Occur topotecan. Medical search. Frequent questions

Topotecan, sold under the brand name Hycamtin among others, is a chemotherapeutic agent medication that is a topoisomerase inhibitor. (wikipedia.org)
HYCAMTIN (topotecan) for injection, for intravenous use is supplied as a sterile, lyophilized, buffered, light yellow to greenish powder available in single-dose vials. (globalrph.com)
In contrast, O'Reilly et al evaluated topotecan (Hycamtin), anothertopoisomerase I inhibitor, in 27 previously untreated advanced pancreatic cancerpatients, and noted no responses. (cancernetwork.com)

Acute vomiting refers to symptoms that occur within 24 hours of the administration of chemotherapy. (medscape.com)
It is important to remember that interactions do occur with all types of drugs, to a great or lesser extent and this article details the interactions of mixing chemotherapy and Weed. (worldsbest.rehab)
After 4 cycles of chemotherapy with topotecan and etoposide, 131 I-MIBG treatment was performed at a dose of 18 mCi/kg. (biomedcentral.com)
Avastin, in combination with paclitaxel, pegylated liposomal doxorubicin or topotecan, is approved to treat platinum-resistant recurrent epithelial ovarian, fallopian tube or primary peritoneal cancer (prOC) in women who received no more than two prior chemotherapy treatments. (avastin.com)
GTHX ), a commercial-stage oncology company, today announced that the U.S. Food and Drug Administration (FDA) has approved COSELA™ (trilaciclib) for injection to decrease the incidence of chemotherapy-induced myelosuppression in adult patients when administered prior to a platinum/etoposide-containing regimen or topotecan-containing regimen for extensive-stage small cell lung cancer (ES-SCLC). (g1therapeutics.com)
The patient arm of Ewing sarcoma patients receiving seclidemstat with chemotherapy drugs topotecan and cyclophosphamide (TC) advanced to the second lead-in safety cohort of patients receiving seclidemstat at 900 mg BID in combination with the two chemo drugs. (biospace.com)
Trying the same chemotherapy regimen again is recommended for relapses that occur more than 6 months after the initial therapy. (healthline.com)
If your relapse occurs within 6 months of your treatment, it's generally recommended to try a different regimen with a single chemotherapy drug. (healthline.com)
The response rate of platinum-based chemotherapy plus etoposide is more than 60% , and a complete response occurs in about 10% of people. (healthline.com)
Symptoms of mouth sores commonly occur three to ten days following your treatment with chemotherapy. (vacancer.com)
All patients received multi-agent induction chemotherapy for 6 cycles, including an initial 2 cycles of high-dose cyclophosphamide plus topotecan followed by blood stem cell collection. (oncologynurseadvisor.com)

If resolution occurs after 7 days, resume capmatinib treatment at a reduced dose. (pdr.net)

Topotecan is often given in combination with paclitaxel as first line treatment for extensive-stage small-cell lung cancer. (wikipedia.org)
After the recurrence of disease on the paclitaxel, cisplatin, and bevacizumab regimen, the next option may be single-agent topotecan or bevacizumab, notes Michael J. Birrer, MD. In August 2014, the FDA approved bevacizumab in combination with paclitaxel plus cisplatin or topotecan as a treatment for women with persistent, recurrent, or metastatic cervical cancer. (onclive.com)
It is indicated in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan. (medscape.com)
Alymsys, in combination with paclitaxel and cisplatin or paclitaxel and topotecan, is indicated for the treatment of patients with persistent, recurrent, or metastatic cervical cancer. (mdtodate.com)
The recommended dosage is 15 mg/kg intravenously every 3 weeks in combination with paclitaxel and cisplatin or in combination with paclitaxel and topotecan. (mdtodate.com)
The recommended dosage is 10 mg/kg intravenously every 2 weeks in combination with paclitaxel, pegylated liposomal doxorubicin, or topotecan (every week). (mdtodate.com)

Phase 1 Study of Cabozantinib in Combination with Topotecan- Cyclophosphamide for Pat. (authorea.com)
Purpose Phase 1 study assessing the safety and toxicity of cabozantinib in combination with topotecan and cyclophosphamide for relapsed osteosarcoma and Ewing sarcoma. (authorea.com)
Topotecan (0.75mg/m 2) and cyclophosphamide (250mg/m 2) were administered IV on days 1-5. (authorea.com)
Conclusions The recommended phase 2 doses and schedules for this combination are topotecan 0.75mg/m 2 IV days 1-5, cyclophosphamide 250mg/m 2 IV days 1-5, and cabozantinib 25mg/m 2 days 8-21. (authorea.com)
Phase I study of oral cyclophosphamide and oral topotecan for children with recurrent or refractory solid tumors. (utsouthwestern.edu)

While FL118 is an analogue of irinotecan and topotecan, two FDA-approved cancer drugs that are also based on the naturally occurring compound camptothecin, our findings add further evidence that FL118 has novel mechanisms of action that may make it especially potent against solid tumors and especially effective as a well-tolerated, targeted therapy," co-lead researcher Fengzhi Li, PhD, said in a press release. (pharmacytimes.com)
Several derivatives of camptothecin, such as irinotecan and topotecan, have been developed and approved for the treatment of various cancers, including colorectal, lung, and ovarian cancers. (selfgrowth.com)

Bone marrow suppression (primary neutropenia) is the dose-limiting toxicity of topotecan. (medicscientist.com)
If an overdose occurs the patient must be monitored for evidence of toxicity. (aiopharma.com)

Myelosuppression is more severe when topotecan is given in combination with cisplatin. (medicscientist.com)
Dosage adjustments for subsequent courses of Topotecan in combination with cisplatin are specific for each drug. (ptmasterguide.com)
Topotecan or lurbinectedin may be used alone to treat SCLC that has spread to other organs, especially if cisplatin and carboplatin are not effective. (healthline.com)

Topotecan is a semi-synthetic derivative of camptothecin. (wikipedia.org)
Topotecan, a water-soluble semisynthetic analogue of camptothecin, is the first topoisomerase I inhibitor to undergo evaluation in pediatric patients with refractory malignancies. (elsevierpure.com)
Nuclear magnetic resonance data indicate that cleavage of the piperazino moiety occurred at the N-C bond of the B-ring, yielding 7-methyl-10,11-ethylenedioxy-20(S)-camptothecin (MEC). (eur.nl)
Tests of the growth inhibition potential of MEC in seven human tumor cell lines showed that the compound was approximately 2-18-fold more cytotoxic than lurtotecan, topotecan, and 7-ethyl-10-hydroxy-20(S)-camptothecin (SN-38). (eur.nl)

The recurrence, which presented with multiple metastases in the bone marrow, occurred 2 years after PBSCT (Figure 1 A). At this time, VAM and HVA had increased to 273.5 and 87.7 μg/mg Cr, respectively. (biomedcentral.com)
To date, approaches have included the use of growth factor agents to accelerate blood cell recovery after the bone marrow injury has occurred, along with antibiotics and transfusions as needed. (g1therapeutics.com)

Using these models, we attempted treatment of xenografts with topotecan - a known anticancer drug and artemisinin dimer oxime or combination of these two drugs. (wjtcm.net)
Objectives: Despite safe handling guidelines published by several groups, health care worker exposure to hazardous drugs continues to occur due to suboptimal engineering control s and low use of protective equipment. (cdc.gov)

Experimental Design: Patients received fludarabine (10 to 15 mg/m2 × 5 days), carboplatin (area under the curve 10 to 12 by continuous infusion over 5 days), followed by escalated doses of topotecan infused over 72 hours (fludarabine, carboplatin, topotecan regimen). (ncl.ac.uk)
Maximum tolerated dose of fludarabine, carboplatin, topotecan regimen was fludarabine 15 mg/m2 × 5, carboplatin area under the curve 12, and topotecan 2.55 mg/m2 over 72 hours. (ncl.ac.uk)
Conclusions: Fludarabine, carboplatin, topotecan regimen is a promising treatment based on potential pharmacodynamic interactions, which merits additional study in poor prognosis, acute leukemia patients. (ncl.ac.uk)

Topotecan belongs to the group of medicines called antineoplastics. (mayoclinic.org)

Administer topotecan under the supervision of a health care provider experienced in the use of cancer chemotherapeutic agents. (medicscientist.com)
From this preliminary study, it appears that combination of dimer oxime and topotecan may be used as chemotherapeutic agents against nonsmall cell lung cancer. (wjtcm.net)

Each 4 mg vial contains 4 mg topotecan hydrochloride as free base. (globalrph.com)

After GlaxoSmithKline received final FDA approval for topotecan on October 15, 2007, it became the first topoisomerase I inhibitor for oral use. (wikipedia.org)
Topotecan inhibits topoisomerase I restoring UBE3A levels to wild-type range in cultured mince neurons. (wikipedia.org)
The binding of topotecan in the cleavage complex prevents topoisomerase-I from religating the nicked DNA strand after relieving the strain. (wikipedia.org)
When the replication-fork collides with the trapped topoisomerase-I, DNA damage occurs. (wikipedia.org)
Topotecan is a topoisomerase inhibitor. (globalrph.com)

Topotecan injection is used to treat patients with metastatic cancer (a cancer that has already spread) of the ovaries after other treatments have failed. (mayoclinic.org)
Topotecan is used to treat metastatic cancer of the ovary after other treatment(s) have failed. (pharmachoice.com)

Each single dose vial of solution contains topotecan HCL equivalent to 4 mg of topotecan as free base in 4 mL of Sterile Water for Injection USP. (pharmachoice.com)

Of these 16 inhibitors, topotecan was found to induce the strongest upregulation of UBE3A. (wikipedia.org)

Protect vials from light in the original cartons at controlled room temperature 20° to 25°C (68° to 77°F). Reconstituted vials of topotecan diluted for infusion are stable at approximately 20° to 25°C (68° to 77°F) and ambient lighting conditions for 24 hr. (medicscientist.com)

Twenty-nine patients received 42 courses of i.v. topotecan administered as a 24-h continuous infusion every 21 days at doses ranging from 2.0 to 7.5 mg/m2. (elsevierpure.com)
Recommended Dosage: The recommended dose of Topotecan is 1.5 mg/m² by intravenous infusion over 30 minutes daily for 5 consecutive days, starting on day 1 of a 21-day course. (ptmasterguide.com)

When tested on mice in vivo, topotecan affected the hippocampus, striatum and cerebral cortex but not the cerebellum unless a higher dose was administered (21.6 micrograms/hour for five days). (wikipedia.org)
Blood from healthy donors was treated ex vivo with topotecan. (precisionformedicine.com)

Although this dose exceeds the MTD identified in heavily pretreated adult patients receiving topotecan on the same schedule, it is less than the MTD for minimally pretreated adult patients. (elsevierpure.com)

This will be a three-arm clinical trial comparing lurbinectedin in monotherapy or in combination with irinotecan, versus the investigators' choice of irinotecan or topotecan. (1stoncology.com)

Alternatively, in the event of severe neutropenia, administer G-CSF (granulocyte-colony stimulating factor) following the subsequent course (before resorting to dose reduction) starting from day 6 of the course (24 hours after completion of topotecan administration). (ptmasterguide.com)

Severe anemia (grade 3/4, Hgb less than 8 g/dL) occurred. (medicscientist.com)

If filgrastim is used, do not initiate until day 6 of the course of therapy, 24 hr after completion of treatment with topotecan. (medicscientist.com)

As well as interfering with the genetic material DNA of cancer cells, topotecan can interfere with some of your normal cells. (pharmachoice.com)
Cancer occurs when something causes cells to divide and grow out of control. (medlineplus.gov)
Late-occurring stroke among long-term survivors of childhood leukemia and brain tumors: a report from the Childhood Cancer Survivor Study. (utsouthwestern.edu)
Infection with HPV is generally believed to be required for cervical cancer to occur. (wikipedia.org)

Some effects may occur after treatment with topotecan has been stopped. (mayoclinic.org)
The implanted cells were allowed to grow for 10 days before initiation of drug treatment (dimer oxime and topotecan, ip). (wjtcm.net)
EGFR and co-occurring/treatment-emergent (TE) genomic alterations in ctDNA were analyzed using Guardant360 NGS platform. (bvsalud.org)
Monitoring co-occurring alterations and aEGFR+ clearance may provide insights into mechanisms of EGFR tyrosine kinase inhibitor resistance and the patients who may benefit from intensified treatment schedules. (bvsalud.org)
The initial screening of cellular phenotypes showed mixed results in γH2AX induction in response to topotecan treatment. (precisionformedicine.com)
These three phenotypes were further examined in two distinct donors after two hour treatment at two concentrations of topotecan as shown in Figure 1 below. (precisionformedicine.com)
Effects of topotecan treatment on γH2AX+ cell counts. (precisionformedicine.com)
The effects of treatment with topotecan were examined in three cell phenotypes in two donors. (precisionformedicine.com)
Your doctor will stop treatment if any serious side effects occur. (avastin.com)
The recommended dose and dosing schedule of topotecan varies according to body size and the results of blood tests carried out before your treatment. (pharmachoice.com)
Most of the side effects that occurred in the trial were manageable and did not lead to treatment discontinuation. (onclive.com)
No treatment-related deaths have occurred. (cancernetwork.com)

It was designed to mimic a naturally occurring variant of the TTR gene (T119M), a so-called "rescue mutation" that has been shown to prevent or minimize ATTR in people carrying disease-causing mutations in the TTR gene. (biospace.com)
These naturally occurring compounds are known for their diverse chemical structures and profound biological activities. (selfgrowth.com)
Alkaloids are a fascinating group of naturally occurring chemical compounds found in various plants, fungi, and some animals. (selfgrowth.com)

To monitor the extent of DNA damage and ultimately the efficacy of topotecan or similar agents, ApoCell was developed a biomarker assay for the detection of the expression levels of γH2AX. (precisionformedicine.com)

PFS was longer in RAM + ERL, irrespective of baseline co-occurring alterations. (bvsalud.org)
RAM + ERL was associated with improved PFS outcomes, irrespective of detectable/undetectable aEGFR, co-occurring baseline alterations, or aEGFR+ clearance by C4. (bvsalud.org)

Treatments with combination of topotecan and dimer oxime resulted in the reduced mortality rates in comparison with untreated mice. (wjtcm.net)

Perform frequent peripheral blood cell counts on all patients receiving topotecan. (medicscientist.com)

Topotecan often causes nausea and vomiting, but you will be given medications to help control this. (pharmachoice.com)

About 10% of the total population of SCLC patients remains free of disease during the 2 years from the start of therapy, which is the time period during which most relapses occur. (cancer.gov)

The tumor may be solitary or multiple and occurs on the head and on the extremities. (ispub.com)

In the GOG-240 study, genitourinary and gastrointestinal fistulas occurred in approximately 6% of patients, Robert A. Burger, MD, notes. (onclive.com)

1000 cells/mm³ with temperature of 38.0°C or 100.4°F), reduce the dose of Topotecan to 0.60 mg/m² for subsequent courses. (ptmasterguide.com)
If febrile neutropenia occurs despite the use of G-CSF, reduce the dose of Topotecan to 0.45 mg/m² for subsequent courses. (ptmasterguide.com)

It occurs almost exclusively in immunosuppressed individuals, e.g., patients with AIDS, hematological and lymphoreticular malignancies, autoimmune rheumatological diseases, or those having undergone organ transplantation. (medscape.com)
Leukopenia, neutropenia, and thrombocytopenia occurred sporadically at the 3.0- to 5.5-mg/m2 dose levels, but at 7.5 mg/m2 4 of 5 patients experienced dose-limiting thrombocytopenia (grade 4) and 2 of 5 had dose-limiting neutropenia (grade 4). (elsevierpure.com)
Grade 3 or greater infections occurred in all of the patients, and there were 2 infection-related deaths. (ncl.ac.uk)
Sensitive Detection of Gamma-H2AX Induction as a Pharmacodynamic Marker for Profiling Patients Treated with Topotecan. (precisionformedicine.com)
Serious symptomatic bradycardia may occur in patients taking amiodarone, particularly in patients also receiving beta-blockers or those with underlying cardiac comorbidities and/or advanced liver disease. (aiopharma.com)

About 70% of cervical cancers and 90% of deaths occur in developing countries. (wikipedia.org)

ADULTS: IV Topotecan 1.5 mg/m 2 /day over 30 min daily for 5 consecutive days starting on day 1 of a 21-day cycle. (medicscientist.com)

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. (drugs.com)

A phase I and pharmacokinetic study was performed to determine the maximum tolerated dose (MTD) and dose-limiting toxicities, the incidence and severity of other toxicities, and the pharmacokinetics of topotecan in children. (elsevierpure.com)

Neuroblastoma is a tumor of neural crest origin that arises in tissue of sympathetic nervous system and occurs in young children," said lead investigator Julie R. Park, MD, professor of medicine at Seattle Children's Hospital and the University of Washington. (oncologynurseadvisor.com)

Periods of viral replication without any clinical symptoms occur and can be detected when it is shed in the urine. (medscape.com)

Such efforts have not occurred in clinical trials of NHL and thus we are left to examine case series and try to discern its value for this disease. (authorea.com)

Since the growth of normal cells may also be affected by the medicine, other effects may also occur. (mayoclinic.org)

Although the patient developed grade II acute GVHD with skin erythema which was controlled additional predonisolone, no other significant complications occurred. (biomedcentral.com)

HIV-associated PML also occurs during immune recovery following the initiation of highly active antiretroviral therapy (HAART). (medscape.com)

Grade 4 thrombocytopenia (less than 25,000 cells/mm 3 ) occurred. (medicscientist.com)

Diseases10

Chemicals and Drugs11

Analytical, Diagnostic and Therapeutic Techniques and Equipment7

Phenomena and Processes4

Health Care1

Hycamtin3

Chemotherapy11

Reduced dose1

Paclitaxel6

Cyclophosphamide5

Irinotecan and topotecan2

Toxicity2

Cisplatin3

Camptothecin4

Bone marrow2

Drugs2

Regimen3

Belongs to the group1

Chemotherapeutic agents2

Hydrochloride1

Topoisomerase5

Metastatic cancer2

Injection1

Inhibitors1

Vials1

Infusion2

Vivo2

Adult patients1

Lurbinectedin1

Administer1

Severe1

Completion1

Cancer4

Treatment12

Naturally3

Efficacy1

Baseline2

Combination1

Counts1

Nausea1

Relapses1

Extremities1

Gastrointestinal1

Subsequent courses2

Patients5

Cancers1

ADULTS1

Interaction1

Phase1

Tumor1

Symptoms1

Clinical1

Medicine1

Acute1

Initiation1

Thrombocytopenia1