Sertoli-Leydig cell tumour (a sex-cord stromal tumor), is a testosterone-secreting ovarian tumor and is a member of the sex cord-stromal tumour group of ovarian and testicular cancers. (wikipedia.org)
Through genetic studies of exome sequence, it was found that gliomatosis is genetically identical to the parent ovarian tumor and developed from cells that disseminate from the ovarian teratoma. (mdwiki.org)
Benign2
The prognosis is generally good as the tumour tends to grow slowly and usually is benign: 25% are malignant. (wikipedia.org)
Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age. (lookformedical.com)
Tissue3
An increase in the number of cells in a tissue or organ without tumor formation. (lookformedical.com)
A teratoma is a tumor made up of several different types of tissue , such as hair , muscle , teeth , or bone . (mdwiki.org)
Mature teratoma of the mediastinum: A horizontal slice of the resected tumor reveals fibrofatty tissue, calcified areas, and a few cystic spaces lined with smooth membrane and containing a hair. (mdwiki.org)
Females1
Due to excess testosterone secreted by the tumour, one-third of adult females present with a recent history of progressive masculinization. (wikipedia.org)
Young adults2
While the tumour can occur at any age, it occurs most often in young adults. (wikipedia.org)
The condition usually occurs in children and young adults and has familial predilection, lasting for several months, sometimes years, before running its course. (lookformedical.com)
Group2
Sertoli-Leydig cell tumour is a group of tumors composed of variable proportions of Sertoli cells, Leydig cells, and in the case of intermediate and poorly differentiated neoplasms, primitive gonadal stroma and sometimes heterologous elements. (wikipedia.org)
Teratomas occur in the coccyx in about one in 30,000 newborns, making them one of the most common tumors in this age group. (mdwiki.org)
Cells1
They are a type of germ cell tumor (a tumor that begins in the cells that give rise to sperm or eggs ). (mdwiki.org)
Children1
[13] They can occur in both children and adults. (mdwiki.org)
Ovarian Sertoli-Leydig Cell Tumors2
In this study, we sought to define the association between DICER1 hotspot mutations and different morphologic subtypes of ovarian Sertoli-Leydig cell tumors. (nih.gov)
We subjected a series of ovarian Sertoli-Leydig cell tumors (n=32), Sertoli cell tumors (n=5) and gynandroblastomas (n=5), testicular sex cord-stromal tumors (n=15) and a diverse group of female genital tract tumors with rhabdomyosarcomatous morphology (n=10) to DICER1 hotspot mutation analysis using Sanger sequencing. (nih.gov)
Testicular3
Sertoli-Leydig cell tumour (a sex-cord stromal tumor), is a testosterone-secreting ovarian tumor and is a member of the sex cord-stromal tumour group of ovarian and testicular cancers. (wikipedia.org)
The tumour occurs in early adulthood (not seen in newborn), is rare, comprising less than 1% of testicular tumours. (wikipedia.org)
Furthermore, we aimed to assess whether DICER1 hotspot mutations occur in other ovarian sex cord-stromal tumors, testicular sex cord-stromal tumors, or other female genital tract tumors with rhabdomyosarcomatous differentiation. (nih.gov)
Mutations2
Recent studies have shown that many cases of Sertoli-Leydig cell tumor of the ovary are caused by germline mutations in the DICER1 gene. (wikipedia.org)
Sertoli-Leydig cell tumors are characterized by the presence of somatic DICER1 hotspot mutations. (nih.gov)
Subtypes1
The tumour is subdivided into many different subtypes. (wikipedia.org)
Presence1
Presence of an ovarian tumour plus hormonal disturbances suggests a Sertoli-Leydig cell tumour. (wikipedia.org)