The halogen atoms of α-halo sulfones, in contrast to halogen atoms α to other electron-withdrawing functionalities, show marked resistance to substitution by external nucleophiles. (organicreactions.org)
To explore highly conductive and alkaline stable anion exchange membrane (AEM) materials, triblock copolymers bearing alkyl-tethered cycloaliphatic quaternary ammonium-head-groups are prepared via nucleophilic substitution, Friedel-Crafts acylation, ketone reduction and Menshutkin reaction. (researcher-app.com)
Copolymers with 4,4' difluorotriphenylphosphine oxide, as well as 4,4' dihydroxydiphenyl ether (DPE), as the nucleophilic partner, were prepared via standard nucleophilic aromatic substitution (NAS) polycondensataion reactions. (wright.edu)
In general, with the exception of fluorinated compounds, haloalkanes readily undergo nucleophilic substitution reactions or elimination reactions . (wikipedia.org)
Carbonyl4
In 1989, Prakash and Olah first reported activation of TMSCF3 by fluoride to perform nucleophilic trifluoromethylation of carbonyl compounds. (wikipedia.org)
That is accompanied by a nucleophilic assault in the lactam carbonyl with a serine side-chain. (cancer-ecosystem.com)
Therefore limitations deacylation by lowering the susceptibility from the carbonyl carbon to nucleophilic strike from the deacylation drinking water. (liveconscience.com)
1999). The warhead carbonyl and epoxide undergo two successive nucleophilic attacks performed by Thr1O and Thr1N, respectively (Groll et al. (euromedh2020.com)
Standard nucleophilic1
Because sulphur and oxygen are easily attacked by nucleophiles, standard nucleophilic electrolytes are incompatible with Mg-S, Mg-O2/air batteries. (tsijournals.com)
Aromatic2
It has also been used with enones, for example with chalcone, a reaction catalysed by diethyl zinc and Wilkinson's catalyst: Trifluoromethyl sulfone (PhSO2CF3) and trifluoromethyl sulfoxide (PhSOCF3) can be used for trifluoromethylations of electrophiles Trifluoromethanesulfonyl chloride (or triflyl chloride, CF3SO2Cl) can be used in a highly efficient method to introduce a trifluoromethyl group to aromatic and heteroaromatic systems, including known pharmaceuticals such as Lipitor. (wikipedia.org)
2) Amination of aromatic C-H centres The use of a N-methyl morpholine (NMM)-derived aminimine as an aminating agent in the vicarious nucleophilic amination (VNA) of electron-deficient (hetero)arenes is also reported. (ndltd.org)
Undergo1
Moreover, because the α-halo sulfones undergo this transformation in alkaline solution, further rearrangement of the initially formed alkenes is precluded. (organicreactions.org)
Maleimide2
Michael-type additions of nucleophilic amino acids to maleimide, vinyl sulfone and acrylamide groups are detected by gel electrophoresis. (uni-regensburg.de)
Dextran, a neutral and hydrophilic polysaccharide, was functionalized with maleimide or vinyl sulfone groups which are able to form covalent bonds with nucleophilic thiols via a thiol-Michael addition reaction. (universiteitleiden.nl)
Inhibitors3
They could be separated in two classes, sulfone inhibitors 477845-12-8 manufacture (sulbactam and tazobactam) as well as the non-sulfone inhibitor, clavulanic acidity (Number 1). (cancer-ecosystem.com)
2009). Amazingly, LN-1-255 and additional 6-alkylidene-2-substituted penam sulfones will also be potent Course D -lactamase inhibitors and also have a similar system of enzyme inhibition (Bou et al. (liveconscience.com)
as previously observed with vinyl sulfone and ,-unsaturated amide-based inhibitors, is partially reversible and gives insight to the design of proteasome inhibitors for cancer chemotherapy. (euromedh2020.com)
Sulfonamides3
A variety of sulfur dioxide derived functional groups, such as sulfonamides, sulfones and sulfonates are present in a large number of biologically significant molecules, which makes this even more surprising. (ox.ac.uk)
These can then be utilised to form a variety of functional groups such as sulfones, sulfonamides and sulfonyl fluorides. (ox.ac.uk)
In general sulfate salts are reactive at sulfur and can be alkylated for form sulfones or can be oxidizes to form sulfonyl halides or sulfonamides. (rutgers.edu)
Inhibitor1
Diaminodiphenylsulfone or dapsone (Figure 1), a sulfone inhibitor of DHPS, has been clinically used for decades to treat leprosy, which is caused by the related organism Mycobacterium leprae (Anand, 1996), and sulfamethoxazole (Figure 1) has been shown to have in vitro effects against Mycobacterium avium and Mycobacterium intracellulare (Raszka et al. (dadospdf.com)
Reactions1
We aimed to expand the use of sulfinates in such reactions in a variant that allowed for simpler purification of the reagents, multistep elaboration and greater diversity of the nucleophilic coupling partners. (ox.ac.uk)
Synthesis5
This extrusion process, frequently referred to as the α-halo sulfone or Ramberg-Bäcklund rearrangement after its discoverers, has found broad utility in olefin synthesis. (organicreactions.org)
Sulfondiimines are the di-aza analogues of sulfones and have potential value in medicinal chemistry owing to their attractive physicochemical properties, but there are limited ways for their synthesis. (ox.ac.uk)
The synthesis of N-heterocycle functionalized triphenylphosphine oxide based PAEs, utilizing 3,5 difluorinated diphenyl sulfone systems was achieved. (wright.edu)
Copper-catalyzed aerobic oxidative N-S bond functionalization for C-S bond formation: regio- and stereoselective synthesis of sulfones and thioethers. (research.com)
One-Pot Synthesis of Strain-Release Reagents from Methyl Sulfones br. (ncsu.edu)
Sulfinates1
We are interested in exploring alternatives to heterocyclic boronic acids in coupling processes, and have established the use of heteroaromatic sulfinates as nucleophilic cross-coupling reagents. (ox.ac.uk)
Moiety3
His Regioselectivity research includes themes of Triple bond, Moiety and Nucleophilic addition. (research.com)
2010). Yet another improvement for LN-1-255 included adding a dihydroxy-phenyl catechol moiety in the C2 placement from the penam sulfone. (liveconscience.com)
7-alkylidenecephalosporin sulfones Like in LN-1-255 and penem 1, the alkylidene moiety may also be integrated on the same placement in cephalosporin sulfones, in the 7 placement (Buynak et al. (liveconscience.com)
Sulfur1
Sulfur(VI) based moieties, in particular, sulfonamide and sulfone-containing compounds have been widely used in medicinal chemistry, for a variety of disease targets. (ox.ac.uk)
Oxidative1
Most nucleophilic Mg electrolytes have low oxidative stability due to the usage of organomagnesium precursors, limiting the use of high-voltage cathode materials. (tsijournals.com)
Compounds1
Few organofluorine compounds exist naturally ( C&EN, May 22, page 12 ), meaning that almost all must be made. (acs.org)
Vinyl4
A simple nucleophilic addition reaction known as the Michael addition was used to add vinyl groups to amines and thiols in ovalbumin at standard conditions. (aiche.org)
Ovalbumin was first cross-linked with divinylsulfone (DVS) then sequences between cross-links were modified with acrylic acid (AA) or ethyl vinyl sulfone (EVS). (aiche.org)
Complete modification with more than five PEG chains is observed after incubation with mPEG5k-vinyl sulfone at pH 9, whereas 96% of the protein remains unmodified after incubation with mPEG5k-acrylamide at pH 4. (uni-regensburg.de)
Described herein are studies into the use of DppONHBoc as a nucleophilic nitrogen transfer agent (NNTA) for the aziridination of enones and vinyl sulfones under mildly basic conditions. (ndltd.org)
Advances1
This chapter summarizes the more important advances in the understanding of α-halo sulfone rearrangements, particular consideration being given to the nature of the intermediates, scope of the available synthetic alternatives, optimization of experimental conditions, and effect of structural features on reactivity. (organicreactions.org)
Widely1
Since then TMSCF3 has been widely used as a nucleophilic trifluoromethylating agent. (wikipedia.org)
Groups1
6-alkylidene-2-substituted penam sulfones: LN-1-255 and book chemistry Just like the penems above, alkylidene group formulated with reactive groups had been added on the C6 placement of penam sulfones (Chen et al. (liveconscience.com)
Basic1
ACS's Basic Package keeps you connected with C&EN and ACS. (acs.org)
Found1
Cysteine, however, is the least commonly found nucleophilic residue in active sites. (rutgers.edu)
Nature1
Grignard-type electrolytes, on the other hand, have intrinsic safety difficulties and limited oxidation stability due to their nucleophilic nature and strong reactivity, which limit the development of rechargeable Mg batteries in terms of practical use. (tsijournals.com)
Active2
ACS's Standard Package lets you stay up to date with C&EN, stay active in ACS, and save. (acs.org)
This brief overview covers recent achievements in non nucleophilic Mg electrolytes, with the goal of providing insights into their electrochemical characteristics and active Mg ion structure. (tsijournals.com)
Reactive3
We have hitherto successfully achieved orthogonal 1,4-difunctionalization of the two reactive sites by using phenyl allyl sulfone or α-CF3-styrene as radical acceptor to capture the radical at Y and TMSCN as nucleophile to intercept the iminium ion at X respectively. (uark.edu)
Two sets of processed jute fabric viz, alkaline scoured-bleached and bioscoured-bleached jute fabrics were dyed separately with two nucleophilic addition type (vinyl sulphone type) of reactive dyes namely, Remazol Yellow FG and Amidazol Brown GR dyes. (hilarispublisher.com)
From the experiment it is revealed that bioscoured-bleached reactive dyed jute fabric shows higher dye uptake than that produced by alkaline scoured-bleached-reactive dyed jute fabric in case of both the vinyl sulphone type of reactive dyes. (hilarispublisher.com)
Electrophilic2
The key reaction involved in this method is a ring-opening process of cyclobutylanilines via single-electron oxidation of the anilines under visible light photoredox conditions to presumably generate distonic radical cation intermediates which possess bimodal reactivity due to the presence of a nucleophilic carbon radical moiety (site Y) and an electrophilic iminium ion moiety (site X) that are spatially separated. (uark.edu)
Poly(ethylene glycol) (PEG) derivatives activated with electrophilic groups are useful for coupling to nucleophilic groups, such as amino groups, of biologically active molecules. (allindianpatents.com)
Reaction2
It has also been used with enones, for example with chalcone, a reaction catalysed by diethyl zinc and Wilkinson's catalyst: Trifluoromethyl sulfone (PhSO2CF3) and trifluoromethyl sulfoxide (PhSOCF3) can be used for trifluoromethylations of electrophiles Trifluoromethanesulfonyl chloride (or triflyl chloride, CF3SO2Cl) can be used in a highly efficient method to introduce a trifluoromethyl group to aromatic and heteroaromatic systems, including known pharmaceuticals such as Lipitor. (wikipedia.org)
Dr. Deng said: "We have developed a nickel-catalyzed intramolecular nucleophilic addition reaction for the formation of benzofuran derivatives. (thieme.de)
Mild1
One-pot, column-free nucleophilic acyl substitutions and one-pot, mild reductions are described in this work. (ubc.ca)
Addition1
The addition of a tetrabutylammonium halide salt additive as much as doubles the rate of formation of the intermediate acyl fluoride, yet there is no effect on the rate of consumption of this intermediate by the nucleophilic coupling partner. (ubc.ca)
Activation1
In 1989, Prakash and Olah first reported activation of TMSCF3 by fluoride to perform nucleophilic trifluoromethylation of carbonyl compounds. (wikipedia.org)