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  • onset
  • however, the onset of stage II occurs within months and offers little time for diagnosis. (wikipedia.org)
  • The specific age of onset for gigantism varies between patients and gender, but the common age that excessive growth symptoms start to appear has been found to be around 13 years. (wikipedia.org)
  • primarily
  • Growth plate injuries are twice as likely to occur in boys as in girls, due primarily to the fact that girls reach physical maturation approximately two years earlier than boys, coupled with the greater degree of participation of boys in physically riskier activities. (faqs.org)
  • Occurring primarily in adolescent boys, OSD is the result of a lesion that grows on the surface of the tibia, in the area of the epiphysis. (faqs.org)
  • Bowing of one or both legs that may: Be rapidly progressive Appear asymmetric Primarily occur just below the knee Failure to treat Blount's disease may lead to progressive deformity.Blount's disease may come back after surgery, especially in younger children. (wikipedia.org)
  • capitellum
  • Some doctors believe that Panner's disease is a precursor to a separate but similar condition called osteochondritis dissecans of the capitellum (OCD), which occurs in older kids. (kidshealth.org)
  • When the cells within the growth plate of the capitellum die, the surrounding bone softens and collapses, causing the knob of the capitellum to become flat. (kidshealth.org)
  • The radiograph will enable the doctor to visualize irregularities and see the shape of the capitellum and also visualize the growth plate. (wikipedia.org)
  • In Panner Disease, the capitellum may appear flat and the bone growth plate will look irregular and fragmented. (wikipedia.org)
  • epiphysis
  • Growth plates are located between the widened part of the shaft of the bone (the metaphysis) and the end of the bone (the epiphysis). (aaos.org)
  • Slipped capital femoral epiphysis (SCFE) is a hip condition that occurs in teens and pre-teens who are still growing. (aaos.org)
  • Causes
  • What causes growth plate injuries? (arthroscopy.com)
  • This typical G380R mutation actually increases the ability of the FGFR-3 protein to slow bone growth and causes the features of achondroplasia. (nemours.org)
  • Despite much research, the causes remain unclear but include repetitive physical trauma, ischemia (restriction of blood flow), hereditary and endocrine factors, avascular necrosis (loss of blood flow), rapid growth, deficiencies and imbalances in the ratio of calcium to phosphorus, and problems of bone formation. (wikipedia.org)
  • Physical stress causes multiple tiny fractures where the middle of the metatarsal meets the growth plate. (wikipedia.org)
  • Blount's disease is a growth disorder of the tibia (shin bone) that causes the lower leg to angle inward, resembling a bowleg. (wikipedia.org)
  • tibia
  • Other times, the growth of just the outer half of the tibia can be surgically restricted to allow the child's natural growth to reverse the bowing process. (wikipedia.org)
  • tenderness
  • Over time, repeated stress (force or pressure) on the already tight Achilles tendon damages the growth plate, causing the swelling, tenderness, and pain of Sever's disease. (kidshealth.org)
  • closure
  • The authors concluded their data suggested that a "cam-type deformity is in part a developmental deformity," and that its appearance in young adults "may be triggered by environmental factors such as high-level sports activity during childhood and around the time of closure of the capital growth plate. (emaxhealth.com)
  • Excessive leaping prior to growth plate closure can create problems in later years. (discdogg.com)
  • infection
  • The infection can occur in the respiratory or urinary tracts, as it is a part of the normal flora in those two areas, and will develop into septicemia or septic arthritis. (wikipedia.org)
  • This may be a birth defect or it may occur after a broken leg, serious infection, or local damage to one of the growth plates in a leg. (wikipedia.org)
  • disease
  • The condition is associated with biochemical abnormalities, bone deformities, developmental delays, impaired growth and sometimes even seizures (in the late course of disease). (news-medical.net)
  • severe
  • In severe cases, surgery can be used to make the longer leg shorter (or impede its growth), and/or make the shorter leg longer. (wikipedia.org)
  • likely
  • The swelling is most likely to be visible if the sarcoma is located on a bone near the surface of the body, but when it occurs in other places deeper in the body, like on the pelvis, it may not be visible. (wikipedia.org)
  • A latent cyst is located away from the epiphyseal plate and is more likely to heal with treatment. (wikipedia.org)
  • young
  • Before attempting airborne maneuvers with a young dog always consult with your vet to be sure growth plates have closed. (discdogg.com)
  • Ewing sarcoma occurs most frequently in teenagers and young adults, with a male/female ratio of 1.6:1. (wikipedia.org)
  • largely
  • Although the Holocaust occurred largely in German-occupied Poland, there was little collaboration with the Nazis by its citizens. (wikipedia.org)
  • In free air, solid fuels burn at a temperature of only about 240 °C (464 °F), which is too low a temperature for perfect combustion reactions to occur, heat produced through convection is largely lost, smoke particles are evolved without being fully burned and the supply of combustion air cannot be readily controlled. (wikipedia.org)
  • temperature
  • B. dendrobatidis can grow within a wide temperature range (4-25 °C), with optimal temperatures being between 17-25 °C. The wide temperature range for growth, including the ability to survive at 4 °C gives the fungus the ability to overwinter in its hosts, even where temperatures in the aquatic environments are low. (wikipedia.org)
  • Thus
  • Near the end of the 18th century, the design was refined by hanging the pots in holes through the top iron plate, thus improving heat efficiency even more. (wikipedia.org)
  • several
  • The conversion of a protein from a monomer to a large, ordered multimer could occur by several mechanisms, but the first step probably involves the formation of a seed. (elifesciences.org)
  • Only in 1735 did the first design that completely enclosed the fire appear: the Castrol stove of the French architect François de Cuvilliés was a masonry construction with several fireholes covered by perforated iron plates. (wikipedia.org)
  • upper
  • Variation in the behaviour of the slides is significant, with some slides barely keeping up with the growth on the upper part of the volcano while others may surge forward great distances, attaining landslide lengths greater than 200 km. (wikipedia.org)
  • Esthesioneuroblastoma occurs in the upper nasal cavity, near the optic nerves and optic chiasm. (wikipedia.org)
  • The petals consist of a claw and plate (or lamina) and the upper two have an almost elliptical lamina, with a blunt tip and wavy margins, each about 12-17×5-12 mm, while the lower three have longer claws, are indented at the tip and about 10-17×3-10 mm. (wikipedia.org)
  • known
  • The growth of martensite phase requires very little thermal activation energy because it is a diffusionless transformation, which results in the subtle but rapid rearrangement of atomic positions, and has been known to occur even at cryogenic temperatures. (wikipedia.org)
  • cell
  • This previously unidentified progenitor occurs as a temporally discrete population during ES cell differentiation, and differs from the preceding and succeeding populations in gene expression and differentiation potential, with the unique ability to form surface ectoderm in response to BMP4 signalling. (biologists.org)
  • Mechanistic studies showed that the synergistic cell death was not due to an increase in viral replication but occurred through an enhancement of apoptotic cell death. (biomedcentral.com)
  • Hyam's Histopathological Grades for Esthesioneuroblastoma Esthesioneuroblastoma can resemble small blue cell tumors like squamous cell carcinoma, sinonasal undifferentiated carcinoma, extranodal NK/T cell lymphoma, nasal type, rhabdomyosarcoma, Ewing/PNET, mucosal malignant melanoma and neuroendocrine carcinomas (NEC) that occur in the intranasal tract. (wikipedia.org)
  • region
  • An example of landslides caused by overpressure due to rapid deposition occurred in 1969 on the Mississippi delta after Hurricane Camile struck the region. (wikipedia.org)
  • During mandible development, most of it is formed through intramembranous ossification, where endochondral ossification will occur in the proximal region. (wikipedia.org)
  • years
  • Naturally occurring as well as synthetic steroidal glucocorticoids have been widely used for over fifty years for the treatment of acute and chronic inflammatory and immune disorders such as rheumatoid arthritis, osteoarthritis, rheumatic fever, asthma, allergic rhinitis, systemic lupus erythematosus, chronic obstructive pulmonary disease, Crohn's disease, inflammatory bowel disease, and ulcerative colitis. (patentsencyclopedia.com)
  • The rhizomes are placed on the surface of the soil facing towards the sun and with at least 45 cm of open ground in front of them - this allows two years growth and flowering. (wikipedia.org)
  • side
  • pontica Illustration from The Botanical Magazine, Plate 16 (Volume 1, 1787 Downward view of iris side view of iris Orris root "Iris variegata L". theplantlist.org. (wikipedia.org)