Nuclear mitogen activated protein kinase 3. Medical search. Frequent questions

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of protein kinase that is specific to the amino acids serine and threonine (i.e., a serine/threonine-specific protein kinase). (wikipedia.org)
citation needed] MAPKs belong to the CMGC (CDK/MAPK/GSK3/CLK) kinase group. (wikipedia.org)
clarification needed] The mammalian MAPK family of kinases includes three subfamilies: Extracellular signal-regulated kinases (ERKs) c-Jun N-terminal kinases (JNKs) p38 mitogen-activated protein kinases (p38s) Generally, ERKs are activated by growth factors and mitogens, whereas cellular stresses and inflammatory cytokines activate JNKs and p38s. (wikipedia.org)
Because MAP2 kinases display very little activity on substrates other than their cognate MAPK, classical MAPK pathways form multi-tiered, but relatively linear pathways. (wikipedia.org)
citation needed] In comparison to the three-tiered classical MAPK pathways, some atypical MAP kinases appear to have a more ancient, two-tiered system. (wikipedia.org)
Effect of p38 mitogen-activated protein kinases (MAPK) inhibitor on nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) activity. (molvis.org)
Here, we review the applications of LIPUS against inflammation through different signaling pathways including nuclear factor-κB (NF-κB), mitogen-activated protein kinase (MAPK), and phosphatidylinositol-3-kinase/serine/threonine kinase (PI3K/Akt), and discuss the underlying mechanisms. (qigonginstitute.org)
Phosphatidic acid is generated from the cleavage of phosphatidylcholine by phospholipase D2 and is a key activator of the mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/AKT survival signaling pathways. (nih.gov)
We then find that small interfering RNA (siRNA) silencing of choline kinase expression in transformed HeLa cells completely abrogates the high concentration of phosphocholine, which in turn decreases phosphatidylcholine, phosphatidic acid and signaling through the MAPK and PI3K/AKT pathways. (nih.gov)
Last, we confirm the relative importance of phosphatidic acid for this pro-survival effect as phosphatidic acid supplementation fully restores MAPK signaling and partially rescues HeLa cells from choline kinase inhibition. (nih.gov)
The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. (wikipathways.org)
Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. (wikipathways.org)
This is often accompanied by chronic low-grade inflammation, driven by the activation of various molecular pathways such as STAT3 (signal transducer and activator of transcription 3), IKK (IκB kinase), MMP9 (matrix metallopeptidase 9), MAPK (mitogen-activated protein kinases), COX2 (cyclooxigenase 2), and NF-Kβ (nuclear factor kappa-light-chain-enhancer of activated B cells). (puppyreading.com)
Furthermore, PGG exhibited anti-inflammatory activity, inhibiting the activation of nuclear factor-kappaB (NF-κB) and mitogen-activated protein kinase (MAPK) signaling, resulting in inhibition of the expression of pro-inflammatory mediators. (molcells.org)
We find that ERK activity is essential for serum-induced osteoblast proliferation in vitro because inhibition of MAPK/ERK kinase activity by U0126 completely abolished both serum-induced activation of ERK and proliferation of mouse (MBA-15.4) and human (MG-63) osteoblast cell lines. (ox.ac.uk)
Coupled with the rapidity of Dex action, this indicates immediate-early gene phosphatase involvement, and we therefore used quantitative, real-time PCR to examine expression profiles of the dual-specificity MAPK phosphatases, MKP-1 and MKP-3. (ox.ac.uk)

We determined the mechanisms of GM-CSF regulation in AM from normal volunteers activated by lipopolysaccharide (LPS) by examining the role of nuclear factor-kappaB (NF-kappaB), and of p38 mitogen-activated protein (MAP) kinase and MAP kinase kinase (MKK-1). (nih.gov)

Phosphorylation of extracellular signal-regulated kinase-1 (ERK-1), ERK-2, and p38 MAP kinase by LPS were demonstrated on Western blot analysis. (nih.gov)
GM-CSF expression and release in AM is controlled by NF-kappaB activation, and this is modulated by phosphorylation of MKK-1 and p38 MAP kinase acting on histone acetylation. (nih.gov)
citation needed] This tandem activation loop phosphorylation (that was proposed to be either distributive or processive, dependent on the cellular environment) is performed by members of the Ste7 protein kinase family, also known as MAP2 kinases. (wikipedia.org)
MAP2 kinases in turn, are also activated by phosphorylation, by a number of different upstream serine-threonine kinases (MAP3 kinases). (wikipedia.org)
Our findings suggest that the phosphorylation of F-peptide by cell-signaling pathways regulates the rate of hnRNP A1 nuclear import. (pasteur.fr)
BMP receptors signal through C-terminal phosphorylation and nuclear translocation of the transcription factor Smad1, whereas MAPKs catalyze inhibitory phosphorylation in the Smad1 linker region. (mdc-berlin.de)
The mitogen-activated protein kinases (MAPKs) ERK2/MAPK1 and ERK1/MAPK3 (hereafter referred to collectively as ERK1/2) are activated by phosphorylation in a canonical Raf MEK ERK kinase cascade in response to most growth factors and cytokines, and ERK1/2 phosphorylate more than 150 cytosolic and nuclear substrates [5], [6]. (scienza-under-18.org)
Considering that a host of intracellular proteins are affected by proteasome inhibition, coupled with evidence that knockdown of MKP3 expression enhances growth factor-stimulated ERK phosphorylation in some contexts [13] but not in others [16], led us to question whether or not the diminution of ERK signaling in MG132-treated cells could be attributed solely to upregulation of MKP3 and other DUSPs. (scienza-under-18.org)
Results We found that VPA sustained Protein kinase B (Akt) phosphorylation and Insulin-like growth factor signaling and modulated the systemic release of interleukin (IL)-1β, tumor necrosis factor alpha, and IL-6 after 2 hours of limb reperfusion. (bmj.com)
Studies investigating valproic acid (VPA) as a therapeutic in models of hemorrhagic shock have shown improved serine/threonine protein kinase (Akt) phosphorylation and survival outcomes. (bmj.com)

MK-8776 ERK1/2) pathway and phosphatidylinositide 3-kinases (PI3K) pathway [1C4]. (phytid.org)

PD 098059 (10 microM), an inhibitor of upstream activator of MKK-1, inhibited GM-CSF expression, but the expression of GM-CSF was not inhibited by SB 203580 (10 microM), an inhibitor of p38-MAP kinase. (nih.gov)
An inhibitor of autophagy, 3-methyladenine (3-MA), was used to pretreat RAW 264.7 cells. (researchsquare.com)
Flavopiridol is a synthetic flavone that has been postulated to be an inhibitor of cyclin-dependent kinases (CDKs) (Schmerwitz et al. (researchsquare.com)
The transient increase of Orai1 protein abundance was abrogated by Rac1 inhibitor NSC23766 (50 μM) and by prevention of actin reorganization with cytochalasin B (1 μM). (biomedcentral.com)
There is also decreased mRNA and proteins great quantity from the transcription element, early development response 1 (Egr1) in inhibitor-treated granulosa cells. (phytid.org)
In its quiescent state NF-κB is found in the cytoplasm bound to two proteins, IκBα and IκBβ (Inhibitor kappa B alpha and beta) that prevent it from translocating to the cell's nucleus for gene expression (Barnes & Karin, 1997). (nature-nurture.org)
We here evaluated the effects of SP600125 (anthra[1,9- cd ]pyrazole-6 (2 H )-one), an inhibitor of c-Jun NH 2 -terminal kinase (JNK), on the activation of PSCs. (aspetjournals.org)
Methods of utilizing a combined administration or a unit dosage of a combination of an HMG-CoA inhibitor and omega-3 fatty acids for the reduction of apolipoprotein-B levels. (patsnap.com)
This inhibition is reversed by cotreatment with the protein synthesis inhibitor, cycloheximide, and by the GC receptor antagonist, RU486, suggesting a classical transcriptional mechanism. (ox.ac.uk)
Phosphatase activity was up-regulated by Dex treatment, and inhibition of ERK activity by Dex was also reversed by the protein tyrosine phosphatase inhibitor, vanadate. (ox.ac.uk)

Growth inhibition was evaluated using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, and apoptosis was assayed by ELISA. (aacrjournals.org)
0.05) erlotinib-induced growth inhibition and apoptosis in BxPC-3, CAPAN-2, and AsPC-1 cells. (aacrjournals.org)
Alternatively, pharmacologic approach to inhibition of the proteins activity is normally economical, less frustrating and not at all hard compared to hereditary manipulation. (phytid.org)
proteasome inhibition interferes with cell cycle progression, upregulates tumor suppressors such as p53, and diminishes activation of pro-proliferation pathways such as those controlled by NFB and extracellular signal-regulated kinases (ERKs) [3], [4]. (scienza-under-18.org)
Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products. (dogcancerblog.com)
Mostajeran M, Wetterling F, Blixt FW, Edvinsson L, Ansar S. Acute mitogen-activated protein kinase 1/2 inhibition improves functional recovery and vascular changes after ischaemic stroke in rat-monitored by 9.4 T magnetic resonance imaging. (lu.se)

Cells stressed by osmotic shock (OSM) activate the mitogen-activated protein kinase kinase(3/6)-p38 signaling pathway, which in turn results in accumulation of hnRNP A1 in the cytoplasm. (pasteur.fr)

MAPKs are involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. (wikipedia.org)
The closest relatives of MAPKs are the cyclin-dependent kinases (CDKs). (wikipedia.org)
These pathways can effectively convey stimuli from the cell membrane (where many MAP3Ks are activated) to the nucleus (where only MAPKs may enter) or to many other subcellular targets. (wikipedia.org)
In contrast to the classical MAP kinases, these atypical MAPKs require only a single residue in their activation loops to be phosphorylated. (wikipedia.org)
Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. (wikipathways.org)

The first mitogen-activated protein kinase to be discovered was ERK1 (MAPK3) in mammals. (wikipedia.org)

In the case of classical MAP kinases, the activation loop contains a characteristic TxY (threonine-x-tyrosine) motif (TEY in mammalian ERK1 and ERK2, TDY in ERK5, TPY in JNKs, TGY in p38 kinases) that needs to be phosphorylated on both the threonine and the tyrosine residues in order to lock the kinase domain in a catalytically competent conformation. (wikipedia.org)
Drug-induced ubiquitination and degradation erbB receptor tyrosine kinases. (mirnamimics.com)

SP600125 inhibited interleukin-1β-induced JNK activity and activator protein-1 activation, but it did not affect the activation of extracellular-regulated kinase, p38 mitogen-activated protein kinase, and nuclear factor-κB. (aspetjournals.org)
Antioxidant activity in lingonberries (Vaccinium vitis-idaea L.) and its inhibitory effect on activator protein-1, nuclear factor-kappa B, and mitogen-activated protein kinases activation. (cdc.gov)

Besides causing Smad1 polyubiquitination, Smurf1 binding inhibits the interaction of Smad1 with the nuclear translocation factor Nup214. (mdc-berlin.de)

Glucocorticoids induce rapid up-regulation of mitogen-activated protein kinase phosphatase-1 and dephosphorylation of extracellular signal-regulated kinase and impair proliferation in human and mouse osteoblast cell lines. (ox.ac.uk)

On a molecular level many Th1 cytokines are permitted expression with the activation of transfer factors, such as AP-1 and NF-κB (nuclear factor-kappa B) (Liz-Grana et al. (nature-nurture.org)
Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells. (dogcancerblog.com)

Thus the role of mammalian ERK1/2 kinases as regulators of cell proliferation is not a generic, but a highly specialized function. (wikipedia.org)
For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. (wikipathways.org)
Antibodies against total ERK1/2, MEK1/2, Akt1/2/3 and MKP3 and phospho-specific antibodies against Rabbit Polyclonal to PHF1 PDGF -receptor pTyr751, Akt pSer473, ERK pThr202/pTyr204, and MEK pSer217/pSer221 were from Cell Signaling Technology (Beverly, MA). (scienza-under-18.org)

Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. (dogcancerblog.com)

TAC treatment of MCF-7 cells was followed by Rac1 activation, actin polymerization, transient increase of Orai1transcript levels and protein abundance, and transient increase of SOCE. (biomedcentral.com)
mAR sensitive Rac1 activation and actin reorganization contribute to the regulation of Orai1 protein abundance and SOCE. (biomedcentral.com)
The present study explored, whether mAR activation is followed by alterations of Orai1 protein abundance and function in MCF-7 breast tumor cells and addressed the role of actin reorganization and actin signaling to this effect. (biomedcentral.com)
In response to pancreatic injury and in cell culture, pancreatic stellate cells (PSCs) are transformed ("activated") into highly proliferative myofibroblast-like cells that express α-smooth muscle actin and produce extracellular matrix components. (aspetjournals.org)

C3H10T1/2 MSCs cultured within extremely adipogenic medium communicate peroxisome proliferator-activated receptor gamma and also adiponectin mRNA along with health proteins, and accumulate intra cellular lipid. (microrna21.com)
Hardware pressure requested Half a dozen l every day limited phrase involving peroxisome proliferator-activated receptor gamma and adiponectin mRNA through up to Thirty five along with 50%, correspondingly, right after Your five n. (microrna21.com)

In the BxPC-3 cell line, significant down-regulation of EGFR, phosphorylated Akt, NF-κB activation, and survivin was observed in the cells treated with the combination compared with the erlotinib-treated cells. (aacrjournals.org)
Metformin (MTF) has been reported to target NLK (Nemo-like kinase) to inhibit non-small lung cancer cells. (cancerindex.org)
Flavopiridol treatment notably upregulated the protein expression of LC3, Beclin-1 and Atg7 in infected corneas as well as in RAW 264.7 cells. (researchsquare.com)
Signaling of tumor-cells may further involve up-regulation of pore forming Ca 2+ channel protein Orai1, which accomplishes store operated Ca 2+ entry (SOCE). (biomedcentral.com)
To this end, MCF-7 cells were exposed to TAC and Orai1 protein abundance at the cell surface was determined by confocal microscopy and flow cytometry as well as intracellular Ca 2+ release and SOCE were quantified utilizing Fura-2 fluorescence. (biomedcentral.com)
To this end, MCF- cells were treated with testosterone-albumin conjugates (TAC, 100 nM), which selectively activate mAR without activating intracellular androgen receptors (iAR). (biomedcentral.com)
As illustrated in Fig. 1 , mAR activation was followed by a rapid increase of Orai1 protein abundance at the surface of MCF-7 cells. (biomedcentral.com)
It has been reported that lung cancer cells exhibit upregulated expression of all key glycolytic enzymes [hexokinase 2 (HK2), phosphofructokinase and pyruvate kinase (PK)] ( 13 ), suggesting that the essential enzymes of the aerobic glycolytic pathway have a critical role in the development of lung carcinoma. (spandidos-publications.com)
The chemopreventive agent curcumin is a potent radiosensitizer of human cervical tumor cells via increased reactive oxygen species production and overactivation of the mitogen-activated protein kinase pathway. (dogcancerblog.com)

Nuclear magnetic resonance (NMR)-based metabolomic studies of human tumors have identified a marked increase in the intracellular concentration of phosphocholine relative to normal tissues. (nih.gov)

Normal killer T-cell cytotoxicity ENMD-2076 t Of breast cancer targets is by two unique mechanisms surveilance old K Entire body surveilance-Dependent cytotoxicity t Re Improves cellular communication LFA towards t 3 and HER2/neu. (mirnamimics.com)
1999). For instance both TRAFs interact with enzymes that mediate cellular activity and is activated in response to cellular stressors, mitogen activating protein kinase/extracellular signal-regulated kinase kinase kinase and mitogen activating protein 3 kinases (MEK kinase and MAPKKK) (Hirano et al. (nature-nurture.org)
Evidence presented suggests that little diversities, neuronal receptors, trans- lyssavirus (family Rhabdoviridae , genomic variation in New World West port, and cellular protein-virus inter- genus Lyssavirus ), also a neurotrope. (cdc.gov)

Here, we show that in primary human femoral head osteoarthritic and normal bovine chondrocytes, TWHF partially or completely inhibited mRNA and protein expression of tumor necrosis factor-α, interleukin (IL)-1, and IL-17-inducible MMP-3 and MMP-13. (aspetjournals.org)
MKP-1, but not MKP-3, mRNA expression was 10-fold up-regulated in both mouse and human osteoblast cell lines within 30 min of Dex treatment and remained elevated for 24 h. (ox.ac.uk)

Flavopiridol significantly alleviated the inflammation of fungal keratitis by activating autophagy. (researchsquare.com)
Activated PSCs are implicated in the pathogenesis of pancreatic fibrosis and inflammation. (aspetjournals.org)

Disclosed are compounds and derivatives thereof, their synthesis, and their use as Rho-kinase inhibitors. (patsnap.com)

What pathways are this gene/protein implicaed in? (cancerindex.org)

These compounds are useful for inhibiting tumor growth, treating erectile dysfunction, and treating other indications mediated by Rho-kinase, e.g., coronary heart disease. (patsnap.com)
Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-kappaB pathway. (dogcancerblog.com)

Methods for detecting infec- tinuous genetic variation may lead to of various proteins in virus infections, tions caused by neurotropic viruses partial protection and escape mutants, neuronal involvement, and apoptosis and for detecting viruses or their which could provide a "pump" that are being recognized. (cdc.gov)

Interleukin-1β activated both 46- and 54-kDa JNK, whereas platelet-derived growth factor-BB activated only 46-kDa JNK. (aspetjournals.org)

ERK signaling is usually inappropriately activated in a wide array of human cancers, which can be caused by an activating mutation in one of the upstream signaling proteins or through overexpression of growth factors or growth factor receptors [7], [8]. (scienza-under-18.org)

What does this gene/protein do? (cancerindex.org)

Journal of Clinical Endocrinology and Metabolism , 90 (3), 1904-1905. (tmu.edu.tw)

Open reading frame 6 (ORF6), the accessory protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that suppresses host type-I interferon signaling, possesses amyloidogenic sequences. (bvsalud.org)

EGFR blockade alone may not be sufficient for the control of growth and invasion of human pancreas cancer because of the independent activation of Akt and nuclear factor-κB (NF-κB). (aacrjournals.org)
In contrast to Orai1 abundance, the Na + /K + ATPase protein abundance was similar without mAR activation (24.5 ± 1.1 a.u., n = 5) and 1 h (24.7 ± 2.2 a.u., n = 5) or 2 h (25.0 ± 1.9 a.u., n = 5) following mAR activation. (biomedcentral.com)
Mechanistic studies revealed no impact on the activation of extracellular signal-regulated kinase, p38, and c-Jun N-terminal kinase mitogen-activated protein kinases. (aspetjournals.org)
2 h) inhibits the sustained phase of ERK activation, required for nuclear shift and mitogenesis. (ox.ac.uk)

Depletion of NUP107 inhibits the growth of GBM cell lines through p53 protein stabilization. (bvsalud.org)

In this way protein dynamics can induce a conformational change in the structure of the protein via long-range allostery. (wikipedia.org)

The basis of hapten- molecular mechanisms of the sensitization pro- protein binding work is the hypothesis that upon cess will result in novel opportunities for the skin absorption, only protein-reactive chemicals development of alternative methods for assessing (or those that can be metabolically or chemically skin sensitization hazard and relative potency of converted to protein-reactive species) are able to chemicals. (cdc.gov)

The ubiquitin-proteasome pathway is an essential quality control mechanism directing degradation of mislocated, misfolded, and damaged proteins, and, by tempering the expression levels Carnosol of specific signaling proteins, it also exerts a level of control over cell physiology [1]. (scienza-under-18.org)

Heterogeneous nuclear ribonucleoprotein (hnRNP) A1 is an alternative splicing factor that is mainly nuclear, although it shuttles rapidly between nuclear and cytoplasmic compartments. (pasteur.fr)
SP600125 inhibited platelet-derived growth factor-induced proliferation, inducible monocyte chemoattractant protein-1 production, and serum-induced type I collagen production. (aspetjournals.org)
ADP ribosylation factor related protein. (gsea-msigdb.org)
Instead, TWHF partially inhibited DNA binding capacity of cytokine-stimulated activating protein-1 (AP-1) and nuclear factor-κB (NF-κB) transcription factors. (aspetjournals.org)
In the poster section, Joanna Shisler (University of Illinois at Urbana-Champaign [UIUC], Urbana) reported that the modified virus, Ankara, activates nuclear factor κB through the mitogen-activated protein kinase, extracellular signal–regulated kinase (MEK)/extracellular signal–regulated kinase (ERK) pathway, possibly facilitating the host immune response. (cdc.gov)

This is conducted by specialized enzymes of the STE protein kinase group. (wikipedia.org)

The method utilizes a single administration or a unit dosage of a combination of dyslipidemic agent and omega-3 fatty acids for the treatment of patients with hypertriglyceridemia, hypercholesterolemia, mixed dyslipidemia, coronary heart disease (CHD), vascular disease, artherosclerotic disease and related conditions, and the prevention or reduction of cardiovascular and vascular events. (patsnap.com)
His MRI thoracic angiography was done that did not reveal any vascular anomaly (Fig: 3). (ispub.com)
1) Agenesis-Complete absence of lung and bronchus and no vascular supply to the affected side, (2) Aplasia-Rudimentary bronchus with complete absence of pulmonary parenchyma (Left Upper Lobe aplasia in present case) (3) Hypoplasia-Presence of variable amounts of bronchial tree, pulmonary parenchyma and supporting vasculature (left lower lobe hypoplasia in present case). (ispub.com)

Later, a number of important biological effects of H 2 S were reported, including its vasorelaxation, antiapoptotic, anti-inflammatory, and antioxidative stress effects [ 3 - 6 ]. (hindawi.com)
1999), IL-6, IL-8 (Imrich, 2002), and IL-1α and β (Kiecolt-Glaser & Glaser, 2002) that when activated fight infection by mediating inflammatory processes. (nature-nurture.org)

In AD, the propensity of neurotoxic proteins to form template or oligomers is higher and accelerates the conversion and aggregation of endogenous proteins, which eventually convert into fibrils ( Schaffert and Carter, 2020 ). (frontiersin.org)
In 1996, Abe and Jincun reported the role of endogenous H 2 S in neuroregulation, which ushered in a new era of H 2 S and revealed its biological and pharmacological functions [ 3 ]. (hindawi.com)

Choline kinase phosphorylates choline to phosphocholine that serves as a precursor for the production of phosphatidylcholine, the major phospholipid constituent of membranes and substrate for the synthesis of lipid signaling molecules. (nih.gov)
A method and composition for blood lipid therapy by administering to the subject an effective amount of a dyslipidemic agent and omega-3 fatty acids. (patsnap.com)

It is a progressive, irreversible, and incurable neurodegenerative disorder that disrupts the synaptic communication between millions of neurons, resulting in neuronal death and functional loss due to the abnormal accumulation of two naturally occurring proteins, amyloid β (Aβ) and tau. (frontiersin.org)
Histological and functional evaluation of extremity skeletal muscle at 3, 7, and 21 days after injury, however, demonstrated no significant differences in myocytic degeneration, necrotic formation, and maximal isometric tetanic torque. (bmj.com)

3-MA pretreatment counteracted the cytokine regulation induced by flavopiridol. (researchsquare.com)

2018. Accepted 19/3. (lu.se)

glycosylated lysosomal membrane protein. (gsea-msigdb.org)

A very conserved family of dedicated phosphatases is the so-called MAP kinase phosphatases (MKPs), a subgroup of dual-specificity phosphatases (DUSPs). (wikipedia.org)

Scope includes mutations and abnormal protein expression. (cancerindex.org)
Metformin Enhances the Effect of Regorafenib and Inhibits Recurrence and Metastasis of Hepatic Carcinoma After Liver Resection via Regulating Expression of Hypoxia Inducible Factors 2α (HIF-2α) and 30 kDa HIV Tat-Interacting Protein (TIP30). (cancerindex.org)
This agent also inhibited cytokine-stimulated MMP-3 protein expression in human synovial fibroblasts. (aspetjournals.org)

the loss of NUP107 affects the integrity of the NPC structure, and thus the proportion of 26S proteasome in the vicinity of nuclear pores significantly decreases. (bvsalud.org)
Poly-ubiquitinated proteins, targeted by E3 ubiquitin ligases, can be acknowledged and degraded by the 26S proteasome, a multi-subunit, Carnosol multi-catalytic protease machine [2]. (scienza-under-18.org)

EBV infects more than 90% of the human population [ 3 ]. (ijbs.com)
In the present study, we identified the skin-protective activity of 1,2,3,4,6-penta-O-galloyl-β-D-glucose (pentagalloyl glucose, PGG) in ultraviolet B (UVB) radiation-induced human dermal fibroblasts and mouse skin. (molcells.org)

Anatomy20

Organisms8

Chemicals and Drugs173

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes39

Information Science3

MAPK16

Examining the role of n1

Phosphorylation10

PI3K1

Inhibitor10

Inhibition6

Signaling pathway1

MAPKs5

MAPK31

Tyrosine2

Activator2

Translocation1

Phosphatase1

Cytokines2

ERK13

Mice1

Actin4

Peroxisome2

Cells9

Intracellular1

Cellular3

MRNA2

Inflammation2

Inhibitors1

Pathways1

Tumor2

Apoptosis1

Interleukin1

Upstream1

Gene1

Metabolism1

Acute1

Activation4

Stabilization1

Induce1

Reactive1

Degradation1

Factor5

Enzymes1

Vascular3

Inflammatory2

Endogenous2

Lipid2

Functional2

Regulation1

20181

Membrane protein1

Dual-specificity1

Expression3

Proteasome2

Human2