Octamer histone acetyltransferase activity protein binding. Medical search. Frequent questions

Though sequence similarity is low between the core histones, each of the four have a repeated element consisting of a helix-loop-helix called the histone fold motif. (wikipedia.org)
Core histones are four proteins called H2A, H2B, H3 and H4 and they are all found in equal parts in the cell. (wikipedia.org)
The formation of histone only-intermediates proceeds when core histones are paired into the interlocked crescent shape quasi-symmetric heterodimer. (wikipedia.org)
Acetylates all four core histones in nucleosomes. (jensenlab.org)
Mutations in the major core histones relieve transcriptional repression and bypass the requirement for SNF/SWI and SAGA. (sdbonline.org)
To counteract constraints imposed by nucleosome structure, cells deploy two major classes of multiprotein enzymes, which covalently modify the nucleosome core histones or catalyze nucleosome mobility in an adenosine triphosphate (ATP)-dependent fashion. (sdbonline.org)
Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. (nih.gov)
Inhibition of core histones acetylation by carcinogenic nickel(II). (nih.gov)
Fluorescence spectroscopy data suggest that PfNapS interacts with core histones (tetramer, octamer, H3, H4, H2A and H2B) at a different site from its interaction with linker histone H1. (biomedcentral.com)
Although initially discovered as a retinoblastoma binding protein it has an affinity for core HISTONES and is a subunit of chromatin assembly factor-1 and polycomb repressive complex 2. (lookformedical.com)
A retinoblastoma-binding protein that has an affinity for core HISTONES. (lookformedical.com)
These octamers consist of duplicates of four core histones (H2A, H2B, H3, and H4). (epigentek.com)
Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). (epigentek.com)

Treatment of nucleosomes with protease trypsin indicates that after histone tails are removed, DNA is able to stay tightly bound to the nucleosome. (wikipedia.org)
Nucleosomes consist of a histone octamer surrounded by 146 base pairs of DNA wrapped in a superhelical manner. (wikipedia.org)
Nucleosomes impose a block to transcription that can be overcome in vivo by remodeling complexes such as SNF/SWI and histone modification complexes such as SAGA. (sdbonline.org)
Histone variant H2A.Z (Htz1 in yeast) replaces conventional H2A in many nucleosomes. (sdbonline.org)
How histone variants such as H2AZ are incorporated into nucleosomes has been obscure. (sdbonline.org)
These advances establish a third mechanism of chromatin reconfiguration, raising fundamental questions about the stability of nucleosomes in nonreplicative phases of the cell cycle and the cellular machinery responsible for incorporating histone variants into nucleosomes (Mizuguchi, 2004). (sdbonline.org)
Furthermore, the Fun30 remodeling enzyme, which has been implicated in DNA repair, binds ssNucs preferentially over nucleosomes, and ssNucs are effective at activating Fun30 ATPase activity. (uthscsa.edu)
The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. (nih.gov)
Nucleosome assembly proteins (NAPs) are histone chaperones that are crucial for the shuttling and incorporation of histones into nucleosomes. (biomedcentral.com)
A histone chaperone protein that plays a role in the deposition of NUCLEOSOMES on newly synthesized DNA. (lookformedical.com)
The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. (epigentek.com)

For instance, a systematic analysis of 486 different histone H3 and H4 mutations in yeast (where every residue was mutated at least one way) showed that only 11 of 79 N-terminal tail deletions resulted in lethality, a phenotype that also depends to some extent on strain background [ 9 ]. (aging-us.com)
Also, more and more accumulating evidence indicates that the different histone modifications are strongly interconnected and can enforce or counteract each other. (musculoskeletalkey.com)

The octamer assembles when a tetramer, containing two copies of H3 and two of H4, complexes with two H2A/H2B dimers. (wikipedia.org)
DNA sequences that form secondary structures or bind protein complexes are known barriers to replication and potential inducers of genome instability. (uthscsa.edu)
Nucleosome-like, Single-stranded DNA (ssDNA)-Histone Octamer Complexes and the Implication for DNA Double Strand Break Repair. (uthscsa.edu)
In addition, we reconstitute histone-ssDNA complexes (termed ssNucs) with ssDNA and recombinant histones and analyze these particles by a combination of native gel electrophoresis, sedimentation velocity, electron microscopy, and a recently developed electrostatic force microscopy technique, DREEM (dual-resonance frequency-enhanced electrostatic force microscopy). (uthscsa.edu)
The 48 kDa subunit, RETINOBLASTOMA-BINDING PROTEIN 4, is also a component of several other protein complexes involved in chromatin remodeling. (lookformedical.com)
It is found as a subunit of protein complexes that are in involved in the enzymatic modification of histones including the Mi2 and Sin3 histone deacetylase complexes and the polycomb repressive complex 2. (lookformedical.com)
The Trithorax group (TrxG) is composed of diverse, evolutionary conserved proteins that form chromatin-associated complexes accounting for epigenetic transcriptional memory. (silverchair.com)
HDACs and HATs not only modify histones, they also form complexes with transcription factors, oncoproteins, and tumor suppressors and regulate their activity by changing the acetylation status. (musculoskeletalkey.com)

Histone post-translational modifications were first identified and listed as having a potential regulatory role on the synthesis of RNA in 1964. (wikipedia.org)
In this context, numerous histone post-translational modifications (PTMs) have been described that include acetylation, phosphorylation, methylation, ubiquitylation and SUMOylation [ 1 ]. (aging-us.com)
Quantitative proteomic analysis of post-translational modifications of human histones. (nih.gov)
Methyl groups are added to the "tails" that protrude from the histone proteins, which is the most common location for post-translational modifications, especially N-terminal tails. (epigentek.com)
These nutrient-driven post-translational modifications are highly altered in cancer and regulate protein functions in various cancer-associated processes. (biomedcentral.com)

Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). (jensenlab.org)
H3 and H4 histones have tails protruding from the nucleosome that can be modified post-translationally to alter the histone's interactions with DNA and nuclear proteins, leading to epigenetic changes for regulating many normal and disease-related processes. (epigentek.com)
The mechanism known as histone methylation is a post-translational epigenetic modification that involves the transfer of methyl groups to histone proteins via histone methyltransferases (HMTs). (epigentek.com)
Histone methylation and histone demethylation are epigenetic modifications that have the power to reduce or bolster gene expression, especially as a result of altering chromatin structure. (epigentek.com)
By measuring histone modifications, researchers can uncover novel epigenetic insight into cellular processes and disease states. (epigentek.com)
In addition to better understanding the epigenetic underpinnings of the pathological disease process, detecting histone modifications can also aid in the development of histone modification-targeted drugs. (epigentek.com)
Giving credit to this view, Bird described epigenetic events as "the structural adaption of chromosomal regions so as to register, signal, or perpetuate altered activity states. (musculoskeletalkey.com)
2 In addition to the well-established epigenetic role of DNA methylation, this definition includes a variety of more transient histone modifications such as acetylation, methylation, or phosphorylation that underlie epigenetic effects, and that will be discussed in this chapter along with the influence of SUMOylation, ubiquitination, adenosine diphosphate (ADP) ribosylation, and microRNA. (musculoskeletalkey.com)
These epigenetic mechanisms are mediated by chemical modifications of DNA, proteins (most commonly histones), and RNA. (activemotif.com.cn)
Epigenetic alterations comprising local and global changes in DNA and histone modifications, transcription factor binding, disorganization of the nuclear lamina, and misfolding of the genome are hallmarks of aging. (oaepublish.com)

Recent studies have revealed that variants of histone H2A and histone H3 play important roles not only in gene expression but also in the repair of DNA breaks and the assembly of chromosome centromeres. (sdbonline.org)
Exceptions to this limitation occur when analyzing histone variants that have few gene copies, or when assessing putative gain-of function histone mutations, such as those identified in pediatric glioblastoma and glioma (e.g. (aging-us.com)
which have a variety of binding sites for sequence-specific transcription factors and specify characteristic chromatin structures mediated by nucleosome positioning specific histone modifications histone variants and other factors (1 2 For the transcription of type-I interferon (IFN)-stimulated genes (ISGs) promoters containing sequence motifs known as IFN-stimulated response element (ISRE) are the binding sites of the sequence-specific transcription factors activated by IFN stimulation. (techblessing.com)
In this model, large portions of genomic DNA operate as 'sinks', which are filled by 'sources', such as available histone variants, covalent modifications to histones, the readers of these modifications and non-coding RNAs. (biologists.com)

Histone tails are subject to a wide array of modifications which includes phosphorylation, acetylation, and methylation of serine, lysine and arginine residues. (wikipedia.org)
The "histone code" attempts to describe the way histone modifications function together in various combinations to control certain cellular processes. (epigentek.com)

Finally, we show that NuA4 can acetylate RPA and regulate the dynamics of its binding to DNA, hence targeting locally both histone and nonhistone proteins for lysine acetylation to coordinate repair. (uthscsa.edu)
and nonhistone proteins (CHROMOSOMAL PROTEINS, NON-HISTONE) found within the nucleus of a cell. (lookformedical.com)

This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. (nih.gov)
This gene encodes a replication-independent member of the histone H2A family that is distinct from other members of the family. (epigentek.com)

Is histone acetylation the most important physiological function for CBP and p300? (aging-us.com)
CREB binding protein (CBP, CREBBP) and its paralog p300 (EP300) constitute the KAT3 family of HATs in mammals, which has mostly unique sequence identity compared to other HAT families. (aging-us.com)
Although studies in yeast show that many histone mutations cause modest or specific phenotypes, similar studies are impractical in mammals and it remains uncertain if histone acetylation is the primary physiological function for CBP/p300. (aging-us.com)
Nonetheless, CBP and p300 mutations in humans and mice show that these coactivators have important roles in development, physiology, and disease, possibly because CBP and p300 act as network "hubs" with more than 400 described protein interaction partners. (aging-us.com)
Analysis of CBP and p300 mutant mouse fibroblasts reveals CBP/p300 are together chiefly responsible for the global acetylation of histone H3 residues K18 and K27, and contribute to other locus-specific histone acetylation events. (aging-us.com)
CBP/p300 can also be important for transcription, but the recruitment of CBP/p300 and their associated histone acetylation marks do not absolutely correlate with a requirement for gene activation. (aging-us.com)
Relevant to the role of CBP/p300 as HATs, hyperacetylation of histone N-terminal tail lysines correlates strongly with active transcription [ 2 ]. (aging-us.com)
Similarly, the recruitment of protein acetyltransferases positively correlates with histone hyperacetylation at active genes as shown by genome-wide chromatin immunoprecipitation (ChIP-Seq) studies of CBP and p300 in human T cells [ 3 ]. (aging-us.com)
STATs interact with histone acetyltransferases (HATs) including p300/CBP and GCN5 and GCN5 acetylates histones on the promoter in an IFN-dependent manner (6 7 Interestingly inhibition of histone deacetylase (HDAC) activity which opposes activity of HAT leads to a global impairment of the ISG transcription (8-10). (techblessing.com)

Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. (jensenlab.org)

These genes are involved in T cell regulation, including interferons, interleukin (IL),tumor necrosis factor (TNF), as well as linker for activation of T cells (LAT), cytotoxic T-lymphocyte-associated antigen 4 (CTLA4), and adapter proteins. (frontiersin.org)
Linker histone H1 binds near to the entry and exit sites of the nucleosome core particle (NPC) which consists of a 147-base-pair (bp)-long deoxyribonucleic acid (DNA) wrapped around a histone octamer consisting of two copies each of the core histone proteins H2A H2B H3 and H4 and facilitates the higher order chromatin structure (17-19). (techblessing.com)

All four of the core histone amino acid sequences contain between 20 and 24% of lysine and arginine and the size or the protein ranges between 11400 and 15400 Daltons, making them relatively small, yet highly positively charged proteins. (wikipedia.org)
Histones are composed of mostly positively charged amino acid residues such as lysine and arginine. (wikipedia.org)
Protein lysine acetyltransferases (HATs or PATs) acetylate histones and other proteins, and are principally modeled as transcriptional coactivators. (aging-us.com)
Classification into the various types (designated histone I, histone II, etc.) is based on the relative amounts of arginine and lysine in each. (lookformedical.com)
For instance, when histone H4 is monomethylated on lysine 20 (H4K20me1), this common histone modification results in the contraction of chromatin. (epigentek.com)

A retinoblastoma-binding protein that is involved in CHROMATIN REMODELING, histone deacetylation, and repression of GENETIC TRANSCRIPTION. (lookformedical.com)
Transcriptional repression or activation can occur as a result of histone methylation or demethylation due to the loosening or restriction of the chromatin structure. (epigentek.com)

These studies suggest that ISG transcription via promoters is under the control of the N-Methyl Metribuzin combined effects of histone modification and specific chromatin structures. (techblessing.com)
Ubiquitination is a multifunctional posttranslational modification controlling the activity, subcellular localization and stability of proteins. (cipsm.de)
We offer the most comprehensive selection of Histone Modification research products to cover every step of the experiment workflow, from upstream to downstream. (epigentek.com)
EpiGentek offers a complete series of kits available for the quantification of methylation, acetylation, and phosphorylation of H3 histones at all sites (see our informative histone modification table ). (epigentek.com)
This may be achieved as a result of two different forms of chemical modification to the structure of chromosome: the DNA and the protein - which are collectively referred to as chromatin . (biotopics.co.uk)
UDP-GlcNAc is then used for N-linked and O-linked glycosylation in the ER and Golgi and for O-GlcNAc modification of nuclear and cytoplasmic proteins by OGT (O-GlcNAc transferase). (biomedcentral.com)

In htz1Delta cells, Sir2 and Sir3 spread into flanking euchromatic regions, producing changes in histone H4 acetylation and H3 4-methylation indicative of ectopic heterochromatin formation. (sdbonline.org)
The conserved histone variant H2AZ has an important role in the regulation of gene expression and the establishment of a buffer to the spread of silent heterochromatin. (sdbonline.org)
Heterochromatin and euchromatin refer to chromatin structures that are either tightly or loosely packed DNA around histones, respectively. (epigentek.com)

The histone octamer interacts with the DNA through both its core histone folds and N-terminal tails. (wikipedia.org)
The histone fold interacts chemically and physically with the DNA's minor groove. (wikipedia.org)

Specific remodeling proteins are constantly altering the chromatin structure by breaking the bonds between the DNA and nucleosome. (wikipedia.org)

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. (nih.gov)
In addition to playing an important role in histone exchange during nuclear processes, histone chaperones function in nucleocytoplasmic shuttling of histones, in histone storage, in nucleosome assembly and they act as a link between chromatin remodeling factors and histones [ 2 , 3 ]. (biomedcentral.com)
Up to now, two main groups of HATs-type A and type B-have been described, whereby the nuclear type A HATs are those believed to influence transcriptional activity. (musculoskeletalkey.com)

The N-terminal tails do not interact with a specific region of DNA but rather stabilize and guide the DNA wrapped around the octamer. (wikipedia.org)
Phenotype and gene expression changes are often surprisingly moderate or specific in yeast that harbor point mutations in the N-terminal tails of histones H2A, H2B, H3 and H4 [ 9 , 16 - 19 ]. (aging-us.com)
The KAT5 (Tip60/Esa1) histone acetyltransferase is part of NuA4, a large multifunctional complex highly conserved from yeast to mammals that targets lysines on H4 and H2A (X/Z) tails for acetylation. (uthscsa.edu)
Alternatively, histone demethylation is the removal of methyl groups from the histone tails catalyzed by histone demethylases (HDMs). (epigentek.com)

Swr1 is required for the deposition of histone H2AZ at specific chromosome locations in vivo, and Swr1 and H2AZ commonly regulate a subset of yeast genes. (sdbonline.org)
Interestingly, replication through a protein barrier but not a DNA structure barrier was modulated by nucleotide pool levels, illuminating a different mechanism by which cells can regulate fork progression through protein-mediated stall sites. (uthscsa.edu)
Histone H2B monoubiquitination functions cooperatively with FACT to regulate elongation by RNA polymerase II. (nih.gov)
Histone chaperones are proteins that regulate the interaction of histones with other proteins and DNA and also prevent the highly basic histones from forming inappropriate aggregates [ 2 , 3 ]. (biomedcentral.com)
Transcription factors contain a DNA-binding domain (DBD), which attaches to the specific sequence of DNA adjacent to the genes that they regulate. (biotopics.co.uk)

The difficulty of testing histone point mutations in mammals has therefore contributed to the uncertainty of whether canonical histone PTMs are correlative with gene expression or causal. (aging-us.com)

The function of histone PTMs in mammals remains uncertain because the multiple genes encoding each canonical histone, renders in vivo mutational analysis unfeasible in most instances. (aging-us.com)
Also, the PCNA binding domain of Srs2 is required for its in vivo role of replication through hairpins. (uthscsa.edu)
In vivo, DSB processing occurs in the context of chromatin, and studies indicate that histones may remain associated with processed DSBs. (uthscsa.edu)
Brpf1 functions in association with the histone acetyltransferase Moz (Myst3), an interaction mediated by the N-terminal domain of Brpf1, and promotes histone acetylation in vivo. (silverchair.com)

The histone H2A.F/Z (H2AZ) variant is a functionally distinct, highly conserved histone subgroup that likely represents a separate evolutionary lineage of histone H2A proteins. (sdbonline.org)

Here, we report a stepwise recruitment of yeast NuA4 to DSBs first by a DNA damage-induced phosphorylation-dependent interaction with the Xrs2 subunit of the Mre11-Rad50-Xrs2 (MRX) complex bound to DNA ends. (uthscsa.edu)

However, H3 and H4 histones first form a heterodimer and then in turn the heterodimer dimerizes to form a tetramer (H3-H4)2. (wikipedia.org)
The repeating unit of chromatin is the nucleosome, formed from two histone H2A-H2B dimers and one histone H3-H4 tetramer around which 147 bp of DNA are wrapped [ 1 ]. (biomedcentral.com)

This family of proteins includes a wide variety of classes, including CYCLIN-DEPENDENT KINASES, mitogen-activated kinases, CYCLINS, and PHOSPHOPROTEIN PHOSPHATASES as well as their putative substrates such as chromatin-associated proteins, CYTOSKELETAL PROTEINS, and TRANSCRIPTION FACTORS. (lookformedical.com)

the transcription of genes to produce functional mRNA molecules that are then translated by ribosomes to form polypeptides the involvement in protein synthesis of tRNA molecules that are also encoded by genes. (biotopics.co.uk)
Being proteins, transcriptional factors are produced by ribosomes in the cytoplasm of eukaryotes, and they are coded for by genes in the nucleus. (biotopics.co.uk)
During thymocyte maturation, enhancers of genes encoding for TCRδ ( Tcrd ) and TCRα ( Tcra ), Eδ 8 , and Eα, work as a developmental switch controlling transition from Tcrd to Tcra activity at the Tcrad locus. (aai.org)
Lysosomal function is critical for organismal homeostasis-mutations in genes encoding lysosomal proteins cause severe human disorders known as lysosomal storage diseases, and lysosome dysfunction is implicated in age-associated diseases including cancer, neurodegeneration and metabolic syndrome. (stanford.edu)

Much of the current understanding of these processes is derived from analyses of nucleosomal histones that represent the major histone species within cells. (sdbonline.org)
In addition fluorescence recovery after photobleaching analyses demonstrated that histone H1 is a highly mobile chromatin component. (techblessing.com)
Our analyses reveal fundamental differences in the replication of DNA structural versus protein barriers, with Srs2 helicase activity exclusively required for fork progression through hairpin structures. (uthscsa.edu)
Here, based on genetic analyses in zebrafish, we identify the multidomain protein Brpf1 as a novel TrxG member with a central role during development. (silverchair.com)

PCNA expression correlates with the proliferation activity of several malignant and non-malignant cell types. (lookformedical.com)

Here, we show that the lncRNA Panct1 regulates the transient recruitment of a putative X-chromosome-encoded protein A830080D01Rik, hereafter referred to as transient octamer binding factor 1 (TOBF1), to genomic sites resembling the canonical Oct-Sox motif. (ku.dk)

Enzymes that catalyze acyl group transfer from ACETYL-CoA to HISTONES forming CoA and acetyl-histones. (lookformedical.com)

The heterodimer formation is based on the interaction of hydrophobic amino acid residue interactions between the two proteins. (wikipedia.org)

The canonical nucleosome is a fundamental unit of chromatin and consists of a protein octamer of two molecules each of histone H2A, H2B, H3 and H4, wrapped by 147 bp of genomic DNA. (aging-us.com)
It is generally believed that the histone code can influence transcriptional activity directly by affecting chromatin structure, thereby making it more or less accessible for transcription factors and indirectly leading to the attraction of effector molecules that in turn recruit and stabilize the transcription machinery. (musculoskeletalkey.com)

This study has found that Swr1, a Swi2/Snf2-related adenosine triphosphatase, is the catalytic core of a multisubunit, histone-variant exchanger that efficiently replaces conventional histone H2A with histone H2AZ in nucleosome arrays. (sdbonline.org)

Extensive sequence and structural comparisons were done with the crystal structures available for NAP/SET family of proteins. (biomedcentral.com)

Recombinant fusion protein containing a sequence corresponding to amino acids 1-128 of human H2AFZ (NP_002097.1). (epigentek.com)

Histone acetylation is catalyzed by histone acetyltransferases (HATs) and is counteracted by histone deacetylases (HDACs). (musculoskeletalkey.com)

Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). (jensenlab.org)
The variant histone H2A.Z regulates gene transcription, and deletion of the gene encoding H2A.Z strongly increases the requirement for SNF/SWI and SAGA. (sdbonline.org)
Phospho-dependent recruitment of the yeast NuA4 acetyltransferase complex by MRX at DNA breaks regulates RPA dynamics during resection. (uthscsa.edu)

We show that the Srs2 protein facilitates replication of hairpin-forming CGG/CCG repeats and prevents chromosome fragility at the repeat, whereas it does not affect replication of G-quadruplex forming sequences or a protein-bound repeat. (uthscsa.edu)
This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. (nih.gov)

The function of specific proteins from this organism are the subject of intense scientific interest and have been used to derive basic understanding of the functioning similar proteins in higher eukaryotes. (lookformedical.com)

These interactions keep the DNA and the histone octamer loosely associated, and ultimately allow the two to re-position or to separate entirely. (wikipedia.org)

In addition TAF-I KD and histone H1 KD affected the chromatin structure near the promoters. (techblessing.com)

Alternatively, monomethylation of histone H3 on arginine 17 (H3R17me1) leads to transcriptional activation. (epigentek.com)

Histones are primary protein components of eukaryotic chromatin and play a role in gene regulation. (epigentek.com)

GFP-fused PfNapS fusion protein targeting indicates cellular localization of PfNapS in the parasite nucleus. (biomedcentral.com)
Proteins found in the nucleus of a cell. (lookformedical.com)
Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)

A histone chaperone that facilitates nucleosome assembly by mediating the formation of the histone octamer and its transfer to DNA. (lookformedical.com)

In baker's yeast, however, histone mutations can be easily made and numerous studies show that histone PTMs might not be as essential as their correlative behavior with transcription would suggest [ 9 - 14 ]. (aging-us.com)

Specific protein-binding measures are often used as assays in diagnostic assessments. (lookformedical.com)

The interactions between the histone octamer and DNA, however, are not permanent. (wikipedia.org)
EαMC resulted in a very potent enhancer indicating that stereospecific interactions among proteins that form an Eα enhanceosome are rather flexible. (aai.org)

Strikingly, mutating an octamer-like motif in Panct1 RNA abrogates the strength of TOBF1 localization and recruitment to its targets. (ku.dk)

Western blot analysis of extracts of various cell lines, using Histone H2A.Z Polyclonal Antibody at 1:1000 dilution. (epigentek.com)

Heterodimers, or histone-only intermediates are formed from histone-fold domains. (wikipedia.org)

As proteins encoded by not only have anti-viral activities but also affect host-cellular events (5) the ISG transcription needs to be silenced in the IFN-unstimulated condition. (techblessing.com)
A family of cellular proteins that mediate the correct assembly or disassembly of polypeptides and their associated ligands. (lookformedical.com)
Lysosomes are membrane-bound compartments that degrade macromolecules and clear damaged organelles to enable cellular adaptation to various metabolic states. (stanford.edu)

Anatomy15

Organisms9

Diseases3

Chemicals and Drugs97

Analytical, Diagnostic and Therapeutic Techniques and Equipment20

Phenomena and Processes64

Disciplines and Occupations1

Information Science3

Core histones13

Nucleosomes11

Different histone2

Complexes8

Post-translational5

Epigenetic10

Variants4

Modifications2

Nonhistone proteins2

Member of the histone2

P3009

Acetylation of histone1

Linker2

Lysine5

Repression2

Modification6

Heterochromatin3

Interacts2

Altering the chromatin structure1

Nuclear3

Tails4

Regulate5

Gene expression1

Vivo4

Highly conserved1

Phosphorylation1

Tetramer2

Chromatin-associated1

Genes4

Analyses4

Correlates1

Transient1

Enzymes1

Interaction1

Molecules2

H2AZ1

Family of proteins1

Recombinant1

HATs1

Regulates3

Chromosome2

Eukaryotes1

Loosely1

Promoters1

Leads to transcriptional1

Eukaryotic1

Nucleus3

Facilitates1

Yeast1

Assays1

Interactions2

Motif1

Polyclonal1

Intermediates1

Cellular3