Novel compound indolizines. Medical search. Frequent questions

Background: 2-amino-3-cyanopyridines are good starting reagents that have been used in synthesis of many heterocyclic compounds such as pyridopyrimidines, [1,2,4]triazolo and [1,2,3,4] tetrazolo derivatives which have biological activities as anti-microbial and cytotoxic activities. (eurekaselect.com)
A broad class of heterocyclic compounds has been studied to demonstrate their biological activity on the structures of DNA and RNA. (eurekaselect.com)
DFT and computational studies were carried out on five of the synthesized poly heterocyclic compounds to show their structural and geometrical parameters involved in the study. (eurekaselect.com)
Molecular docking using Tankyrase I enzyme as a target showed how the studied heterocyclic compounds act as a ligand interacting most of active sites on Tankyrase I with a type of interactions specified for H-bonding and VDW. (eurekaselect.com)
Pyrazolopyrimidine scaffolds are one of the most important heterocyclic compounds in drug discovery. (chemenu.com)

Iron-Catalyzed Indolizine Synthesis from Pyridines, Diazo Compounds, and Alkynes: Organic Letters Organic Letters. (nottingham.ac.uk)
Higuchi Hiroyuki, Yamamoto Hiroyuki, Ojima Juro, Yamamoto Gaku: Synthesis of Dibenzotrisdehydro(16)annulene-1,4-dione and the Related Compounds. (iupac.org)

Conformational equilibria in novel C-nitroso derivatives of indolizines and 3- and 5-azaindolizines have been studied by NMR . (rsc.org)
In particular, the invention seeks to provide new methodology for preparing compound 1 and substituted derivatives thereof. (justia.com)
Aliphatic hydrocarbons and their derivatives (including halogenated hydrocarbons) and alicyclic hydrocarbons and their derivatives are collectively referred to as aliphatic compounds. (chemenu.com)
1. Indazole and indolizine-3-carboxylic acid derivatives. (chemchart.com)

Bridged ring compounds are a class of organic compounds that are widely present in nature and usually have important physiological activities, such as the famous anticancer drug paclitaxel and antimalarial drug artemisinin. (chemenu.com)
Spiro compounds have rigid structures, stable structures, and have special properties that general organic compounds do not possess, such as anomeric effect, spiro conjugation and spiro hyperconjugation. (chemenu.com)

Compounds based on benzene fused to oxole. (nih.gov)
Compounds with BENZENE fused to AZEPINES . (nih.gov)

Compounds acting as selective antagonists of Transient Receptor Potential cation channel subfamily M member 8 (hereinafter referred to as TRPM8), having formula: Wherein R is selected from: H, Br, CN, NO2, SO2NH2, SO2NHR? (justia.com)
Here, we present a systematic, multidisciplinary approach to the development of selective antiparasitic compounds. (bvsalud.org)
The approach yielded compounds showing apparent picomolar inhibition of T. brucei pteridine reductase 1 (PTR1), nanomolar inhibition of L. major PTR1, and selective submicromolar inhibition of parasite dihydrofolate reductase (DHFR) versus human DHFR. (bvsalud.org)
In 1966, (20S)-camptothecin, a pent acyclic natural alkaloid, has re-emerged as one of the most important lead compounds for the discovery of new and selective anticancer drugs because of the disclosure of its unique mechanism of action as a selective inhibitor DNA topoisomerase Ⅰ, a process causing irreversible DNA damage and subsequent cell death. (watsonnoke.com)

13 C chemical shifts of the carbon alpha to the nitroso group confirmed that these compounds are present in solution as monomers. (rsc.org)
In aliphatic compounds, carbon atoms are arranged in straight chain, branched chain or cyclic, which are respectively called straight chain aliphatic hydrocarbons, branched chain aliphatic hydrocarbons and alicyclic hydrocarbons. (chemenu.com)
Bridged ring compound refers to any two rings in the compound, which share two non-directly connected carbon atoms, and are classified into bicyclic hydrocarbons, tricyclic hydrocarbons, tetracyclic hydrocarbons, etc. (chemenu.com)

The GC-MS analysis of the methanolic extract of BG revealed 23 compounds which are reported to possess different biological activities. (biomedcentral.com)

A database including 5494 structures of compounds was created. (scipeople.ru)

Crystal packing of title compound showing the formation of mol-ecular sheets parallel to the bc plane via C-H⋯O, C-H⋯ π and C-H⋯F inter-actions. (iucr.org)

Therefore, spiro compounds occupy a very important position in drug development. (chemenu.com)

An organic tricyclic compound in which at least one of the rings of the tricyclic skeleton contains one or more heteroatoms. (zfin.org)

The cognition-enhancing activity testing showed that all of the selected compounds had a pronounced antiamnesic effect and were found to reduce significantly scopolamine-induced amnesia of passive avoidance reflex (PAR). (scipeople.ru)
The compounds have been found to regulate phospholamban phosphorylation by interfering with the A-kinase anchor protein 18delta (AKAP185) binding to the PKA substrate phospholamban. (justia.com)
The Brine Shrimp Lethality Assay found extracts to be bioactive suggesting extracts as a promising candidate for plant-derived anti-tumor compounds. (biomedcentral.com)
Studies have found very good relationship between this simple, inexpensive, and bench-top assay and the antitumor potential of the cytotoxic compounds [ 10 ]. (biomedcentral.com)
Moreover, by combining design for polypharmacology with a property-based on-parasite optimization, we found three compounds that exhibited micromolar EC50 values against T. brucei brucei while retaining their target inhibition. (bvsalud.org)

The compounds share a tri(alkylaryl/alkylheteroaryl)amine structure. (justia.com)

Indolizine is an heterocyclic compound with the formula C8H7N). (wikipedia.org)
In embodiments, the compound has a structure according to Formula (I-A). (justia.com)

Barriers to rotation in these compounds were unusually high, particularly for substituents in position 3 of indolizine . (rsc.org)

A group of compounds with the heterocyclic ring structure of benzo(c)pyridine. (jefferson.edu)

A transition-metal-free synthetic approach to synthesize indolizines from α-bromo-substituted enals and simple 2-substituted azaarenes has been developed. (arizona.edu)
Our results provide a basis for the further development of pteridine-based compounds, and we expect our multitarget approach to be generally applicable to the design and optimization of anti-infective agents. (bvsalud.org)

The present invention relates to a process for preparing compound 1 that is useful as an antifungal agent. (justia.com)

Aliphatic hydrocarbons are hydrocarbons with the basic properties of aliphatic compounds. (chemenu.com)

On the basis of the PASS and DEREK prediction results, eight compounds with the highest probability of cognition-enhancing effect were selected. (scipeople.ru)

Herein are provided, inter alia, compounds capable of modulating the level of activity of low molecular weight protein tyrosine phosphatase (LMPTP) and methods of using the same. (justia.com)

The iron (III) catalyzed synthesis of indolizines from commercially available alkyne, pyridine, and diazo precursors is reported. (nottingham.ac.uk)
A domino Michael-aldol double elimination route to indolizines having two different acyl groups at the C5 and C7 positions is described where chromone is employed as a two-carbon unit for the synthesis of a pyridine moiety for the first time. (nih.gov)
Iodine-Mediated Domino Cyclization for One-Pot Synthesis of Indolizine-Fused Chromones via Metal-Free sp 3 C-H Functionalization. (nih.gov)
2. New indolizine-chalcones as potent inhibitors of human farnesyltransferase: Design, synthesis and biological evaluation. (nih.gov)
In 2014, Bi and co-workers reported the synthesis of pyrroles and indolizines from cyclization of 2-pyridyl alkynyl carbinols 16 with isocyanides (Scheme 11) [26]. (lempotee.fr)
It is proposed the physicochemical study of organofluorinated compounds, which include their synthesis and characterization and the monitoring of its reaction mechanisms with the integrated use of 1H, 13C and 19F NMR and infrared spectroscopy and theoretical calculations of electronic structure. (fapesp.br)

Indolizine is an heterocyclic compound with the formula C8H7N). (wikipedia.org)
Tetrahydrothiophene is a sulfur-containing saturated heterocyclic compound obtained by catalytic hydrogenation of thiophene. (chemenu.com)
Pyridine is a six-membered heterocyclic compound containing one nitrogen heteroatom. (chemenu.com)

Domino Knoevenagel condensation/intramolecular aldol cyclization route to diverse indolizines with densely functionalized pyridine units. (nih.gov)
Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. (chemenu.com)

This method can be used to synthesize a wide range of tertiary propargyl compounds such as pyrroles, indolizines, furans, and nitriles. (lempotee.fr)

It is particularly useful for acyl radical formation from carboxylic acids, terminal alkynes, and 1,3-dicarbonyl compounds. (lempotee.fr)

Saturated indolizines that are fused six and five-membered rings with a nitrogen atom at the ring fusion. (nih.gov)
HN - 2008(2004) BX - Acetogenin Compounds MH - Acridones UI - D054831 MN - D3.132.32 MN - D3.494.46.109 MS - Compounds based on acridone, which have three linear rings, with the center ring containing a ring nitrogen and a keto oxygen opposite to each other. (nih.gov)
Tetrahydroquinoline is one of the most important simple nitrogen heterocycles, widely found in nature and in a variety of pharmacologically active compounds. (chemenu.com)
Thiazine is an organic compound containing four carbon rings, one nitrogen atom and one sulfur atom. (chemenu.com)

However, to date, a detailed understanding of the physiological role of these compounds has been severely hampered by a lack of selective, high affinity, metabolically stable neurokinin receptor antagonists that possess both good bioavailability and CNS penetration. (justia.com)
Thienopyridines are similar in structure to quinoline and isoquinoline, and are a class of heterocyclic compounds with important physiological activity and medicinal value. (chemenu.com)

Evaluation of their biological properties as microtubule-interacting agents and as melanoma targeting compounds. (nih.gov)

Natural products and relevant compounds with biological and pharmaceutical activity are often characterized by complex molecular structures. (frontiersin.org)

材料に関する。 TECHNICAL FIELD The present invention relates to a diarylethene photochromic compound and an optical recording material using the compound. (google.com)
The invention generally relates to the field of neurokinin antagonists, and more particularly to new substituted aminopyrimidine compounds which are neurokinin antagonists and use of these compounds and their use in treatment and prevention of neurokinin conditions. (justia.com)

These are compounds with a structure based on harmaline, harmine, harmalol, harman or a derivative of those parents. (drugbank.com)

7. Studies on phenothiazines: New microtubule-interacting compounds with phenothiazine A-ring as potent antineoplastic agents. (nih.gov)
9. Studies on indolizines. (nih.gov)

Most of the non-peptide tachykinin receptor antagonists described to date directly or indirectly arose out of large compound collection screening using a robust radioligand binding assay as the primary screen. (justia.com)

Heterocyclic Compounds5

Synthesis2

Derivatives4

Organic compounds2

Benzene2

Selective4

Carbon3

Possess1

Structures1

Formation1

Important1

Rings1

Found5

Share1

Formula2

Position1

Structure1

Approach2

Present1

Properties1

Basis1

Activity1

Synthesis6

Heterocyclic compound3

Pyridine2

Furans1

Alkynes1

Nitrogen4

Physiological2

Evaluation1

Biological1

Invention2

Structure1

Studies2

Date1