• At least five subtypes of these libraries exist, and the distinguishing characteristic is the method of synthesis of each library. (wikipedia.org)
  • This form of peptide synthesis is limited to a peptide chain length of approximately 70 amino acids, and is generally unsuitable for the study of larger proteins. (wikipedia.org)
  • Large random peptide libraries are often used for the synthesis of certain peptide molecules, such as ultra-large chemical libraries for the discovery of high-affinity peptide binders, and an increase in the library size severely affects parameters, such as the synthesis scale, the number of library members, the sequence deconvolution and peptide structure elucidation. (wikipedia.org)
  • Chapter 2 discusses the synthesis of a library of N-terminal modified peptides created using a one-bead one-compound (OBOC) approach. (uwo.ca)
  • Chapter 4 discusses the synthesis of an OBOC library with an imaging moiety integrated within the peptide structures. (uwo.ca)
  • A two-pool OBOC strategy was developed to distribute the fluorine-containing amino acid throughout the peptide sequence during library synthesis. (uwo.ca)
  • To explain the broad-spectrum activity of the peptide, I hypothesized that it acted to inhibit a common stress response, and that the stringent response, mediating (p)ppGpp synthesis through the enzymes RelA and SpoT, was targeted. (ubc.ca)
  • Consistent with this notion, increasing (p)ppGpp synthesis led to reduced susceptibility to the peptide. (ubc.ca)
  • NovoPro has a rapid high-throughput parallel peptide synthesis platform that enables our customers to synthesize larger quantities of high purity peptides at lower cost than traditional methods. (novoprolabs.com)
  • However, since there are 20 natural amino acids, the synthesis of a linear peptide ( n amino acids in length) can be produced in 20 n different combinations. (peptidesguide.com)
  • Libraries in and of themselves can prove even more uniform than other methods in demonstrating full-length ligands during screening since molecular weight degeneracy can be eliminated right during the sequencing process versus during the synthesis, thus making the entirety of the technique much more simplified and less costly. (peptidesguide.com)
  • With ProteoGenix's cost-effective method of peptide library synthesis , you can now employ high-quality peptides for a fraction of the cost. (proteogenix.science)
  • Why choose ProteoGenix for overlapping peptide library synthesis? (proteogenix.science)
  • Our custom peptide synthesis service offers high-quality, reliable and cost-effective products to support your research. (2bscientific.com)
  • We have unrivalled expertise in the synthesis of complex, constrained and other special peptides and our scientists are happy to assist in selecting the most appropriate peptide specification for your application. (2bscientific.com)
  • A typical custom synthesis peptide run will yield between 5 - 50 mg of the peptide in question, depending upon the number of amino acids and complexity of the product. (2bscientific.com)
  • Turnaround time for a peptide synthesis is typically 1-3 weeks but may be longer for peptides over 60 amino acids, those with difficult modifications or if TFA removal, or non-routine analysis is required. (2bscientific.com)
  • Our custom peptide synthesis partner is able to synthesize any kinds of peptides from 2 to 100+ amino acids with a 99% purity rate. (2bscientific.com)
  • They also have state of the art Peptide Library Synthesis for hundreds of peptides. (2bscientific.com)
  • A peptide library is a tool for studying proteins. (wikipedia.org)
  • Since displayed proteins longer than 20-30 amino acids have a deleterious effect on the infectivity function of pIII, this vector is suitable only for the display of short peptides. (neb.com)
  • Several covalent bonds, called peptide bonds , join amino acids together to form proteins . (peptidesguide.com)
  • Human peptide spectral library constructed from 350k HCD spectra from synthetic peptides generated in the ProteomeTools and Bioplex (bait proteins) experiments. (ucsd.edu)
  • Phage display is a laboratory technique for the study of protein-protein, protein-peptide, and protein-DNA interactions that uses bacteriophages (viruses that infect bacteria) to connect proteins with the genetic information that encodes them. (wikipedia.org)
  • The proteins that the phages are displaying can then be screened against other proteins, peptides or DNA sequences, in order to detect interaction between the displayed protein and those of other molecules. (wikipedia.org)
  • In this way, large libraries of proteins can be screened and amplified in a process called in vitro selection, which is analogous to natural selection. (wikipedia.org)
  • A cell-penetrant peptide blocking C9ORF72-repeat RNA nuclear export reduces the neurotoxic effects of dipeptide repeat proteins. (le.ac.uk)
  • Through intestinal protein sensing, dietary proteins regulate glucose homeostasis and food intake by secreting gut hormones, such as glucagon-like peptide 1 (GLP-1), cholecystokinin (CCK), peptide YY (PYY) and glucose-dependent insulinotropic polypeptide (GIP). (bvsalud.org)
  • Recently it has become possible to accurately predict spectra from peptide sequences 14 , 15 , but direct searching of single-injection DIA data has remained problematic, in part due to the false discovery rate (FDR) correction required when considering all possible tryptic peptides in a FASTA database. (nature.com)
  • The display system is best used to display small peptides, i.e. sequences of 50 amino acids or less. (neb.com)
  • M13KE is a simple M13 derivative in which cloning sites have been introduced at the 5´ end of gene III for display of short peptide sequences as N-terminal pIII fusions. (neb.com)
  • The sequences of the randomized 24 nucleotide/eight amino acid regions of representatives of the plasmid and virus libraries were analyzed. (elsevierpure.com)
  • Phage display was first described by George P. Smith in 1985, when he demonstrated the display of peptides on filamentous phage (long, thin viruses that infect bacteria) by fusing the virus's capsid protein to one peptide out of a collection of peptide sequences. (wikipedia.org)
  • Applications of phage display technology include determination of interaction partners of a protein (which would be used as the immobilised phage "bait" with a DNA library consisting of all coding sequences of a cell, tissue or organism) so that the function or the mechanism of the function of that protein may be determined. (wikipedia.org)
  • Concept of bioinspired compatibilizer was expanded to the implementation of different peptide sequences. (hu-berlin.de)
  • Evaluation of secondary interactions revealed that the smaller the affinity for peptide-peptide interaction, the higher the availability of peptide sequences for an inorganic surface. (hu-berlin.de)
  • Antibacterial drugs were originally isolated from natural sources, but as the threat of antibacterial resistance looms, the development of intelligently designed antimicrobial drugs, including small molecules and custom antimicrobial peptides has been fostered. (genscript.com)
  • Antimicrobial peptides(AMPs) are short peptide ranging from 10 to 50 amino acids and has a broad spectrum of antibiotic activities against bacteria, yeasts, fungi, and viruses, as well as cytotoxic activity on cancer cells, anti-inflammatory, and immunomodulatory activities. (genscript.com)
  • The distinct activity of antimicrobial peptides governs their sequence, namely, the incorporation of these peptides into microbial cell membranes. (genscript.com)
  • Due to the negative charge of many microbial membrane components (e.g. phospholipids, lipopolysaccharides and teichonic acids), antimicrobial peptides are often cationic in nature. (genscript.com)
  • The defensins are a large family of small, cationic, cysteine- and arginine-rich antimicrobial peptides. (eurogentec.com)
  • Phage display libraries have provided an extraordinarily versatile technology to facilitate the isolation of peptides, growth factors, single chain antibodies, and enzymes with desired binding specificities or enzymatic activities. (elsevierpure.com)
  • In this study, methods were developed to construct a model library of randomized eight amino acid peptides using the ALV eukaryotic display platform and screen the library for specific epitopes using immobilized antibodies. (elsevierpure.com)
  • Different populations of peptide epitopes were selected from the virus library when different monoclonal antibodies were used as the target. (elsevierpure.com)
  • When experiment-specific spectrum library generation is either impossible or impractical, as is frequently the case with non-model organisms, sequence variants, splice isoforms, or scarce sample quantities, software tools such as Pecan 10 and DIA-Umpire 11 can detect peptides from DIA experiments without a spectrum library by directly searching every peptide in FASTA databases. (nature.com)
  • The use of this Group II of distinct 18 peptide mixtures, in combination with Group I of 180 distinct peptide mixtures (cat# 62017-1), can provide sequence preference information of different kinases. (anaspec.com)
  • To clone a single peptide sequence, reactions can be scaled down. (neb.com)
  • Schematic shows the sequence of the peptide cloning site as well as the strategy for designing and cloning a peptide library into M13KE. (neb.com)
  • This assists in knowing what is the most important within a sequence, thus avoiding the use of lengthy peptide chains. (peptidesguide.com)
  • The overall diversity of peptides in phage display libraries can be significantly limited by Escherichia coli protein folding and processing machinery, which result in sequence censorship. (elsevierpure.com)
  • No significant sequence censorship was observed in producing the virus display library from the plasmid library. (elsevierpure.com)
  • Comparison of the individual amino acid content and sequence of this oxytocin-like peptide with authentic oxytocin would confirm unequivocally that Leydig cells are the biosynthetic machinery involved in testicular oxytocin production. (thesisabstracts.com)
  • The current concept is based on the sequence specific recognition of the inorganic surface by peptides. (hu-berlin.de)
  • Peptide-polyethylene oxide (PEO) conjugates, consisting of a previously identified specifically binding peptide sequence and polymer-block, are incorporated in the polymer composite material, composed of MgF2 nanoparticles particles and PEO. (hu-berlin.de)
  • By using experimental techniques such as circular dichroism, small angle X-ray scattering, quartz crystal microbalance with dissipation monitoring, and neutron reflectometry, it was determined that changing the number of histidines in the peptide sequence did not affect the structure of the peptide dissolved in solution. (lu.se)
  • MEMs extracted over 10000 matching and overlapped peptides across six different proteases mAb samples, achieving a 100% sequence coverage for 8 of the ten polypeptide chains. (lu.se)
  • Synthetic peptide libraries are synthesized without utilizing phage or other biological systems. (wikipedia.org)
  • This positional scanning synthetic peptide combinatorial library (PS-SPCL) has been used in rapid identification of serine/threonine kinase phosphorylation motif. (anaspec.com)
  • Peptide libraries are collections of synthetic peptides, invaluable for studying protein-protein interactions. (proteogenix.science)
  • Human peptide spectral library constructed from 1.25 billion spectra from in vivo proteomics and synthetic peptide experiments, including spectra from multiple data types. (ucsd.edu)
  • Use for searching newly-acquired HCD data against the best representative HCD spectra for synthetic peptides. (ucsd.edu)
  • To further understand the principles underlying thyroid receptor-coregulator selectivity, we designed a high-throughput in vitro binding assay to measure the equilibrium affinity of thyroid receptor to a library of potential coregulators in the presence of different ligands including the endogenous thyroid hormone T3, synthetic thyroid receptor beta-selective agonist GC-1, and antagonist NH-3. (nih.gov)
  • 2006). The LLNA is based upon characterization of chemicals comprising allergens of different potencies and non- induced proliferative responses in draining lymph nodes allergenic chemicals were evaluated for their ability to react with following topical exposure of mice to chemicals (Gerberick reduced glutathione (GSH) or with two synthetic peptides et al. (cdc.gov)
  • In 1990, Jamie Scott and George Smith described creation of large random peptide libraries displayed on filamentous phage. (wikipedia.org)
  • successfully identified a human motilin receptor using the Phoenix Gastrointestinal Peptide Library and HEK293 cells in which a human motilin receptor was coexpressed with aequorin, a bioluminescent calcium sensitive reporter protein. (phoenixbiotech.net)
  • Phage-displayed peptide that mimics aflatoxins and its application in immunoassay. (cdc.gov)
  • In this case, instead of screening hundreds of peptides individually, researchers can focus on identifying positive peptide pools. (proteogenix.science)
  • Hundreds of Peptides - 1 to 5 mg unpurified (desalted) Ideal size 5 to 20aa, up to 60. (2bscientific.com)
  • The ability of ESI-MS to estimate simultaneously the relative binding affinities of a protein to soluble ligands in a library, if general, should be useful in drug development. (figshare.com)
  • This method identifies peptide ligands as well as cytoxic peptides that may prove useful in developing anti-cancer agents. (peptidesguide.com)
  • More than 40 families of identified or suspected G Protein Coupled Receptor Peptide Ligands as well as its related agonists and antagonists enable a 'reverse pharmacology approach' for large scale screening Orphan G Protein Coupled Receptors included over five hunderd peptides which are HPLC-purified and fluorescein free. (phoenixbiotech.net)
  • However, even when using GPF, these tools still generally detect fewer peptides than library search engines, which can leverage previously acquired instrument-specific fragmentation and measured retention times. (nature.com)
  • When offset numbers are high and peptides long, the resulting library will have fewer peptides. (proteogenix.science)
  • The structure of the complex may explain the fact that the library-derived peptide binds alpha-BTX with a 15-fold higher affinity than that shown by the acetylcholine receptor peptide (alpha185-196). (rcsb.org)
  • Phage display technology has been used as a powerful tool in the discovery of peptides capable of exhibiting specific affinity to various metals or metal ions. (korea.ac.kr)
  • In this study, phage display technique was incorporated with chromatography procedure with the use of a monolithic column, facilitating multiple phage-binding equilibrium states and online monitoring of the selection process in search of affinity peptides to Pb 2+ . (korea.ac.kr)
  • It is expected that this monolith-based chromatographic biopanning will provide a promising approach for a high throughput screening of affinity peptides cognitive of a wide range of target species. (korea.ac.kr)
  • This displayed the different peptides on the outer surfaces of the collection of viral clones, where the screening step of the process isolated the peptides with the highest binding affinity. (wikipedia.org)
  • This ultrasound-based method enables single-step selection of a high-affinity peptide. (wikipedia.org)
  • HLA-DR molecules were affinity purified and bound peptides acid eluted. (jci.org)
  • With over 25 years of peptide manufacturing experience, AnaSpec is your trusted source of highly complex peptides. (anaspec.com)
  • Our partner has the technology to synthesize 96 complex peptides in parallel and offers various grades of quality controls. (2bscientific.com)
  • We can synthesise difficult peptides (greater than 100 amino acids) and peptides with a wide and increasing range of amino acid modifications including N-terminal, C-terminal and side-chain modifications, multiple disulphide bridges, fluorescent labels, lipidation, D-amino acid and heavy isotope incorporation, biotinylation, glycosylation, post translational modifications, PEGylation and more. (2bscientific.com)
  • Kinase Substrates Library, Group II, biotinylat. (anaspec.com)
  • PepChip Kinase is a family of peptide microarrays containing up to 3,000 kinase substrates (phosphorylation sites) for rapid target identification. (mimotopes.com)
  • The Ph.D.™ Peptide Display Cloning System contains M13KE vector, the parent vector of NEB's Ph.D. libraries. (neb.com)
  • Human peptide spectral library constructed from 1 billion spectra from in vivo proteomics experiments, including only high resolution spectra from label-free HCD experiments. (ucsd.edu)
  • This thesis will document a method of combinatorial chemistry to construct libraries of new potential peptide-based imaging agents for positron emission tomography (PET) imaging. (uwo.ca)
  • It is widely used in peptide library screening for drug discovery, target validation, epitope mapping, vaccine development, and structure-activity studies. (novoprolabs.com)
  • For instance, in epitope mapping experiments, peptides should contain between 9 and 22 amino acids because epitopes typically fall within that size range. (proteogenix.science)
  • The kinetics and products of degradation of HIV-1 Gag favored the production of peptides encompassing the immunodominant epitope and destruction of the subdominant one. (jci.org)
  • the modulation of epitope immunodominance and the processing and presentation of HIV peptides for MHC class I recognition were shown to be dependent on flanking residues that were N terminal to the natural epitopes (see the related article beginning on page 3563). (jci.org)
  • For example, a peptide chain of 10 residues in length is used in native chemical ligation with a larger recombinantly expressed protein. (wikipedia.org)
  • The peptide fills an alpha-BTX pocket made of residues located at fingers I and II, as well as at the C-terminal region. (rcsb.org)
  • Of the peptide residues, the largest contact area is formed by Tyr-3 and Tyr-4. (rcsb.org)
  • These findings are in accord with the previous data in which it had been shown that substitution of these aromatic residues by aliphatic amino acids leads to loss of binding of the modified peptide with alpha-BTX. (rcsb.org)
  • Further, a hexapeptide is a peptide that contains six amino acid residues. (peptidesguide.com)
  • In practice, this parameter is defined by the number of amino acid residues shared by neighboring peptides. (proteogenix.science)
  • Although smaller libraries are much easier and less expensive to synthesize, the likelihood of researchers finding the precise interface residues in complex projects is often limited. (proteogenix.science)
  • In contrast, when offset numbers are low and peptides short, the resulting library will have more peptides, making it easier to identify the interface residues but also resulting in more time-consuming experiments. (proteogenix.science)
  • By producing large numbers of peptides, for which each differs from the other by one single amino acid, it is possible to ascertain which amino acid substitutions make binding to a receptor the strongest, and which make that binding process weaker. (peptidesguide.com)
  • Phoenix's Peptide Receptor Ligand Libraries, a broad set of peptides (thousands), enables a "reverse pharmacology" approach to identify unknown membrane receptors, G-protein-coupled receptors, ion channels, intracellular signaling enzymes and receptors. (phoenixbiotech.net)
  • Through screening and profiling applications, libraries help researchers determine relevant antigen-antibody recognition sites, unravel enzyme-substrate specificity, or determine the sites responsible for receptor binding - particularly useful when studying pathogenic viruses. (proteogenix.science)
  • Prearranged positive allosteric modulators (PAMs) inspired by photopharmacology are synthesized and applied to the glucagon-like peptide-1 receptor (GLP-1R), a class B G protein-coupled receptor. (wiley.com)
  • One subset of the G-protein coupled receptor (GPCR) superfamily is that which is activated by a peptide carrying an obligatory positively charged residue (GPCR-PA+). (sbir.gov)
  • Peptide used as insulin receptor tyrosine kinase substrate. (anaspec.com)
  • After activating the sensory receptors, such as calcium-sensing receptor (CaSR), peptide transporter-1 (PepT1), and taste 1 receptors (T1Rs), protein digests induced Ca2+ influx and thus triggered gut hormone release. (bvsalud.org)
  • We have demonstrated proof of concept by creating a general plasma membrane bound decoy receptor, by displaying a protein or a peptide genetically fused to a trunctated version of the CD40 molecule. (lu.se)
  • When this decoy receptor is engaged by a ligand to the displayed protein/peptide, the receptor expressing cell is rescued from apoptosis. (lu.se)
  • One specific peptide-displaying cell could be identified and amplified, based on a specific receptor engagement, in a background of 12 500 wild-type cells after four selections. (lu.se)
  • Stringent quality control: NovoPro provides Certificate of Analysis, MS, and HPLC validation data for each peptide. (novoprolabs.com)
  • All the peptides synthesized are controlled by MS and HPLC. (proteogenix.science)
  • The majority of peptides are in freeze dried form and will contain counter ions and physically bound water as a result of cleavage from resin, hplc and drying. (2bscientific.com)
  • Peptide and biochemical purity is assessed using an array of techniques including HPLC, NMR, microanalysis, high voltage electrophoresis, TLC, and mass spectrometry as appropriate. (2bscientific.com)
  • Peptides purified by reversed phase HPLC or ion exchange chromatography have their purity given as the area under the curve of the major peak when analysed at a specific wavelength, usually 230nm. (2bscientific.com)
  • Subsequently, peptides were separated by reversed-phase HPLC and analyzed by liquid chromatography-mass spectrometry. (jci.org)
  • PEC increases the speed of peptide development since it can be used for parallel purifications, whereas high-pressure liquid chromatography (HPLC) only allows one-by-one processing of single samples. (bachem.com)
  • Each peptide in the library contains a single fluorine atom incorporated through established SPAAC chemistry. (uwo.ca)
  • This 18 F-azadibenzocyclooctyne (ADIBO-F) was radiolabelled from its toluenesulfonate precursor in 21-35 % radiochemical yields, and subsequently incorporated into two cancer-targeting peptides through SPAAC chemistry. (uwo.ca)
  • The unique screening technique as described above uses peptide chemistry along with the OBOC library format. (peptidesguide.com)
  • After screening a ligand against a library of fifteen different peptides, a unique peptide profile will figuratively illustrate the induced ER conformation. (umsystem.edu)
  • Each ligand was found to have a unique peptide profile and, implicitly, a distinct ER conformation. (umsystem.edu)
  • Synthetizing methods for developing one-bead, one-compound (OBOC) peptide libraries have shown to be superior to that of standard assay formats and pooling strategies. (peptidesguide.com)
  • In an off-bead assay, the peptide is released from the resin bead, but it maintains its proximity to the bead. (peptidesguide.com)
  • Our method specifically enables rapid, experiment-specific library generation for non-model organisms, which we demonstrate using the malaria parasite Plasmodium falciparum , and non-canonical databases, which we show by detecting missense variants in HeLa. (nature.com)
  • We hypothesize that this is due to the ability of the histidines to charge titrate, which charges up the peptide, and enables it to penetrate and translocate through the lipid bilayer. (lu.se)
  • The Peptide Easy Clean (PEC) technology is universally applicable and enables the efficient and innovative manufacturing of new peptide based drug modalities. (bachem.com)
  • Providing services for all stages of drug development for small (including highly potent) molecules and peptides. (almacgroup.com)
  • We provide a range of services for small molecules (including highly potent) and peptides. (almacgroup.com)
  • We offer a full suite of analytical testing for a range of different product types including small molecules, peptides, biologics, conjugates, potent and controlled substances. (almacgroup.com)
  • As a result of our continued collaboration, development of the linker molecules was achieved by Belyntic, with Bachem assisting as an industry partner for early testing on pharmaceutically relevant peptides. (bachem.com)
  • Further studies identified even more potent D-enantiomeric anti-biofilm peptides DJK-5 and DJK-6 that also prevented (p)ppGpp accumulation, were highly synergistic with conventional antibiotics and exhibited in vivo activity. (ubc.ca)
  • For the first time, to our knowledge, we have identified HLA-bound peptides presented in vivo during an inflammatory condition. (jci.org)
  • The next step will be to determine each ligand's tissue specific activity and identify the unique peptide fingerprint that predicts its in vivo biological response. (umsystem.edu)
  • This method can detect all seven known BoNT serotypes and involves incubating BoNT with a peptide substrate that mimics each toxin's natural in vivo neuronal protein target. (cdc.gov)
  • Although a limited number of immunodominant peptide epitopes are consistently observed in diseases such as HIV-1 infection, the relationship between immunodominance and antigen processing in humans is largely unknown. (jci.org)
  • This paper describes the use of electrospray ionization-mass spectrometry (ESI-MS) to screen two libraries of soluble compounds to search for tight binding inhibitors for carbonic anhydrase II (EC 4.2.1.1). (figshare.com)
  • Peptide-polymer conjugates can be considered as the simplified version of natural compatibilizers. (hu-berlin.de)
  • This bioinspired concept of interface modification via peptide-polymer conjugates represents a versatile tool for new material development. (hu-berlin.de)
  • Usually, the peptide library is synthesized on a solid phase, mostly on resin, which can be made as a flat surface or beads. (wikipedia.org)
  • Thus, the question arises whether a Leydig cell oxytocin-like peptide is also synthesized de novo or is taken up and stored by the cell from some other intra- or extra-gonadal source. (thesisabstracts.com)
  • The free thesis, dissertation and paper abstract - digital online library! (thesisabstracts.com)
  • Traceless parallel peptide purification by a first-in-class reductively cleavable linker system featuring a safety-release. (bachem.com)
  • Thus, it is possible to develop a library of 20 different polypeptides along with just one amino acid residue randomly, with all the rest being the same. (peptidesguide.com)
  • Additional screens identified 1018 as a potent anti-biofilm peptide that prevented biofilm formation and led to the eradication of mature biofilms in both Gram-negative and Gram-positive bacteria. (ubc.ca)
  • The results of these two studies clearly demonstrate the potential of ALV as a eukaryotic platform for the display and selection of eukaryotic polypeptides libraries. (elsevierpure.com)
  • An on-bead two-colour screen was performed in one step and resulted in the discovery of three CXCR4-specific peptide-based imaging agents with micromolar affinities of 28, 86 and 109 µM. (uwo.ca)
  • Allocation of the library and a test cell line within a soft agar matrix followed by a partial peptide release will result in high concentrations of peptide in the agar surrounding each bead. (peptidesguide.com)
  • In total, 17 candidate peptides were found and their specificity toward Pb 2+ was further investigated with bead-based enzyme immunoassay (EIA). (korea.ac.kr)
  • High-throughput capacity: More than 10,000 peptides/month. (novoprolabs.com)
  • In this study, we identified two peptides (QKRKRKKSRKKH and RKRKRKKSRYIVLS) derived from VEGF125-136 that displayed high binding affinities to VEGFR and strong inhibition of A549 cell growth. (phoenixpeptide.com)
  • 99mTc- and 188Re-labeled peptides displayed high labeling efficiency and favorable stability in saline and human plasma. (phoenixpeptide.com)
  • From this number of total combinations, the scope of the peptide library can be narrowed down for a more specific purpose by selecting which amino acids are desired at each point in the chain. (wikipedia.org)
  • The two libraries, H 2 NO 2 SC 6 H 4 C(O)NH-AA 1 -AA 2 -C(O)NHCH 2 CH 2 CO 2 H ( 1 ), where AA 1 and AA 2 are l-amino acids (library size: 289 compounds) or d-amino acids (256 compounds), were constructed by attaching tripeptides to the carboxyl group of 4-carboxybenzenesulfonamide. (figshare.com)
  • Standard peptides are routinely provided as free N-terminal amines and C-terminal acids. (2bscientific.com)
  • A collection of cloned peptides, or chemically synthesized peptides, frequently consisting of all possible combinations of amino acids making up an n-amino acid peptide. (bvsalud.org)
  • To search for an alternative to using protein conjugated aflatoxin as a coating antigen in aflatoxin detection by an ELISA method, a random-8-peptide library was constructed and used as a source of peptides that mimic aflatoxins (termed as mimotopes). (cdc.gov)