Molecular Sequence DataPolymorphism, Single NucleotidePolymorphism, GeneticNucleotidesProtein ConformationModels, MolecularGenetic Predisposition to DiseaseGene FrequencyAllelesAmino Acid SequenceBase SequenceHaplotypesBinding SitesGenotypePolymorphism, Single-Stranded ConformationalPolymerase Chain ReactionCase-Control StudiesProtein BindingMutationGenetic VariationKineticsAdenine NucleotidesProtein Structure, TertiarySequence Analysis, DNANucleic Acid ConformationDNAProtein Structure, SecondaryCrystallography, X-RayLinkage DisequilibriumGenetic Association StudiesMolecular ConformationCircular DichroismGuanine NucleotidesEscherichia coliThermodynamicsAsian Continental Ancestry GroupCloning, MolecularSpectrometry, FluorescenceAmino Acid SubstitutionPurine NucleotidesAdenosine TriphosphateDNA PrimersPhylogenyPromoter Regions, GeneticPhenotypeProtein FoldingMagnetic Resonance SpectroscopyStructure-Activity RelationshipSequence AlignmentGenetic MarkersSequence Homology, Nucleic AcidCodonMolecular Dynamics SimulationExonsDNA Mutational AnalysisSequence Homology, Amino AcidBacterial ProteinsHomozygoteLigandsTemperatureNuclear Magnetic Resonance, BiomolecularRecombinant ProteinsChromosome MappingMutagenesis, Site-DirectedHydrogen-Ion ConcentrationModels, ChemicalPoint MutationGuanine Nucleotide Exchange FactorsRisk FactorsProtein DenaturationAdenosine DiphosphateHydrogen BondingIntronsComputer SimulationNucleotides, CyclicSpecies SpecificityEuropean Continental Ancestry GroupChinaDNA, BacterialSubstrate SpecificityProteinsCattleHeterozygoteModels, GeneticHydrolysisPyrimidine NucleotidesTranscription, GeneticMethylenetetrahydrofolate Reductase (NADPH2)Cell LineCatalytic DomainGenesCatalysisProtein Structure, QuaternaryAmplified Fragment Length Polymorphism AnalysisEvolution, MolecularRNA, MessengerDimerizationPlasmidsGenome-Wide Association StudyAllosteric Regulation