• guanine nucleot
  • Guanine-nucleotide exchange factors (RAPGEF3/RAPGEF4) induce sperm membrane depolarization and acrosomal exocytosis in capacitated stallion sperm. (umass.edu)
  • Due to the recent discovery of cAMP-activated guanine nucleotide exchange factors RAPGEF3 and RAPGEF4 , we sought to investigate the separate roles of PRKACA and RAPGEF3 / RAPGEF4 in modulating capacitation and acrosomal exocytosis. (umass.edu)
  • Three classes of proteins, GTPase‐activating proteins (GAPs), guanine nucleotide dissociation inhibitors (GDIs), and guanine nucleotide exchange factors (GEFs), regulate the cycling of these GTP‐binding proteins between their GDP‐bound and GTP‐bound states ( Boguski and McCormick, 1993 ). (embopress.org)
  • SNPs
  • one of them is the rapid advancement in high‐throughput single nucleotide polymorphisms (SNPs) genotyping technologies which has enabled researchers to comprehensively interrogate the entire human genome. (els.net)
  • Here, we analyzed 2,893 single nucleotide polymorphisms (SNPs) that have been identified in 593 published GWAS as associated with a disease phenotype with respect to their genomic location. (diva-portal.org)
  • We questioned the significance of haplotype structure in gene regulation by testing whether individual single nucleotide polymorphisms (SNPs) within a gene promoter region [interleukin-1-beta (IL1B)] might affect promoter function and, if so, whether function was dependent on haplotype context. (oup.com)