• The OECD welcomed a Memorandum of Understanding (MOU) between the Guangdong Provincial Centre for Disease Control and Prevention and the OECD which will support China's efforts in chemicals regulation and policy making. (oecd.org)
  • Read more on the OECD work in developing and harmonising methods for assessing the exposure of chemicals to humans and the environment. (oecd.org)
  • This test guideline is a laboratory test method, designed to assess the acute oral toxicity of pesticides and other chemicals to adult worker bumblebees. (oecd.org)
  • OECD guidelines for the Testing of Chemicals are periodically reviewed in the light of scientific progress or changing assessment practices. (indexindex.com)
  • In 1985, Bruce proposed to use an up-and-down procedure (UDP) for the determination of acute toxicity of chemicals (5). (indexindex.com)
  • The acute fish toxicity (AFT, OECD TG 203) is required to provide information on the acute toxicity of chemicals for environmental hazards and risk assessment. (ufz.de)
  • Extrapolation based on available guidelines on route-to-route extrapolation of toxicity data when assessing health risks of chemicals. (europa.eu)
  • Procedure referred to OECD Guidelines for the Testing of Chemicals, Test No. 420: Acute Oral Toxicity - Fixed Dose Procedure with single-dose administration of 2000 mg/kg bw. (ugm.ac.id)
  • Fish Embryo Acute Test is designed to determine the acute toxicity of chemicals in vivo in just a few days. (zeclinics.com)
  • 2000. Guideline for Testing of Chemicals. (europa.eu)
  • OECD Guideline for Testing of Chemicals, Earthworm Acute Toxicity. (ac.ir)
  • The method followed that described in the OECD Guidelines for Testing of Chemicals (1992) No 203, 'Fish, Acute Toxicity Test', referenced as Method C1 of Commission Regulation (EC) No. 440/2008. (reach-manganese.org)
  • For this reason, the skin is often exposed to potentially hazardous agents, including chemicals, which may contribute to the onset of a spectrum of adverse health effects ranging from localized damage (e.g., irritant contact dermatitis and corrosion) to induction of immune-mediated responses (e.g., allergic contact dermatitis and pulmonary responses), or systemic toxicity (e.g., neurotoxicity and hepatoxicity). (cdc.gov)
  • Acute toxicity OECD 202: There are data for 1 trophic level for crustaceans (Daphnia magna) 2.4 mg/L. (janusinfo.se)
  • OECD Guideline 202 (Daphnia sp. (europa.eu)
  • Final Results on an OECD 202 Acute Toxicity to Daphnia magna and an OECD 211 21-Day Reproduction Test, Conducted with 1,1,3,3-Tetramethylbutyl Hydroperoxide. (epa.gov)
  • For the environmental risk assessment, the applicant has conducted the following studies: Ready biodegradability (OECD 301 D), Aerobic Transformation in Water (OECD 308), Respiration Inhibition Test (OECD 209), Daphnia immobilisation (OECD 202), Daphnia reproduction Test (OECD 211), Acute Toxicity to Fish (OECD 203), Fish Early Life Stage Toxicity Test (OECD 210) and Algae Growth Inhibition Test (OECD 201). (janusinfo.se)
  • For the already available studies where no dose-response is available (limit-tests), the guidance proposes to apply an extrapolation factor to the available endpoint, depending on mortality rate at the highest tested dose, together with a worst-case default slope value. (industryintel.com)
  • 2000 mg/kg bw , key study with 6 female rats according to OECD Test Guideline 423. (europa.eu)
  • From the available data on two acute oral toxicity studies, it is concluded that the oral LD50 for the substance is greater than 2000 mg/kg bw (study 1: no mortality was observed) and greater from 10000 mg/kg bw (study 2: mortality was observed). (europa.eu)
  • Results demonstrated that during 14 days of the experiment, neither mortality and sublethal effects as signs of toxicity were detected. (ugm.ac.id)
  • The signs of toxicity observed were decreased motor activity, poor startle reaction, excessive micturition, decreased respiratory depth and rate, tail lashing and body tremor. (innspub.net)
  • Draft Results on an OECD 429 Skin Sensitization: Local Lymph Node Assay with 1,1,3,3-tetramethylbutyl 2-ethylperoxyhexanoate. (epa.gov)
  • Toward that end, a new assay for the determination of skin sensitisation in the mouse, the Local Lymph Node Assay (LLNA) has been sufficiently validated and accepted to justify its adoption as a new Test Guideline (1)(2)(3). (cdc.gov)
  • Biodegradation is determined according to OECD test method guidelines. (givaudan.com)
  • 60% in a ready biodegradation test within 28 days and passing the 10 day window criterion following OECD 301, 310 and equivalent ISO guidelines. (givaudan.com)
  • Toxicological observations were completed for 14 days according to the guidelines set by OECD. (innspub.net)
  • Safety of both strains was confirmed by acute oral toxicity in rats. (frontiersin.org)
  • In acute oral toxicity study, administration of AESO (5,000 mg/kg, p.o.) did not show any sign of toxicity and mortality. (springermedizin.de)
  • Single-dose Acute Oral Toxicity Study of Chloroform Extract of Snake Plant ( Sansevieria trifasciata Prain. (ugm.ac.id)
  • Based on this finding, we will continue to conduct further study to assess the repeated-dose acute oral toxicity. (ugm.ac.id)
  • Acute Oral Toxicity of P-tert-butylbenzaldehyde in Rats with Cover Letter dated 092386 (company Sanitized). (epa.gov)
  • Acute Oral Toxicity Study (Up and Down Method) in Rats with N,N-dimethyl-1, 1,2,2-tetrafluoroethylamine. (epa.gov)
  • Draft Report of a Combined 28-Day Repeated Dose Oral (Gavage) Toxicity Study with Reproduction/Developmental Toxicity Screening Test in Rats. (epa.gov)
  • Therefore, the objective of this study was to obtain data on avian high-dose toxicity of MCs and compute LD50, if possible, following the natural oral route of administration. (nel.edu)
  • 90-day Dermal Toxicity Study in Rats of Simulated Cutting Fluid Containing Para-tert-butyl Benzoic Acid with Cover Letter dated 071186. (epa.gov)
  • Acute Dermal Irritation and Acute Dermal Toxicity with 1,1-2-trifluoro- 2-(perfluoroethoxy)ethane sulfonate, potassium salt. (epa.gov)
  • Acute Dermal Toxicity Study of P-tert-butylbenzoic Acid on Rats with Attacments and Cover Letter Dated 07/23/1987. (epa.gov)
  • Unlike guinea pig tests the LLNA does not require that challenged-induced dermal hypersensitivity reactions be elicited. (cdc.gov)
  • Volume 7 of the Series compiles the OECD consensus documents for use in environmental risk assessment of transgenic organisms (biosafety) issued in 2016 and 2017. (oecd.org)
  • To reduce the number of tests on animals, the REACH Regulation promotes alternative methods for the hazard assessment of substances. (ufz.de)
  • 3Rs-aligned method for fast and high throughput acute toxicity assessment in vivo . (zeclinics.com)
  • The existing fish embryo data (acute - 96h LC50) were compared to data on adult fish toxicity (acute - 96h LC50) and the limits of applicability investigated by analysis of the relation of the results with respect to physicochemical parameters, structural domains, excess toxicities (i.e. the ratio of predicted baseline toxicity LC50 versus observed acute LC50, also called toxic ratio). (ufz.de)
  • Chemical analysis of the products using principal component analysis, revealed similar chemistry whereas the LC50 values of HoSU preparation were safest followed by commercial preparations and the reference marker compound when tested on zebrafish. (informaticsjournals.com)
  • In addition, the applicant has initiated a sediment-water chironomid toxicity test using spiked Sediment (OECD 218). (janusinfo.se)
  • They found that "under worst-case exposure conditions, acute toxicity is unlikely in wild mammals exposed to naphthenic acids in AOS tailings pond water, but repeated exposure may have adverse health effects. (wikipedia.org)
  • However, damage induced by NAs while transient in acute or discontinuous exposure, may be cumulative in repeated exposure. (wikipedia.org)
  • Marine tests showed an inhibition of growth with the two different algal species (P. tricornutum and D. tertiolecta), an inhibition of bioluminescence in the bacterium A. fischeri, an alteration on the correct early development of the serpulid F. enigmaticus larvae and immobilization of the copepod A. tonsa individuals at both 24 and 48 hours of exposure. (easychair.org)
  • Acute Sulfolane Exposure Produces Temperature-Independent and Dependent Changes in Visual Evoked Potentials. (epa.gov)
  • In the 2023 version, it becomes time-reinforced toxicity (TRT), reflecting the fact that some substances may be more toxic at low doses after long-term exposure than at higher doses after short-term exposure. (industryintel.com)
  • Dose-response curves for mortality at 96 hpf after exposure of embryos to a vehicle (negative control), a toxic compound (positive control) and a study molecule that shows some toxicity. (zeclinics.com)
  • As such, we assessed potential differences in exposure/toxicity and pharmacologic effect of a model ASO (RTR5001) in the juvenile Göttingen Minipig in an 8-week repeat-dose toxicity study (weekly subcutaneous dosing starting at postnatal day 1). (uantwerpen.be)
  • A study comparing the results obtained with the UDP, the conventional LD50 test and the Fixed Dose Procedure (FOP, Guideline 420) was published in 1995 (7). (indexindex.com)
  • Naphthenic acids have both acute and chronic toxicity to fish and other organisms. (wikipedia.org)
  • Chlorothene Vg: a Chronic Inhalation Toxicity and Oncogenicity Study in Rats and Mice (part 1 & 2) with Cover Letter dated 08/21/1984. (epa.gov)
  • Tier 1 includes various scenarios, considering bee taxonomic groups (honeybees, bumblebees, and solitary bees), life stages (adults and larvae), timescales of effects (acute and chronic), as did the previous version from 2013. (industryintel.com)
  • In many cases, acute studies for honeybees and bumble bees (and in some cases, chronic studies) lead to unbound values for the endpoints obtained from limit-test design. (industryintel.com)
  • Please see the cross-referenced supporting information to justify the waiving of chronic aquatic toxicity data. (europa.eu)
  • This research aimed to evaluate toxicity and safety of consuming chloroform extract of S. trifasciata leaf (CESTL) in acute phase using female Wistar rats as model animal. (ugm.ac.id)
  • Acute Inhalation Study of Five Male Rats/Group using Propane, 1,2-dibromo-1-1-2-3-3-hexafluoro. (epa.gov)
  • Acute Inhalation Toxicity Study in Rats with 1,2,2,2- Tetrafluoroethane (HFC-134). (epa.gov)
  • Acute Inhalation Toxicity Study of MTDID 18132 in Male and Female Rats: 09-123. (epa.gov)
  • Acute Inhalation Toxicity Study of MTDID 19763 in Female Rats: 09-173. (epa.gov)
  • Acute Vapor Inhalation Study in Fischer 344 Rats Using Aerothene Tt with Cover Letter Dated 03/22/1988. (epa.gov)
  • Data on Acute Inhalation Toxicity Study Conducted in Sprague-Dawley Rats with Ethane, 1,1,2,2-tetrafluoro- 1-methoxy. (epa.gov)
  • In this study, zebrafish embryos were used to evaluate fetal embryo toxicity of the belladonna mother tincture. (ijpsonline.com)
  • The study was conducted according to the appropriate OECD test guideline, and in compliance with GLP. (europa.eu)
  • Introduction: The study was performed to assess the contact sensitisation potential of the test material in the albino guinea pig. (europa.eu)
  • Method: Ten test and five control animals were used for the main study. (europa.eu)
  • The aim of this study was to assess the capacity of the FET test in predicting acute fish toxicity and to define the applicability domain of the FET test for regulatory purposes. (ufz.de)
  • In this study, the antinociceptive activity of (-)-linalool was examined in two different pain models in mice: the acetic acid-induced writhing response, a model of inflammatory pain, and the hot plate test, a model of supraspinal analgesia. (researchgate.net)
  • Acute Inhalation Toxicity Study with 1,1-Difluoroethane (HFC-152a) and Denatonium Benzoate (DB). (epa.gov)
  • Combined Repeated Dose Toxicity Study with the Reproduction/Developmental Toxicity Screening Test in the Han Wistar Rat. (epa.gov)
  • This emphasizes the need for conducting an equivalence study in terms of chemistry and toxicity between HoSU products and commercially available products. (informaticsjournals.com)
  • However, the adult Göttingen Minipig has been recognized as a suitable alternative to NHPs in the safety testing of ASOs, as it showed similar pharmacokinetic, pharmacodynamic, and safety profiles in a previous study. (uantwerpen.be)
  • A study was performed to assess the acute toxicity of the test item to rainbow trout ( Oncorhynchus mykiss ). (reach-manganese.org)
  • In the hot plate test, only the dose of 100 mg/kg of (-)-linalool resulted in a significant effect. (researchgate.net)
  • Such new calculations imply that, although in the OECD guidance document No.239 on the repeated toxicity to honeybee larvae, the test is designed for the determination of a NOED (No Observed Effect Dose), the larval NOED is no more used for assessing the risk to bees. (industryintel.com)
  • Avian high-dose toxicity of cyanobacterial biomass. (nel.edu)
  • Controls received an equal dose of drinking water instead of the test substance. (nel.edu)
  • Significance testing of synergistic/antagonistic, dose level-dependent, or dose ratio-dependent effects in mixture dose-response analysis. (ac.ir)
  • Liver abnormalities such as calcification along the portal tract and focal periportal necrosis in the liver of mice treated with 5000 mg/kg anthocyanin while periportal degenerative change (focal and extensive) manifested by loss of cytoplasmic eosinophilia in mice administered with polyphenol at the same dose level confirm their toxicity. (innspub.net)
  • The LLNA assesses this proliferation as a dose- response in which the proliferation in test groups is compared to that in vehicle treated controls. (cdc.gov)
  • Alternative experimental method to reduce animal testing while evaluating toxicity in vivo . (zeclinics.com)
  • WHO is not responsible, and does not accept any liability, for the testing of pesticides for compliance with the specifications, nor for any methods recommended and/or used for testing compliance. (who.int)
  • For example, testing according to OECD Technical Guideline 236 (fish embryo acute toxicity test (FET)) has been suggested as one of the alternative methods to toxicity testing in adult fish. (ufz.de)
  • 1975. Methods for Acute Toxicity Tests with Fish, Macroinvertebrates and Amphibians. (europa.eu)
  • In addition, it should be noted that the mild/moderate sensitisers, which are recommended as suitable positive control substances for guinea pig test methods, are also appropriate for use with the LLNA (6)(8)(9). (cdc.gov)
  • In this view, some phytoconstituents were initially screened for antioxidant and anti-inflammatory activities through in vitro testing. (ijpsonline.com)
  • Toxicity and carcinogenicity studies of quercetin, a natural component of foods. (innspub.net)
  • This Test Guideline describes a method to assess effects of a test chemical on the phagocytotic activity of activated sludge containing protozoan organisms under defined conditions in the presence of different concentrations of the test chemical. (oecd.org)
  • It is described in the OECD 236 Guideline as a test required for ecotoxicological regulatory purposes, and it is also useful to assess the safety of compounds in preclinical research. (zeclinics.com)
  • Our free-standing greenhouses for seedling emergence and vegetative vigor tests and complete package of pollinator, earthworm and collembola acute and reproduction tests, provides a comprehensive set of capabilities to support new active ingredient testing, reregistration projects, and plant protection products / formulations. (smithersapex.com)
  • 70% in an inherent biodegradability test e.g. (givaudan.com)
  • Several experiments were performed in Mohaghegh Ardabili University on 2019 to evaluate the relative toxicity of metribuzin, halosulfuron, flumioxazin individually and combination of metribuzin:halosulfuron and metribuzin:flumioxazin on Eisenia fetida . (ac.ir)
  • Acute toxicity: There are data for 3 trophic levels, most sensitive algae (Scenedesmus subspicatus) 26 mg/L. (janusinfo.se)
  • The generated data indicated that chemical composition of all 4 samples tested were similar qualitatively, though variations were observed quantitatively. (informaticsjournals.com)
  • Up to date, there are no available data about the toxicity of the fruit extract, anthocyanins and polyphenols from D. philippinensis fruits. (innspub.net)
  • Highly predictive for acute toxicity effects in humans. (zeclinics.com)
  • Capacity for Allergic Sensitization Determined by the Intradermal Test with Freund's Complete Adjuvant (fcat) on Guinea Pigs with Cover Letter dated 092386 (sanitized). (epa.gov)
  • Analysis of the relevance and adequateness of using Fish Embryo Acute Toxicity (FET) Test Guidance (OECD 236) to fulfil the information requirements and addressing concerns under REACH. (ufz.de)
  • 2013. Test No. 236: Fish Embryo Acute Toxicity (FET) Test. (zeclinics.com)
  • the terms used were postnatal development, toxicity, rodents and physical and reflexological parameters. (bvsalud.org)
  • Macroinvertebrates respond to long-term conditions, and can, for example, be knocked out by an acute discharge, which is not captured by chemical sampling. (researchgate.net)
  • Environmental Tests on the Subject Substance with Butane, 1,1-oxybis(3-methyl): Diisoamyl Ether: Isopentyl Ether: Diisopentyl Ether. (epa.gov)
  • The ratio of the proliferation in treated groups to that in vehicular controls, termed the Stimulation Index, is determined, and must be at least three before a test substance can be further evaluated as a potential skin sensitiser. (cdc.gov)
  • Accordingly, the model ASO that had been previously characterized in adult Göttingen Minipigs and NHPs showed comparable clinical chemistry and toxicity profiles in the juvenile minipigs. (uantwerpen.be)
  • Birds were observed for clinical signs of acute toxicity. (nel.edu)
  • Single and Binary-Combined Toxicity of Methamidophos, Acetochlor and Copper Acting on Earthworms Esisenia Foelide Bulletin of Environmental Contamination and Toxicology , 71, 1158-1166. (ac.ir)
  • The use of fish embryos allows high throughput screening while providing similar predictivity to adult fish and reducing animal testing. (zeclinics.com)
  • Further developmental toxicity studies on animals need to be carried out to validate use of belladonna mother tincture clinically in low concentration or high dilution.s. (ijpsonline.com)
  • therefore, toxicity studies must be carried out to investigate adverse effects prior to further exploration as potent candidates of medicinal plants. (ugm.ac.id)
  • 1,2-Benzenediol, Mixture with Methanol (22:78)-Acute Toxicologic Properties, with Cover Letter dated 11/02/1995 (Sanitized). (epa.gov)
  • The results indicated that the (50:50) and (25:75)% mixture ratios of metribuzin:halosulfuron and metribuzin:flumioxain provided higher toxicity than the other mixture ratios (100:0) and (0:100)%, respectively. (ac.ir)
  • Given that toxicity cannot be attributed to a single component or mixture of components but to the test item as a whole, the results were based on nominal loading rates only. (reach-manganese.org)
  • OECD guidance document No. 239 for the toxicity to honeybee larvae, that were developed to comply with the 2013 guidance requirements based on Regulation (EU) 1107/2009. (industryintel.com)
  • In the 2013 version, accumulative toxicity was considered, but almost never assessed due to lacking guidance. (industryintel.com)
  • Acute toxicity of magnetic nanopartic les in mice. (nel.edu)
  • Both tested extracts demonstrated promising antidepressant-like activity in mice. (bvsalud.org)
  • This OECD database allows regulatory officials and stakeholders to share information on products derived from the use of modern biotechnology, as well as some products with novel traits acquired by the use of conventional breeding or mutagenesis, that have been approved for commercial application in at least one country, in terms of food, feed or environmental safety. (oecd.org)
  • Samples of the freshly-prepared test media were only analysed if the samples taken at the end of the test showed concentrations significantly different from expected. (europa.eu)
  • The test results are presented and interpreted with reference to the nominal concentrations. (europa.eu)
  • The test concentrations were monitored by analysis of the test samples for manganese only. (reach-manganese.org)
  • Sampling method: An aliquot of freshly prepared test medium was taken from each test concentration before filling the test vessels. (europa.eu)
  • Smithers is one of the first laboratories to introduce reproduction tests with the red manure worm, Eisenia fetida . (smithersapex.com)
  • Effects of Glyphosate and 2,4-D on Earthworms ( Eisenia fetida ) in Laboratory Tests. (ac.ir)
  • c) the LD 50 or LC 50 or both, as the case may be, of the product or of the layer as determined by the results of tests conducted with the toxic product by the responsible person in accordance with a test methodology that conforms with good scientific practices. (gc.ca)
  • b) a source that reports test results that conform with good scientific practices and that disclose the greatest hazard must be used. (gc.ca)
  • Persistence: 'CO2 evolution test, guideline OECD 301B (80).Test results 0% degradation in 28 days. (janusinfo.se)
  • Persistence:'Test results from 'closed bottle test' (guideline 301 D) shows that the biological degradation is 5,5% in 28 days. (janusinfo.se)
  • This does not necessarily imply that in all instances the LLNA should be used in place of guinea pig tests, but rather that the assay is of equal merit and may be employed as an alternative in which positive and negative results generally no longer require further confirmation. (cdc.gov)
  • It was considered unnecessary and unrealistic to test at loading rates in excess of 100 mg/l. (reach-manganese.org)
  • Moreover, the LLNA offers a substantial refinement of the way in which animals are used for contact sensitisation testing. (cdc.gov)
  • The acute toxicity of magnetic nanopartic les was effectively lowered by their encapsulation with poly(D,L lactide). (nel.edu)
  • However, due to its toxic nature and adverse teratogenic effect, it is important to investigate the possible toxicity and safety level of belladonna mother tincture. (ijpsonline.com)
  • In this thesis, we evaluated the juvenile Göttingen Minipig as a pediatric safety testing model for ASOs. (uantwerpen.be)