Onset atherosclerosis 1999 type i diabetes patients diabetes mellitus type 1. Medical search. Frequent questions

Excessive ROS generation by NOX enzymes has been linked to a range of diseases including cardiovascular diseases such as atherosclerosis and hypertension, diabetes, neurodegenerative disease and ischemia/reperfusion injury. (wikipedia.org)
How- senting symptoms, response to treatment ever, over the last 2 decades, DM2 has and presence of other co-morbid condi- been emerging as a public health problem in tions (such as hypertension, acanthosis ni- children and adolescents [ 1-3 ]. (who.int)
The physiopathological process of ACS is the atherosclerosis, the build-up of an atherosclerotic plaque starts at lesion-prone areas in large- and medium-sized arteries where the endothelium is dysfunctional, induced by cardiovascular risk factors like chronic smoking, hypertension, and permeation of macromolecules such as lipoproteins to the intima layer [ 6 , 7 ]. (hindawi.com)
Ismail N, Becker B, Strzelczyk P, Ritz E. Renal disease and hypertension in non-insulin-dependent diabetes mellitus. (edu.iq)
Conventional stroke risk factors such as hypertension, atrial fibrillation, cigarette smoking, diabetes mellitus and obesity are well established. (bmj.com)
Hypertension is a very common clinical syndrome characterized by elevated arterial blood pressure ( 1 ). (frontiersin.org)
in other words, there are more than 1.3 billion patients with hypertension at present ( 2 ). (frontiersin.org)
The incidence of hypertension is still on the rise, and the age of onset of hypertension tends to be younger in recent years. (frontiersin.org)
A better understanding of the relationship between the risk of hypertension and dietary habits is essential to prevent the onset and development of hypertension. (frontiersin.org)
Inflammation plays a pivotal role in hypertension, as a large number of studies have already demonstrated that systemic inflammation levels of patients with hypertension are elevated, which are closely associated with arterial stiffness ( 4 ). (frontiersin.org)
Many individuals with diabetes experience impaired cardiac contractility that cannot be explained by hypertension and atherosclerosis. (diabetesjournals.org)
Diabetic cardiomyopathy, a diabetes-related myopathic state and a major cause of disability and morbidity for patients with diabetes, has been documented to lead to congestive heart failure even in the absence of any other risk factors such as hypertension or coronary artery disease, suggesting that diabetic cardiomyopathy is a specific cardiomyopathy associated with diabetes and independent of macrovascular complications. (diabetesjournals.org)
Retina is as a rule damaged in case of the following diseases: hypertension, diabetes mellitus, renal insufficiency etc. (antiaging-peptides.com)
This includes therapeutic lifestyle changes and the medical treatment of hypertension, hyperlipidemia, and diabetes mellitus. (medscape.com)
A rare, genetic form of obesity characterized by morbid obesity, hypertension, type 2 diabetes mellitus and dyslipidemia leading to early coronary disease, myocardial infarction and congestive heart failure. (nih.gov)
Diabetic patients often combined with metabolic disorders like hypertension, and hyperlipidemia, easily lead to cardio-cerebrovascular diseases like coronary heart disease, which is a risk factor leading to death [ 2 ]. (biomedcentral.com)
Up to 60% of patients with TA have renal artery involvement, often resulting in refractory hypertension (HTN) and impaired renal function 4 , 5 , 6 . (jrheum.org)
Aging is the most profound risk factor for many non-communicable diseases and in itself confers a greater risk for cardiovascular disease than the traditional risk factors such as lipid levels, smoking, diabetes, hypertension and sedentary lifestyle. (jscimedcentral.com)
The presence of diabetes and prediabets is associated with increased PWV and synergistically effects vascular stiffness expressed by diabetes and hypertension, too. (jscimedcentral.com)
Any increase of arterial stiffness above 9 m/s, which is not correlated with chronologic age, can suggest and direct us to investigate additional comorbidities such a diabetes, hypertension or chronic renal disease that increase arterial stiffness and hence cardiovascular mortality. (jscimedcentral.com)
Ageing in itself confers a greater risk for cardiovascular disease than the traditional risk factors such as lipid levels, smoking, diabetes, hypertension and sedentary lifestyle [3]. (jscimedcentral.com)
Atrial fibrillation (AF) has strong associations with other cardiovascular diseases, such as heart failure, coronary artery disease (CAD), valvular heart disease, diabetes mellitus, and hypertension. (medscape.com)

The syndromes of insulin resistance actually make up a broad clinical spectrum, which includes obesity, glucose intolerance, diabetes, and the metabolic syndrome, as well as an extreme insulin-resistant state. (medscape.com)
Soon after the introduction of atypical antipsychotics, which antagonize serotonin receptors and dopamine D 2 receptors (D 2 R), numerous case reports appeared showing that the use of these drugs were associated with increased obesity and the development of type 2 diabetes mellitus (T2DM) ( 5 ). (frontiersin.org)
The clinical characteristics were: pubertal onset, female preponderance, obesity, strong family history of type 2 diabetes mellitus, high plasma glucose at presentation, adequate cell reserve and serum pancreatic islet cell antibody negativity. (who.int)
One potential benefit of fenugreek is improving elevated blood glucose and lipid levels associated with chronic conditions such as diabetes and obesity. (lww.com)
1,2 Within this pandemic, there are patients who are outliers in the development and progression of obesity and insulin resistance. (bariatrictimes.com)
In individuals who have early onset of extreme obesity that is resistant to weight loss attempts, early onset insulin resistance, and a strong family history of these symptoms, obesity may potentially be attributed to a monogenic cause. (bariatrictimes.com)
3 Recent research has focused on these individuals as "experiments of nature," giving us insight into the physiologic mechanisms of obesity, yet clinical treatments for these patients are often symptomatic in nature. (bariatrictimes.com)
In diabetic men, components of the insulin resistance syndrome (IRS) loaded on Factor 1 (the insulin resistance factor), which reflected high fasting insulin, obesity (high BMI), central obesity (high waist-to-hip ratio), high total triglycerides, and a short duration of diabetes. (diabetesjournals.org)
The insulin resistance syndrome (IRS), which is characterized by hyperinsulinemia, glucose intolerance, hypertriglyceridemia, low HDL cholesterol level, elevated blood pressure, and central obesity, accompanies the majority of cases of type 2 diabetes and has been suggested to be one of the links between diabetes and an excess risk of CHD. (diabetesjournals.org)
There was a statistically significant association of triglycerides and HDL-C with increasing age, female sex, obesity, physical inactivity and poor glycaemic control of diabetes. (who.int)
Dyslipidaemia obesity and insulin changes highly acceler- encompasses changes in HDL-cholesterol ate the progression to atherosclerosis [ 2 ]. (who.int)

It has been over 30 years since Reaven first described metabolic syndrome, which commonly affects overweight individuals ( 1 ). (frontiersin.org)
Metabolic syndrome, thought to be due to insulin resistance, can occur in patients with overtly normal glucose tolerance, prediabetes, or diabetes. (medscape.com)
In recent decades, the world has seen expanding waistlines in expanding numbers, and with this, an increased prevalence of metabolic syndrome, a collection of risk factors predisposing toward cardiovascular disease (CVD) and type 2 diabetes mellitus (T2DM). (bariatrictimes.com)
The aim of this study was to analyze the effect exerted by combined antiretroviral therapy (cART) administration on plasma levels of HMGB1 (high mobility group box protein-1), AGEs (advanced glycation end products), their soluble receptor sRAGE, cytokines, C-reactive protein (CRP), and some metabolic markers in asymptomatic PLWHA. (hindawi.com)
The high prevalence of CAN in patients newly diagnosed with T2D suggests that its pathophysiology is rooted in an earlier stage of metabolic derangement, possibly being prediabetes. (encyclopedia.pub)
Interestingly, comparisons between type 1 and type 2 diabetic individuals further confirm the fact that CAN processes in T2D start earlier than the onset of overt metabolic impairment [2] [ 1 ] . (encyclopedia.pub)
It is correlated with several metabolic and cardiovascular complications in both adults and children [ 1 , 2 ]. (e-apem.org)
Steatosis due to secondary causes, such as viruses, autoimmune responses, metabolic or hereditary factors, and drugs or toxins, should be ruled out (Table 1 ). (biomedcentral.com)
Conclusions: Salivary parameters can act as adjuncts in assessing the overall metabolic status of the patient. (bvsalud.org)
Diabetes mellitus (DM) comprises a group of common metabolic disorders that share the salient feature of hyperglycemia. (bvsalud.org)
The metabolic deregulation associated with DM causes secondary pathophysiological changes in multiple organ systems and imposes a tremendous burden on the individual with diabetes and the health care system. (bvsalud.org)
An optimum metabolic control level correlates positively with the well being of the patient. (bvsalud.org)
Assessing the metabolic control of the patient has traditionally been done through testing of glycosylated hemoglobin, fructosamine, and glycoalbumin along with other criteria such as Body Mass Index, microalbuminuria and dyslipidemia 6-7 . (bvsalud.org)
Hypothyroidism contributes to the increased risk for cardiovascular diseases and metabolic syndrome in RA patients and may be correlated with RA disease activity and response to treatment. (springer.com)

Approximately 31% of patients with T2DM suffer from depressive symptoms, with 11.4% having major depressive disorders, which is twice as high as the prevalence of depression in patients without T2DM. (frontiersin.org)
Low serum 25-hydroxyvitamin D (25OHD) concentrations are highly prevalent among older adults with prevalence reaching 90% [ 1 ], and have been associated with deterioration of global cognitive performance [ 2,3,4,5,6,7 ]. (karger.com)
Aydin S, Mete B, Yilmaz M, Yenidünya G, Zaras R, Tunckale A, Tabak F. A patient with HIV infection presenting with diffuse membranous glomerulonephritis in a country with a low HIV prevalence--remarkable remission with therapy. (florence.com.tr)
Racial and ethnic differences in microalbuminuria prevalence in a diabetes population: the pathways study. (edu.iq)
Prevalence and risk factors for microalbuminuria in a referred cohort of type 2 diabetic patients: a global perspective. (edu.iq)
Considering the high prevalence of diabetes in Iran and its implications on cardiovascular diseases [ 18 ], it is of interest to determine the relationship between the levels of liver enzymes and diabetes. (biomedcentral.com)
Although the HIV epidemics affect more than 36 million individuals worldwide, with a global prevalence of almost 1% [ 1 ], life expectancy of people living with HIV/AIDS (PLWHA) is very similar to that of the general uninfected population, which makes the clinical approach to the infection similar to that of other chronic diseases that characterize aging [ 1 - 3 ]. (hindawi.com)
Prevalence, characteristics and clinical diagnosis of maturity onset diabetes of the young due to mutations in HNF1A, HNF4A, and glucokinase: Results from the SEARCH for Diabetes in Youth. (medarhive.ru)
The Centers for Disease Control and Prevention and the National Institutes of Health performed a population-based observational study of diabetes in youth also demonstrating an increasing prevalence of T2D in United States between 2001 and 2009. (e-apem.org)
RA patients are more likely to have thyroid-related antibodies, and some studies indicate an increased prevalence of thyroid diseases in RA. (springer.com)
Pregnant SLE patients are more prone to develop thyroid diseases and pospartum thyroitidis, and in case they suffer from thyroid disease, they have an increased prevalence of preterm delivery. (springer.com)
The prevalence of SS among patients with autoimmune thyroiditis is increased by two- to tenfold. (springer.com)

This study was to explore the effect of hyperlipidemia on the incidence of cardio-cerebrovascular diseases in patients with type 2 diabetes. (biomedcentral.com)
The incidence of cardio-cerebrovascular diseases between diabetes combined with hyperlipidemia group (195 patients) and diabetes group (200 patients) were made a comparison. (biomedcentral.com)
Multivariable Cox's proportional hazards regression model was used to analyze the effect of hyperlipidemia on the incidence of cardio-cerebrovascular diseases in patients with type 2 diabetes. (biomedcentral.com)
The analysis results of multivariable Cox's proportional hazards regression model showed that the risks of myocardial infarction and total cardiovascular events in diabetes combined with hyperlipidemia group were respectively 1.54 times (95% CI 1.13-2.07) and 1.68 times (95% CI 1.23-2.24) higher than those in diabetes group. (biomedcentral.com)
Population attributable risk percent of all-cause mortality and total cardiovascular events in patients with type 2 diabetes combined with hyperlipidemia was 9.6% and 26.8%, respectively. (biomedcentral.com)
Hyperlipidemia may promote vascular endothelial injury, increasing the risk of cardio-cerebrovascular diseases in patients with type 2 diabetes. (biomedcentral.com)
Three hundred ninety five patients with type 2 diabetes in our hospital from January 2012 to January 2016 were divided into diabetes combined with hyperlipidemia group (195 patients) and diabetes group (200 patients). (biomedcentral.com)

Like other members of its class (the "statins"), simvastatin lowers total serum cholesterol and particularly low density lipoprotein (LDL) cholesterol concentrations, thereby reducing the risk of atherosclerosis and its complications - myocardial infarction and stroke. (nih.gov)
Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. (jscientia.org)
Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. (jscientia.org)
Cox regression models were used to investigate whether these clusters (factors) predict CHD events (CHD death or nonfatal myocardial infarction) during a 7-year follow-up in 229 type 2 diabetic subjects aged 65-74 years. (diabetesjournals.org)
A meta-analysis of nearly 5000 patients found that statins administered before invasive procedures significantly reduced the risk for postprocedural myocardial infarction. (medscape.com)
[ 2 ] In 1958, streptokinase was first used in patients with acute myocardial infarction (AMI), and this changed the focus of treatment. (medscape.com)
Coronary artery disease (CAD) is a progressive atherosclerotic condition and is, together with thrombus formation, the most important underlying mechanism of an acute myocardial infarction (AMI) [ 1 - 4 ]. (biomedcentral.com)
There is, however, limited knowledge about activation of the coagulation cascade in the acute phase of ST-elevation myocardial infarction (STEMI) and also limited data on the degree of hypercoagulability in relation to the degree of myocardial injury and severity of the disease in these patients. (biomedcentral.com)
An epidemiological survey showed the incidence of acute stroke in patients with high hyper-sensitive C-reactive protein (hs-CRP) level was two times higher than healthy people and myocardial infarction was three times higher [ 9 ]. (biomedcentral.com)

The diagnosis of diabetes mellitus was tries [ 6,7 ]. (who.int)
Guideline] Diagnosis and classification of diabetes mellitus. (medscape.com)
To this end, guidelines recommend CAN screening in T2D patients as early as their first diagnosis as opposed to 5 years after onset in T1D [3] [ 2 ] . (encyclopedia.pub)
All patients underwent an aortic computed tomography (CT) scan and/or conventional angiography at the time of TA diagnosis. (jrheum.org)
Here we review single gene disorders that have the potential to mimic multiple sclerosis, provide an overview of clinical and investigational characteristics of each disorder, and present guidelines for when clinicians should suspect an underlying heritable disorder that requires diagnostic confirmation in a patient with a definite or probable diagnosis of multiple sclerosis. (medscape.com)
Early, accurate diagnosis is critical to effective patient management and counselling, but assignment of an incorrect diagnosis of multiple sclerosis remains a frequent concern. (medscape.com)
In the absence of pathognomonic clinical findings or a definitive laboratory test, the diagnosis of multiple sclerosis remains challenging in many patients, and diagnostic criteria emphasize the caveat of 'no better explanation' for a patient's clinical presentation and MRI findings. (medscape.com)

There is increasing evidence from clinical and experimental studies for a causative role of chronic inflammation in initiation and progression of atherosclerosis [ 10 ], where the release of cytokines from platelets, immune, endothelial and smooth muscle cells play a key role [ 10 , 11 ]. (hindawi.com)
Development and progression of nephropathy in type 2 diabetes: The United Kingdom Prospective Diabetes study (UKPDS 64). (edu.iq)
The goals of therapy should include arresting atherosclerosis or even reversing its progression. (medscape.com)
Recent knowledge about the nature of disease progression has led researchers to study the status of CAN in patients with recent-onset diabetes. (encyclopedia.pub)

Using a large, population-based administrative cohort, we found little evidence that type 2 diabetes increases the risk of depression once comorbid diseases and the burden of diabetes complications were accounted for. (cmaj.ca)
9 , 10 When associated with diabetes, depression increases the risks of work loss, 11 functional disability, 11 , 12 and micro- 13 and macrovascular complications, 14 and adds to health care costs. (cmaj.ca)
Such knowledge could influence clinical practice by suggesting who would most effectively be screened for depression and by evaluating ways to prevent people with diabetes from becoming depressed, in order to decrease both the patients' risk of complications and the cost of the ensuing treatments. (cmaj.ca)
There is convincing experimental and clinical evidence that the generation of ROS is increased in both types of diabetes and that the onset of diabetes and its complications, including diabetic cardiomyopathy, are closely associated with oxidative stress ( 7 , 8 ). (diabetesjournals.org)
Several studies have suggested that depression in patients with diabetes is associated with worse health outcomes, due to poor adherence to treatment regimens [ 9 - 11 ], which leads to poor glycemic control and an increased risk for complications. (e-dmj.org)
Diabetes complications, cardio-cerebrovascular diseases are the common factors that cause the death of patients. (biomedcentral.com)
The dental management of these medically compromised patients can be problematic in terms of oral complications, dental therapy, and emergency care. (medscape.com)
The dental clinician needs to understand the potential complications that can occur as a consequence of dental treatment of a medically compromised patient and when pretreatment or post-treatment medication or emergency care is indicated. (medscape.com)
The rheumatic manifestations may result from a direct effect of the hormones, the occurrence of several autoimmune phenomena in the same person (due to genetic or environmental influences), secondary to endocrine disease complications or effects of advanced glycation end products in the case of diabetes. (springer.com)

Ain, the records of every child with diabetes attending a teaching hospital in the city from January 1990 to December 2001 were retrospectively examined. (who.int)
RÉSUMÉ Afin d'établir les spécificités du diabète de type 2 chez les enfants et les adolescents à Al Ain, les dossiers de chaque enfant diabétique ayant fréquenté un hôpital universitaire de la ville entre janvier 1990 et décembre 2001 ont été examinés rétrospectivement. (who.int)
Although all diabetic cells are exposed to elevated levels of plasma glucose, hyperglycemic damage is limited to those cell types that are unable to down regulate glucose transport into the cell (e.g., endothelial cells), leading to intra-cellular hyperglycemia ( Brownlee, 2001 ). (scialert.net)
The most recent data 1 , 2 reveals that, between 2001 and 2009, type 2 diabetes among children aged 10-19 rose by 30 percent. (detailshere.com)

Insulin resistance in maturity onset diabetes of the young. (medarhive.ru)
Patients with RA have an increased risk of insulin resistance (IR) and diabetes (DM) secondary to genetic, inflammatory components or to comorbidities and treatment. (springer.com)
An association between SLE and insulin resistance and DM type II is described. (springer.com)

The treatment goals for patients with coronary artery atherosclerosis are to relieve symptoms of coronary artery disease (CAD) and to prevent future cardiac events, such as unstable angina, AMI, and death. (medscape.com)
[6] Coronary artery disease, stroke, and peripheral artery disease involve atherosclerosis . (wikipedia.org)

After a median followup of 90.6 months, 11 (17.7%) of the 62 patients had refractory HTN and 6 (9.7%) had chronic renal insufficiency. (jrheum.org)
Renal insufficiency [5/15 (33.3%) vs 3/47 (6.4%), p = 0.016] and bilateral involvement [12/15 (80.0%) vs 23/47 (48.9%), p = 0.041] were significantly more frequent in patients with poor than good outcomes. (jrheum.org)
Further, relatively little is known about longterm clinical outcomes, such as chronic renal insufficiency and death, in TA patients with renal artery stenosis. (jrheum.org)
Therefore, our study analyzed longterm outcomes and clinical variables associated with poor outcomes (e.g., refractory HTN, chronic renal insufficiency, or death) in all patients with TA-associated renal artery involvement, regardless of whether they underwent revascularization procedures. (jrheum.org)

Diabetes is a methabolic disease characterized by hyperglycemia, with high morbidity and mortility worldwide. (scialert.net)
However, if they are not excreted in the urine or their formation is exacerbated as in the case of diabetes hyperglycemia and other diseases, they accumulate in the vascular tissue, causing harmful effects [ 10 , 11 ]. (hindawi.com)
On the onset of hyperglycemia, however, elevated mitochondrial aerobic respiration and activity of the electron transport chain, as well as advanced glycated end products, aggravates oxidative stress, which presents another activator of inflammatory cascades mediated by NF-κB, cAMP-regulated element-binding protein, and activator protein 1 [31] [ 22 ] . (encyclopedia.pub)

High levels of these coagulation markers in patients with low LVEF and high NTproBNP may indicate a hypercoagulable state in patients with impaired myocardial function. (biomedcentral.com)

The aim of this study was therefore to evaluate the plasma levels of FABP3 at different stages of estimated glomerular filtration rate (eGFR) in patients with type 2 diabetes mellitus (T2DM). (medsci.org)
Our results indicate that circulating FABP3 in patients with T2DM is associated with eGFR, which suggests that increased plasma FABP3 may be involved in the pathogenesis of CKD. (medsci.org)
Type 2 diabetes mellitus (T2DM) and depression are significant public health and socioeconomic issues. (frontiersin.org)
Conversely, the D 2 R agonist bromocriptine, which has been used for over 40 years to treat Parkinson's disease and hyperprolactinemia ( 6 ), was found to lower blood glucose levels and improve insulin sensitivity in patients with T2DM ( 7 ). (frontiersin.org)

In support of improving patient care, this activity has been planned and implemented by Medscape, LLC and Emerging Infectious Diseases. (cdc.gov)
Proinflammatory actions of MIF have been reported in various inflammatory diseases such as sepsis, rheumatoid arthritis, and atherosclerosis [ 16 , 17 ]. (hindawi.com)
Proteinuria and other markers of chronic Kidney disease: a position statement of the national Kidney foundation (NKF) and the national institute of diabetes and digestive and kidney diseases (NIDDK). (edu.iq)
target: catalog of the Candidate and elevated diseases after Medial of a mellitus system. (siriuspixels.com)
These liver diseases are regarded as major contributors to death among diabetic patients [ 9 ]. (biomedcentral.com)
Current indications for simvastatin are hypercholesterolemia and reduction in risk for death from coronary, cerebrovascular and peripheral artery disease in patients with these diseases. (nih.gov)
However, the great challenge today is to delay the onset and severity of non-AIDS-defining comorbidities, which appear much earlier in HIV-infected individuals [ 5 ] and include cardiovascular diseases, diabetes mellitus , kidney, liver, and bone alterations, and neoplasia [ 4 - 8 ]. (hindawi.com)
Medical staffs should pay attention to the control of blood lipids in patients with type 2 diabetes to delay the occurrence of cardio-cerebrovascular diseases. (biomedcentral.com)
This review describes, analyzes and compares the effects of different types of diets in reducing the onset of typical Western countries non-communicable diseases (NCDs) (cardiovascular diseases, tumors, chronic respiratory diseases, diabetes, etc.), thus increasing the average lifespan. (iospress.com)
Cardiovascular diseases (CVDs) account for most NCDs deaths (17.7 million people annually), followed by cancers (8.8 million), respiratory diseases (3.9 million) and diabetes (1.6 million) [ 1 ]. (iospress.com)
Moreover, the simultaneous usage of different types of drugs for the treatment of various chronic diseases makes the patient health status even weaker [ 4 ]. (iospress.com)
Aging is time-dependent physiological functional decline that affects most living organisms, which is underpinned by alterations within molecular pathways, and is the most profound risk factor for many non-communicable diseases [1]. (jscimedcentral.com)
In most studies, thyroid diseases (mainly hypothyroidism) are more common in SLE patients. (springer.com)

The aim of this study was to assess the mRNA expression of MIF gene and its serum levels in the clinical manifestations of ACS and unrelated individuals age- and sex-matched with patients as the control group (CG). (hindawi.com)
K/DOQ1 clinical practice guidelines and clinical practice recommendations for diabetes and chronic kidney disease. (edu.iq)
These advances are at the cusp of making important changes to clinical practice of some monogenic forms of stroke and, in the future, are likely to revolutionise the care provided to these patients. (bmj.com)
[ 1 ] Streptokinase found its initial clinical application in combating fibrinous pleural exudates, hemothorax, and tuberculous meningitis. (medscape.com)
In the last 12 years, I have expanded my scholarly work to address the critical intersection between patient and family-centered care and related areas of faculty and trainee career development and mentoring, and wellbeing and professional fulfillment for physicians and the entire clinical team. (stanford.edu)
Several single gene disorders share clinical and radiologic characteristics with multiple sclerosis and have the potential to be overlooked in the differential diagnostic evaluation of both adult and paediatric patients with multiple sclerosis. (medscape.com)
Patients with multiple sclerosis are classified according to their clinical phenotype, with ~85% following a relapsing-remitting course (relapsing-remitting multiple sclerosis) characterized by recurrent, acute neurological deficits punctuating periods of latency or remission (Lublin and Reingold, 1996). (medscape.com)

21 - 31 Most reported an increased risk of diabetes associated with a history of depression or depressive symptoms, but often only in selected subpopulations. (cmaj.ca)
Acute coronary syndrome (ACS) is a cardiovascular disease, which describes any condition characterized by signs and symptoms of sudden myocardial ischaemia and reduction in blood flow to the heart [ 1 ]. (hindawi.com)
The usual latency to onset of symptoms of liver disease ranges from one week to as long as 3 years, but most cases have a latency of 1 to 6 months. (nih.gov)
We suggest that more attention should be given to patients with diabetes who present with depressive symptoms. (e-dmj.org)
Blood samples were drawn at a median time of 24 h after onset of symptoms. (biomedcentral.com)
Approximately 15% of patients follow a primary progressive or progressive relapsing course from disease onset, usually characterized by symptoms of progressive myelopathy (gait instability, spasticity, bladder symptoms) and cognitive impairment. (medscape.com)

Of 96 young people newly diagnosed with diabetes mellitus, 11 were identified as type 2. (who.int)
Induction of long-term glycemic control in newly diagnosed type 2 diabetic patients by transient intensive insulin treatment. (florence.com.tr)

Chronic kidney disease (CKD) is a chronic complication of diabetes, characterized by the presence of pathological quantities of urine albumin excretion and/or accompanied by a gradual deterioration in the glomerular filtration rate (GFR). (medsci.org)
Other chronic conditions such as arthritis (HR 1.18) and stroke (HR 1.73) were associated with the onset of depression. (cmaj.ca)
mellitus: cardiac and invisible items in the chance of refractive chronic acid diabetes. (siriuspixels.com)
Chronic overexpression of MT or acute in vitro treatment with the flavoprotein inhibitor diphenyleneiodonium or the angiotensin II type I receptor antagonist losartan eliminated excess ROS production in diabetic cardiomyocytes. (diabetesjournals.org)
The onset and severity of these comorbidities are strictly dependent on the intense immune activation and chronic inflammation affecting PLWHA, regardless of cART administration, which can only partly reduce these conditions and the derived products [ 3 , 7 ]. (hindawi.com)
Diabetes is a chronic disease that has reached epidemic levels globally. (e-dmj.org)
Takayasu arteritis (TA) is a chronic, large vessel vasculitis that primarily affects the aorta and its main branches, including the renal artery 1 , 2 . (jrheum.org)
In type 2 diabetes, your pancreas is still producing some insulin in fact, usually too much insulin is being produced on a chronic basis but your pancreas is unable to recognize the insulin and use it properly. (detailshere.com)
In a 15-year prospective cohort study of 132,250 Japanese subjects, Xu et al found that anemia and chronic kidney disease, alone and in combination, were associated with an increased risk of new-onset AF. (medscape.com)

failure of the signals or of the B cells to adapt adequately in relation to insulin sensitivity results in inappropriate insulin levels, impaired fasting glucose (IFG), impaired glucose tolerance (IGT), and type 2 diabetes. (medscape.com)
These potential signaling mediators include glucose, free fatty acids, autonomic nerves, fat-derived hormones (eg, adiponectin), and the gut hormone glucagonlike peptide-1 (GLP-1). (medscape.com)
13 , 15 Diabetes with comorbid depression is also linked with poorer adherence to medications and self-care activities such as self-monitoring of blood glucose levels and adhering to a proper diet and exercise program. (cmaj.ca)
Traditionally this has involved studying both central and peripheral molecules involved in hunger and satiety, such as leptin, orexin (also known as hypocretin), insulin, alpha-melanocyte-stimulating hormone (α-MSH), glucagon-like peptide -1 (GLP-1), amylin, glucose-dependent insulinotropic polypeptide (GIP, also known as a gastric inhibitory polypeptide), adiponectin and cholecystokinin (CCK). (frontiersin.org)
Human investigations suggest that fenugreek can be beneficial as an adjunct in controlling high blood glucose and lipid levels in people with diabetes. (lww.com)
Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. (edu.iq)
The liver has an essential part in the maintenance of glucose homeostasis [ 1 ]. (biomedcentral.com)
When in doubt, the emergency department patient should be treated with insulin and his or her glucose levels should be closely monitored. (medscape.com)
The patients had their saliva collected and evaluated for glucose, cholesterol, total protein and albumin. (bvsalud.org)

ABSTRACT This study investigated the patterns and determinants of lipid disorders among a group of 250 type 2 adult diabetic patients and 60 age- and sex-matched healthy controls in Sudan. (who.int)

Appendices A. Notice of Change, Number 1, December 1998. (cdc.gov)

Catheter and surgical ablation of atrial fibrillation (AF) have evolved from investigational procedures to their current role as effective treatment options for patients with AF. (e-arrhythmia.org)

Evaluation of the left ventricular systolic and diastolic functions by echocardiography in patients with acute leukemia. (florence.com.tr)

However, these methods are unable to identify the types of relationships between features. (biomedcentral.com)
Methods: 32 children with type 1 diabetes mellitus formed the study group (DC) and 32 non-diabetic children formed the control group (ND). (bvsalud.org)

Correctly determining whether a patient has type 1 or type 2 diabetes is important because patients with type 1 diabetes require continuous exogenous insulin for survival. (medscape.com)

Fortunately, the natural history of CAD is characterized by early onset and a long dormant phase. (medscape.com)

The objective of our study was to evaluate whether people with diabetes have a greater incidence of depression than those without diabetes. (cmaj.ca)
The incidence of new-onset depression was similar in both groups (6.5 v. 6.6 per 1000 person-years among people with and without diabetes, respectively). (cmaj.ca)
Little information is currently available on the obverse of that temporal chain: the incidence of depression among people who have diabetes. (cmaj.ca)
We therefore conducted a population-based retrospective cohort study to evaluate the incidence of new-onset depression among people with diabetes, compared with those who do not have diabetes. (cmaj.ca)
12 ] described the incidence of T2D at 0.29 cases per 100,000 per year between 1999 and 2007 in Austrian children and adolescents. (e-apem.org)
The incidence of childhood onset type 1 diabetes is increasing in many countries in the world, at least in the under 15-year-old age group. (bvsalud.org)
There are strong indications of geographic differences in trends but the overall annual increase is estimated to be around 3%.Two international collaborative projects, the Diabetes Mondiale study (DiaMond)1 and the Europe and Diabetes study (EURODIAB) 2 have been instrumental in monitoring trends in incidence. (bvsalud.org)
Of the estimated 480,000 children with type 1 DM, 24% come from the South-East Asian Region, but the European Region, where the most reliable and up-to-date estimates of incidence are available, comes a close second (23%) 3 .The incidence rate of type 1 DM in India is 4.2/100,000 population per year. (bvsalud.org)

[ 1 ] The prevention and treatment of atherosclerosis requires control of the known modifiable risk factors for this disease. (medscape.com)
Nevertheless, prevention of cardiac events is likely to have the largest impact on decreasing the burden of atherosclerosis. (medscape.com)
These findings strongly suggest that the largest impact on decreasing the global burden of atherosclerosis will come from prevention of events. (medscape.com)
In addition, addressing risk factors with lifestyle changes is an integral part of atherosclerosis prevention. (medscape.com)
Substantial evidence supports the use of statins in the secondary prevention of CAD, and the efficacy of statins has recently been extended to include primary prevention of CAD in patients with average cholesterol levels. (medscape.com)

But in view of the wide use of simvastatin, clinically apparent liver injury is exceeding rare and is estimated to occur in 1 per 100,000 patient years of exposure. (nih.gov)

The burden of diabetes is growing more severe as a result of the increasing number of deaths from diabetes and medical costs [ 1 ]. (biomedcentral.com)

Patients with CKD are at a high risk of cardiovascular disease and mortality and are associated with increased treatment costs [ 2 ]. (medsci.org)
Patients with diabetic foot ulceration may be at considerably higher risk of all-cause mortality compared with those patients with diabetes but no history of foot ulceration. (forumdiabetologicum.sk)
The aim of this study was to evaluate the risk of cardiovascular disease (CVD) and mortality in patients with diabetes with comorbid depression. (e-dmj.org)
Coexisting depression in patients with diabetes has a deleterious effect on the development of CVD and mortality. (e-dmj.org)
However, only few studies have been conducted in a large population to evaluate the risk of CVD and mortality in patients with diabetes and comorbid depression. (e-dmj.org)
TA typically occurs in young women, resulting in substantial morbidity and mortality related to involvement of the major vessels 1 , 2 , 3 . (jrheum.org)
Psychiatric patients suffer from a substantial reduction (ranging between 7 and 20 years) in life expectancy, with high rates of all-cause mortality [ 1 ]. (biomedcentral.com)
26 H. WHO Mortality Tabulation List 1, General Mortality, Condensed List. (cdc.gov)

Damage can be attributed to ROS production, and diabetes increases ROS production via angiotensin II and flavoprotein enzyme‐dependent pathways. (diabetesjournals.org)
By studying diabetic dyslipid- in diabetes mellitus because insulin resist- aemia among a group of our patients we ance or deficiency affects key enzymes hoped to draw attention of the medical com- and pathways in lipid metabolism [ 1 ]. (who.int)

There are 2 major types of lipids in the study comprising 1155 diabetic type 2 pa- blood: cholesterol and triglycerides. (who.int)
Atherosclerosis accounts for up to 80% of cholesterol (LDL-C) and the total choles- deaths in diabetic patients due to coronary terol/HDL-C ratio (TC/HDL-C) [ 1 ]. (who.int)

The objective of this longitudinal study was to determine whether serum vitamin D deficiency at baseline could predict the onset of non-Alzheimer dementias (NAD) within 7 years among older women. (karger.com)
Serum liver enzymes levels within the normal range were categorized into quartiles, and their relationship with diabetes was evaluated by logistic regressions. (biomedcentral.com)
Up to 5% of patients taking simvastatin chronically may experience minor elevations in serum ALT levels during therapy, but confirmed elevations to above three times the upper limit of normal (ULN) occur in only 1% to 2% of patients. (nih.gov)
Fructosamine reflects the glycemic control over the previous 1-2 weeks and has been correlated positively with serum albumin and serum total protein5. (bvsalud.org)

Prediabetes often precedes overt type 2 diabetes. (medscape.com)
It constitutes the major cause of silent cardiovascular events in patients without overt cardiac disease. (encyclopedia.pub)

Typically, patients with CAD are first seen after they present with a cardiac event. (medscape.com)
Cardiac autonomic neuropathy (CAN) is one of the earliest manifestations of type 2 diabetes (T2D). (encyclopedia.pub)

People older than 20 years with newly identified type 2 diabetes were identified by means of diagnostic codes and prescription records and compared with a nondiabetic cohort. (cmaj.ca)
We evaluated the relation between ALT, AST, GGT and ALP with diabetes in the Rafsanjan Cohort Study. (biomedcentral.com)
In our cohort of STEMI patients we demonstrated that levels of D-dimer and F1 + 2 were significantly associated with myocardial necrosis as assessed by peak TnT. (biomedcentral.com)

Type 2 diabetes (T2D) is an emerging health risk in obese children and adolescents. (e-apem.org)
This review focuses on the current knowledge regarding IR and T2D in children and adolescents and showcases interesting opportunities and stimulating challenges for the development of new preventative approaches and therapeutic strategies for young patients with T2D. (e-apem.org)

1. Division of Cardiology, Department of Internal Medicine, E-Da Hospital, Kaohsiung 82445 Taiwan. (medsci.org)
She is also appointed in the Department of Medicine, Division of Cardiology and sees general cardiology patients. (ucsf.edu)

Long term diabetes and poor glycemic control are the most important risk factors for DN development ( DCCT Research Group, 1993 ). (scialert.net)

Cette série de cas confirme que le diabète de type 2 augmente chez les enfants dans cette région. (who.int)
L'ancienneté moyenne du diabète était de 9,4 ans et chez 46,0 % des patients, la glycémie n'était pas bien contrôlée. (who.int)

Sur 96 jeunes pour lesquels le diagnostic de diabète sucré a été récemment établi, 11 ont été identifiés comme souffrant d'un diabète de type 2. (who.int)

While stroke remains principally a common sporadic disorder, our understanding of monogenic disorders has improved considerably 1 , 2 We begin therefore with the monogenic disorders before addressing the more common sporadic condition. (bmj.com)
Of these organizations, 342 entered patients into the study population, which included Medicare fee-for-service beneficiaries aged 40 to 79 years with no previous MI or stroke and with high or medium CVD risk (a 10-year predicted probability of MI or stroke [ie, CVD risk score] ≥15%) in 2017-2018. (bvsalud.org)
Coronary heart disease (CHD) is the leading cause of death for adults in the United States, and stroke ranks third (1). (cdc.gov)
the age-adjusted CHD death rate in 2003 was 1.7 times the national rate, and the age-adjusted stroke death rate was half the national rate (1,2). (cdc.gov)

2002;13(1):37-40. (jscientia.org)

The age of onset, family history, pre- understood to be a disease of adults. (who.int)
Some adolescents or young adults, mostly Hispanic or African American patients, who present with classic DKA are subsequently found to have type 2 diabetes. (medscape.com)
Screening for Type 2 Diabetes Mellitus in Adults. (medscape.com)
Globally, the number of older adults (aged 65 years and older) is projected to increase even more dramatically - more than doubling from 420 million in 2000 to 973 million in 2030 (1). (cdc.gov)

As stated by International Diabetes Federation (IDF), approximately 1 out of 11 adult people in the world would be afflicted with diabetes mellitus [ 6 ]. (biomedcentral.com)
According to the International Diabetes Federation, diabetes is associated with an increased risk of developing cardiovascular disease (CVD), leading to a reduced life expectancy, higher healthcare expenditure, and a decreased quality of life [ 1 ]. (e-dmj.org)
The latest data from the International Diabetes Federation revealed that there were 387 million diabetics worldwide in 2014. (biomedcentral.com)

DSN: CC37.NHAMCS94.EMRGENCY (Emergency Department File) CC37.NHAMCS94.OPATIENT (Out-Patient Department File) DESCRIPTION OF THE NATIONAL HOSPITAL AMBULATORY MEDICAL CARE SURVEY A. INTRODUCTION The National Hospital Ambulatory Medical Care Survey (NHAMCS) was initiated to learn more about the ambulatory care rendered in hospital emergency and outpatient departments in the United States. (cdc.gov)

We recently conducted a large, population-based, nested case- control study 21 that suggested an association between a history of depression and the onset of type 2 diabetes, but this increased risk was limited to people no older than 50 years. (cmaj.ca)
Baseline vitamin D deficiency predicted the onset of NAD within 7 years among older women. (karger.com)
As summarized elsewhere (1), the combination of a declining birth rate and an increased average life span is expected to increase the proportion of the population aged 65 years and older in the United States from 12.4% in 2000 to 19.6% in 2030. (cdc.gov)
In recent years, many researchers have focused on the psychosocial aspects of diabetes and have suggested relationships between mental disorders and diabetes [ 5 - 8 ]. (e-dmj.org)
Furthermore I allele was present in all male patients younger than 55 years, making this allele a likely predisposing factor for NAION in young males. (molvis.org)
Three hundred ninety five patients with type 2 diabetes in our hospital from January 2012 to January 2016 were followed up with an average of 3.8 years. (biomedcentral.com)
By 2010, it is estimated that annually some 76,000 children aged less than 15 years develop type 1 DM worldwide. (bvsalud.org)
The mean duration of diabetes was 9.4 years and 46.0% of patients had poor glycaemic control. (who.int)

It is more prevalent in patients with diverse mental disorders, being part of the comorbidity driving loss of life expectancy and quality of life, yet remains a neglected entity. (biomedcentral.com)

Although diabetes mellitus has a strong association with the presence of depression, it is unclear whether diabetes itself increases the risk of developing depression. (cmaj.ca)
patients: oxidative rules at which a onset increases with a goal order. (siriuspixels.com)

When dealing with patients with known diabetes in the emergency department, distinguishing the type of diabetes can be difficult in 2 groups: (1) patients who are treated with insulin and are young but clinically appear to have type 2 diabetes, and (2) older patients with late-onset of diabetes who nonetheless take insulin and seem to share characteristics of patients with type 1 diabetes. (medscape.com)
In fact, a Mediterranean-type dietary pattern is associated with specific gut microbiota characteristics. (karger.com)
Furthermore, hospital ambulatory patients are known to differ from office patients in their demographic characteristics and are also thought to differ in medical aspects (reference 3). (cdc.gov)

We examined the association of the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme gene, of the M235T polymorphism of the angiotensinogen gene, and of the A1166C polymorphism of the angiotensin II type 1 receptor gene with NAION. (molvis.org)
NAION occurrence was not associated with the M235T polymorphism of the angiotensinogen gene and the A1166C polymorphism of the angiotensin II, type 1 receptor gene. (molvis.org)
The renin-angiotensin system genes exhibit three common polymorphisms: the insertion/deletion (I/D) polymorphism of the angiotensin-converting enzyme ( ACE ) gene, the M235T polymorphism of the angiotensinogen gene ( AGT ), and the A1166C polymorphism of the angiotensin II type 1 receptor gene ( AT1-receptor ). (molvis.org)

[3] Treating risk factors, such as high blood pressure, blood lipids and diabetes is also beneficial. (wikipedia.org)

5 Mutations in leptin (LEP) and its receptor (LEPR), melanocortin 4 receptor (MC4R), pro-opiomelanocortin (POMC), prohormone convertase 1 (PCSK1), brain-derived neurotrophic factor (BDNF), neurotrophic tyrosine kinase receptor type 2 (NTRK2), and single-minded homolog 1 (SIM1) have all been shown to influence appetite and weight gain. (bariatrictimes.com)

Rheumatoid arthritis is the most common coexisting autoimmune disorder in patients with Grave's disease and Hashimoto thyroiditis. (springer.com)

A lean patient who has had diabetes since childhood, who has always been dependent on insulin, or who has a history of diabetic ketoacidosis (DKA) almost certainly has type 1 diabetes. (medscape.com)

It affects approximately 20-40% of patients with diabetes mellitus and is recognized as the most common cause of end-stage renal disease (ESRD) [ 1 ]. (medsci.org)
High iron intake in the diet might increase the risk of heart disease in females with type 2 diabetes . (webmd.com)
As previously stated, patients with type 2 diabetes mellitus can usually be differentiated from those with type 1 disease on the basis of history and physical examination findings and through simple laboratory tests. (medscape.com)
Persons with prediabetes are at increased risk for macrovascular disease, as well as diabetes. (medscape.com)
In the first step, a drug-disease knowledge graph named DDKG-V1 is constructed by defining new relationship types, and then numerical vector representations for the nodes are created using the distributional learning method. (biomedcentral.com)
Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial. (jscientia.org)
Usually a prognosis for a disease in these patients is unfavorable (gradual and progressive decrease in the visual functions up to blindness). (antiaging-peptides.com)
It is also used for heart disease, premenstrual syndrome (PMS), depression, morning sickness, Alzheimer disease, menstrual cramps, diabetes, and many other conditions, but there is no good scientific evidence to support many of these other uses. (medlineplus.gov)
OBJECTIVE -To investigate whether cardiovascular risk factors cluster with hyperinsulinemia in elderly type 2 diabetic subjects and, if so, whether this clustering predicts coronary heart disease (CHD) events during a 7-year follow-up. (diabetesjournals.org)
Coronary heart disease (CHD) is two- to fourfold more common in subjects with type 2 diabetes than in nondiabetic subjects ( 1 ). (diabetesjournals.org)
the second step is for the clinician to fully understand the significance of the disease that may be endorsed by the patient. (medscape.com)
In the patient with pre-existing disease, preparation for dental treatment should include determination of disease status. (medscape.com)
The impact of diabetes on disease activity is yet to be fully elucidated. (springer.com)

Grover and colleagues showed statin therapy in diabetic patients without CAD to be as cost-effective as statin therapy in nondiabetic patients with CAD. (medscape.com)

Several prospective studies have evaluated the risk of diabetes in those with previous depression. (cmaj.ca)

Our aim in this study to assess the efficacy of albuminuria in type 2 diabetes mellitus to be as predictor and independent marker of atherosclerosis by measurement of carotid intimal-medial thickness (CIMT) by high frequency ultrasonography. (edu.iq)
Although in all diabetic patients, GFR is initially normal or mildly elevated with no histological alterations, it progresses to produce thick glomerular basement membrane and expand to mesangial, followed by high glomerular capillary pressure and microalbuminuria. (scialert.net)
High mobility group box protein-1 (HMGB1) is another key factor in promoting inflammation. (hindawi.com)
In high-income countries, type 2 diabetes accounted for 85%~ 95% of diabetes, which might be higher in middle-income and low-income countries. (biomedcentral.com)
Intervention: Organizations agreed to perform guideline-concordant care, including routine CVD risk assessment and cardiovascular care management for high-risk patients. (bvsalud.org)
However, previous studies on vascular interventions in patients with TA have shown inconsistent results, ranging from a high risk of restenosis to good longterm efficacy and patency, although open revascularization resulted in superior patency rates compared with endovascular intervention 4 , 6 , 9 , 10 , 11 . (jrheum.org)
Polyautoimmunity is reported in a high percentage of SS patients. (springer.com)

We identified 31 635 people with diabetes and 57 141 without. (cmaj.ca)
Several investigations 5 - 8 have documented that people with diabetes experience depression from 1.3 to 3 times as often as those without the disorder. (cmaj.ca)

Patients can clinically present with disorders ranging from migraine with aura (20-40% of affected patients), ischaemic events (60-80%), dementia, seizures, 10 apathy and mood disturbances. (bmj.com)

Individual patients are screened based on the presence of comorbid conditions. (medscape.com)

These results indicated the potential of elevated liver enzymes as biomarkers for the possible presence of diabetes. (biomedcentral.com)
Specific focus has been made on the contribution of liver enzymes to prediction of diabetes. (biomedcentral.com)
In this respect, although many studies have shown a relation between diabetes and elevated liver enzymes, the results remain inconsistent [ 12 ]. (biomedcentral.com)
Our aim was to investigate the correlation of the level of liver enzymes with diabetes in the adult population of Rafsanjan. (biomedcentral.com)
Moreover, we evaluated the association between liver enzyme levels within their normal ranges and the odds of diabetes. (biomedcentral.com)

In 1994, there were 26,547 Patient Record forms provided by 418 EDs and 29,095 Patient Record forms provided by 260 OPDs that participated in the survey. (cdc.gov)

Anatomy23

Organisms10

Diseases50

Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment57

Psychiatry and Psychology5

Phenomena and Processes41

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena6

Technology, Industry, Agriculture1

Humanities1

Information Science8

Named Groups6

Health Care47

Geographicals7

Hypertension22

Obesity11

Metabolic14

Prevalence12

Hyperlipidemia7

Myocardial infarction9

Diagnosis7

Progression4

Complications9

20014

Insulin resistance3

Coronary artery2

Renal insufficiency4

Hyperglycemia3

Hypercoagulable1

T2DM4

Diseases13

Clinical7

Symptoms6

Newly diagnosed2

Chronic9

Glucose9

Abstract1

19981

Atrial fibrillation1

Acute1

Methods2

Exogenous1

Early onset1

Incidence8

Prevention5

100,0001

Burden1

Mortality8

Pathways2

Cholesterol2

Serum4

Overt2

Cardiac2

Cohort3

Children and adolescents2

Division of Cardiology2

Glycemic control1

Chez2

Diagnostic1

Stroke4

20021

Adults4

International Diabetes F3

Introduction1

Years8

Prevalent1

Increases2

Characteristics3

Angiotensin II type3

Blood lipids1

Receptor1

Rheumatoid1

Childhood1

Disease13

Nondiabetic1

Risk of diabetes1

High7

People with diabetes2

Disorders1

Comorbid1

Liver5

19941