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RibavirinNucleosidesAntiviral AgentsPurine NucleosidesInterferon-alphaNucleoside Transport ProteinsPolyethylene GlycolsPyrimidine NucleosidesHepatitis C, ChronicRibonucleosidesEquilibrative Nucleoside Transporter 1Drug Therapy, CombinationHepacivirusGuanosineThioinosineRecombinant ProteinsPurine-Nucleoside PhosphorylaseInosineUridineNucleoside-Diphosphate KinaseHepatitis CEquilibrative-Nucleoside Transporter 2RNA, ViralCytidineViral LoadNucleotidesNucleoside QNucleoside-TriphosphataseTreatment OutcomeAdenosineIMP DehydrogenaseFormycinsAmantadineGenotypePentosyltransferasesNM23 Nucleoside Diphosphate KinasesInterferonsReverse Transcriptase InhibitorsEquilibrative Nucleoside Transport ProteinsDeoxyribonucleosidesAdenineDrug Resistance, ViralDeoxyadenosinesHemorrhagic Fever, CrimeanKineticsDilazepZidovudineOrganophosphonatesDideoxynucleosidesTubercidinVirus ReplicationAdenosine KinaseArabinonucleosidesAnti-HIV AgentsPurinesDeoxycytidine KinaseHIV InfectionsPyrimidine PhosphorylasesDipyridamoleThymidineAlanine TransaminaseAerosolsThionucleosidesRibonucleotidesDeoxyuridineZalcitabineUridine PhosphorylaseHypoxanthineChromatography, High Pressure LiquidSubstrate SpecificityMolecular Sequence DataUridine MonophosphateHIV Reverse TranscriptaseHypoxanthinesPyrophosphatasesThymine NucleotidesAcid Anhydride HydrolasesRecurrenceTime FactorsBiological TransportAdenosine TriphosphateDidanosineMolecular StructureCell LineInosine MonophosphateLiver CirrhosisViral Nonstructural ProteinsDideoxynucleotides5'-NucleotidaseNucleoside DeaminasesMutationStavudineMembrane Transport ProteinsGuanineProdrugsDeoxyguanosineRepliconThiouridineHemorrhagic Fever Virus, Crimean-CongoPurine Nucleotides
AnaloguesInterferonAnalogsProdrug of ribavirinRitonavirPurineEquilibrative nucleoside transporterPeginterferon alfa-2a and ribaInhibitorMutagenesisRemdesivirAntiviral agentsAnalogue reverseCapsuleInduceDoseHepatitis C virDoctor or pharmacistSyntheticVitroENT1AdenosineViral infectionsMechanismPatientsAnemiaAnalog drugsDrugZidovudineTreatmentReplicationLiverActivityDrugsPresenceSynthesisChemicalCasesTime
Analogues10
  • Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases, have been reported with the use of nucleoside analogues including lamivudine and zidovudine (components of lamivudine and zidovudine tablets). (nih.gov)
  • Ribavirin is in a class of antiviral medications called nucleoside analogues. (medlineplus.gov)
  • The pyrazole-3-carboxamide derivatives (which are formally considered as 4-deaza-analogues of ribavirin) have shown activity against T-cell lymphocytes and influenza viruses in vitro . (news-medical.net)
  • Ribavirin is a chemically derived pharmaceutical and belongs to a class of drugs called nucleoside analogues. (pharmaceutical-business-review.com)
  • The in vitro susceptibility of the prototype of SARS associated coronavirus to a panel of nucleoside analogues and protease inhibitors currently licensed for clinical use was studied. (bmj.com)
  • Nucleoside analogues such as remdesivir and ribavirin are thought to prevent viral RNA synthesis. (woofahs.com)
  • Although other medications can cause lactic acidosis, most cases have occurred in people using nucleoside analogues (nukes). (catie.ca)
  • The synthesis and in vitro anti-measles virus (anti-MV) activity of a class of ring-expanded ('fat') nucleoside analogues (1-4) containing the title heterocyclic ring system are reported. (usu.edu)
  • Here we apply for the first time phylogenetic methods and Partition Analysis of Quasispecies (PAQ) to monitor genetic distances and intra-population structures of mutant spectra of foot-and-mouth disease virus (FMDV) quasispecies subjected to mutagenesis by base and nucleoside analogues. (biomedcentral.com)
  • Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus. (neb.com)
Interferon9
  • Hepatic decompensation, some fatal, has occurred in HIV-1/HCV co-infected patients receiving combination antiretroviral therapy and interferon alfa with/without ribavirin. (nih.gov)
  • Discontinue lamivudine and zidovudine tablet as medically appropriate and consider dose reduction or discontinuation of interferon alfa, ribavirin, or both. (nih.gov)
  • Ribavirin is used with an interferon medication such as peginterferon alfa-2a [Pegasys] or peginterferon alpha-2b [PEG-Intron]) to treat hepatitis C in people who have not been treated with an interferon before. (medlineplus.gov)
  • Ribavirin BioPartners As a standard treatment, Ribavirin is indicated for use in combination with Interferon Alpha to treat chronic Hepatitis C (HCV) infection. (pharmaceutical-business-review.com)
  • Discontinue RETROVIR as medically appropriate and consider dose reduction or discontinuation of interferon alfa, ribavirin, or both. (drugs.com)
  • COSMOS is a randomized, open-label study investigating the efficacy and safety of 12 or 24 weeks of simeprevir and sofosbuvir with or without ribavirin in HCV genotype 1 patients who are treatment naïve or have prior null response to pegylated interferon and ribavirin therapy. (natap.org)
  • Simeprevir, an investigational NS3/4A protease inhibitor jointly developed by Janssen R&D Ireland and Medivir AB, is currently in late phase III studies as a once-daily capsule (150 mg) taken in combination with pegylated interferon and ribavirin for the treatment of genotypes 1 and 4 HCV. (natap.org)
  • Pegylated interferon alpha 2a (PEG-IFN-α 2a) or 2b plus ribavirin is currently the standard regimen for patients with HCV infection. (biomedcentral.com)
  • Immune globulin and antiviral agents (e.g., interferon with or without ribavirin) are not recommended for PEP of hepatitis C. For HCV postexposure management, the HCV status of the source and the exposed person should be determined, and for HCP exposed to an HCV positive source, follow-up HCV testing should be performed to determine if infection develops. (cdc.gov)
Analogs2
  • This is primarily due to poorly characterized RNA polymerases and weak clinical activity of nucleoside analogs (ribavirin for respiratory syncytial virus [RSV] and parainfluenza). (ccjm.org)
  • Hydroxyurea potentiates the antiherpesvirus activities of purine and pyrimidine nucleoside and nucleoside phosphonate analogs. (neb.com)
Prodrug of ribavirin1
  • It is a 3-carboxamidine prodrug of ribavirin, developed to target the liver and subsequently avoid the erythrocyte accumulation (with resulting anemia) often associated with ribavirin therapy. (news-medical.net)
Ritonavir5
  • The clinical response of patients with severe acute respiratory syndrome (SARS) to a combination of lopinavir/ritonavir and ribavirin was examined after establishing the in vitro antiviral susceptibility of the SARS associated coronavirus to a panel of antiviral agents. (bmj.com)
  • Forty one patients with SARS followed for 3 weeks were treated with a combination of lopinavir/ritonavir and ribavirin. (bmj.com)
  • The apparent favourable clinical response with lopinavir/ritonavir and ribavirin supports further randomised placebo controlled trials in patients with SARS. (bmj.com)
  • All of them completed 12-week treatment protocol of ombitasvir, paritaprevir and ritonavir as an oral dose combination with ribavirin. (bvsalud.org)
  • This real-world setting study confirms that the combination of ombitasvir, paritaprevir, ritonavir, and ribavirin is highly effective in the treatment of HCV- GT4 infection with a good safety and tolerability profile. (bvsalud.org)
Purine4
  • Ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) is a purine analogue and a commonly used antiviral agent against both RNA and DNA viruses. (news-medical.net)
  • 1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamidine (TCNR) and 5-amino-TCNR act as competitive reversible inhibitors of human lymphoblast purine nucleoside phosphorylase (PNP). (news-medical.net)
  • Ribavirin is a pro drug, which when metabolised resembles purine RNA nucleotides. (heethealthcare.net)
  • Ki Ribazole 400mg Capsule (Ribavirin) is a synthetic nucleoside analogue (purine analogue) with antiviral activity. (almishkat.pk)
Equilibrative nucleoside transporter1
Peginterferon alfa-2a and riba3
  • Standard treatment for the most common type of hepatitis C is 48 weeks of a combination of two drugs, peginterferon alfa-2a and ribavirin, which cures less than half of patients and has significant side effects that make it very difficult for some patients to continue their treatment," said John McHutchison, M.D., a hepatologist and gastroenterologist and researcher at the DCRI, and lead investigator on this study. (sciencedaily.com)
  • In a randomized, Phase IIb, double-blinded, 37-center study of telaprevir in combination with peginterferon alfa-2a and ribavirin, the researchers examined the responses of 250 patients on four trial arms. (sciencedaily.com)
  • They compared a 12-week regimen of telaprevir combined with two different durations of the standard therapy - peginterferon alfa-2a and ribavirin - to a control group taking 48 weeks of standard therapy alone. (hepatitiscentral.com)
Inhibitor5
  • Stavudine is a nucleoside reverse transcriptase inhibitor that is FDA approved for the treatment of human immunodeficiency virus (HIV)-1 infection. (wikidoc.org)
  • Abacavir tablet, a nucleoside analogue human immunodeficiency virus (HIV-1) reverse transcriptase inhibitor, is indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. (nih.gov)
  • But ABT-267, an NS5A inhibitor, is now ombitasvir and the non-nucleoside polymerase inhibitor ABT-333 is now called dasabuvir. (medpagetoday.com)
  • 04-Mar-13 Stockholm, Sweden - Medivir AB (OMX: MVIR) today announced first interim results from the cohort 1 of a Phase IIa study of the investigational protease inhibitor simeprevir (TMC435) administered once daily with Gilead's investigational nucleotide inhibitor sofosbuvir (GS-7977) with and without ribavirin for 12 and 24 weeks in genotype 1 prior null-responder hepatitis C patients with mild to moderate fibrosis (METAVIR F0-2). (natap.org)
  • Ribahep (Ribavirin) triphosphate (RTP) is a potent competitive inhibitor of inosine monophosphate (IMP) dehydrogenase, viral RNA polymerase and messenger RNA (mRNA) guanylyltransferase (viral) and can be incorporated into RNA in RNA viral species. (heethealthcare.net)
Mutagenesis3
  • Airaksinen A, Pariente N, Menendez-Arias L, Domingo E (2003) Curing of foot-and-mouth disease virus from persistently infected cellsby ribavirin involves enhanced mutagenesis. (springer.com)
  • Ribahep (Ribavirin) is also incorporated into the viral genome causing lethal mutagenesis and a subsequent decrease in specific viral infectivity. (heethealthcare.net)
  • Human genetic risk of treatment with antiviral nucleoside analog drugs that induce lethal mutagenesis - the special case of molnupiravir. (cdc.gov)
Remdesivir1
  • Modeling the Binding Mechanism of Remdesivir, Favilavir, and Ribavirin to SARS-CoV-2 RNA-Dependent RNA Polymerase. (cdc.gov)
Antiviral agents1
Analogue reverse1
  • Lamivudine and zidovudine tablets, a combination of 2 nucleoside analogue reverse transcriptase inibitors, are indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. (nih.gov)
Capsule3
  • Ribavirin comes as a tablet, a capsule and an oral solution (liquid) to take by mouth. (medlineplus.gov)
  • Pioneers in the industry, we offer ribahet ribavirin 200mg capsule, ribahep ribavirin 200mg capsules, ribamac ribavirin 200mg and ribamune ribavirin 200 mg from India. (heethealthcare.net)
  • The chemical name of ribavirin is 1-ß-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide.Ki Ribazole 400mg Capsule molecular formula is C8H12N4O5. (almishkat.pk)
Induce2
  • The introduction of vismodegib, which targets glioma-associated protein 1 (GLI1) through the Smoothened receptor (Smo), was based on the novel discovery by this group that UDP-glucuronosyltransferase 1 A (UGT1A) and GLI1 have increased expression in resistant AML cells and induce glucuronidation of ribavirin and cytarabine. (haematologica.org)
  • Besides, virus C infection may induce insulin resistance by blocking intracellular signaling, and lastly, insulin resistance has been associated with a decreased rate of sustained response to peginterferon alpha plus ribavirin in patients with chronic hepatitis C. (isciii.es)
Dose3
  • Your doctor may decrease your dose or tell you to stop taking ribavirin if you develop side effects of the medication or if certain laboratory tests show that your condition has not improved. (medlineplus.gov)
  • Seven patients reduced the dose of ribavirin during therapy owing to reduced hemoglobin or anemia -- a known effect of ribavirin -- but the change did not affect treatment success. (medpagetoday.com)
  • In most of these cases, ribavirin was administered intravenously at dosage up to and in some cases exceeding four times the recommended maximum oral daily dose. (almishkat.pk)
Hepatitis C vir1
Doctor or pharmacist1
  • Your doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with ribavirin and each time you refill your prescription. (medlineplus.gov)
Synthetic2
Vitro4
  • Although ribavirin has in vitro activity against this virus, the benefit of administering it in the early viremic stage has not been established. (medscape.com)
  • In vitro antiviral activity against SARS associated coronavirus was demonstrated for lopinavir and ribavirin at concentrations of 4 µg/ml and 50 µg/ml, respectively, only at 48 hours. (bmj.com)
  • The synthesis and in vitro anti-measles virus activity of ring-expanded nucleosides 1-4 are reported. (usu.edu)
  • SIGNIFICANCE STATEMENT This study developed computational models of human equilibrative nucleoside transporters (ENTs) to predict drug interactions and validated these models with two compounds in vitro. (arizona.edu)
ENT11
  • Mizoribine and ribavirin mapped to the ENT1 substrate pharmacophore and proved to be substrates of the ENTs. (arizona.edu)
Adenosine2
Viral infections2
  • The combination is given with ribavirin, a nonspecific drug that modifies host factors in viral infections. (medpagetoday.com)
  • Ribavirin is an anti-viral drug indicated for severe RSV infection (individually), hepatitis C infection (used in conjunction with peginterferon alfa-2b or peginterferon alfa-2a) and other viral infections. (heethealthcare.net)
Mechanism1
Patients9
  • Exacerbation of anemia has been reported in HIV-1/HCV co-infected patients receiving ribavirin and zidovudine. (nih.gov)
  • The clinical progress and virological outcomes were monitored and compared with 111 patients treated with ribavirin only who served as historical controls. (bmj.com)
  • report on a phase II clinical trial (clinicaltrials.gov: identifier NCT02073838) conducted with vismodegib and ribavirin, with or without decitabine in AML patients. (haematologica.org)
  • In the current study, 23 patients were enrolled, 15 in the vismodegib and ribavirin plus decitabine arm and 8 in the vismodegib and ribavirin arm. (haematologica.org)
  • The overall response rate was 40% for the arm with decitabine, while there were no responders among the patients who received only vismodegib and ribavirin, although 3 had prolonged stable disease. (haematologica.org)
  • Cohort 1 of the phase IIa open-label COSMOS study randomized 80 genotype 1 patients into one of four arms including 150 mg of once-daily simeprevir plus 400 mg of sofosbuvir for 24 weeks with or without ribavirin or for 12 weeks with or without ribavirin. (natap.org)
  • The regimen of once-daily simeprevir and sofosbuvir with or without ribavirin was generally well tolerated and no serious adverse events occurred during the treatment period for the patients involved in the study. (natap.org)
  • Cohort 1 of the COSMOS study enrolled 80 genotype 1 prior null-responder HCV patients with METAVIR scores of F0-F2, who were stratified by IL28B status and genotype 1 subtype, into one of four arms including once-daily simeprevir (150 mg) plus sofosbuvir (400 mg) for 24 weeks with or without ribavirin, or once-daily simeprevir (150 mg) plus sofosbuvir (400 mg) for 12 weeks with or without ribavirin. (natap.org)
  • The treatment of insulin resistance by decreasing hyperinsulinemia could improve sustained response rates in patients with chronic hepatitis C treated with peginterferon plus ribavirin. (isciii.es)
Anemia3
  • Ribavirin may cause anemia (condition in which there is a decrease in the number of red blood cells) that can worsen any heart problems you have and can cause you to have a heart attack that can be life-threatening. (medlineplus.gov)
  • it works in conjunction with a drug called ribavirin, a nucleoside analogue, to suppress the viral activity of hepatitis C. Side effects can include severe flu-like symptoms, depression, fatigue, insomnia and anemia. (sciencedaily.com)
  • The primary observed serious adverse side effect of ribavirin treatment is hemolytic anemia. (biomedcentral.com)
Analog drugs1
  • Equilibrativenucleoside transporters (ENTs) participate in the pharmacokinetics and disposition of nucleoside analog drugs. (arizona.edu)
Drug4
  • For the developed non-nucleoside drugs (neuraminidase inhibitors and adamantanes for influenza) clinical challenges include short therapeutic windows, limited effects on the severely ill, and drug resistance. (ccjm.org)
  • Cases have also been reported with the hepatitis C drug ribavirin, as well as the drug hydroxyurea (Hydrea), which raises the concentration of many nukes inside cells. (catie.ca)
  • Both compounds showed higher anti-MV activity than the control drug ribavirin. (usu.edu)
  • The efficacy of ribavirin, which is the only antiviral drug in the treatment of CCHF, remains controversial. (bvsalud.org)
Zidovudine1
Treatment6
  • Your doctor will order blood tests before you start taking ribavirin and often during your treatment. (medlineplus.gov)
  • It is not known if treatment that includes ribavirin and another medication cures hepatitis C infection, prevents liver damage that may be caused by hepatitis C, or prevents the spread of hepatitis C to other people. (medlineplus.gov)
  • Of the responders in the vismodegib and ribavirin plus decitabine arm, the majority of them had been previously treated with hypomethylating agents, demonstrating a possible re-sensitization with the vismodegib and ribavirin treatment. (haematologica.org)
  • Indeed, Cohen noted, the recently reported PEARL studies showed that ribavirin can be dropped entirely without affecting treatment success rates, but that data wasn't available when this trial was designed. (medpagetoday.com)
  • The current study was aimed to assess the efficacy and safety of this combination plus ribavirin in non-cirrhotic, treatment-naïve and -experienced Egyptians with HCV-GT4 infection in a real-world setting. (bvsalud.org)
  • In individual cases, when the benefit of the combined use of ribavirin and azathioprine is greater than the potential risk, the blood counts should be closely monitored, and in the appearance of signs of the damaging effect of chemotherapy on the hematopoietic tissue of the bone marrow, stop treatment. (happyfamilymedstore.com)
Replication1
Liver3
Activity3
  • Conversely, the 2' deoxyribose version of ribavirin does not exhibit antiviral activity, suggesting that ribavirin requires RNA-dependent enzymes. (news-medical.net)
  • Compounds were screened for anti-MV activity in African green monkey kidney cells (CV-1), employing ribavirin as the control standard. (usu.edu)
  • Ribavirin and mycophenolic acid markedly potentiate the anti-hepatitis B virus activity of entecavir. (neb.com)
Drugs1
  • 5 This group also demonstrated that GLI1-inducible glucuronidation by UGT1A was not limited to these two drugs but included approximately forty other drugs from a variety of families, including nucleosides, antifolates, and anthracyclines. (haematologica.org)
Presence2
  • 4-chlorophenyl dichlorophosphate is initially reacted with various alcohols and amines in the presence of triethylamine, and then further treated with ribavirin using Et3N as a base. (news-medical.net)
  • Atypical Mutational Spectrum of SARS-CoV-2 Replicating in the Presence of Ribavirin. (cdc.gov)
Synthesis1
Chemical2
  • To minimize ribavirin-induced hemolysis and increase its antiviral effect, considerable efforts have been made involving chemical prodrugs and various formulations. (news-medical.net)
  • The chemical name of ribavirin is 1-��-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide and has the following structural formula: Ribavirin is a white, crystalline powder. (linkedlifedata.com)
Cases1
Time1