• Mutations
  • Mutations in this gene have been associated with congenital insensitivity to pain with anhidrosis, self-mutilating behavior, mental retardation and cancer. (wikipedia.org)
  • In recent years, researchers have identified specific gene mutations linked to gastrointestinal stromal tumors (GIST), which primarily occur in the stomach or small intestine, with 5,000 to 6,000 new cases per year in the United States. (eurekalert.org)
  • In their paper published online Dec. 14 in the Journal of Translational Medicine , researchers at University of California San Diego School of Medicine and Moores Cancer Center have identified new gene fusions and mutations associated with this subset of GIST patients. (eurekalert.org)
  • Many current therapies for GIST are ineffective in patients whose tumors lack mutations in the classic oncogenic drivers of GIST. (eurekalert.org)
  • Treatment with imatinib (marketed as Gleevec) has proven effective in many GIST cases associated with KIT oncogene mutations, the most common driver of the disease. (eurekalert.org)
  • A variety of alterations in the ALK gene such as mutations, overexpression, amplification, translocations, or other structural rearrangements have been implicated in tumorigenesis [ 7 ]. (omicsonline.org)
  • showed that STRN-ALK fusion occurred with a higher prevalence in poorly-differentiated ATCs without other overlapping known driver mutations in these tumors [ 11 ]. (omicsonline.org)
  • RNAi silencing can also strongly inhibit proliferation of cells with genetic mutations that encourage oncogenic activation. (wikipedia.org)
  • We will then focus on the genes and proteins encoded by HERV-K(HML-2) as well as inactivation of these proviruses by postinsertional mutations and their inhibition by antiretroviral factors. (frontiersin.org)
  • Lowe's landmark results implicated p53 as part of a failsafe mechanism that actively reacts to cells that acquire other oncogenic mutations and responds by shutting down tumor formation. (pnas.org)
  • KIAA1549-BRAF fusion was identified in five cases, and hotspot FGFR1/NF1/PTPN11 mutations in one. (springer.com)
  • Some mutations create a more potent Bcr-Abl oncogene and accelerate disease progression[ 9 ]. (pubmedcentralcanada.ca)
  • Mutations in the ABL1 gene are associated with chronic myelogenous leukemia (CML). (wikipedia.org)
  • Due to evidence of conserved homology between the v-Src gene and its host (animal) genomes, and its non-essential status for viral reproduction, the v-Src gene is likely to have been acquired from a host genome and altered by subsequent mutations. (wikipedia.org)
  • These subsequent mutations are responsible for the oncogenic capabilities of the virus, as the normal (host) version of the Src gene, c-Src promotes survival, angiogenesis, proliferation and invasion pathways. (wikipedia.org)
  • Through loss-of-function and gain-of-function mutations in tumor suppressor genes as well as the K-ras oncogene, mouse models of many types of cancer have been constructed, including pancreatic cancer, astrocytoma, endometrioid ovarian cancer, colorectal cancer, sarcoma, retinoblastoma, and tumors of the peripheral nervous system. (wikipedia.org)
  • The ALK gene can be oncogenic in three ways - by forming a fusion gene with any of several other genes, by gaining additional gene copies or with mutations of the actual DNA code for the gene itself. (wikipedia.org)
  • tumors
  • Aim of this study was to assess, whether the ERG rearrangement and the distinct deletion site between TMPRSS2 and ERG , both predominantly resulting in a TMPRSS2-ERG fusion, occurs in tumors other than PCa. (pubmedcentralcanada.ca)
  • Arvand A and Denny CT (2001) Biology of EWS/ETS fusions in Ewing's family tumors. (els.net)
  • The drug is orally administered, once daily, and is being studied in patients whose tumors have been shown to have fusions in NTRK1/2/3, ALK, or ROS1. (wikipedia.org)
  • Interim results from two ongoing phase 1 trials have been reported at the 2016 AACR American Association for Cancer Research Conference in April 2016: among the patients treated with entrectinib, four patients had tumors harboring NTRK fusions, including patients with non-small cell lung cancer (NSCLC), mCRC, salivary gland cancer, and astrocytoma. (wikipedia.org)
  • The preliminary results seen with entrectinib in the phase I studies of patients with NTRK/ROS1/ALK fusions have led to the initiation of an open-label, multicenter, global, phase II basket study to examine the use of entrectinib in patients having tumors with these gene rearrangements. (wikipedia.org)
  • Nonetheless, as gene rearrangement events involving ROS1 have been described in lung and other cancers, and since such tumors have been found to be remarkably responsive to small molecule tyrosine kinase inhibitors, interest in identifying ROS1 rearrangements as a therapeutic target in cancer has been increasing. (wikipedia.org)
  • Gene rearrangements involving the ROS1 gene were first detected in glioblastoma tumors and cell lines. (wikipedia.org)
  • Among the top 20 receptor tyrosine kinases identified in this analysis, 15 were identified in both cell lines and tumors, and among these were both ALK and These initial findings paved the way for more expansive analyses of ROS1 kinase fusions in NSCLC and other cancers. (wikipedia.org)
  • oncogenes
  • The latter is common in lymphomas, where oncogenes are juxtaposed to the promoters of the immunoglobulin genes. (wikipedia.org)
  • Thus, the sequential one-by-one gene testing approach initially used in the clinic to identify just a few genes, is no longer optimal as it would involve high tissue demands to provide results for all the oncogenes of interest. (omicsonline.org)
  • Most oncogenes began as proto-oncogenes, normal genes involved in cell growth and proliferation or inhibition of apoptosis. (wikipedia.org)
  • If normal genes promoting cellular growth, through mutation, are up-regulated, (gain of function mutation) they will predispose the cell to cancer and are thus termed oncogenes. (wikipedia.org)
  • Usually multiple oncogenes, along with mutated apoptotic and/or tumor suppressor genes will all act in concert to cause cancer. (wikipedia.org)
  • The expression of oncogenes can be regulated by microRNAs (miRNAs), small RNAs 21-25 nucleotides in length that control gene expression by downregulating them. (wikipedia.org)
  • The phenomenon that drew his interest was called oncogene cooperation-the idea that it takes multiple oncogenes working together to turn a normal cell into a tumor cell. (pnas.org)
  • One of his early observations was that certain oncogenes, such as oncogenic Ras, turned on p53 but, instead of causing cell death, drove the cell to a cell-cycle arrest similar to senescence ( 4 ). (pnas.org)
  • An elevated percentage of oncogenes and tumour suppressor genes encode TFs. (els.net)
  • Note that since the viral oncogenes originated from a host genome, the transformation event is different from transduction, which describes the process of introducing non-native genes to a host organism via a viral infection. (wikipedia.org)
  • Proteins
  • The detecting methods to inventory gene fusion events on a large biological scale can provide insights about the multi modular architecture of proteins. (wikipedia.org)
  • For example, by characterizing how MLL fusion proteins promote self-renewal, we identified the Myb transcription factor as specifically required for the maintenance of AMLs that are refractory to conventional chemotherapy, such that transient suppression of Myb eradicates these leukemias (1) . (mskcc.org)
  • Other parameters considered to be critical are the location of the miRNAs on the strand, cancer associated genomic regions, epigenetic alteration of miRNA expression and abnormalities in processing target genes and proteins. (wikipedia.org)
  • Several reports suggest that the activity of the GLI proteins is regulated by several proliferative and oncogenic inputs, in addition or independent of upstream HH signalling. (nih.gov)
  • Here we review recent findings on the cooperative integration of HH-GLI signalling with the major oncogenic inputs and we discuss how these cues modulate the activity of the GLI proteins in cancer. (nih.gov)
  • Transcription factors (TFs) are a class of proteins that are essential for the regulation of gene expression and for the control of protein expression in normal physiological conditions. (els.net)
  • Expression of the proteins encoded by these tyrosine kinase fusion genes can, in most cases, be shown to function independently as oncogenic drivers, capable of activating critical downstream pathways involved in the malignant phenotype, resulting in transformation of cells in vitro. (wikipedia.org)
  • Entrectinib is a selective tyrosine kinase inhibitor with specificity, at low nanomolar concentrations, for all of three Trk proteins (encoded by the NTRK1, 2, and 3 genes, respectively) as well as the ROS1, and ALK receptor tyrosine kinases. (wikipedia.org)
  • The tyrosine kinase of the ETV6-NTRK3 fusion protein is dysfunctional in that it is continuously active in phophorylating tyrosine residues on, and thereby continuously stimulating, proteins that promote the growth, survival, and proliferation of their parent cells. (wikipedia.org)
  • ERG and its fusion proteins EWS-ERG and TLS/FUS-ERG inhibit apoptosis. (wikipedia.org)
  • Gag genes are part of a general architecture for retroviruses, viruses that replicate through reverse transcription, where the gag region of the genome encodes proteins that constitute the matrix, capsid and nucleocapsid of the mature virus particles. (wikipedia.org)
  • Rous sarcoma virus Fusion protein Fusion gene Fusion transcript Chimeric gene Bcr-abl fusion protein Oncovirus Retrovirus Retrotransposon Retroposon Integrase gag-onc Fusion Proteins at the US National Library of Medicine Medical Subject Headings (MeSH) http://www.ijbs.com/v06p0730.htm#headingA7 Lewin, Benjamin (1999). (wikipedia.org)
  • Unlike conventional oncogenic chimeric proteins, the fusion product lacks functional domain from respective genes, indicative of an amorphic rearrangement. (wikipedia.org)
  • The transcription of RUNX1 is regulated by 2 enhancers (regulatory element 1 and regulatory element 2), and these tissue specific enhancers enable the binding of lymphoid or erythroid regulatory proteins, therefore the gene activity of RUNX1 is highly active in the haematopoietic system. (wikipedia.org)
  • apoptosis
  • Hallmarks of cancer, such as control of cell cycle, protection from apoptosis, induction of angiogenesis, proliferation, migration and invasion are controlled by gene expression patterns and signalling pathways that are regulated by TFs. (els.net)
  • murine leukemia
  • Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9. (wikipedia.org)
  • In the case of the murine leukemia viruses, a species of viruses capable of causing cancer in murines (mice), the viral life cycle can also be responsible for oncogenesis through a Gag-v-Onc fusion protein called "Mo-MuLV(src)", which is a Gag-v-Src protein capable of inducing oncogenesis in living mice. (wikipedia.org)
  • characterization
  • Although for years the approach to treat advanced disease has been based on the systemic treatment with chemotherapy , the comprehensive characterization of the tumor genome has allowed identifying several oncogenic drivers facilitating the advent of directed targeted therapies which have transformed the outcomes of these patients [ 2 ]. (omicsonline.org)
  • The Gene Fusion Markup Language (GFML) presented here could facilitate the development of a standard format for organizing, integrating and representing the significant features of gene fusion data in an inter-operable and query-able fashion that will enable biologically intuitive access to gene fusion findings and expedite functional characterization. (biomedcentral.com)
  • 2009) Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration‐resistant prostate cancer. (els.net)
  • pathways
  • In the cytoplasm Bcr-Abl acts as an oncogene by interacting with multiple signal transduction pathways that transmit anti-apoptotic and mitogenic signals[ 14 ]. (pubmedcentralcanada.ca)
  • Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy. (nih.gov)
  • The identification of this complex crosstalk and the understanding of how the major oncogenic signalling pathways interact in cancer is a crucial step towards the establishment of efficient targeted combinatorial treatments. (nih.gov)
  • Cooperative integration between HH-GLI signalling and other oncogenic pathways. (nih.gov)
  • In fact, the majority of oncogenic signalling pathways converge on sets of TFs that ultimately control gene expression patterns, resulting in aggressive phenotype, disease progression and increased resistance to drug therapy. (els.net)
  • These native pathways are disrupted in the presence of the mutant Src gene (v-Src) such that oncogenesis becomes more likely for the infected host cells, since the v-Src gene is translated into a functionally distinct version of its host counterpart. (wikipedia.org)
  • cancer
  • The first fusion gene was described in cancer cells in the early 1980s. (wikipedia.org)
  • BCAM-AKT2 is a fusion gene that is specific and unique to high-grade serous ovarian cancer. (wikipedia.org)
  • This database is called Mitelman Database of Chromosome Aberrations and Gene Fusions in Cancer. (wikipedia.org)
  • In prostate cancer ERG protooncogene frequently gains hormonal control by seizing gene regulatory elements of TMPRSS2 through genomic fusion events. (spotidoc.com)
  • Rearrangements between the androgen regulated TMPRSS2 gene promoter and the ETS-related ERG gene result in TMPRSS2-ERG fusion transcripts that have been found in approximately half of prostate cancer cases in the Western world . (spotidoc.com)
  • BMC Cancer 2014, 14:16 http://www.biomedcentral.com/1471-2407/14/16 Page 2 of 12 Results region of the TMPRSS2 gene on chromosome 21 (NCBI build 36.3) for further analyses. (spotidoc.com)
  • This genomic region encompasses upstream regulatory elements (−13.5 kb) shown to control cancer-associated expression of the ERG oncogene . (spotidoc.com)
  • NTRK1 fusions are estimated to occur in 3.3% of lung cancer as assessed through next generation sequencing or fluoresence in situ hybridization. (wikipedia.org)
  • We are continuing to slice the GIST pie into thinner pieces based upon identifying new driver genes," said Jason Sicklick, MD, associate professor of surgery at UC San Diego School of Medicine and surgical oncologist at Moores Cancer Center at UC San Diego Health. (eurekalert.org)
  • Is this why, new multiplexing assays with potential diagnostic for several genes at a time are entering with strength into the field of lung cancer molecular testing. (omicsonline.org)
  • An oncogene is a gene that has the potential to cause cancer. (wikipedia.org)
  • Later on the term "oncogene" was rediscovered in 1969 by National Cancer Institute scientists George Todaro and Robert Heubner. (wikipedia.org)
  • As one example that illustrates our overall approach, we developed and used a mouse model that recapitulates the genetics and pathology of human cholangiocarcinoma (bile duct cancer) to validate the FIG-ROS fusion protein as a therapeutic target in this disease (Figure 4). (mskcc.org)
  • Through the course of investigating that hypothesis, we stumbled across p53, which was a gene that is known to inhibit cancer," he says. (pnas.org)
  • The drug and compound response, gene expression, and microRNA expression data are publicly available at http://sarcoma.cancer.gov . (aacrjournals.org)
  • 2015) Improvements in radiographic progression‐free survival stratified by ERG gene status in metastatic castration‐resistant prostate cancer patients treated with abiraterone acetate. (els.net)
  • 2007) Reduced PDEF expression increases invasion and expression of mesenchymal genes in prostate cancer cells. (els.net)
  • Clinical data supports the use of crizotinib in lung cancer patients with ROS1 gene fusions. (wikipedia.org)
  • Although the most preclinical and clinical studies of ROS1 gene fusions have been performed in lung cancer, ROS1 fusions have been detected in multiple other tumor histologies, including ovarian carcinoma, sarcoma, cholangiocarcinomas and others. (wikipedia.org)
  • Crizotinib or other ROS1 inhibitors may be effective in other tumor histologies beyond lung cancer as demonstrated by a patient with an inflammatory myofibroblastic tumor harboring a ROS1 fusion with a dramatic response to crizotinib. (wikipedia.org)
  • ERG can fuse with TMPRSS2 protein to form an oncogenic fusion gene that is commonly found in human prostate cancer, especially in hormone-refractory prostate cancer. (wikipedia.org)
  • The fusion gene is critical to the progression of cancer because it inhibits the androgen receptor expression and it binds and inhibits androgen receptors already present in the cell. (wikipedia.org)
  • The gag-onc fusion protein (also written as Gag-v-Onc, with "v" indicating that the Onc sequence resides in a viral genome) is a general term for a fusion protein formed from a group-specific antigen ('gag') gene and that of an oncogene ('onc'), a gene that plays a role in the development of a cancer. (wikipedia.org)
  • He also sits on the board of directors at Thermo Fisher Scientific, Inc. and Aveo Pharmaceuticals Inc. He is a member of the Scientific Advisory Board at T2Biosystems, Inc. and at Epizyme, Inc. He has pioneered the use of gene-targeting technology in mice to study cancer-associated genes and to construct mouse models of many human cancer types. (wikipedia.org)
  • The EML4-ALK fusion gene is responsible for approximately 3-5% of non-small-cell lung cancer(NSCLC). (wikipedia.org)
  • NTRK3
  • It is a selective pan-trk receptor tyrosine kinase inhibitor (TKI) targeting gene fusions in trkA, trkB, and trkC (coded by NTRK1, NTRK2, and NTRK3 genes) that is currently in phase 2 clinical testing. (wikipedia.org)
  • This new gene consists of the 5' end of ETV6 fused to the 3' end of NTRK3. (wikipedia.org)
  • Entrectinib is a pan-NTRK as well as an ALK and ROS1 tyrosine kinase inhibitor has been found useful in treating a single patient with ETV6-NRTK3 fusion gene-associated mammary analogue secretory carcinoma and has lend support to the clinical development of NTRK3-directed tyrosine kinase inhibitors to treat ETV6-NTRK3 fusion protein associated malignancies. (wikipedia.org)
  • transcripts
  • Oncogenic fusion transcripts may also be caused by trans-splicing or read-through events. (wikipedia.org)
  • RNA‑sequencing showed that the t(4;5)(q24;q31) resulted in recombination of the genes TBCK on 4q24 and P4HA2 on 5q31.1 with generation of an in‑frame TBCK‑P4HA2 and the reciprocal but out‑of‑frame P4HA2‑TBCK fusion transcripts. (cancerindex.org)
  • The nCounter platform allows multiplexed tests of fusion transcripts (mRNA) using direct digital profiles or counting technology [ 7 ]. (omicsonline.org)
  • genetic
  • Our findings indicate that, in spite of the recurrence of AHRR‑NCOA2 in angiofibroma of soft tissue, additional genetic events (or fusion genes) might be required for the development of this tumor. (cancerindex.org)
  • fluorescence in situ hybri
  • Detection of these fusion genes, generally identified by standard fluorescence in situ hybridization (FISH) or immunohistochemistry (IHC) techniques, is thus very important in guiding specific treatment decisions and selecting the most appropriate targeted therapy. (omicsonline.org)
  • The standard test used to detect this gene in tumor samples is fluorescence in situ hybridization (FISH) by a US FDA approved kit. (wikipedia.org)
  • ROS1
  • 8 ] we have validated this platform in the clinical setting, demonstrating that it allows effective detection of ALK, ROS1 and RET fusion genes from FFPE samples and identifies a greater number of positive cases that could benefit from targeted therapies. (omicsonline.org)
  • The study will enroll any patient with a solid tumor having evidence of an NTRK/ROS1/ALK fusion, assuming the patient meets all other entry criteria. (wikipedia.org)
  • unreliable medical source] ROS1 fusion-positive patients tend to be younger, with a median age of 49.8 years, and never-smokers, with a diagnosis of adenocarcinoma. (wikipedia.org)
  • ROS1 expression was found in approximately 2% of NSCLC patients, and its expression was limited to those patients with ROS1 gene fusions. (wikipedia.org)
  • An open label, multicenter, global phase 2 clinical trial called STARTRK-2 is currently underway to test the drug in patients with ROS1/NTRK/ALK gene rearrangements. (wikipedia.org)
  • genome
  • In recent years, next generation sequencing technology has already become available to screen known and novel gene fusion events on a genome wide scale. (wikipedia.org)
  • c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene. (wikipedia.org)
  • Human ASPSCR1 genome location and ASPSCR1 gene details page in the UCSC Genome Browser. (wikipedia.org)
  • tumorigenesis
  • Conclusions: These observations imply that the frequently noted loss-of-function of NKX3.1 cooperates with the activation of TMPRSS2-ERG fusions in prostate tumorigenesis. (spotidoc.com)
  • Keywords: Tumor suppressor, NKX3.1, Prostate, ERG, NFкB, Oncogene Background Activation of the ERG oncogene represents an early event in pre-neoplastic to neoplastic transition during prostate tumorigenesis [2- (spotidoc.com)
  • TMPRSS2
  • Although, the androgenic activation of TMPRSS2 gene has been established, little is known about other elements that may interact with TMPRSS2 promoter sequences to modulate ERG expression in TMPRSS2-ERG gene fusion context. (spotidoc.com)
  • In contrast, other control elements of the TMPRSS2 promoter are largely unexplored both in the wild type, as well as, in the TMPRSS2-ERG fusion genomic context. (spotidoc.com)
  • TMPRSS2 , SLC45A3 , and NDRG1 ) and ETS genes (e.g. (pubmedcentralcanada.ca)
  • 5 Within this distinct subgroup of PCa, the TMPRSS2-ERG fusion occurs through a deletion of the genomic material spanning from TMPRSS2 to ERG in the majority of these cases. (pubmedcentralcanada.ca)
  • Essentially TMPRSS2-ERG fusion disrupts the ability of the cells to differentiate into proper prostate cells creating unregulated and unorganized tissue. (wikipedia.org)
  • novel
  • These studies have also identified many novel gene fusion candidates with more detailed resolution than previously achieved. (biomedcentral.com)
  • NCOA2 is a novel negative growth regulatory gene repressing the Wnt/β-catenin pathway in CRC, where recurrent fusion with LACTB2 contributes to its disruption. (wikipedia.org)
  • target genes
  • In these instances siRNA has been used in direct contact with the tissue for transport and the resulting RNAi has been extremely successful in focusing on target genes. (wikipedia.org)
  • expression
  • When gene fusion happens in non-coding sequence region, it can lead to the misregulation of the expression of a gene now under the control of the cis-regulatory sequence of another gene. (wikipedia.org)
  • NKX3.1 and ERG genes expressions were evaluated by immunoblot or by quantitative Real-Time PCR (qRT-PCR) assays in response to siRNA knockdown or heterologous expression. (spotidoc.com)
  • QRT-PCR assay was used for monitoring the gene expression levels of NKX3.1-regulated genes. (spotidoc.com)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • Gene expression was derived from exon array data and microRNA expression was derived from direct digital detection assays. (aacrjournals.org)
  • Chemical structures, IC 50 heat maps, concentration response curves, gene expression, and miR expression heat maps are presented for selected examples. (aacrjournals.org)
  • This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. (wikipedia.org)
  • TFs are essential for controlling gene expression during normal physiological conditions and disease. (els.net)
  • Gene rearrangements, leading to the expression of constitutively activated fusion tyrosine kinase receptors, have been increasingly identified as a common feature of malignancies over the last three decades, and success has been demonstrated using these rearrangements as targets for drug development. (wikipedia.org)
  • The expression of such gene fusions in a tumor can create a phenomenon termed 'oncogene addiction' in which the tumor becomes dependent on signaling by the aberrant kinase pathway, thus rendering its survival and continued proliferation exquisitely sensitive to targeted inhibition with small molecule tyrosine kinase inhibitor drugs. (wikipedia.org)
  • Enforced expression of wild-type NCOA2 but not the LACTB2-NCOA2 fusion protein impaired the pro-tumorigenic phenotypes of CRC cells, whereas knockdown of endogenous NCOA2 in normal colonocytes had opposite effects. (wikipedia.org)
  • At a molecular level, expression of the gene RUNX1 is upregulated by the RUNX1 intronic cis-regulatory element (+23 RUNX1 enhancer). (wikipedia.org)
  • sarcoma
  • The first confirmed oncogene was discovered in 1970 and was termed src (pronounced sarc as in sarcoma). (wikipedia.org)
  • As a specific case, a Gag-v-Onc fusion protein from the Rous sarcoma virus is useful in illustrating the dual role that the fusion protein plays in both the viral and host cellular life cycle. (wikipedia.org)
  • For example, the viral gene Src (as in "sarcoma") is not necessary for viral reproduction, but does affect virulence. (wikipedia.org)
  • This gene is a candidate gene for alveolar soft part sarcoma (ASPS). (wikipedia.org)
  • ABL1
  • The broken end of chromosome 22 contains the "BCR" gene, which fuses with a fragment of chromosome 9 that contains the "ABL1" gene. (wikipedia.org)
  • Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. (wikipedia.org)
  • The ABL1 gene is expressed as either a 6- or a 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. (wikipedia.org)
  • Alternatively
  • In the case of a fusion with C-jun, the resulting "gag-jun" protein is known alternatively as p65). (wikipedia.org)
  • Several alternatively spliced transcript variants of this gene have been described, but their full length nature has not been determined. (wikipedia.org)
  • NCOA2
  • Gene fusions AHRR-NCOA2, NCOA2-ETV4, ETV4-AHRR, P4HA2-TBCK, and TBCK-P4HA2 resulting from the translocations t(5;8;17)(p15;q13;q21) and t(4;5)(q24;q31) in a soft tissue angiofibroma. (cancerindex.org)