• patients
  • This is a Single arm, Single centre trial to check the safety and efficacy of bone marrow derived autologous mono nuclear cell(100 millions per dose )clinical trial to be conducted for 36 months in patients with optic nerve diseases. (clinicaltrials.gov)
  • This study aimed to characterize the presence of amyloid- beta (a RAGE ligand) and its precursor protein in optic nerves and retinas from patients with AD. (arvojournals.org)
  • Patients who had active systemic diseases such as those affecting the liver, biliary system, pancreas and kidney and infectious diseases or malignant tumours that could influence the serum bilirubin concentrations were also excluded. (clinicaltrials.gov)
  • occur
  • Many types of sense loss occur due to a dysfunctional sensation process, whether it be ineffective receptors, nerve damage, or cerebral impairment. (wikipedia.org)
  • Alzheimer's
  • The receptor for advanced glycation end products (RAGE) and amyloid-beta have both been implicated in the pathogenesis of Alzheimer's disease (AD) in brain. (arvojournals.org)
  • However in Alzheimer's there was a greater accumulation of these proteins suggesting a pathologic role for them in this disease. (arvojournals.org)
  • intraocular
  • Impaired balance of ANS, resulting in increased demand for oxygen in the tissues and subsequent low threshold of hypoxia in all organs (including the eye) can be an important link in the pathogenetic pathway of NTG, making the optic nerve more sensitive to small and short-term changes in perfusion pressure and prone to damage even under a statistically 'normal' intraocular pressure (IOP). (clinicaltrials.gov)
  • genetic
  • Because this grouping of diseases is of heterogenic origin, the causes can be singular or additive consequences of genetic, toxic, or nutritional stress. (wikipedia.org)
  • Causes
  • Two significant causes of vision loss due to sensory failures include media opacity and optic nerve diseases, although hypoxia and retinal disease can also lead to blindness. (wikipedia.org)
  • Primary causes of hearing loss due to an impaired sensory system include long-term exposure to environmental noise, which can damage the mechanoreceptors responsible for receiving sound vibrations, as well as multiple diseases, such as HIV or meningitis, which damage the cochlea and auditory nerve, respectively. (wikipedia.org)
  • Astrocytoma: Manifestation: Causes hypermetabolic lesions in the brain Since hypermetabolism itself is a symptom and not an independent disease, treatment first and foremost requires attention to the underlying disease. (wikipedia.org)
  • Differentiation
  • We show that both Cdon −/− mutation and prenatal ethanol exposure independently cause ONH through a similar pathogenic mechanism that involves selective inhibition of Shh signaling in retinal progenitor cells, resulting in their premature cell-cycle arrest, precocious differentiation and failure to properly extend axons to the optic nerve. (biologists.org)
  • Disc
  • Juxtapapillary subretinal pigment epithelial polypoid pseudocysts associated with unilateral tilted optic disc. (springer.com)
  • The eye and pituitary develop in close proximity to the source of SHH in the anterior hypothalamus and depend on this signal for formation of the optic disc, from where the optic nerve exits the eye, and for coordinating pituitary morphogenesis. (biologists.org)
  • Structural examination of the optic disc (confocal microscopy) will be performed. (clinicaltrials.gov)
  • The morning glory disc anomaly (MGDA) is a congenital deformity resulting from failure of the optic nerve to completely form in utero. (wikipedia.org)
  • The optic disc may be mildly hyperemic with small splinter hemorrhages on or around the disc. (wikipedia.org)
  • nuclei
  • The Pax2 gene encodes for the transcription factor which appears to be essential in the organization of the midbrain and hindbrain regions, and at the earliest can be detected on either side of the sulcus limitans, which separates motor and sensory nerve nuclei. (wikipedia.org)
  • glaucomatous
  • Recent findings have confirmed that there is a direct correlation between the levels of venous oxygen saturation and the degree of the glaucomatous disease, presumably due to a decrease in retinal cell metabolism. (clinicaltrials.gov)
  • methods
  • Due to its role in these diseases, Pax2 is an attractive therapeutic target and a number of methods for inhibiting its activity have been investigated. (wikipedia.org)
  • Damage
  • In contrast, a permanent loss of smell may be caused by death of olfactory receptor neurons in the nose or by brain injury in which there is damage to the olfactory nerve or damage to brain areas that process smell. (wikipedia.org)
  • Clinical
  • This combines practical skills in eye surgery with clinical academic application in research, to investigate the diseases of the eye 'from bench to bedside': aiming to improve patient outcomes, at least by arresting or slowing the progress of a disease, or - ideally - by reversing the effects, partially or totally. (wikipedia.org)
  • utero
  • During the second month of development in utero, a seam-like structure called the optic fissure closes up to form the structures of the eye. (nih.gov)
  • Pediatrics
  • Since 2001 till 2011 she was a head of the Eye Disease Department of Pediatrics at Russian State Medical University (now Pirogov National Medical Research University). (wikipedia.org)
  • vision
  • Since 1998 till 2001 Nisan was a Head Lecturer of Optometry and Contact Vision correction Course of Vision disease Department at the Federation Institute for Biomedical Problems of the Healthcare Ministry of the Russian Federation. (wikipedia.org)
  • Inflammatory eye disease can develop early in the disease course and lead to permanent vision loss in 20 percent of cases. (wikipedia.org)
  • It addressed the progress of the disease choroideremia, or choroideraemia, in which a faulty gene, CHM, leads to a loss of REP1 protein, affecting the retinal pigment epithelium (RPE) and causing progressive loss of vision. (wikipedia.org)
  • indicates
  • Tyler indicates with geometric reconstructions at his web site Art Optics that the art works under discussion are brilliant paintings by eye rather than those compatible with optical projections. (wikipedia.org)