Occurs humans abnormalities drug induced. Medical search. Frequent questions

Dantrium is metabolized by the liver, and it is theoretically possible that its metabolism may be enhanced by drugs known to induce hepatic microsomal enzymes. (druglib.com)
FSGS occurring concomitantly to administration of drugs known to induce FSGS, including but not limited to lithium, interferon, and bisphosphonates (e.g., pamidronate), or FSGS occurring in a subject using intravenous illicit drugs at the time of diagnosis. (who.int)

Because long-term quinolone exposure has been shown to result in accumulation of the drug in pigmented tissues, retinal degenerative changes may be observed. (entokey.com)
but at higher doses Jacovides (1923) described optic-nerve and retinal ischemic changes with pupillary, accommodation, vision and visual field abnormalities. (entokey.com)
Age-Related Macular Degeneration (AMD) occurs due to an abnormality of the retinal pigment epithelium (RPE) and causes damage to the macula [1, 2]. (chemdiv.com)

Individuals in the United States can also be exposed to radioiodine, primarily 123I and 131I, as a result of clinical procedures in which radioiodine compounds are administered to detect abnormalities of the thyroid gland or to destroy the thyroid gland to treat thyrotoxicosis or thyroid gland tumors. (cdc.gov)
Administration of the β2-agonist formoterol (0.3 mg/kg for 7 days) in rats bearing Yoshida AH-130 ascites hepatoma tumors, a model which induces a strong loss of both body and muscle weight, resulted in a significant reversal of the muscle wasting process, as reflected by individual muscle weights. (spandidos-publications.com)
In vivo, Interferon alfa-2a, recombinant has been shown to inhibit the growth of several human tumors growing in immunocompromised (nude) mice. (drugs.com)
In a study in which albino hairless mice were exposed to both UVR and topically applied calcipotriene, a reduction in the time required for UVR to induce the formation of skin tumors was observed (statistically significant in males only), suggesting that calcipotriene may enhance the effect of UVR to induce skin tumors. (globalrph.com)

Pazopanib is susceptible to drug-drug interactions with agents that inhibit or induce hepatic CYP 3A4 activity. (nih.gov)

In addition to the increased muscle protein degradation found during cancer growth, the presence of the tumor also induces an increased rate of DNA fragmentation in skeletal muscle in both rats and mice ( 8 ). (spandidos-publications.com)
In the anesthetic-induced malignant hyperthermia syndrome, evidence points to an intrinsic abnormality of skeletal muscle tissue. (nih.gov)

Therefore, mitochondrial DNA abnormalities such as overproliferation and or deletion can be used as a key marker for diseases differentiation and effectiveness of the treatment. (nih.gov)
Future potential exploration using mtDNA markers can be considered more accurate hallmarks for diagnosis and monitoring treatment of human diseases. (nih.gov)
Nevertheless, MDS are thought to be immunologically responsive diseases, as immunomodulatory drugs can induce remissions, and allogeneic bone marrow transplantation can be curative in the small fraction of patients for whom this is an option. (acgtfoundation.org)
The use of mouse models, as well as human diseases resulting from deficiencies in the methylation machinery, have been integral parts of understanding the role of these proteins in development and cellular homeostasis. (caister.com)
Clinical trials of pazopanib in malignant diseases in humans have shown activity against renal cell carcinoma and soft tissue sarcoma and promising effects in ovarian and thyroid cancer. (nih.gov)
As a result, nutrition affects the incidence, natural progression and therapeutic response of malignant diseases, both in humans and in preclinical animal models. (nature.com)
Ocular Disease Therapeutics: Design and Delivery of Drugs for Diseases of the Eye. (chemdiv.com)

DESCRIPTION (provided by applicant): The objective of this project is to develop a genetic test, involving the protein, RGS9, to identify patients that are at risk for developing tardive dyskinesia (TD) or L-DOPA induced dyskinesia (LID). (sbir.gov)
Extensive thin-section computed tomographic abnormalities, including traction bronchiolectasis, suggest that fibroproliferative changes were independently predictive of poor prognosis in ARDS patients within 7 days of onset [ 4 ]. (ersjournals.com)
Transforming growth factor (TGF)-β, especially its isoform TGF-β1, is a profibrotic cytokine that is overexpressed in patients with fibrosis and was directly associated with fibrosis in multiple human settings and animal models [ 5 ]. (ersjournals.com)
Evidence exists that immune activation against hematopoietic elements frequently occurs in MDS patients, based on the identification of lymphocytic infiltrates in the marrow, oligoclonal expansion of T cells, and excessive production of tumor necrosis factor alpha. (acgtfoundation.org)
SCLE may occur in patients with systemic lupus erythematosus (SLE), Sjögren syndrome , deficiency of the second component of complement (C2d), or it may be drug-induced. (medscape.com)
Subacute cutaneous lupus erythematosus (SCLE) occurs in genetically predisposed individuals, most often in patients with human leukocyte antigen B8 (HLA-B8), human leukocyte antigen DR3 (HLA-DR3), human leukocyte antigen DRw52 (HLA-DRw52), and human leukocyte antigen DQ1 (HLA-DQ1). (medscape.com)
Exacerbation of disease or induction of lesions is more common following UV-B exposure, but it can also occur in patients exposed to UV-A. Some patients exhibit sensitivity to only UV-A or to UV-A and UV-B. (medscape.com)
In perhaps as many as 30% of patients with SCLE, drugs may exacerbate or induce their disease. (medscape.com)
The prelicensure clinical trials of ibalizumab included a limited number of patients, many of whom had other serious comorbidities including cirrhosis and chronic hepatitis B and C. In these trials, serum aminotransferase elevations occurred in 14% to 25% of patients, but the abnormalities were generally mild and self-limited and often attributable to other underlying conditions. (nih.gov)
While this is a limited-use drug and most of the data are from the older literature, the basic ingredient in ipecac is emetine hydrochloride, which is used off label to induce vomiting in patients with anorexia nervosa. (entokey.com)
In large clinical trials, abnormalities in routine liver tests were common in patients treated with pazopanib, with serum aminotransferase elevations occurring in up to half of patients and total serum bilirubin in approximately one-third. (nih.gov)
Cancer cachexia occurs in the majority of cancer patients before death, and it is responsible for the death of 22% of cancer patients. (spandidos-publications.com)
The administration of intravenous dantrolene sodium to human volunteers is associated with loss of grip strength and weakness in the legs, as well as subjective CNS complaints (see also PRECAUTIONS, Information for Patients ). (nih.gov)
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (nih.gov)
Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. (nih.gov)
Over the course of a typical 10-week controlled trial, the rate of death in drug-treated patients was about 4.5%, compared to a rate of about 2.6% in the placebo group. (nih.gov)
The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. (nih.gov)
Discontinuation of Mn supplementation and levodopa treatment improved the symptoms and MRI abnormalities in the both patients . (lookfordiagnosis.com)
In controlled clinical trials, the most frequent adverse reactions reported for Dovonex® (calcipotriene ointment) were burning, itching and skin irritation, which occurred in approximately 10-15% of patients. (globalrph.com)
It can also result in the reactivation of syphilis in patients with HIV (human immunodeficiency virus) infection. (hearingreview.com)
Clinically it is mainly used for high levels of estrogen in breast cancer patients, which combines with androgen and other anticancer drugs (such as doxorubicin, etc., enhancing the effectiveness and showing good effect in postmenopausal patients with advanced breast cancer. (lookchem.com)

Severe systemic disease is unusual, but when it occurs, the patient may develop life-altering sequelae. (medscape.com)
Nervous system abnormalities, as well as a variety of complications related to severe spasm and prolonged hospitalization, can accompany generalized tetanus. (cdc.gov)
Cases of severe thalidomide-induced phocomelia. (wikipedia.org)
Drug-induced death of the filaria can result in a severe allergic reaction due to the release of foreign protein. (entokey.com)
Dose Modifications: If severe adverse reactions or laboratory abnormalities develop during combination REBETOL/INTRON A therapy the dose should be modified, or discontinued if appropriate, until the adverse reactions abate. (linkedlifedata.com)
In addition to first- and second-line antimalarial drug treatments, adjunctive and supportive care measures (e.g., intravenous fluids, blood transfusions, supplemental oxygen, antiseizure medications) may be needed for severe manifestations. (nationalacademies.org)

Intermittent spasms of the neck muscles or abnormal head movements occur because of contractions of the sternocleidomastoid, trapezius, and posterior cervical muscles. (medscape.com)
The red blood cell abnormality can involve the cell membrane (the outer covering of the cell), the chemistry inside the cell, or the production of abnormal types or amounts of hemoglobin. (daviddarling.info)
When this occurs, abnormal heart rhythms can occur, often leading to heart failure. (petmd.com)
This article reviews the diagnostic approach to hematologic laboratory abnormalities and abnormal bleeding in adults, as well as basic preventive care and hemostatic management of adults with bleeding disorders. (medscape.com)

We propose that hypometabolism, coupled with oxidative stressors, is responsible for most Alzheimer disease (AD) and cerebrovascular accidents (CVAs) and appears to be a central initiating factor for vascular abnormalities, mitochondrial damage and an imbalance in the activity of vasoactive substances, such as different isoforms of nitric oxide synthase (NOS), endothelin-1 (ET-1), oxidative stress markers, mtDNA and mitochondrial enzymes in the vascular wall and in brain parenchymal cells. (nih.gov)
We have recently reported that HD brains are also characterised by vascular abnormalities, which include changes in blood vessel density/diameter as well as increased blood-brain barrier (BBB) leakage. (bmj.com)
Objectives Seeking to elucidate the origin of these vascular and BBB abnormalities, we studied platelets that are known to play a role in maintaining the integrity of the vasculature and thrombotic pathways linked to this, given they surprisingly contain the highest concentration of mHtt of all blood cells. (bmj.com)

Ibalizumab therapy has not been associated with serum enzyme elevations or to instances of clinically apparent drug induced liver injury. (nih.gov)
Treatment should continue until the patient is no longer clinically benefiting from therapy or until unacceptable toxicity occurs. (wikidoc.org)

If SCLE is drug-induced, withdrawal of the culprit medication in conjunction with medical therapy is often necessary for disease control. (medscape.com)
Liver test abnormalities are frequent during pazopanib therapy and routine monitoring is recommended at 3 to 4 week intervals. (nih.gov)
In mice with surgically induced transmural myocardial infarction, relaxin therapy inhibited scar density. (onteenstoday.com)
Epigenetic drugs show significant effects on both preclinical and clinical studies in which the target development and research offer a promising direction for cancer therapy. (frontiersin.org)
The principal proven methods of treatment are (1) IOP reduction based on the use of topical drugs, (2) laser therapy, and surgical intervention. (chemdiv.com)
Antibody therapy, a medication given to bind with a powerful cardiac stimulant that is in the blood stream, is used in humans with digoxin toxicity and has been used on animals. (petmd.com)

Diabetes, a history of immunosuppression, and intravenous drug use may be risk factors for tetanus. (cdc.gov)
Intravenous drug users accounted for 14% of cases from 2000 through 2019. (cdc.gov)
Correspondingly, the volume of distribution after intravenous administration has been reported to be 30.0 ± 8.2 L. After prolonged administration, aminocaproic acid has been found to distribute throughout extravascular and intravascular compartments of the body, penetrating human red blood cells as well as other tissue cells. (globalrph.com)
The efficacy of intravenous dantrolene in the treatment of human and porcine malignant hyperthermia crisis, when considered along with prophylactic experiments in malignant hyperthermia susceptible swine, lends support to prophylactic use of oral or intravenous dantrolene in malignant hyperthermia susceptible humans. (nih.gov)
After single intravenous administration of [ 3 H] caspofungin acetate, excretion of caspofungin and its metabolites in humans was 35% of dose in feces and 41% of dose in urine. (theodora.com)
It is recommended that the combination of intravenous dantrolene sodium and calcium channel blockers, such as verapamil, not be used together during the management of malignant hyperthermia crisis until the relevance of these findings to humans is established. (druglib.com)

A team has developed a system to model Huntington's in human embryonic stem cells for the first time. (neurodegenerationresearch.eu)
In a report published in Development , they describe early abnormalities in the way Huntington's neurons look, and how these cells form larger structures that had not previously been associated with the disease. (neurodegenerationresearch.eu)

Detection of human include gastrointestinal discomfort, lular marrow with complete absence bocavirus in Japanese children with lower rash, allergy, hepatitis, and peripheral respiratory tract infections. (cdc.gov)

Although operations may improve some abnormalities, many are not surgically treatable due to the lack of nerves and other related structures. (wikipedia.org)

The approaches that inhibit myofibroblast formation have been demonstrated to prevent cardiac fibrosis, including systemic delivery of antifibrotic drugs, localized delivery of biomaterials, localized delivery of biomaterials and antifibrotic drugs, and localized delivery of cells using biomaterials. (onteenstoday.com)
CANCIDAS is the first of a new class of antifungal drugs (echinocandins) that inhibit the synthesis of (beta) (1,3)-D-glucan, an integral component of the fungal cell wall. (theodora.com)

At higher concentrations, ROS induces cell injury and death, which occurs during the aging process, where accelerated generation of ROS and a gradual decline in cellular antioxidant defense mechanisms, especially in the mitochondria. (nih.gov)
Bexarotene may induce metabolic enzymes and cause a reduction in the plasma concentrations of oral or other systemic hormonal contraceptives. (pdr.net)
The first group includes papers describing structural changes of the chromosomes produced by LSD in vitro , ** in these experiments various concentrations of LSD are added to cultures of cells from human, animal, or plant tissues in a test-tube. (druglibrary.net)

line drug in the treatment of tuberculo- antigen showed no abnormalities, 2. (cdc.gov)

neither the etiology of sperm abnormalities nor the cause of sister-chromatid exchange in spontaneous abortions has been established (11,12). (cdc.gov)

Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. (nih.gov)

Antiepileptic drugs should be used carefully, with consideration of medication interactions and potential side effects. (medscape.com)
Due to system maintenance, the drug interactions feature you are attempting to access is temporarily unavailable. (medscape.com)

Over many years, several theories have arisen based on clinical and scientific data obtained in human and animal studies, including oxidative stress, apoptosis, mitochondrial dysfunction, derangements of fatty acid metabolism/transport, and accelerated protein catabolism. (medscape.com)

Adults with bleeding disorders may present to their family physician with minor bleeding symptoms or hematologic laboratory abnormalities discovered during evaluation for surgery or another purpose. (medscape.com)
In cases of asymptomatic hematologic laboratory abnormalities, the particular abnormality should narrow down the potentially affected hemostatic component(s), ideally streamlining subsequent investigation. (medscape.com)

Generalized spasms occur, frequently induced by sensory stimuli. (cdc.gov)
Glutamate is the principal neurotransmitter in humans, carrying nerve impulses from glutamate stimuli to glutamate receptors throughout the body. (truthinlabeling.org)

Administration of dantrolene may potentiate vecuronium-induced neuromuscular block. (druglib.com)

Reduce the daily bexarotene dose in 100-mg increments (from 300 mg/m2 to 200 mg/m2 and from 200 mg/m2 to 100 mg/m2) if clinical toxicity occurs. (pdr.net)

For patient education information, see the Mental Health Center, as well as Alcoholism, Alcohol Intoxication, Drug Dependence and Abuse, and Substance Abuse. (medscape.com)

Maternal exposure after conception may result in death of the fetus or structural and functional abnormalities in the newborn. (cdc.gov)
Neonatal tetanus is a form of generalized tetanus occurring in newborn infants who lack the passive protection derived from maternal antibodies. (cdc.gov)

Specific metabolic pathways for the degradation and elimination of dantrolene sodium in humans have been established. (nih.gov)

2] In addition, the literature reports alcohol withdrawal being associated with takotsubo, or stress-induced, cardiomyopathy. (medscape.com)

These results suggest that sivelestat alleviated bleomycin-induced pulmonary fibrosis via inhibition of both TGF-β activation and inflammatory cell recruitment in the lung. (ersjournals.com)
Whether this represents a secondary event in response to cell injury and the generation of neo-antigens, or an initiating event inducing immunopathology, remains controversial. (acgtfoundation.org)
The human erythroleukemia cell line K562 has been stably transfected to secrete GM-CSF. (acgtfoundation.org)
On February 16, 1985, Wyeth Laboratories recalled Wyeth human diploid cell rabies vaccine (WYVACTM) from the market. (cdc.gov)
This resulted from two postlicensure studies of antibody responses after postexposure prophylaxis with human diploid cell rabies vaccine (HDCV) conducted by CDC over the last 6 months. (cdc.gov)
In affected humans, it has been postulated that "triggering agents" (e.g., general anesthetics and depolarizing neuromuscular blocking agents) produce a change within the cell which results in an elevated myoplasmic calcium. (nih.gov)
In the United States, sickle cell anemia occurs most often in African Americans. (daviddarling.info)
Suspecting that the disease works differently in humans, the researchers developed a cell-based human system for their research. (neurodegenerationresearch.eu)
They used the gene editing technology CRISPR to engineer a series of human embryonic stem cell lines, which were identical apart from the number of DNA repeats that occurred at the ends of their HTT genes. (neurodegenerationresearch.eu)
Some drugs work only during a specific phase of the cell cycle, requiring prolonged administration to catch dividing cells during the phase of maximal sensitivity. (msdmanuals.com)
Preclinical studies show that T cell-mediated immunity is required for protection and is readily induced in humans after vaccination. (cdc.gov)
These data suggest that PfSPZ Vaccine-induced T cell immunity is age-dependent and may be influenced by V2(+)V9(+) T cell frequency. (cdc.gov)

Because the drug is seldom used for longer than five days, these signs and symptoms quickly resolve once the drug is discontinued ( Fontana 1948 ). (entokey.com)
Symptoms which may occur in case of overdose include, but are not limited to, muscular weakness and alterations in the state of consciousness (e.g., lethargy, coma), vomiting, diarrhea, and crystalluria. (druglib.com)

Sixty-five percent of the dose is recovered in the urine as unchanged drug and 11% of the dose appears as the metabolite adipic acid. (globalrph.com)
The use of diethylcarbamazine eye drops for treatment of ocular onchocerciasis produces dose-related inflammatory reactions similar to those seen with systemic use of the drug. (entokey.com)

To elucidate the antifibrotic mechanisms of sivelestat, we examined a murine model of bleomycin-induced early-stage pulmonary fibrosis. (ersjournals.com)
In the bleomycin-induced early-stage pulmonary fibrosis model, the neutrophil elastase level was increased in the lungs. (ersjournals.com)
Sivelestat significantly inhibited the increase in lung collagen content, fibrotic changes, the numbers of total cells (including macrophages, neutrophils and lymphocytes), the levels of the active form of TGF-β1 and phospho-Smad2 in bleomycin-induced early-stage pulmonary fibrosis. (ersjournals.com)
Pulmonary fibrosis is caused by a variety of insults to the lung, such as acute lung injury, irradiation and drugs [ 1 ]. (ersjournals.com)
Bleomycin (BLM)-induced inflammation and fibrosis represent an experimental model for IPF as well as ALI/ARDS. (ersjournals.com)
Recent studies have suggested that increased collagen turnover and fibrotic changes are earlier events within 14 days in the BLM-induced fibrosis [ 8 - 11 ] and these changes were used commonly as a pulmonary fibrosis model. (ersjournals.com)
Aortic stenosis and hypertension result in pressure overload of the left ventricle where the increased wall stress induces hypertrophy and interstitial fibrosis (2-4). (onteenstoday.com)
Spironolactone and eplerenone have been shown to reduce myocardial fibrosis in animals and humans, though results in humans are mixed. (onteenstoday.com)
Cardiac fibrosis is a process of pathological extracellular matrix (ECM) remodeling, leading to abnormalities in matrix composition and quality, as well as an impaired heart muscle function [4]. (onteenstoday.com)

Reuben A. Hepatotoxicity of immunosuppressive drugs. (nih.gov)

5. Smuts H, Hardie D. Human bocavirus in disorder in adults. (cdc.gov)
Most reported cases occur in adults. (cdc.gov)

Abnormalities associated with cancer cachexia include anorexia, weight loss, muscle loss and atrophy, anemia and alterations in carbohydrate, lipid and protein metabolism ( 2 , 3 ). (spandidos-publications.com)

This may occur in stroke or dystonia-parkinsonism syndrome and lead to painful positioning of the leg, impaired gait, and altered bone development. (medscape.com)
DESCRIPTION (provided by applicant): Turner syndrome (TS) is the most common genetic problem effecting women, with an incidence of 1 in 1,500 to 2,000 live female births and occurs when an entire, or portions of an X-chromosome is deleted. (sbir.gov)
When an individual is born with phocomelia due to drugs or pharmaceuticals, it is known as thalidomide syndrome. (wikipedia.org)

Although localized tetanus often occurs in people with partial immunity and is usually mild, progression to generalized tetanus can occur. (cdc.gov)

As a consequence, preclinical evaluation of Interferon alfa-2a, recombinant has involved in vitro experiments with human cells and some in vivo experiments. (drugs.com)

The possibility of inducing structural changes in the chromosomes by exogenous agents such as radiation, viruses, and a variety of chemicals, has been a subject of great scientific interest for a long time. (druglibrary.net)

Drug-induced liver disease. (nih.gov)

In 1910, phenobarbital (PHB), which then was used to induce sleep, was found to have antiseizure activity and became the drug of choice for many years. (medscape.com)

Immunosuppressive drugs may reduce the immune response to influenza vaccine. (medscape.com)

The biological activities of Interferon alfa-2a, recombinant are species-restricted, i.e., they are expressed in a very limited number of species other than humans. (drugs.com)
1 Using human cells in culture, Interferon alfa-2a, recombinant has been shown to have antiproliferative and immunomodulatory activities that are very similar to those of the mixture of interferon alfa subtypes produced by human leukocytes. (drugs.com)

8) PIR reversed typical EEG slowing associated with "normal" and pathological human aging, increasing alpha and beta (fast) EEG activity and reducing delta and theta (slow) EEG activity, while simultaneously increasing vigilance, attention and memory. (worldhealth.net)

1) Yet already by 1972 PIR's pharmacologic uniqueness led C.E. Giurgea, UCB's principal PIR researcher and research co-ordinator, to formulate an entirely new category of drugs to describe PIR: the nootropic drug. (worldhealth.net)

If elevation in serum calcium outside the normal range should occur, discontinue treatment until normal calcium levels are restored. (globalrph.com)

Various cells and molecules are involved in this process, providing targets for potential drug therapies. (onteenstoday.com)

It is believed that inhibition of human VAP-1 enzyme could be a promising approach to the treatment of diabetic macular edema. (chemdiv.com)

Until recently, the potential hazards to human reproduction posed by occupational exposures received little attention. (cdc.gov)

Emerg ondary to drug exposure in 5% of pa- in this case. (cdc.gov)
Emetine hydrochloride is somewhat unique in that somewhere between 4-10 hours after exposure in humans, the drug is probably secreted in the tears to give significant bilateral foreign-body sensation, epiphoria, photophobia, lid edema, blepharospasm and conjunctival hyperemia. (entokey.com)
Emetine hydrochloride is highly toxic when inadvertent direct ocular exposure occurs. (entokey.com)
In the in vitro studies, the blood samples were drawn from normal, healthy persons with no history of prior drug injection, radiation exposure, or recent viral infection. (druglibrary.net)

fetal death occurred at doses greater than 10 mg/kg per day. (pdr.net)
Doses are initially based on lean body weight, yet each dog metabolizes the drug differently. (petmd.com)
Overdosage (possibly occurring with trimetrexate doses above 90 mg/m2 without concomitant administration of calcium folinate): after stopping trimetrexate, calcium folinate 40 mg/m2 IV every 6 hours for 3 days. (janusinfo.se)

Epidemiological profi le and clini- ceiving antituberculous treatment with Although rechallenge with isoniazid cal associations of human bocavirus and rifampin (400 mg/day), isoniazid (150 could have confi rmed isoniazid as the other human parvoviruses. (cdc.gov)
This compound is currently in use in humans for the treatment of bronchospasm associated with asthma. (spandidos-publications.com)
TB389 trade name] is indicated in combination with other tuberculosis medicines for the treatment of drug- resistant tuberculosis caused by Mycobacterium tuberculosis . (who.int)
In 1940, phenytoin (PHT) was found to be an effective drug for the treatment of epilepsy, and since then it has become a major first-line antiepileptic drug (AED) in the treatment of partial and secondarily generalized seizures. (medscape.com)
Ethosuximide has been used since 1958 as a first-choice drug for the treatment of absence seizures without generalized tonic-clonic seizures. (medscape.com)
It became the drug of choice in primary generalized epilepsies and in the mid 1990s was approved for treatment of partial seizures. (medscape.com)
The cellular kinetics of particular cancers is an important consideration in the design of antineoplastic drug regimens and may influence the dosing schedules and timing intervals of treatment. (msdmanuals.com)

The cells studied were in most cases human white blood cells (lymphocytes). (druglibrary.net)
In other types of hemolytic anemia, the body's immune system , infections, certain drugs, or other agents attack normal red blood cells, causing them to hemolyze. (daviddarling.info)

Central to this proposal is the observation that all three classes of drugs augment discrete elements of host immunity, making their integration with therapeutic cancer vaccines ripe for exploration. (acgtfoundation.org)

This chapter describes antimalarial drugs currently in use, with an emphasis on the artemisinins. (nationalacademies.org)
It also reviews the way drug resistance develops and spreads, methods used to assess the presence and level of drug resistance, and the extent to which chloroquine and sulfadoxine/pyrimethamine (SP)-the two most widely used antimalarial drugs in the world today-have now lost efficacy. (nationalacademies.org)
In other words, in each life-cycle stage the parasite manifests unique biological properties that can offer a target for the action of one or more antimalarial drugs. (nationalacademies.org)
they are recommended only in combination with other antimalarial drugs. (nationalacademies.org)

They are also less susceptible to injury by drugs or irradiation. (msdmanuals.com)

5) They should lack the usual pharmacology of other psychotropic drugs (e.g. sedation, motor stimulation) and possess very few side effects and extremely low toxicity. (worldhealth.net)

Our Lithostat (acetohydroxamic acid) Tablets Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
Further investigations on failure of the medication to helminth species concurrently harbored within the human host hiv infection classification [url=https://pmsttc.edu.pk/buy/Acivir-Pills/]buy cheap acivir pills 200 mg online[/url]. (ehd.org)

Many antineoplastic drugs, such as antimetabolites, are most effective when cells are actively dividing. (msdmanuals.com)

Recent achievements highlight the accelerated development of epigenetics, such as the definition of a human DNA methylome at single-nucleotide resolution, the various discoveries of histone variants and modifications, the study of the CpG island in the genome, and the progress of genome-wide nucleosome positioning maps ( Baldi, 2019 ). (frontiersin.org)

in this type of research the effect of LSD is studied after the substance has been ingested by or injected into animals or humans. (druglibrary.net)
Mood disorders may also be substance induced, or occur in response to a medical condition . (wikipedia.org)

It is important to understand the mechanisms of action and the pharmacokinetics of antiepileptic drugs (AEDs) so that these agents can be used effectively in clinical practice, especially in multidrug regimens (see the image below). (medscape.com)

Limosilactobacillus reuteri is a lactic acid bacterium found in a variety of natural environments, including the gastrointestinal tract of humans and other animals. (wikipedia.org)

It appears to be essentially ubiquitous in the animal kingdom, having been found in the gastrointestinal tracts and feces of healthy humans, sheep, chickens, pigs, and rodents. (wikipedia.org)

Additional implicated agents include calcium channel blockers, angiotensin-converting enzyme inhibitors, nonsteroidal anti-inflammatory drugs, antifungal agents (particularly terbinafine), chemotherapy agents, immunotherapies, proton pump inhibitors, and tumor necrosis factor (TNF) antagonists. (medscape.com)

DESCRIPTION (provided by applicant): The central goal of this application is to develop a combination product comprising two fully human monoclonal antibodies (mAbs) produced in plants for the prevention of serious disease caused by respiratory syncytial virus (RSV). (sbir.gov)
Ibalizumab is a human monoclonal antibody and is unlikely to be inherently hepatotoxic. (nih.gov)

Anatomy45

Organisms15

Diseases59

Chemicals and Drugs17

Analytical, Diagnostic and Therapeutic Techniques and Equipment62

Psychiatry and Psychology12

Phenomena and Processes74

Disciplines and Occupations2

Anthropology, Education, Sociology and Social Phenomena1

Information Science7

Named Groups1

Health Care17

Known to induce2

Retinal3

Tumors4

Hepatic1

Skeletal muscle2

Diseases7

Patients21

Severe6

Abnormal4

Vascular3

Clinically2

Therapy6

Intravenous6

Huntington's2

Marrow1

Surgically1

Inhibit2

Concentrations3

Antigen1

Etiology1

Antipsychotic1

Interactions2

Apoptosis1

Laboratory2

Stimuli2

Potentiate1

Toxicity occurs1

Intoxication1

Newborn2

Dantrolene1

Withdrawal1

Cell12

Symptoms2

Dose2

Fibrosis9

Hepatotoxicity1

Adults2

Anorexia1

Syndrome3

Mild1

Preclinical1

Structural1

Liver disease1

Phenobarbital1

Immunosuppressive1

Interferon2

Pathological1

Describe1

Serum1

Therapies1

Inhibition1

Exposures1

Exposure4

Doses3

Treatment7

Blood2

Immunity1

Antimalarial4

Susceptible1

Pharmacology1

Medication2

Antineoplastic1

Modifications1

Substance2

Regimens1

Gastrointestinal tract1

Feces1

Antifungal1

Monoclonal2