• primarily
  • Occurring primarily in adolescent boys, OSD is the result of a lesion that grows on the surface of the tibia, in the area of the epiphysis. (faqs.org)
  • Bowing of one or both legs that may: Be rapidly progressive Appear asymmetric Primarily occur just below the knee Failure to treat Blount's disease may lead to progressive deformity.Blount's disease may come back after surgery, especially in younger children. (wikipedia.org)
  • capitellum
  • Some doctors believe that Panner's disease is a precursor to a separate but similar condition called osteochondritis dissecans of the capitellum (OCD), which occurs in older kids. (kidshealth.org)
  • When the cells within the growth plate of the capitellum die, the surrounding bone softens and collapses, causing the knob of the capitellum to become flat. (kidshealth.org)
  • The radiograph will enable the doctor to visualize irregularities and see the shape of the capitellum and also visualize the growth plate. (wikipedia.org)
  • In Panner Disease, the capitellum may appear flat and the bone growth plate will look irregular and fragmented. (wikipedia.org)
  • Symptoms
  • The specific age of onset for gigantism varies between patients and gender, but the common age that excessive growth symptoms start to appear has been found to be around 13 years. (wikipedia.org)
  • Causes
  • This typical G380R mutation actually increases the ability of the FGFR-3 protein to slow bone growth and causes the features of achondroplasia. (nemours.org)
  • Despite much research, the causes remain unclear but include repetitive physical trauma, ischemia (restriction of blood flow), hereditary and endocrine factors, avascular necrosis (loss of blood flow), rapid growth, deficiencies and imbalances in the ratio of calcium to phosphorus, and problems of bone formation. (wikipedia.org)
  • Physical stress causes multiple tiny fractures where the middle of the metatarsal meets the growth plate. (wikipedia.org)
  • tibia
  • Other times, the growth of just the outer half of the tibia can be surgically restricted to allow the child's natural growth to reverse the bowing process. (wikipedia.org)
  • hormone
  • Growth hormone releasing hormone (GHRH) is produced by the ________________ (specific region of brain). (brainscape.com)
  • Gigantism is characterized by an excess of growth hormone (GH). (wikipedia.org)
  • They can also cause overproduction of GH's hypothalamic precursor known as growth hormone releasing hormone (GHRH). (wikipedia.org)
  • As a result of the excessive amounts of growth hormone, children achieve heights that are well above normal ranges. (wikipedia.org)
  • Growth hormone (GH) and insulin-like growth factor-I (IGF-I) are two different substances that have been identified as influencing growth plate formation and bone growth and, therefore, gigantism. (wikipedia.org)
  • Growth hormone is a precursor (upstream) of IGF-I, but each have their own independent roles in hormonal pathways. (wikipedia.org)
  • Evaluation of growth hormone hyper-secretion cannot be excluded with a single normal GH level due to diurnal variation. (wikipedia.org)
  • Gigantism is the primary example of growth hormone hyper-secretion disorders, a group of illnesses that are not yet deeply understood. (wikipedia.org)
  • embryonic
  • More broadly, GH and IGF have both been identified to be involved most stages of growth: embryonic, prenatal, and postnatal. (wikipedia.org)
  • tenderness
  • Over time, repeated stress (force or pressure) on the already tight Achilles tendon damages the growth plate, causing the swelling, tenderness, and pain of Sever's disease. (kidshealth.org)
  • closure
  • The authors concluded their data suggested that a "cam-type deformity is in part a developmental deformity," and that its appearance in young adults "may be triggered by environmental factors such as high-level sports activity during childhood and around the time of closure of the capital growth plate. (emaxhealth.com)
  • Excessive leaping prior to growth plate closure can create problems in later years. (discdogg.com)
  • infection
  • The infection can occur in the respiratory or urinary tracts, as it is a part of the normal flora in those two areas, and will develop into septicemia or septic arthritis. (wikipedia.org)
  • This may be a birth defect or it may occur after a broken leg, serious infection, or local damage to one of the growth plates in a leg. (wikipedia.org)
  • disease
  • The condition is associated with biochemical abnormalities, bone deformities, developmental delays, impaired growth and sometimes even seizures (in the late course of disease). (news-medical.net)
  • severe
  • In severe cases, surgery can be used to make the longer leg shorter (or impede its growth), and/or make the shorter leg longer. (wikipedia.org)