• necrosis
  • Warfarin necrosis usually occurs three to five days after drug therapy is begun, and a high initial dose increases the risk of its development. (wikipedia.org)
  • In one third of cases, warfarin necrosis occurs in patients with an underlying, innate and previously unknown deficiency of protein C. The condition is related to purpura fulminans, a complication in infants with sepsis (blood stream infection) which also involves skin necrosis. (wikipedia.org)
  • Many conditions mimic or may be mistaken for warfarin necrosis, including pyoderma gangrenosum or necrotizing fasciitis. (wikipedia.org)
  • Based on the assumption that low levels of protein C are involved in the underlying mechanism, common treatments in this setting include fresh frozen plasma or pure activated protein C. Since the clot-promoting effects of starting administration of 4-hydroxycoumarins are transitory, patients with protein C deficiency or previous warfarin necrosis can still be restarted on these drugs if appropriate measures are taken. (wikipedia.org)
  • Warfarin necrosis List of cutaneous conditions Rapini, Ronald P. (wikipedia.org)
  • spontaneously
  • This condition can cause a tendency toward prolonged or excessive bleeding (bleeding diathesis), which may occur spontaneously or following an injury or medical and dental procedures. (wikipedia.org)
  • In hemophilia it may occur spontaneously, and recurrent hemarthroses are a major cause of disability in that patient group due to hemophilic arthropathy, requiring synovectomy, joint replacement and increased medical therapy to prevent further bleeding episodes. (wikipedia.org)
  • arterial
  • However, at least one retrospective series 6 showed a tendency for arterial strokes to occur throughout pregnancy, with a higher incidence in the third trimester and postpartum period. (bmj.com)
  • A venous ulcer tends to occur on the medial side of the leg, typically around the medial malleolus in the 'gaiter area' whereas arterial ulcer tends to occur on lateral side of the leg and over bony prominences. (wikipedia.org)
  • purple toe synd
  • Cholesterol embolism (often cholesterol crystal embolism or atheroembolism, sometimes blue toe or purple toe syndrome or trash foot or warfarin blue toe syndrome) occurs when cholesterol is released, usually from an atherosclerotic plaque, and travels as an embolus in the bloodstream to lodge (as an embolism) causing an obstruction in blood vessels further away. (wikipedia.org)
  • nonsteroidal
  • Side effects and drug interactions with nonsteroidal anti-inflammatory drugs may occur, and caution exists for a variety of conditions, such as pregnancy and cardiovascular disorders. (wikipedia.org)
  • clinical
  • Although the clinical covariates and key pharmacogenetic loci for warfarin have been characterized, our association metric identifies a significant association with mutations distributed throughout the pathway of warfarin metabolism. (biomedcentral.com)
  • It should also be remembered that there are interactions that, from a theoretical standpoint, may occur but in clinical practice have no important repercussions. (wikipedia.org)
  • different mechanism
  • Prevention of clotting in arteries is usually undertaken with antiplatelet drugs, which act by a different mechanism from warfarin (which normally has no effect on platelet function). (wikipedia.org)
  • venous
  • The same study showed that most venous events occurred in the puerperium. (bmj.com)
  • Venous ulcers (venous insufficiency ulceration, stasis ulcers, stasis dermatitis, varicose ulcers, or ulcus cruris) are wounds that are thought to occur due to improper functioning of venous valves, usually of the legs (hence leg ulcers). (wikipedia.org)
  • It is in the crus that the classic venous stasis ulcer occurs. (wikipedia.org)
  • citation needed
  • When it occurs repeatedly in different locations, it is known as thrombophlebitis migrans, (migrating thrombophlebitis)[citation needed] Play media The following symptoms or signs are often associated with thrombophlebitis, although thrombophlebitis is not restricted to the veins of the legs. (wikipedia.org)
  • Interactions
  • These interactions may occur out of accidental misuse or due to lack of knowledge about the active ingredients involved in the relevant substances. (wikipedia.org)
  • It is also possible for interactions to occur outside an organism before administration of the drugs has taken place. (wikipedia.org)
  • effects
  • Although not all of these side effects may occur, if they do occur they may need medical attention. (drugs.com)
  • Some side effects of warfarin may occur that usually do not need medical attention. (drugs.com)
  • In particular, we find that at least 1% of the missing heritability in warfarin dose may be due to the aggregated effects of variations in the warfarin metabolic pathway, even though the SNPs do not individually show a significant association. (biomedcentral.com)
  • The interaction of the two drugs may also increase the risk that side effects will occur. (wikipedia.org)
  • An "additive synergy" occurs when the final effect is equal to the sum of the effects of the two drugs (Although some authors argue that this is not true synergy). (wikipedia.org)
  • A few days are required for full effect to occur and these effects can last for up to five days. (wikipedia.org)
  • The drug should not be taken with any MAOIs (monoamine oxidase inhibitors), as unknown and potentially fatal effects may occur. (wikipedia.org)
  • Hemorrhage
  • If emboli have spread to the digestive tract, reduced appetite, nausea and vomiting may occur, as well as nonspecific abdominal pain, gastrointestinal hemorrhage (vomiting blood, or admixture of blood in the stool), and occasionally acute pancreatitis (inflammation of the pancreas). (wikipedia.org)
  • stable
  • intervals between tests can be lengthened if the patient manages stable therapeutic INR levels on an unchanged warfarin dose. (wikipedia.org)
  • kidney
  • It is specifically used to prevent gout, prevent specific types of kidney stones, and for the high uric acid levels that can occur with chemotherapy. (wikipedia.org)
  • drugs
  • Competition between two drugs for cytochrome P450 isozymes will occur. (podiatrytoday.com)
  • People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). (wikipedia.org)
  • If a patient is taking two drugs and one of them increases the effect of the other it is possible that an overdose may occur. (wikipedia.org)
  • This can occur when two drugs are mixed, for example, in a saline solution prior to intravenous injection. (wikipedia.org)
  • cases
  • Complete resolution of endometrial lesions occurs in the majority of cases. (nih.gov)
  • Very rarely the ulcerated plaque is below the aortic bifurcation and those cases the changes occur only in one lower extremity. (wikipedia.org)
  • levels
  • Coagulopathy may also occur as a result of dysfunction or reduced levels of platelets (small disk-shaped bodies in the bloodstream that aid in the clotting process). (wikipedia.org)
  • registry
  • 5543-58-8 (R)-(+) isomer RTECS registry number: GN4550000 1.2 Physical and Chemical Properties Warfarin forms colourless crystals. (inchem.org)