Loading...
  • spontaneously
  • This condition can cause a tendency toward prolonged or excessive bleeding (bleeding diathesis), which may occur spontaneously or following an injury or medical and dental procedures. (wikipedia.org)
  • In hemophilia it may occur spontaneously, and recurrent hemarthroses are a major cause of disability in that patient group due to hemophilic arthropathy, requiring synovectomy, joint replacement and increased medical therapy to prevent further bleeding episodes. (wikipedia.org)
  • intracranial
  • Tested in the PROTECT-AF study, the Watchman device was found to be non-inferior to warfarin in the occurrence of stroke, cardiovascular or unexplained death, or systemic emboli for up to 3 years with less intracranial haemorrhages. (royalsocietypublishing.org)
  • Intracranial hemorrhage (ie, the pathological accumulation of blood within the cranial vault) may occur within brain parenchyma or the surrounding meningeal spaces. (medscape.com)
  • dose
  • Active interventions in the review were low-dose aspirin and warfarin. (york.ac.uk)
  • Adjust the warfarin dose to maintain a target INR of 2.5 (INR range, 2.0 to 3.0) for all treatment durations. (rxlist.com)
  • In particular, we find that at least 1% of the missing heritability in warfarin dose may be due to the aggregated effects of variations in the warfarin metabolic pathway, even though the SNPs do not individually show a significant association. (biomedcentral.com)
  • Approximately 30% of the variability in warfarin dose requirement is explained by the genetics of VKORC1 and CYP2C9. (biomedcentral.com)
  • intervals between tests can be lengthened if the patient manages stable therapeutic INR levels on an unchanged warfarin dose. (wikipedia.org)
  • arterial
  • However, at least one retrospective series 6 showed a tendency for arterial strokes to occur throughout pregnancy, with a higher incidence in the third trimester and postpartum period. (bmj.com)
  • purple toe synd
  • Cholesterol embolism (often cholesterol crystal embolism or atheroembolism, sometimes blue toe or purple toe syndrome or trash foot or warfarin blue toe syndrome) occurs when cholesterol is released, usually from an atherosclerotic plaque, and travels as an embolus in the bloodstream to lodge (as an embolism) causing an obstruction in blood vessels further away. (wikipedia.org)
  • therapy
  • A significant correlation was identified between increasing factor VIII levels and years on warfarin therapy ( r =0.78, P =0.01), suggesting a possible factor VIII compensatory mechanism. (ahajournals.org)
  • Standardization of warfarin therapy with the INR is a great improvement over monitoring by PT alone. (ahajournals.org)
  • Warfarin was not included in the adherence measure as frequent dosing adjustments that occur with warfarin therapy make accurate adherence calculation improbable. (bio-medicine.org)
  • Heparin can lower the platelet count through two mechanisms: a direct effect on platelets that occurs within 2 days, usually resolves despite continued therapy, and is of no clinical consequence, or immune heparin-induced thrombocytopenia (HIT). (renalandurologynews.com)
  • When initiating warfarin therapy ("warfarinization"), the doctor will decide how strong the anticoagulant therapy needs to be. (wikipedia.org)
  • This drug eruption usually occurs between the third and tenth days of therapy with warfarin derivatives. (wikipedia.org)
  • This therapy may be given either to treat bleeding that has already begun or to prevent bleeding from occurring. (wikipedia.org)
  • It is not clear, due to lack of sufficient data, if preventative therapy with clotting factor concentrate is also effective at reducing joint deterioration if treatment is started after joint damage has occurred. (wikipedia.org)
  • dicoumarol
  • Dicoumarol does affect coagulation, and was discovered in mouldy wet sweet-clover hay, as the cause of a naturally occurring bleeding disease in cattle. (wikipedia.org)
  • Dicoumarol itself, for a short time, was employed as a medicinal anticoagulant drug, but since the mid-1950s has been replaced by its simpler derivative warfarin, and other 4-hydroxycoumarin drugs. (wikipedia.org)
  • dabigatran
  • However, concerns exist about potential worse outcomes in dabigatran users if bleeding occurs, given the lack of approved reversal agents. (ahajournals.org)
  • Propensity score-adjusted risk ratios and 95% confidence intervals of in-hospital mortality comparing current users of dabigatran versus warfarin were estimated using relative risk regression. (ahajournals.org)
  • Compared with warfarin users, the propensity score-adjusted risk ratio (95% confidence interval) of mortality in dabigatran users was 0.93 (0.62-1.37). (ahajournals.org)
  • Pursuit of novel drug alternatives have led to the licence of a new contender (Dabigatran) with a more attractive pharmacotherapeutic profile, some 50 years after warfarin was introduced for human use. (royalsocietypublishing.org)
  • different mechanism
  • Prevention of clotting in arteries is usually undertaken with antiplatelet drugs, which act by a different mechanism from warfarin (which normally has no effect on platelet function). (wikipedia.org)
  • veins
  • When it occurs repeatedly in different locations, it is known as thrombophlebitis migrans, (migrating thrombophlebitis)[citation needed] Play media The following symptoms or signs are often associated with thrombophlebitis, although thrombophlebitis is not restricted to the veins of the legs. (wikipedia.org)
  • onset
  • Warfarin has a reasonably predictable onset and duration of action, along with excellent bioavailability. (ahajournals.org)
  • peak incidence occurs in the second and third decades and a late-onset minor peak between 60 and 80 years. (uspharmacist.com)
  • effects
  • Although not all of these side effects may occur, if they do occur they may need medical attention. (drugs.com)
  • Some side effects of warfarin may occur that usually do not need medical attention. (drugs.com)
  • The interaction of the two drugs may also increase the risk that side effects will occur. (wikipedia.org)
  • An "additive synergy" occurs when the final effect is equal to the sum of the effects of the two drugs (Although some authors argue that this is not true synergy). (wikipedia.org)
  • A few days are required for full effect to occur and these effects can last for up to five days. (wikipedia.org)
  • The drug should not be taken with any MAOIs (monoamine oxidase inhibitors), as unknown and potentially fatal effects may occur. (wikipedia.org)
  • Hemorrhage
  • If emboli have spread to the digestive tract, reduced appetite, nausea and vomiting may occur, as well as nonspecific abdominal pain, gastrointestinal hemorrhage (vomiting blood, or admixture of blood in the stool), and occasionally acute pancreatitis (inflammation of the pancreas). (wikipedia.org)
  • drug
  • Warfarin oral tablet is available as both a generic and brand-name drug. (healthline.com)
  • People taking antidepressant drugs such as monoamine oxidase inhibitors should not take food containing tyramine as hypertensive crisis may occur (an example of a drug-food interaction). (wikipedia.org)
  • It is possible that an interaction will occur between a drug and another substance present in the organism (i.e. foods or alcohol). (wikipedia.org)
  • Or in certain specific situations a drug may even react with itself, such as occurs with dehydration. (wikipedia.org)
  • Both synergy and antagonism can both occur during different phases of the interaction of a drug with an organism, with each effect having a different name. (wikipedia.org)
  • Tissue damage and edema may also occur if the drug is injected repetitively into the same vein. (wikipedia.org)
  • Thiamazole is a drug used to treat hyperthyroidism such as in Graves' disease, a condition that occurs when the thyroid gland begins to produce an excess of thyroid hormone. (wikipedia.org)
  • levels
  • It is specifically used to prevent gout, prevent specific types of kidney stones, and for the high uric acid levels that can occur with chemotherapy. (wikipedia.org)
  • Coagulopathy may also occur as a result of dysfunction or reduced levels of platelets (small disk-shaped bodies in the bloodstream that aid in the clotting process). (wikipedia.org)