• Neuropathy
  • Previous studies performed in our lab have demonstrated increased expression of RAGE in AD optic nerves, hence suggesting a possible causative role in AD optic neuropathy. (arvojournals.org)
  • The overall objective of the proposed research is to test the hypothesis that Near-infrared Light-emitting Diode (NIR-LED) therapy will stimulate mitochondrial function, attenuate oxidative stress, and improve cell survival and vision in subjects with Leber's Hereditary Optic Neuropathy (LHON). (clinicaltrials.gov)
  • Study H6D-MC-LVHQ is an observational, non-interventional, multi-center, prospective, case-crossover study to evaluate the possible association between the use of phosphodiesterase type 5 (PDE5) inhibitors and the risk of acute nonarteritic anterior ischemic optic neuropathy (NAION) in males. (clinicaltrials.gov)
  • Leber's Optic Neuropathy The Scottish Sensory Centre provides an outline of the condition, as well as explaining how affected individuals can be helped by family and friends. (inter.rs)
  • Leber's Optic Neuropathy Explains the hereditary nature of the disease, and provides FAQ and details of current research. (inter.rs)
  • However, cases of acute optic neuropathy (specifically anterior ischemic optic neuropathy) have also been reported to occur. (wikipedia.org)
  • Signs and symptoms of acute optic neuropathy include painless loss of vision which may affect either one or both eyes, reduced visual acuity, reduced color vision, relative afferent pupillary defect, central scotoma, swollen optic disc, macular edema, or retrobulbar pain. (wikipedia.org)
  • When these symptoms occur with concurrent mucocutaneous ulcerations, they raise suspicion of acute optic neuropathy in Behçet's Disease. (wikipedia.org)
  • The three most common neuro-ophthalmic abnormalities seen in mitochondrial disorders are bilateral optic neuropathy, ophthalmoplegia with ptosis, and pigmentary retinopathy. (wikipedia.org)
  • Genetic mutations, toxic insult, and nutritional depletion can all have a negative impact on the structure and function of mitochondria within the optic system, resulting in this type of neuropathy. (wikipedia.org)
  • citation needed] A possible synergism between genetic and acquired mitochondrial optic neuropathies has been suggested and there are only a few case reports to support this phenomenon, requiring further research and demonstration of evidence to corroborate these findings Nutritional deficiency may be the cause of a genuine optic neuropathy, sometimes associated with involvement of the peripheral nervous system, called peripheral neuropathy. (wikipedia.org)
  • Most often, they present as a non-specific retrobulbar optic neuropathy. (wikipedia.org)
  • occur
  • Coloboma of the optic nerve may occur sporadically , may be due to a genetic mutation and be inherited , or may occur as a feature of an underlying syndrome or other genetic condition. (nih.gov)
  • Many types of sense loss occur due to a dysfunctional sensation process, whether it be ineffective receptors, nerve damage, or cerebral impairment. (wikipedia.org)
  • patients
  • This is a Single arm, Single centre trial to check the safety and efficacy of bone marrow derived autologous mono nuclear cell(100 millions per dose )clinical trial to be conducted for 36 months in patients with optic nerve diseases. (clinicaltrials.gov)
  • This study aimed to characterize the presence of amyloid- beta (a RAGE ligand) and its precursor protein in optic nerves and retinas from patients with AD. (arvojournals.org)
  • Patients who had active systemic diseases such as those affecting the liver, biliary system, pancreas and kidney and infectious diseases or malignant tumours that could influence the serum bilirubin concentrations were also excluded. (clinicaltrials.gov)
  • intraocular
  • Impaired balance of ANS, resulting in increased demand for oxygen in the tissues and subsequent low threshold of hypoxia in all organs (including the eye) can be an important link in the pathogenetic pathway of NTG, making the optic nerve more sensitive to small and short-term changes in perfusion pressure and prone to damage even under a statistically 'normal' intraocular pressure (IOP). (clinicaltrials.gov)
  • Damage
  • Primary causes of hearing loss due to an impaired sensory system include long-term exposure to environmental noise, which can damage the mechanoreceptors responsible for receiving sound vibrations, as well as multiple diseases, such as HIV or meningitis, which damage the cochlea and auditory nerve, respectively. (wikipedia.org)
  • In contrast, a permanent loss of smell may be caused by death of olfactory receptor neurons in the nose or by brain injury in which there is damage to the olfactory nerve or damage to brain areas that process smell. (wikipedia.org)
  • In English, the word was used as early as 1587 but did not become commonly used until after 1850, when the development of the ophthalmoscope allowed people to see the optic nerve damage. (wikipedia.org)
  • Disc
  • Juxtapapillary subretinal pigment epithelial polypoid pseudocysts associated with unilateral tilted optic disc. (springer.com)
  • The eye and pituitary develop in close proximity to the source of SHH in the anterior hypothalamus and depend on this signal for formation of the optic disc, from where the optic nerve exits the eye, and for coordinating pituitary morphogenesis. (biologists.org)
  • Structural examination of the optic disc (confocal microscopy) will be performed. (clinicaltrials.gov)
  • The morning glory disc anomaly (MGDA) is a congenital deformity resulting from failure of the optic nerve to completely form in utero. (wikipedia.org)
  • The optic disc may be mildly hyperemic with small splinter hemorrhages on or around the disc. (wikipedia.org)
  • The only signs are gradually progressive visual field loss, and optic nerve changes (increased cup-to-disc ratio on fundoscopic examination). (wikipedia.org)
  • genetic
  • Because this grouping of diseases is of heterogenic origin, the causes can be singular or additive consequences of genetic, toxic, or nutritional stress. (wikipedia.org)
  • Causes
  • Two significant causes of vision loss due to sensory failures include media opacity and optic nerve diseases, although hypoxia and retinal disease can also lead to blindness. (wikipedia.org)
  • Astrocytoma: Manifestation: Causes hypermetabolic lesions in the brain Since hypermetabolism itself is a symptom and not an independent disease, treatment first and foremost requires attention to the underlying disease. (wikipedia.org)
  • Differentiation
  • We show that both Cdon −/− mutation and prenatal ethanol exposure independently cause ONH through a similar pathogenic mechanism that involves selective inhibition of Shh signaling in retinal progenitor cells, resulting in their premature cell-cycle arrest, precocious differentiation and failure to properly extend axons to the optic nerve. (biologists.org)
  • nuclei
  • The Pax2 gene encodes for the transcription factor which appears to be essential in the organization of the midbrain and hindbrain regions, and at the earliest can be detected on either side of the sulcus limitans, which separates motor and sensory nerve nuclei. (wikipedia.org)
  • structural
  • However, this explanation is still hypothetical, since the relation between these oximetry results and structural changes in the optic nerve have not been studied yet. (clinicaltrials.gov)
  • glaucomatous
  • Recent findings have confirmed that there is a direct correlation between the levels of venous oxygen saturation and the degree of the glaucomatous disease, presumably due to a decrease in retinal cell metabolism. (clinicaltrials.gov)
  • treatment
  • Research helps us better understand diseases and can lead to advances in diagnosis and treatment. (nih.gov)
  • If treated early it is possible to slow or stop the progression of disease with medication, laser treatment, or surgery. (wikipedia.org)
  • vision
  • Since 1998 till 2001 Nisan was a Head Lecturer of Optometry and Contact Vision correction Course of Vision disease Department at the Federation Institute for Biomedical Problems of the Healthcare Ministry of the Russian Federation. (wikipedia.org)
  • Inflammatory eye disease can develop early in the disease course and lead to permanent vision loss in 20 percent of cases. (wikipedia.org)
  • It addressed the progress of the disease choroideremia, or choroideraemia, in which a faulty gene, CHM, leads to a loss of REP1 protein, affecting the retinal pigment epithelium (RPE) and causing progressive loss of vision. (wikipedia.org)
  • In optometry, ophthalmology, and neurology, a visual field test is used to determine whether the visual field is affected by diseases that cause local scotoma or a more extensive loss of vision or a reduction in sensitivity (increase in threshold). (wikipedia.org)
  • utero
  • During the second month of development in utero, a seam-like structure called the optic fissure closes up to form the structures of the eye. (nih.gov)
  • occurs
  • Nystagmus also occurs when the semicircular canals are being stimulated (e.g. by means of the caloric test, or by disease) while the head is not in motion. (wikipedia.org)
  • An example of disease state in which this occurs is Benign paroxysmal positional vertigo (BPPV). (wikipedia.org)
  • Pediatrics
  • Since 2001 till 2011 she was a head of the Eye Disease Department of Pediatrics at Russian State Medical University (now Pirogov National Medical Research University). (wikipedia.org)
  • indicates
  • Tyler indicates with geometric reconstructions at his web site Art Optics that the art works under discussion are brilliant paintings by eye rather than those compatible with optical projections. (wikipedia.org)
  • affects
  • citation needed] Again, the pathophysiological mechanisms involved in nutritional optic neuropathies is common to all mitochondrial optic neuropathies: it affects biochemical pathways involved in cell energetic production, correction of oxidative stress and quenching of free radicals. (wikipedia.org)
  • The disease affects about 2 million people in the United States. (wikipedia.org)