
  • Bisphosphonate-induced orbital inflammation is not a well recognised complication and there have been only a few published case reports of this. (nih.gov)
  • Orbital findings result from an increase in the volume of orbital tissues secondary to inflammation, edema, and congestion. (medscape.com)
  • Inflammatory orbital disease, also called idiopathic orbital inflammatory syndrome and non-specific orbital inflammation, refers to eye disorders that involve the orbit. (orbit-eyecenter.com)
  • There is a risk, however, that orbital dermoids can open up and cause inflammation around the eye. (aapos.org)
  • Imaging with 18 F-fluorodeoxyglucose positron emission tomography/computerized tomography (18F-FDG PET/CT) highlights the extent of disease, although it may not distinguish IgG4-RD from other causes of inflammation or malignancy (3). (aad.org)
  • Orbital infection and inflammation. (medlineplus.gov)
  • Therefore, diseases such as retinal degeneration, retinitis (inflammation of the retina), and optic neuritis (inflammation of the optic nerve) do not cause outward signs of pain. (petplace.com)
  • Ocular complications are rare and even more so, inflammatory orbital disease. (nih.gov)
  • What are the Different Types of Inflammatory Orbital Disease? (orbit-eyecenter.com)
  • There are different types of inflammatory orbital disease based on the region that is affected in your eye. (orbit-eyecenter.com)
  • Inflammatory orbital disease occurs due to an underlying condition. (orbit-eyecenter.com)
  • What are the Signs and Symptoms of Inflammatory Orbital Disease? (orbit-eyecenter.com)
  • How is Inflammatory Orbital Disease Diagnosed? (orbit-eyecenter.com)
  • Inflammatory orbital disease is diagnosed based on the patient's medical history, eye examination, laboratory tests, and imaging studies such as an orbital MRI (magnetic resonance imaging) or CT (computed tomography) scan. (orbit-eyecenter.com)
  • What are the Treatment Options for Inflammatory Orbital Disease? (orbit-eyecenter.com)
  • How can you Prevent Inflammatory Orbital Disease? (orbit-eyecenter.com)
  • Chronic disease is treated with tear supplements, warm compresses, and occasionally oral antibiotics (eg, a tetracycline or azithromycin) for meibomian gland dysfunction or with eyelid hygiene and tear supplements for seborrheic blepharitis. (merckmanuals.com)
  • Rhino-orbital-cerebral mucormycosis (ROCM) is a rare angioinvasive fungal infection known to be associated with high morbidity and over 50% mortality and has increased lately due to increasing predisposing immunocompromising comorbidities as well as COVID-19. (researchgate.net)
  • The presence of the tough, fibrous orbital septum reduces but does not completely remove the risk of spread of infection to the orbital structures. (bestbets.org)
  • orbital assessment for the identification of tumours, haemorrhage, infection and disease. (nuffieldhealth.com)
  • Given that Johnathan had not shown any improvement on IV antibiotics, had a reassuring MRI without abscess, and had no systemic signs of infection, we started him on IV steroids (1 mg/kg) for presumed idiopathic orbital inflam-mation (IOI). (aao.org)
  • This paper presents and discusses the management of six patients admitted with orbital infection by service Oral and Maxillofacial Surgery General Hospital Roberto Santos in Salvador, Bahia. (bvsalud.org)
  • 1) describe the epidemiology, clinical manifestation, management and prevention of Zika virus disease, 2) discuss diagnostic testing for Zika virus infection and interpretation of test results, 3) articulate the importance of early recognition and reporting of cases, 4) state the recommendations for pregnant women and possible Zika virus exposure, and 5) discuss evaluation of infants with microcephaly and relationship of Zika in microcephaly. (cdc.gov)
  • Author of more than 150 publications on retinal diseases and surgery, Dr. Elman is an Assistant Professor of Ophthalmology at the Johns Hopkins University School of Medicine. (medstarhealth.org)
  • He received fellowship training in Retinal Vascular Diseases at the Wilmer Eye Institute of the Johns Hopkins University and fellowship training in Diseases and Surgery of the Retina and Vitreous at Barnes Hospital/Retina Consultants, Ltd. of Washington University. (medstarhealth.org)
  • Following his training he completed a 1 year subspecialty fellowship in oculoplastic, lacrimal and orbital surgery at the University Hospital of Wales in Cardiff. (plymouthhospitals.nhs.uk)
  • Dr. Butler's clinical interests include complex cataract surgery, uveitis and ocular inflammatory disease, and he has particular expertise in infectious uveitis and inflammatory macular edema. (va.gov)
  • This discussion is not meant to be a comprehensive tome on orbital surgery but merely an overview of commonly described orbitotomies. (medscape.com)
  • Michael Elman, MD, has practiced ophthalmology for more than 30 years and specializes in diseases of the retina and vitreous. (medstarhealth.org)
  • Dr. Schiller is pleased to be able to offer state-of-the-art minimal incision orbital decompression with the incisions placed inside the eyelids. (beautifuleyes.com)
  • Orbital decompression (a complex procedure for advanced disease) requires a plastic surgeon. (medicinenet.com)
  • Regardless, the processes show a predilection for the orbital tissues, the extraocular muscles, and periorbital structures. (medscape.com)
  • Idiopathic orbital inflammatory (IOI) disease refers to a marginated mass-like enhancing soft tissue involving any area of the orbit. (wikipedia.org)
  • IgG4-related ophthalmic disease (IgG4-ROD), the preferred nomenclature for IgG4-RD affecting the ocular adnexa or orbit, is a common manifestation of IgG4-RD. A large IgG4-RD disease registry in North America found ophthalmic involvement in 23 % of all IgG4-RD cases. (aad.org)
  • OR exp Orbit/OR exp Orbital Diseases/OR periorbital.mp. (bestbets.org)
  • The orbital complications were less common (46.15% of all complications). (b-ent.be)
  • Screening is carried out in Chunampet district for diabetes and its complications especially diabetic eye diseases by using a mobile telemedicine van with satellite connectivity. (hindawi.com)
  • Screening for other diabetes-related complications like nephropathy (by measuring proteinuria/microalbuminuria), neuropathy (by biothesiometry, and monofilament) and coronary artery disease (by electrocardiogram) is also done in the telemedicine van. (hindawi.com)
  • Several studies have described cases where onset of orbital pseudotumor was seen simultaneously or several weeks after upper respiratory infections. (wikipedia.org)
  • Orbital infections. (medlineplus.gov)
  • The presence of protozoa in these infections of the corneospectacular space has been demonstrated repeatedly although their role in the disease is uncertain. (vin.com)
  • Orbital infections are diseases that require special attention and care. (bvsalud.org)
  • The diagnosis of GCA requires age more than 50 years at disease onset, new headache in the temporal area, temporal artery tenderness, and/or reduced pulse, jaw claudication, systemic symptoms, erythrocyte sedimentation rate (ESR) exceeding 50 mm/hr, and typical histologic findings (granulomatous involvement) in temporal artery biopsy (TAB) [ 5 ]. (intechopen.com)
  • It is imperative for ophthalmologists to be aware of the early ophthalmological manifestations of AML which will allow for earlier diagnosis and treatment of this life-threatening disease. (dovepress.com)
  • PURPOSE: To report a case of subperiosteal orbital and subgaleal hemorrhage with optic nerve compromise in a patient with a factor IX deficiency. (wustl.edu)
  • We will trace the history of ideas about optic nerve anatomy and function in the Western world from the ancient Greeks to the early 20th century and show how these influenced causal theories of optic nerve diseases. (nature.com)
  • Most (85%) patients with MS begin their clinical disease course with episodes of neurologic dysfunction (relapses) followed by complete or incomplete recovery. (medscape.com)
  • What if there was a book that covers clinical information, history, sports, and the arts-and all are related to eye disease? (slackbooks.com)
  • Ren MY, Li J, Wu YX, Li RM, Zhang C, Liu LM, Wang JJ, Gao Y. Clinical characteristics and prognosis of orbital solitary fibrous tumor in patients from a Chinese tertiary eye hospital. (wjgnet.com)
  • In her career at CDC, she has focused on the development of evidence-based clinical guidelines for infectious diseases. (cdc.gov)
  • Neuro-ophthalmic manifestations frequently are encountered in persons with multiple sclerosis (MS) and other central nervous system (CNS) inflammatory disorders, including neuromyelitis optica spectrum disorders (NMOSD) and myelin oligodendrocyte glycoprotein antibody associated disease (MOGAD). (medscape.com)
  • To identify tissue metabolomic profiles in biopsy specimens with IgG4-related ophthalmic disease (IgG4-ROD) and mucosa-associated lymphoid tissue (MALT) lymphoma and investigate their potential implication in the disease pathogenesis and biomarkers. (elsevierpure.com)
  • A dermatologic riddle: How is IgG4-related ophthalmic disease parliamentary? (aad.org)
  • The causes of these lesions are often identical to those responsible for inducing ophthalmic disease in mammals and birds. (vin.com)
  • Ophthalmic involvement can be the initial manifestation of the systemic disease or the first sign of relapse. (dovepress.com)
  • Idiopathic orbital inflammatory syndrome, also known as orbital pseudotumor, was first described by Gleason in 1903 and by Busse and Hochheim. (wikipedia.org)
  • Its former name, orbital pseudotumor, is derived due to resemblance to a neoplasm. (wikipedia.org)
  • Orbital pseudotumor has also been observed in association with Crohn's disease, systemic lupus erythematosus, rheumatoid arthritis, diabetes mellitus, myasthenia gravis, and ankylosing spondylitis all of which strengthen the basis of IOI being an immune-mediated disease. (wikipedia.org)
  • Trauma has also been seen to precede some cases of orbital pseudotumor. (wikipedia.org)
  • Orbital inflammatory disease (pseudotumor) usually is treated medically with systemic steroids. (medscape.com)
  • We conducted a comprehensive analysis of the metabolomes and lipidomes of biopsy-proven IgG4-ROD (n = 22) and orbital MALT lymphoma (n = 21) specimens and matched adjacent microscopically normal adipose tissues using liquid chromatography time-of-flight mass spectrometry. (elsevierpure.com)
  • Finally, an independent set of 18 IgG4-ROD and 17 orbital MALT lymphoma specimens were used to validate the identified biomarkers. (elsevierpure.com)
  • The principal component analysis showed a significant difference of both IgG4-ROD and orbital MALT lymphoma for biopsy specimens and controls. (elsevierpure.com)
  • Interestingly, lesions in IgG4-ROD were uniquely enriched in arachidonic metabolism, whereas those in orbital MALT lymphoma were enriched in tricarboxylic acid cycle metabolism. (elsevierpure.com)
  • We identified spermine as the best discriminator between IgG4-ROD and orbital MALT lymphoma, and the area under the receiver operating characteristic curve of the spermine to discriminate between the two diseases was 0.89 (95% confidence interval, 0.803-0.984). (elsevierpure.com)
  • The results of validation revealed that four tissue metabolites: N 1 ,N 12 diacetylspermine, spermine, malate, and glycolate, had statistically significant differences between IgG4-ROD and orbital MALT lymphoma with receiver operating characteristic values from 0.708 to 0.863. (elsevierpure.com)
  • These data revealed the characteristic differences in metabolomic profiles between IgG4-ROD and orbital MALT lymphoma, which may be useful for developing new diagnostic biomarkers and elucidating the pathogenic mechanisms of these common orbital lymphoproliferative disorders. (elsevierpure.com)
  • For medially located lesions, such as those encroaching on the nasal orbital apex, this approach is possible. (medscape.com)
  • Transnasal, transantral, and transethmoidal endoscopic approaches are being used more frequently to gain access to orbital lesions. (medscape.com)
  • De Hauwere RC, Leroy JG, Adriaenssens K, Van Heule R. Iris dysplasia, orbital hypertelorism, and psychomotor retardation: a dominantly inherited developmental syndrome . (arizona.edu)
  • Dr. Dana Meaney-Delman is a senior medical advisor in the National Center for Emerging and Zoonotic Infectious Diseases at the Centers for Disease Control and Prevention. (cdc.gov)
  • Maximal operative exposure of the lesion with ginger and minimal manipulation of the orbital contents must be well orchestrated for successful surgical outcomes. (medscape.com)
  • Inferiorly, the orbital lesion is approachable from a transconjunctival or a transcutaneous approach. (medscape.com)
  • Exenteration for benign orbital disease. (bmj.com)
  • CONCLUSION: Delayed-onset subgaleal and subperiosteal orbital hematoma can rarely be an initial manifestation of Christmas disease. (wustl.edu)
  • Rarely, orbital dermoids are found deeper in the eye socket close to the brain. (aapos.org)
  • Other commonly reported symptoms include myalgia, headache, retro-orbital pain and vomiting. (bvsalud.org)
  • The disease is usually mild with symptoms that last from several days to a week. (bvsalud.org)
  • The surrounding tissues-in-cluding orbital fat, periosteum, and bone-were normal. (aao.org)
  • In addition to the common acute disease progression, chronic less aggressive courses have. (researchgate.net)
  • In the setting of extensive sclerosis there may be restriction, compression, and destruction of orbital tissue. (wikipedia.org)
  • Woeller and his collaborators have already discovered and patented promising new therapies that may arrest this process and could be used in treating diseases that manifest with excessive scar formation and/or excessive fat tissue, like TED. (rochester.edu)
  • It is the most common painful orbital mass in the adult population, and is associated with proptosis, cranial nerve palsy (Tolosa-Hunt syndrome), uveitis, and retinal detachment. (wikipedia.org)
  • Overall, radiographic features for idiopathic orbital inflammatory syndrome vary widely. (wikipedia.org)
  • This symptom, called photophobia, is commonly associated with serious eye diseases. (petplace.com)
  • Orbital abscesses are commonly encountered in some groups of lizards (especially chameleons). (vin.com)
  • Patients with SPMS present with features of progressive neurologic disability, with or without clinically overt relapses, and insidious disease progression. (medscape.com)
  • IgG4-related disease (IgG4-RD) is a chronic fibro-inflammatory disorder that potentially affects virtually every organ system. (aad.org)
  • Swelling of salivary and lacrimal glands, lymphadenopathy, and type 1 autoimmune pancreatitis are the most common manifestations of the disease. (aad.org)
  • Bilateral presentation may have a higher incidence of systemic disease. (wikipedia.org)