• In particular, the NS5B region contained long stem-loop structures of up to 38 internally paired nucleotides which were evolutionarily conserved between human and chimpanzee HGV/GBV-C variants. (ox.ac.uk)
  • The RNA-binding protein NANOS3 poses as an interesting candidate gene for POI since members of the Nanos family have an evolutionarily conserved function in germ cell development and maintenance by repressing apoptosis. (hindawi.com)
  • Members of the evolutionarily conserved Nanos gene family are preferentially expressed in the ovaries and are known to play an important role in germ cell development, maintenance, and survival [ 24 - 30 ]. (hindawi.com)
  • A FKBP59 homologue complexed with hsp90-hsp70 was also detected in yeast, which suggests that the immunophilin-heat shock protein association has been evolutionarily conserved. (broadinstitute.org)
  • Advances in high-throughput DNA sequencing and protein mass spectrometry has substantially increased the availability of protein sequences and whole genomes for comparison since the early 2000s. (wikipedia.org)
  • Alignment of HACNS4 to orthologous sequences from nonhuman genomes. (yale.edu)
  • Identifying the sequences that direct the spatial and temporal expression of genes and defining their function in vivo remains a significant challenge in the annotation of vertebrate genomes. (ox.ac.uk)
  • Sequence analysis of the Daphnia pulex genome holds some surprises that could not have been anticipated from what was learned so far from other arthropod genomes. (biomedcentral.com)
  • Simple sequence repeats (SSRs) are highly variable features of all genomes. (biomedcentral.com)
  • Indeed, starting from ~2,800 mouse lncRNAs we could predict that between 4 and 11% present conserved sequence fragments in fish genomes. (sissa.it)
  • We believe this study will result useful as a reference to analyze the conservation of lncRNAs in newly sequenced genomes and transcriptomes. (sissa.it)
  • We similarly analyzed patient-derived hypermutated HIV-1 genomes using a new method for estimating reference sequences. (ox.ac.uk)
  • Now researchers combing through the DNA sequences of vertebrate genomes have identified three distinct periods of evolutionary innovation that accompanied this remarkable diversification. (sciencedaily.com)
  • By comparing the genomes of species whose evolutionary lineages diverged at different times in the past, researchers can see when in evolutionary history a particular conserved sequence first appeared. (sciencedaily.com)
  • Twenty-three additional A. urinae genomes were sequenced using Illumina HiSeq technology. (lu.se)
  • The nucleic acid sequence of a protein coding gene may also be conserved by other selective pressures. (wikipedia.org)
  • Nucleic acid sequences that cause secondary structure in the mRNA of a coding gene may be selected against, as some structures may negatively affect translation, or conserved where the mRNA also acts as a functional non-coding RNA. (wikipedia.org)
  • Non-coding sequences important for gene regulation, such as the binding or recognition sites of ribosomes and transcription factors, may be conserved within a genome. (wikipedia.org)
  • For example, the promoter of a conserved gene or operon may also be conserved. (wikipedia.org)
  • Each candidate enhancer sequence is PCR amplified from genomic DNA, cloned into an expression vector upstream of a minimal promoter driving expression of a reporter gene (e.g., lacZ) and the resulting construct injected into single cell mouse embryos. (yale.edu)
  • In this study, we made use of extreme evolutionary sequence conservation as a filter to identify putative gene regulatory elements, and characterized the in vivo enhancer activity of a large group of non-coding elements in the human genome that are conserved in human-pufferfish, Takifugu (Fugu) rubripes, or ultraconserved in human-mouse-rat. (ox.ac.uk)
  • Here we report that 45% of these sequences functioned reproducibly as tissue-specific enhancers of gene expression at embryonic day 11.5. (ox.ac.uk)
  • A search for short sequence patterns revealed a number of motifs which are over-represented in EC-CNSs relative to CNSs from the control gene sets. (duke.edu)
  • We now report that all TAChR-reactlve B6 T cell clones which responded to the dominant antigenlc epltope and expressed the dominant TCR V β 6 gene segment exhibited conservation of amlno acid sequence in the VDJ junctional region (CDR3) of the TCR β chain. (uthscsa.edu)
  • In particular, the unusually conserved CDR3 sequence suggests that the conserved V β gene utilization seen previously is directly related to recognition of the immunodominant peptlde epltope in association with the experimental autoimmune myasthenia gravls-susceptlbllity determining MHC class II molecule I-A b . (uthscsa.edu)
  • The sequences of these clones revealed an intronless gene conding for 380 amino acids, with 85% identity the predicted human sequence. (wustl.edu)
  • This evolutionary comparison has helped to clarify the derived amino acid sequence in the human and strongly supports the hypothesis that the F8A gene encodes a protein. (wustl.edu)
  • Background: MicroRNAs (miRNA) are small, highly conserved, non-coding RNAs that regulate gene expression of target mRNAs through cleavage or translational inhibition. (usda.gov)
  • Changes in the SEPTIN9 gene may alter the sequence of amino acids in certain septin-9 isoforms in ways that interfere with their function. (medlineplus.gov)
  • High frequencies of sequence duplications and transposable element insertions contributed to the degeneration of the MSY resulting in low gene density. (usda.gov)
  • Conserved sequences outside of known genes are likely to be gene regulatory elements. (sciencedaily.com)
  • Because regulatory elements are typically located near the genes they govern, the researchers assigned each conserved element to the closest gene. (sciencedaily.com)
  • The 16S rRNA gene is highly conserved with certain variable regions. (folkhalsomyndigheten.se)
  • The laboratory procedure is based on amplifying and sequencing four variable regions of the 16S rRNA gene with two amplicons. (folkhalsomyndigheten.se)
  • RNA interference is an evolutionary conserved gene regulatory mechanism that can be used by introducing exogenous synthetic double-stranded RNAs, so called small interfering RNA (siRNA). (lu.se)
  • siRNAs are sequence-specific inhibitors that are easily designed and could in theory target any gene of interest, making siRNA a promising modality for targeted therapy. (lu.se)
  • In evolutionary biology, conserved sequences are identical or similar sequences in nucleic acids (DNA and RNA) or proteins across species (orthologous sequences), or within a genome (paralogous sequences), or between donor and receptor taxa (xenologous sequences). (wikipedia.org)
  • Conserved proteins undergo fewer amino acid replacements, or are more likely to substitute amino acids with similar biochemical properties. (wikipedia.org)
  • As with proteins, nucleic acids that are important for the structure and function of non-coding RNA (ncRNA) can also be conserved. (wikipedia.org)
  • We show that this conserved RNA interactome harbours many proteins without previously assigned roles in RNA biology (enigmRBPs), including surprisingly many metabolic enzymes. (nature.com)
  • In order to investigate the role of this motif in the structure and function of sHsps, we have made constructs deleting this sequence from alpha A- and alpha B-crystallin, overexpressed, purified, and studied these engineered proteins. (nih.gov)
  • P59 (FK506 binding protein 59) interaction with heat shock proteins is highly conserved and may involve proteins other than steroid receptors. (broadinstitute.org)
  • In the first period of evolutionary innovation, in addition to changes affecting developmental genes, the study found a dramatic enrichment in conserved elements near genes for proteins known as "transcription factors," which bind to DNA and regulate whole groups of other genes. (sciencedaily.com)
  • These proteins had a signal sequence in the amino-terminal end and a cell. (lu.se)
  • These proteins had a signal sequence in the amino-terminal end and a cell wall-sorting region in the carboxy-terminal end, which contained an LPATG-motif, a hydrophobic domain and a positively charged tail. (lu.se)
  • All isolates had either one or two of these asp-genes located in a conserved locus, designated Locus encoding Aerococcal Surface Proteins (LASP). (lu.se)
  • A superfamily of proteins that share a highly conserved MADS domain sequence motif. (bvsalud.org)
  • In the absence of antigenically matched hemagglutinin-based vaccines, DNA vaccination with conserved influenza genes may provide a useful first line of defense against a rapidly spreading pandemic virus. (cdc.gov)
  • In summary, we show that interesting genomic regions in zebrafish could be marked based on their sequence homology to a mouse lncRNA, overlap with ESTs and proximity to genes involved in nervous system development.Conclusions: Conservation at the sequence level can identify a subset of putative lncRNA orthologs. (sissa.it)
  • The reports on base sequences of spider silk protein genes have gained importance as the mechanical properties of silk fibers have been revealed. (bioone.org)
  • The DNA sequences for the genes encoding the heavy and light subunits of methanol dehydrogenase from Methylophilus methylotrophus W3A1 have been determined. (rcsb.org)
  • Current diagnostic PCR assays target a variety of SARS CoV-2 genes and the vast majority target sequences in regions of the SARS CoV-2 genome that are highly conserved. (who.int)
  • Whole genome sequencing can also provide insights into the specific genes or mutations that may be linked to antibiotic resistance. (folkhalsomyndigheten.se)
  • A computational evaluation of the lncRNAs through systematic conservation analyses of both sequences as well as their genomic architecture is required.Results: Our results show that a subset of mouse candidate lncRNAs could be distinguished from random sequences based on their alignment with zebrafish phastCons elements. (sissa.it)
  • hA3-induced G-to-A mutation rates were significantly influenced by the wider sequence context of the target G. Moreover, hA3G, and to a lesser extent hA3F, displayed clear tetranucleotide preference hierarchies, irrespective of the genomic region examined and overall hypermutation rate. (ox.ac.uk)
  • He thanked CDC and KTL for their support in providing accurate genomic sequencing results of polioviruses in a timely manner, as this greatly facilitated planning and targeting the polio eradication activities. (who.int)
  • Furthermore, using sequence analysis of human genomic DNA, researchers concluded that the amino acids important for catalysis by COX-1 are conserved and are equally important for catalysis by COX-2. (medscape.com)
  • Genetic analysis of patients with leukocyte adhesion deficiency: genomic sequencing reveals otherwise undetectable mutations. (lu.se)
  • Many sHsps, including alpha A- and alpha B-crystallin, contain a well conserved SRLFDQFFG sequence motif in the N-terminal region. (nih.gov)
  • The conserved sequence motif contained a glutamlc acid residue in the CDR3 of TCR β. (uthscsa.edu)
  • Mutations that disrupted secondary RNA structure or the AAACA/G motif, without altering the amino acid sequence of 3D(pol), ablated replication of a subgenomic HAV replicon in transfected human hepatoma cells. (ox.ac.uk)
  • The substituted amino acid is located within the second C2HC motif in the conserved zinc finger domain of NANOS3 and in silico molecular modelling suggests destabilization of protein-RNA interaction. (hindawi.com)
  • A helix initiation motif and a helix termination motif segment can be found at either end of the alpha-helical rod and are highly conserved in sequence between keratins. (medscape.com)
  • The study of sequence conservation overlaps with the fields of genomics, proteomics, evolutionary biology, phylogenetics, bioinformatics and mathematics. (wikipedia.org)
  • Over many generations, nucleic acid sequences in the genome of an evolutionary lineage can gradually change over time due to random mutations and deletions. (wikipedia.org)
  • The second, more practical consideration is that evolutionary conservation provides a means to interpret the statistical and ultimately biological importance of human-specific sequence changes. (yale.edu)
  • Conserved RBPs harbour defined repetitive motifs within disordered regions, which display striking evolutionary expansion. (nature.com)
  • Since protein structure is more conserved over evolutionary timescales than its amino acid sequence, reliable structure prediction by AlphaFold has revolutionised our ability to predict protein function. (lu.se)
  • The extent to which a sequence is conserved can be affected by varying selection pressures, its robustness to mutation, population size and genetic drift. (wikipedia.org)
  • In coding sequences, the nucleic acid and amino acid sequence may be conserved to different extents, as the degeneracy of the genetic code means that synonymous mutations in a coding sequence do not affect the amino acid sequence of its protein product. (wikipedia.org)
  • First, human-specific developmental features, as elaborations on the common theme of mammalian development, are likely to arise in part from changes in the conserved genetic architecture of the developmental regulatory machinery. (yale.edu)
  • Metagenomic sequencing engables a thorough mapping of the genetic material in the clinical sample, providing a broader understanding of the microbiological profile. (folkhalsomyndigheten.se)
  • In contrast to metagenomic detection of unknown pathogens which sequences all available genetic material, 16S sequencing specifically targets the small ribosomal subunit. (folkhalsomyndigheten.se)
  • By sequencing the entire genome, a comprehensive understanding of the genetic composition is obtained. (folkhalsomyndigheten.se)
  • In epidemiological contact tracing, this technology enables the mapping of infection spread and identification of sources of infection through the comparison of genetic sequences. (folkhalsomyndigheten.se)
  • With the advent of next generation sequencing, our understanding of the genetic diversity of cellular and viral life has expanded exponentially. (lu.se)
  • HACNSs show a statistically significant excess of human-specific sequence changes (circled) at positions highly conserved in other species. (yale.edu)
  • To this end, we have focused on identifying noncoding sequences highly conserved in nonhuman vertebrate species that display high rates of nucleotide substitution on the human lineage, which may indicate positive selection for new regulatory functions. (yale.edu)
  • In our approach, sites within CNSs were binned based on their degree of sequence conservation in six nonhuman species: chimpanzee, rhesus macaque, mouse, rat, dog and chicken, and human-specific substitutions were identified by parsimony (Fig. 1A). (yale.edu)
  • A sequence of amino acids in a polypeptide or of nucleotides in DNA or RNA that is similar across multiple species. (usda.gov)
  • Though the species of this group show a high degree of karyotypic similarity, D. soaresi was unique in presenting large blocks of het- ITSs (heterochromatic internal telomeric sequences) in the majority of the centromeres. (pensoft.net)
  • The amino acid sequence of PACAP is identical in all mammals , and in species such as chicken, frog, salmon, only 1-3 amino acids are different. (eurogentec.com)
  • Mdm12p is the third mitochondrial outer membrane protein required for normal mitochondrial morphology and distribution to be identified in S. cerevisiae and the first such mitochondrial component that is conserved between two different species. (rupress.org)
  • Nanos was first identified in Drosophila , where it represses the translation of target mRNAs through binding to their 3′ UTR and has a conserved function in germ cell development across species. (hindawi.com)
  • The rainbow trout genome sequence is not available yet, which does not allow miRNA prediction for this species which is of great economic interest for aquaculture and sport fisheries, and is a model research organism for studies related to carcinogenesis, toxicology, comparative immunology, disease ecology, physiology and nutrition. (usda.gov)
  • The new study identified millions of these regulatory innovations by using computational methods to look for DNA sequences that are still the same in species that have evolved separately over long periods of time. (sciencedaily.com)
  • RESULTS: We find extensive epigenetic divergence between the taurine and indicine cattle breeds across immune cell types, which is linked to the levels of local DNA sequence divergence between the two cattle sub-species. (bvsalud.org)
  • 16S sequencing is performed to determine which bacterial species are present in a clinical sample or isolate. (folkhalsomyndigheten.se)
  • The testing of the top predictions in transgenic mice resulted in a threefold enrichment for sequences with forebrain enhancer activity. (ox.ac.uk)
  • Analysis of TCR β sequences from antigen-primed lymph node cells (LNC) showed a similar enrichment for sequences having a glutamlc acid in CDR3, although the overall appearance of the LNC sequences was somewhat more heterogeneous and consistent with a gradual In vitro selection of the subset of TCR found in the T cell clones. (uthscsa.edu)
  • This thematic series of companion papers constitutes the initial exploration of the genome biology of the waterflea (Daphnia) building on the first complete crustacean genome sequence. (biomedcentral.com)
  • Many functional sequences are also modular, containing regions which may be subject to independent selection pressures, such as protein domains. (wikipedia.org)
  • In contrast, ubiquitous mAbs A4 and B7 and sub-ubiquitous mAb A8 may have their epitopes on the commonly conserved regions of the three isozyme groups. (elsevierpure.com)
  • Find regions of similarity between this sequence and other sequences using BLAST. (nih.gov)
  • Finds sub-sequences or patterns in the sequence and highlights the matching regions. (nih.gov)
  • Highly conserved regions are less likely to mutate, therefore there is a high likelihood that the diagnostic test will remain accurate in the presence of variants. (who.int)
  • Conserved sequences are sequences which persist in the genome despite such forces, and have slower rates of mutation than the background mutation rate. (wikipedia.org)
  • The most common mutation results in the replacement of the protein building block (amino acid) arginine with the amino acid tryptophan at position 88 in the septin-9 protein sequence, written as Arg88Trp or R88W. (medlineplus.gov)
  • Scan several protein sequences or a whole genome (all ORFs) against HAMAP family profiles. (expasy.org)
  • For contact tracing or inquiries related to antibiotic resistance, whole genome sequencing (WGS) of bacterial isolates is offered. (folkhalsomyndigheten.se)
  • It is a platform and database for the automated analysis of whole genome sequencing data. (folkhalsomyndigheten.se)
  • Conserved sequences are typically identified by bioinformatics approaches based on sequence alignment. (wikipedia.org)
  • Is the Subject Area "Sequence alignment" applicable to this article? (plos.org)
  • Amino acid sequences can be conserved to maintain the structure or function of a protein or domain. (wikipedia.org)
  • Triangles indicate the 12 conserved cysteine residues discovered within the Crustins, which includes the WAP domain.The deduced amino acid sequences of Al-crus three and Al-crus 7 had been compared with the deduced amino acid sequences of Al-crus and Al-crus sequence was Crustin those of other close Crustins (Figure 1). (hivinhibitor.com)
  • Therefore, Al-crus three and Al-crus 7 shared around 51 amino acid sequences. (hivinhibitor.com)
  • This review aims to link recent molecular data, often translated into amino acid sequences and predicted three dimensional structural motifs, to known mechanical properties. (bioone.org)
  • Homology search tools may take an individual nucleic acid or protein sequence as input, or use statistical models generated from multiple sequence alignments of known related sequences. (wikipedia.org)
  • B) Amino acid sequence alignments. (hivinhibitor.com)
  • However, a region of markedly suppressed synonymous codon variability was identified in alignments of HAV sequences near the 5' end of the 3D(pol)-coding sequence of HAV, consistent with noncoding constraints imposed by an underlying RNA secondary structure. (ox.ac.uk)
  • The mechanisms of heterosubtypic immunity are not completely understood but likely include both T-cell immunity, in particular CD8+ cytotoxic T-lymphocytes (CTL) ( 16 , 17 ) and CD4+ T cells (13) , as well as antibodies to conserved epitopes (18) . (cdc.gov)
  • Aldolase C-specific mAbs B8, H1, B4, and E10, but not D9, have their epitopes on a region within amino acid positions 79-193 of antigens, where the type-C isozyme group-specific sequence-3 (IGS-3) is situated. (elsevierpure.com)
  • To identify putative regulatory sequences evolving rapidly on the human lineage, we developed a test statistic (in collaboration with Shyam Prabhakar of the Genome Institute of Singapore) for assessing the significance of human-specific sequence acceleration in conserved noncoding sequences (CNSs). (yale.edu)
  • In 1987 the sdhCAB operon of B. subtilis was cloned and sequenced. (lu.se)
  • The codon usage bias in some organisms may restrict the types of synonymous mutations in a sequence. (wikipedia.org)
  • These sequences have presumably been conserved by natural selection because they serve an important function, so most mutations that change them would be harmful to the organism. (sciencedaily.com)
  • As with most other keratin disorders, most mutations in pachyonychia congenita occur in these highly conserved helix boundary domains at the end of the rod domain. (medscape.com)
  • A highly conserved sequence is one that has remained relatively unchanged far back up the phylogenetic tree, and hence far back in geological time. (wikipedia.org)
  • Examples of highly conserved sequences include the RNA components of ribosomes present in all domains of life, the homeobox sequences widespread amongst eukaryotes, and the tmRNA in bacteria. (wikipedia.org)
  • Highly conserved DNA sequences are thought to have functional value, although the role for many highly conserved non-coding DNA sequences is poorly understood. (wikipedia.org)
  • Within a sequence, amino acids that are important for folding, structural stability, or that form a binding site may be more highly conserved. (wikipedia.org)
  • Science: molecular biology) a base sequence in a dna molecule (or an amino acid sequence in a protein) that has remained essentially unchanged throughout evolution . (biologyonline.com)
  • QIV66989), having a Crustin from of other close nipponense (NCBI GenBank accession closest sequence was similarfrom 63 in the amino acid level. (hivinhibitor.com)
  • By contrast, for Al-crus 7, the closest sequence was a ity ofMacrobrachium nipponense (NCBI GenBank accession no. (hivinhibitor.com)
  • By contrast, for Al-crus 7, the closest sequence was a Crustin-like peptide from Homarus americanus (NCBI GenBank accession no. (hivinhibitor.com)
  • Amino acid motifs are often composed of conserved sequences. (usda.gov)
  • Scholars@Duke publication: Distant conserved sequences flanking endothelial-specific promoters contain tissue-specific DNase-hypersensitive sites and over-represented motifs. (duke.edu)
  • Thus, our study shows that the SRLFDQFFG sequence is one of the critical motifs in structure-function regulation of alpha A- and alpha B-crystallin. (nih.gov)
  • Conservation indicates that a sequence has been maintained by natural selection. (wikipedia.org)
  • Conservation can occur in coding and non-coding nucleic acid sequences. (wikipedia.org)
  • However, sequence conservation in ncRNAs is generally poor compared to protein-coding sequences, and base pairs that contribute to structure or function are often conserved instead. (wikipedia.org)
  • Low sequence conservation and lack of functional annotations make it difficult to identify homologs of mammalian lncRNAs in other vertebrates. (sissa.it)
  • Therefore, strategies based on conserved influenza antigens should be explored. (cdc.gov)
  • Concerted evolution refers to the pattern in which copies of multigene families show high intraspecific sequence homogeneity but high interspecific sequence diversity. (biomedcentral.com)
  • Conserved region 2 (CR2) is a serine-rich region that functions as a hinge on the molecule. (news-medical.net)
  • The similar protein-coding neighborhood and transcriptional information about the conserved candidates provide support to the hypothesis that they share functional homology. (sissa.it)
  • A potentially homologous RNA structure was identified in this region of the avian encephalitis virus genome, despite little nucleotide sequence relatedness between it and HAV. (ox.ac.uk)
  • The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. (nih.gov)
  • Finds sub-sequence or patterns in the sequence and highlights the matching region. (nih.gov)
  • Dive into the research topics of 'Monoclonal anti-human aldolase C antibodies that react to the isozyme group-specific sequences and generally conserved sequences of human aldolase C'. Together they form a unique fingerprint. (elsevierpure.com)
  • Kaihara R, Matsuhashi S , Kusakabe T , Kondo T, Iwanaga A, Hori K. Monoclonal anti-human aldolase C antibodies that react to the isozyme group-specific sequences and generally conserved sequences of human aldolase C . Journal of biochemistry . (elsevierpure.com)
  • Human-specific substitutions at sites conserved from chimpanzee to chicken are expected to be uncommon events, and were consequently given more weight than substitutions at less conserved sites. (yale.edu)
  • We are dissecting a number of elements in detail using a synthetic approach, in which subsets of the human-specific sequence changes in each element are transferred into the chimpanzee enhancer sequence. (yale.edu)
  • Identification of "human accelerated" conserved noncoding sequences (HACNSs). (yale.edu)
  • The systematic identification of conserved developmental regulatory elements has made it possible to study the impact of human-specific changes in regulatory DNAs on a genome-wide scale. (yale.edu)
  • Using this approach, we identified 992 conserved noncoding sequences that are evolving rapidly on the human lineage (Fig. 1B and 1C). (yale.edu)
  • We termed these elements human-accelerated conserved noncoding sequences (HACNSs). (yale.edu)
  • In vivo enhancer analysis of human conserved non-coding sequences. (ox.ac.uk)
  • We identified sequence signatures enriched in a subset of these elements that targeted forebrain expression, and used these features to rank all approximately 3,100 non-coding elements in the human genome that are conserved between human and Fugu. (ox.ac.uk)
  • Here we identify a large set of RBPs that are conserved between yeast and human cells. (nature.com)
  • Broad Genomics Platform sequences a whole human genome every four minutes. (broadinstitute.org)
  • In November 2022, Broad's Genomics Platform sequenced its 500,000th whole human genome, a mere four years after sequencing its 100,000th. (broadinstitute.org)
  • Sequence-based prediction shows that it exhibits helical propensity with amphipathic character, suggesting that it plays a critical role in the structure and function of alpha-crystallins. (nih.gov)
  • MiRNAs are most often identified through computational prediction from genome sequences. (usda.gov)
  • The Fp and Ip subunits are both very conserved with respect to composition and polypeptide sequence [1]. (lu.se)
  • Conserved region 1 (CR1) is a Ras-GTP-binding self-regulatory domain. (news-medical.net)
  • Conserved region 3 (CR3) is a catalytic protein kinase domain. (news-medical.net)
  • A phylogenetically conserved sequence within viral 3'untranslated RNA pseudoknots regulates translation. (oregonstate.edu)
  • Urea-induced denaturation study shows that the SRLFDQFFG sequence contributes significantly to the structural stability. (nih.gov)
  • Using ROC analyses we were able to define a measure to select significantly conserved lncRNAs. (sissa.it)
  • Pituitary adenylate cyclase-activating polypeptide (PACAP), a member of the vasoactive intestinal peptide/secretin/glucagon family , has an amino acid sequence identity of 68% with vasoactive intestinal polypeptide (VIP). (eurogentec.com)
  • In the Fp subunit of SQR, and the closely related membrane-associated fumarate reductase of anaerobic organisms, FAD is covalently attached via an 8α-N(3)-histidyl linkage to a histidine (His) in a conserved sequence in the N-terminal part of the polypeptide. (lu.se)
  • Identification of a conserved RNA replication element (cre) within the 3Dpol-coding sequence of hepatoviruses. (ox.ac.uk)
  • Identification of sequence variations in the miRNA -target interactions may be particularly useful for rainbow trout breeding programs. (usda.gov)
  • Circular dichroism spectroscopic studies show changes in tertiary and secondary structure on deletion of the sequence. (nih.gov)
  • Metagenomic sequencing is offered in cases where infection is suspected but other methods have failed to identify a pathogen. (folkhalsomyndigheten.se)
  • Here, we generate, sequence and analyse over 150 libraries at base-pair resolution to explore the dynamics of DNA methylation and chromatin accessibility of the bovine immune system across three distinct cattle lineages. (bvsalud.org)
  • Sequences that match HAMAP profiles will be annotated in the UniProtKB format by the associated annotation rules. (expasy.org)