a Simplified representations of transgenes and the RAS-ERK and Wnt/β-catenin pathways, indicating relative positions of the KRAS and BRAF proto-oncogenes. (researchgate.net)
In addition, these alterations affect 3 principal categories of genes, as follows: proto-oncogenes, tumor suppressor genes, and DNA repair genes. (medscape.com)
This article briefly discusses tumor suppressor genes and then focuses on the role of proto-oncogenes in childhood cancer. (medscape.com)
Mutations8
Carcinogenesis is a process driven by multiple co-operating oncogenic mutations in which features of the cancer cell phenotype, such as proliferative advantage, only emerge as a result of the interplay between these mutations. (rochester.edu)
The Land laboratory has pioneered investigation of the nature and underlying principles of cancer gene cooperation originating with the discovery that multiple oncogenic mutations are required for malignant cell transformation. (rochester.edu)
Plac8 Links Oncogenic Mutations to Regulation of Autophagy and Is Critical to Pancreatic Cancer Progression. (rochester.edu)
Synergistic response to oncogenic mutations defines gene class critical to cancer phenotype. (rochester.edu)
Oncogenic mutations in KRAS or BRAF are frequent in colorectal cancer and activate the ERK kinase. (researchgate.net)
To form a cancer, cells need to accumulate oncogenic mutations that confer tumor-initiating properties. (news-medical.net)
Mutations that activate the oncogene K-ras or interfere with the tumor suppressors p53 and Arf are common in human NSCLCs. (eurekalert.org)
Oncogenic mutations result in functional activation of Ras family proteins by impairing GTP hydrolysis. (rcsb.org)
KRAS or BRAF1
Oncogenic mutation or overexpression of oncogenic KRAS or BRAF is not sufficient to confer oncogene addiction. (go.jp)
Tumor suppr1
Among 61 samples with fusions, there were 103 different fusions, involving 167 different genes, including 20 known oncogenes or tumor suppressor genes (TSGs), 16 associated with cancer but not oncogenes or TSGs, and 32 not associated with cancer but previously shown to be involved in fusions in gliomas. (bvsalud.org)
Putative2
The genomic investigation has led to the identification of two putative oncogenes, IRX2 and TBL1XR1. (cancer.gov)
Here, we review the relevance of OGT in cancer progression and the potential targeting of this metabolic enzyme as a putative oncogene. (qub.ac.uk)
Mutants3
2004. Phosphorylation and ubiquitination of oncogenic mutants of beta-catenin containing substitutions at Asp32. . (oregonstate.edu)
The signaling pathways activated by the oncogenic mutants are in part overlapping with those normally activated by these receptors, but there are also signal transduction pathways that are unique to the oncogenic mutants. (lu.se)
The aim of this project is to elucidate the mechanism of signal transduction of the oncogenic mutants of FLT3 and KIT and find such molecules. (lu.se)
Serine1
Our current research specifically focuses on therapeutic strategies aiming to exploit MYC oncogene-induced vulnerabilities and therapeutically intervenable oncogenic functions of transmembrane serine proteases. (helsinki.fi)
Proteins2
[ 9 ] RET fusion proteins (the RET/PTC family) appear to play an oncogenic role in approximately 20% of papillary thyroid carcinomas, with RET/PTC1, RET/PTC2, and RET/PTC3 accounting for most cases. (medscape.com)
Oncogenic transformation can take place when c-mos proteins are expressed at the wrong time. (bvsalud.org)
Transformation1
Proto-oncogene activation and genomic instability of cadmium -induced cell transformation in BALB/c-3T3 cells. (cdc.gov)
Sarcoma2
Rat sarcoma (RAS), as a frequently mutated oncogene, has been studied as an attractive target for treating RAS-driven cancers for over four decades. (researchgate.net)
This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. (nih.gov)
Chromosomal1
The first oncogenic events identified in papillary thyroid carcinoma were chromosomal rearrangements involving the rearranged during transfection ( RET ) proto-oncogene, which arises from a paracentric inversion of chromosome 10. (medscape.com)
Activation2
Experiments are presented that localize the genetic lesion that led to activation of the oncogene. (nature.com)
The activation loop tyrosine 823 is essential for the transforming capacity of the c-Kit oncogenic mutant D816V. (lu.se)
20211
Gialeli C., Tuysuz E., Staaf J., Guleed S., Paciorek V., Mörgelin M., Papadakos K.S. and Blom A.M. (2021) Complement inhibitor CSMD1 modulates epidermal growth factor receptor oncogenic signaling and sensitizes breast cancer to chemotherapy. (lu.se)
Cancers1
The most cited oncogenic types are the 16 and 18 related to cancers of the uterus, anus, penis, vagina, mouth, among others. (bvsalud.org)
Addiction1
Specifically, the concepts of tumour heterogeneity, oncogene addiction, non-oncogene addiction, tumour initiating cells, tumour microenvironment, non-coding sequences and DNA damage response will be reviewed. (bmj.com)
Potential3
Antisense inhibition of translation initiation factor 3 reverses its oncogenic potential. (cdc.gov)
Antisense inhibition of translation elongation factor-1 delta reverses the oncogenic potential of cadmium transformed cells. (cdc.gov)
Using multiple data bases, we have performed an in silico analysis of fusions detected by RNA-Seq in tumor samples from 139 newly diagnosed glioblastoma patients to identify in-frame fusions with predictable oncogenic potential. (bvsalud.org)
Viruses2
Professor Dilworth's group has been world leading in the study of the oncogenes encoded by small DNA viruses for over 25 years. (mdx.ac.uk)
Among oncogenic viruses are those in the Polyomaviridae family, whose members infect an array of vertebrate species, including birds, humans, nonhuman primates, bovids, rodents, and sea lions ( 1 , 2 ). (cdc.gov)
Survival3
Gene sets identified with oncogene cooperativity analysis regulate in vivo growth and survival of leukemia stem cells. (rochester.edu)
b Organoid survival 4 days after induction of oncogenic KRASG12V or BRAFV600E. (researchgate.net)
The most frequent oncogenic miRs investigated were miR-21, miR-181a, miR-182, miR-183, miR-210 and miR-224 and the hyperexpression of these miRs was associated with distant metastasis, lymph node metastasis and worse survival in patients with CRC. (biorxiv.org)
Protein2
Instead, it affects the structure of the oncogene-encoded protein. (nature.com)
2018). FGFR3-TACC3 is an oncogenic fusion protein in respiratory epithelium. (edu.au)
Cellular2
The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. (nature.com)
Our laboratory studies oncogene and tumor suppressor induced cancer-specific cellular programs, which cause therapeutic vulnerabilities in breast cancer. (helsinki.fi)
Efforts1
Efforts to target this oncogene directly have faced difficulties owing to its picomolar affinity for GTP/GDP and the absence of known allosteric regulatory sites. (rcsb.org)
Human2
The human papillomavirus (HPV) is a prevalent viral infection in the sexually active population, which can be oncogenic and non-oncogenic. (bvsalud.org)
High SEPT9_v1 expression in human breast cancer cells is associated with oncogenic phenotypes. (medlineplus.gov)
Breast1
The detection of high-oncogenic HPV genotypes in patients with breast cancer supports the hypothesis of an etiologic role for the virus in breast cancer development. (who.int)
Role1
In conclusion, ARG1 might play a pivotal role as an oncogene in the progression of HCC through promoting the EMT process. (hindawi.com)
Cells3
SOX2 is the determining oncogenic switch in promoting lung squamous cell carcinoma from different cells of origin. (edu.au)
We also identified that ARG1 functioned as an oncogene in HCC, based on the fact that knockdown of ARG1 by shARG1 interference could decrease cell proliferation activity and motility of HCC cell, while ARG1 overexpression could promote tumor-related phenotypes in HCC cells. (hindawi.com)
Contrasting the functions of any candidate oncogene between normal and cancer cells is rarely done, but only by understanding the normal functions of a given factor, it is possible to understand these functions gone awry. (qub.ac.uk)
Functions1
Here we review oncogenic functions of OGT. (qub.ac.uk)
Small1
Here we report the development of small molecules that irreversibly bind to a common oncogenic mutant, K-Ras(G12C). (rcsb.org)
Expression1
The lesion has no affect on levels of expression of the oncogene. (nature.com)