• Discovery
  • The first experimental antivirals were developed in the 1960s, mostly to deal with herpes viruses, and were found using traditional trial-and-error drug discovery methods. (wikipedia.org)
  • He has published more than 120 manuscripts in a variety of journals including Science, Nature, PLoS Biology, Drug Discovery Today, the Proceedings of the National Academy of Sciences, and the Journal of the American Medical Association. (wikipedia.org)
  • In 2010, he again became a finalist and went on to receive the Pioneer Award for his Computational Analysis of Novel Drug Opportunities (CANDO) drug discovery platform to screen every known drug against every known target structure in a shotgun manner to discover new repurposeable therapeutics, particularly for underserved diseases. (wikipedia.org)
  • Samudrala has extended this theoretical framework to explain how evolution works by recursion of existing information and has used it to solve research problems with practical applications in medicine, such as therapeutic discovery based on docking with dynamics, multitargeting, and drug repurposing in a shotgun manner, as well as in nanobiotechnology, such as engineering tooth tissue by designing novel peptides that bind to various inorganic substrates. (wikipedia.org)
  • The discovery of direct Xa inhibitors was a long process which started in the early 1980s. (wikipedia.org)
  • In early 1990s, the determination of biological crystal structure of influenza virus surface protein led to the discovery of the active site and provided the opportunities to discover and design new and specific inhibitors. (wikipedia.org)
  • Furthermore, in vitro experiments complemented with computation methods are increasingly used in early drug discovery to select compounds with more favorable ADME (absorption, distribution, metabolism, and excretion) and toxicological profiles. (wikipedia.org)
  • In contrast to traditional methods of drug discovery (known as forward pharmacology), which rely on trial-and-error testing of chemical substances on cultured cells or animals, and matching the apparent effects to treatments, rational drug design (also called reverse pharmacology) begins with a hypothesis that modulation of a specific biological target may have therapeutic value. (wikipedia.org)
  • In the field of drug discovery, retrometabolic drug design is a strategy for the design of safer drugs using either a soft drug or targeted drug delivery approaches. (wikipedia.org)
  • receptor
  • Hormonal therapy aims at depriving estrogen signaling either by using selective estrogen receptor modulators (SERM)-that interfere with the binding of E2 to its receptor (ER)-or aromatase inhibitors (AI)-that block the aromatase-dependent synthesis of E2. (pubmedcentralcanada.ca)
  • development
  • Since its introduction by Nicholas Bodor in the late 1970s, the soft drug concept generated considerable research both in academic and in industrial settings and there are several rationally designed soft drugs that have either already reached the market, such as esmolol (Breviblock) landiolol (Onoact) remifentanil (Ultiva) loteprednol etabonate (Lotemax, Alrex, Zylet) clevidipine (Cleviprex) or are in late-stage development (remimazolam, budiodarone, celivarone, AZD3043, tecafarin). (wikipedia.org)
  • molecular
  • The emergence of antivirals is the product of a greatly expanded knowledge of the genetic and molecular function of organisms, allowing biomedical researchers to understand the structure and function of viruses, major advances in the techniques for finding new drugs, and the pressure placed on the medical profession to deal with the human immunodeficiency virus (HIV), the cause of acquired immunodeficiency syndrome (AIDS). (wikipedia.org)
  • Irrespective of the approach, the altered chemical structure is designed to advantageously adjust the molecular properties such as, stability or biological activity. (wikipedia.org)
  • several
  • When you recommend your Langeweile, Überdruß und Lebenssinn: Eine geistesgeschichtliche und, you present conducting that several restrictions will design you what you attempt integrated not and easily infinite countries about how to sign download better. (ecombinatii.ro)
  • CDSs are biologically inert molecules intended to enhance drug delivery to a particular organ or site and requiring several conversion steps before releasing the active drug. (wikipedia.org)
  • virus
  • This makes it difficult to find targets for the drug that would interfere with the virus without also harming the host organism's cells. (wikipedia.org)
  • different
  • The protocol described here focuses on the technical details of designing and preparing for an intracranial injection, performing the surgery, and ensuring successful and reproducible tumor growth and provides starting points for a variety of conditions that can be customized for a range of different brain tumor models. (jove.com)
  • require
  • They have a fast onset, predictable pharmacokinetics and don't require as strict monitoring as the older anticoagulant drugs. (wikipedia.org)