• Neuropathy
  • Previous studies performed in our lab have demonstrated increased expression of RAGE in AD optic nerves, hence suggesting a possible causative role in AD optic neuropathy. (arvojournals.org)
  • The overall objective of the proposed research is to test the hypothesis that Near-infrared Light-emitting Diode (NIR-LED) therapy will stimulate mitochondrial function, attenuate oxidative stress, and improve cell survival and vision in subjects with Leber's Hereditary Optic Neuropathy (LHON). (clinicaltrials.gov)
  • Study H6D-MC-LVHQ is an observational, non-interventional, multi-center, prospective, case-crossover study to evaluate the possible association between the use of phosphodiesterase type 5 (PDE5) inhibitors and the risk of acute nonarteritic anterior ischemic optic neuropathy (NAION) in males. (clinicaltrials.gov)
  • Leber's Optic Neuropathy The Scottish Sensory Centre provides an outline of the condition, as well as explaining how affected individuals can be helped by family and friends. (inter.rs)
  • Leber's Optic Neuropathy Explains the hereditary nature of the disease, and provides FAQ and details of current research. (inter.rs)
  • However, cases of acute optic neuropathy (specifically anterior ischemic optic neuropathy) have also been reported to occur. (wikipedia.org)
  • Signs and symptoms of acute optic neuropathy include painless loss of vision which may affect either one or both eyes, reduced visual acuity, reduced color vision, relative afferent pupillary defect, central scotoma, swollen optic disc, macular edema, or retrobulbar pain. (wikipedia.org)
  • When these symptoms occur with concurrent mucocutaneous ulcerations, they raise suspicion of acute optic neuropathy in Behçet's Disease. (wikipedia.org)
  • The three most common neuro-ophthalmic abnormalities seen in mitochondrial disorders are bilateral optic neuropathy, ophthalmoplegia with ptosis, and pigmentary retinopathy. (wikipedia.org)
  • Genetic mutations, toxic insult, and nutritional depletion can all have a negative impact on the structure and function of mitochondria within the optic system, resulting in this type of neuropathy. (wikipedia.org)
  • citation needed] A possible synergism between genetic and acquired mitochondrial optic neuropathies has been suggested and there are only a few case reports to support this phenomenon, requiring further research and demonstration of evidence to corroborate these findings Nutritional deficiency may be the cause of a genuine optic neuropathy, sometimes associated with involvement of the peripheral nervous system, called peripheral neuropathy. (wikipedia.org)
  • Most often, they present as a non-specific retrobulbar optic neuropathy. (wikipedia.org)
  • glaucoma
  • Our long-term goal is to improve outcomes by identifying biomarkers and environmental factors that profile a patient at risk for glaucoma by age-of-onset, rate of disease progression, 'poor response' to treatment, and large IOP fluctuation. (mayo.edu)
  • Evidence has accumulated that systemic and ocular mechanisms, responsible for regulating blood flow in the area of the optic disc, such as reduced ocular perfusion pressure, abnormal autoregulation and vascular dysregulation may be involved in the pathogenesis of normal tension glaucoma (NTG). (clinicaltrials.gov)
  • Healthy volunteers with no family history of glaucoma, an increased or asymmetrical cup/disc ratio or any other optic disc structural change (notching, disc hemorrhage) or an intraocular pressure (IOP) above 21 mmHg that could suggest possible glaucoma suspects. (clinicaltrials.gov)
  • Glaucoma is a group of diseases affecting the optic nerve that results in vision loss and is frequently characterized by raised intraocular pressure (IOP). (wikipedia.org)
  • hypoplasia
  • Mouse embryos with mutations in the Shh co-receptor, Cdon , were treated in utero with ethanol or saline at embryonic day 8 (E8.0) and evaluated for optic nerve hypoplasia (ONH), a prominent feature of SOD. (biologists.org)
  • Septo-optic dysplasia (SOD) is a clinically heterogeneous disorder that is diagnosed on the presence of at least two of the following conditions: optic nerve hypoplasia (ONH), hypopituitarism and absence of the septum pellucidum ( Webb and Dattani, 2010 ). (biologists.org)
  • Mutations within PAX2 have been shown to result in optic nerve colobomas and renal hypoplasia. (wikipedia.org)
  • occur
  • Many types of sense loss occur due to a dysfunctional sensation process, whether it be ineffective receptors, nerve damage, or cerebral impairment. (wikipedia.org)
  • intraocular
  • Impaired balance of ANS, resulting in increased demand for oxygen in the tissues and subsequent low threshold of hypoxia in all organs (including the eye) can be an important link in the pathogenetic pathway of NTG, making the optic nerve more sensitive to small and short-term changes in perfusion pressure and prone to damage even under a statistically 'normal' intraocular pressure (IOP). (clinicaltrials.gov)
  • genetic
  • Because this grouping of diseases is of heterogenic origin, the causes can be singular or additive consequences of genetic, toxic, or nutritional stress. (wikipedia.org)
  • Causes
  • Two significant causes of vision loss due to sensory failures include media opacity and optic nerve diseases, although hypoxia and retinal disease can also lead to blindness. (wikipedia.org)
  • Primary causes of hearing loss due to an impaired sensory system include long-term exposure to environmental noise, which can damage the mechanoreceptors responsible for receiving sound vibrations, as well as multiple diseases, such as HIV or meningitis, which damage the cochlea and auditory nerve, respectively. (wikipedia.org)
  • Astrocytoma: Manifestation: Causes hypermetabolic lesions in the brain Since hypermetabolism itself is a symptom and not an independent disease, treatment first and foremost requires attention to the underlying disease. (wikipedia.org)
  • nuclei
  • The Pax2 gene encodes for the transcription factor which appears to be essential in the organization of the midbrain and hindbrain regions, and at the earliest can be detected on either side of the sulcus limitans, which separates motor and sensory nerve nuclei. (wikipedia.org)
  • structural
  • The correlations between all above systems, as well as between them and the structural and functional parameters of the optic nerve, and the retina in both groups will be also analyzed. (clinicaltrials.gov)
  • Structural examination of the optic disc (confocal microscopy) will be performed. (clinicaltrials.gov)
  • However, this explanation is still hypothetical, since the relation between these oximetry results and structural changes in the optic nerve have not been studied yet. (clinicaltrials.gov)
  • blindness
  • Robert E. MacLaren FRCOphth FRCS FACS VR is a British ophthalmologist who has led pioneering work in the treatment of blindness caused by diseases of the retina. (wikipedia.org)
  • treatment
  • Research helps us better understand diseases and can lead to advances in diagnosis and treatment. (nih.gov)
  • In 1994 Lapthisophon suffered a major deterioration of his vision because of an optic nerve disease, and became legally blind after intensive medical treatment. (wikipedia.org)
  • Damage
  • In contrast, a permanent loss of smell may be caused by death of olfactory receptor neurons in the nose or by brain injury in which there is damage to the olfactory nerve or damage to brain areas that process smell. (wikipedia.org)
  • disc
  • The eye and pituitary develop in close proximity to the source of SHH in the anterior hypothalamus and depend on this signal for formation of the optic disc, from where the optic nerve exits the eye, and for coordinating pituitary morphogenesis. (biologists.org)
  • The optic disc may be mildly hyperemic with small splinter hemorrhages on or around the disc. (wikipedia.org)
  • utero
  • During the second month of development in utero, a seam-like structure called the optic fissure closes up to form the structures of the eye. (nih.gov)
  • vision
  • Since 1998 till 2001 Nisan was a Head Lecturer of Optometry and Contact Vision correction Course of Vision disease Department at the Federation Institute for Biomedical Problems of the Healthcare Ministry of the Russian Federation. (wikipedia.org)
  • Inflammatory eye disease can develop early in the disease course and lead to permanent vision loss in 20 percent of cases. (wikipedia.org)
  • It addressed the progress of the disease choroideremia, or choroideraemia, in which a faulty gene, CHM, leads to a loss of REP1 protein, affecting the retinal pigment epithelium (RPE) and causing progressive loss of vision. (wikipedia.org)
  • occurs
  • Nystagmus also occurs when the semicircular canals are being stimulated (e.g. by means of the caloric test, or by disease) while the head is not in motion. (wikipedia.org)
  • An example of disease state in which this occurs is Benign paroxysmal positional vertigo (BPPV). (wikipedia.org)
  • Pediatrics
  • Since 2001 till 2011 she was a head of the Eye Disease Department of Pediatrics at Russian State Medical University (now Pirogov National Medical Research University). (wikipedia.org)
  • protein
  • Formalin-fixed, paraffin-embedded 5µm sections of 30 optic nerves and retinas from 15 donors previously diagnosed with AD and 30 age-matched control optic nerves and retinas from 15 individuals with no AD, other neurodegenerative diseases, diabetes mellitus, or sepsis were stained with antibodies reactive against amyloid-beta (AB) and amyloid precursor protein (APP). (arvojournals.org)
  • Both amyloid-beta (AB) and amyloid precursor protein (APP) appear to be present in AD and normal optic nerves and retinas. (arvojournals.org)
  • indicates
  • Tyler indicates with geometric reconstructions at his web site Art Optics that the art works under discussion are brilliant paintings by eye rather than those compatible with optical projections. (wikipedia.org)
  • Cataract
  • A cataract is an opacification or cloudiness of the eye's crystalline lens due to aging, disease, or trauma that typically prevents light from forming a clear image on the retina. (wikipedia.org)
  • renal
  • For example, Pax2 is highly expressed in polycystic kidney disease (PKD), Wilms' tumor (WT), and renal cell carcinoma (RCC). (wikipedia.org)
  • Clinical
  • This combines practical skills in eye surgery with clinical academic application in research, to investigate the diseases of the eye 'from bench to bedside': aiming to improve patient outcomes, at least by arresting or slowing the progress of a disease, or - ideally - by reversing the effects, partially or totally. (wikipedia.org)
  • affects
  • citation needed] Again, the pathophysiological mechanisms involved in nutritional optic neuropathies is common to all mitochondrial optic neuropathies: it affects biochemical pathways involved in cell energetic production, correction of oxidative stress and quenching of free radicals. (wikipedia.org)
  • disk
  • Pseudopapilledema is a normal variant of the optic disk, in which the disk appears elevated, with indistinct margins and a normal vascular pattern. (wikipedia.org)
  • sympathetic
  • Graves' disease: Manifestation: Excess hypermetabolically-induced thyroid hormone activates sympathetic pathways, causing the eyelids to retract and remain constantly elevated. (wikipedia.org)