Novel characterization 1997 receptors interleukin 1 type i. Medical search. Frequent questions

This glucocorticoid-PD-1 pathway limited production of the cytokine IFN-γ by spleen NK cells, which prevented immunopathology. (nature.com)
The chemokine (C-X-C motif) ligand 1 (CXCL1) is a small cytokine belonging to the CXC chemokine family that was previously called GRO1 oncogene, GROα, KC, neutrophil-activating protein 3 (NAP-3) and melanoma growth stimulating activity, alpha (MGSA-α). (wikidoc.org)
Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. (sagepub.com)
The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling. (sagepub.com)
This fact was confirmed by changes detected in a cytokine profile in blood serum samples [MIP-1α, interleukin 1 (IL-1) α, IL-2, IL-5, IL-1β, MCP-1, RANTES]. (frontiersin.org)
In his review article, Professor Wim van den Berg argues that both TNF-α and IL-1 must be blocked in RA and that although TNF is clearly a potent inflammatory molecule, the dominant cytokine in the subsequent degradation of the joint tissue is IL-1. (biomedcentral.com)
More broadly, it discusses the biology of TNF-α and IL-1 and suggests explanations of why TNF-α is a pivotal cytokine in this disease. (biomedcentral.com)
In his review article [ 1 ], Professor van den Berg discusses anti-cytokine therapy of RA and hypothesises that, in order to prevent joint destruction, it is necessary to block IL-1 in addition to TNF. (biomedcentral.com)
BMP-7, also called osteogenic protein-1, is a member of the TGF-β superfamily of cysteine-knot fold cytokine-growth factors [ 18 ] . (encyclopedia.pub)
Babin-Ebell J, Misoph M, Müllges W, Elert O. Cytokine release during cardiopulmonary bypass related to roller / centrifugal pumps: effect of pump-type on cytokine release. (2medicalcare.com)
CPC-mediated depot delivery of IGF-1 protected cartilage by suppressing cytokine-induced catabolism with only a single dose. (biomedcentral.com)
Intracerebral disulfide HMGB-1 mimicked the effect of the stressor, because microglia isolated from HMGB-1-treated rats expressed exaggerated NLRP3 and proinflammatory cytokine expression after LPS treatment, whereas fully reduced HMGB-1 had no effect. (jneurosci.org)

Fig. 3: Infection with MCMV induces glucocorticoid-dependent PD-1 expression in spleen NK cells. (nature.com)
IL-1β induces cyclooxygenase-2 (COX-2) and prostaglandin E2 (PGE2). (biomedcentral.com)
Figure 1: CD3/CD46 stimulation induces IL-10 production in human peripheral blood CD4 + T lymphocytes. (nature.com)
Interleukin-35 induces regulatory B cells that suppress autoimmune disease [J].2014,20(6). (wanfangdata.com.cn)
The integration of pathogen-associated molecular patterns (PAMPs) from microorganisms with their surface receptors in the immune cells, induces the production of several cytokines and chemokines that presents either a pro- and/or anti-inflammatory role by stimulating the secretion of a great variety of antibody subtypes and the activation of mechanisms of controlling the disease, such as the regulatory T cells. (bvsalud.org)

This protein is structurally related to interferon receptors. (wikipedia.org)
The serum mediators responsible for the down-regulation of P450 isoforms were interferon-γ, interleukin-1β (IL-1β), and IL-2. (aspetjournals.org)
Banchereau J, Ueno H, Dhodapkar M, Connolly J, Finholt JP, Klechevsky E, Blanck JP, Johnston DA, Palucka AK, Fay J. Immune and clinical outcomes in patients with stage IV melanoma vaccinated with peptide-pulsed dendritic cells derived from CD34+ progenitors and activated with type I interferon. (nwbio.com)
Tissue explants were treated with proinflammatory cytokines relevant to RA pathogenesis (interleukin 1β (IL-1β), tumour necrosis factor (TNF), interferon γ, IL-15, IL-17, IL-23). (bmj.com)
Glutamic acid decarboxylase (GAD) sequence 206-220 (designated GAD2) represents a late-stage epitope, but GAD2-specific T cell receptor transgenic T cells producing interferon γ (IFNγ) protect against passive TID. (rupress.org)
Garcia-Sastre A. Induction and evasion of type I interferon responses by influenza viruses. (smw.ch)

Interleukin 10 receptor, alpha subunit is a subunit for the interleukin-10 receptor. (wikipedia.org)
Interleukin 10 receptor, alpha subunit has been shown to interact with: Interleukin 10 and Janus kinase 1. (wikipedia.org)
1990). Characterization and Expression of the Gene for the Human Fc Receptor γ Subunit. (igem.org)
These calpains work as a heterodimer, comprising a big (80 kDa) and a little (28 kDa) subunit (1,4,5). (exposed-skin-care.net)
B29), and the -subunit of the E-mail: [email protected] interleukin (IL)-7 receptor [5, 6]. (lu.se)

CD123 + and BDCA2 + pDCs were detected by immunohistochemistry in RA synovial tissue in which expression of the IFN-α-inducible protein MxA was also found, suggesting production of type I IFN by maturing pDCs. (aai.org)
Mechanistically, endogenous glucocorticoids produced shortly after infection induced selective and tissue-specific expression of the checkpoint receptor PD-1 on NK cells. (nature.com)
Fig. 4: Specific combinations of cytokines and corticosterone act together to induce PD-1 expression on NK cells. (nature.com)
Therefore, we explored here in the trigeminal ganglion (TG) whether IL-1β upregulated Nav1.7 expression and whether the IL-1β located in the SGCs upregulated Nav1.7 expression in the neurons contributing to TMJ inflammatory hypernociception. (biomedcentral.com)
Glial IL-1β upregulated neuronal Nav1.7 expression via the crosstalk between signaling pathways of the glial IL-1β/COX-2/PGE2 and the neuronal EP2/PKA/CREB/Nav1.7 in TG contributing to TMJ inflammatory hypernociception. (biomedcentral.com)
In vivo, the increase in CYP3A6 by hypoxia is associated with the increased expression and nuclear translocation of hypoxia-inducible factor-1 (HIF-1), activator protein 1 (AP-1), and constitutive androstane receptor ( Fradette and du Souich, 2003 ). (aspetjournals.org)
[ 16 ] Expression of protease-activated receptor 1 and 2 occurs in orofacial granulomatosis. (medscape.com)
It is involved in various metabolic processes, such as acting on white adipose tissue to upregulate brown adipose tissue-specific genes, enhancing PGC-1α expression to increase lipid oxidation, suppressing inflammation in skeletal muscles, inhibiting cardiometabolic risk factors, and suppressing endoplasmic reticulum stress in hepatoblastoma cells. (encyclopedia.pub)
OA onset results in the upregulation of several inflammatory cytokines including interleukin 1 (IL-1) and tumor necrosis factor-alpha (TNF-α) which in turn upregulate the expression of proteolytic enzymes that break down the cartilage matrix [ 3 , 4 ]. (biomedcentral.com)
Expression of the LH/CG receptor gene in rat ovarian tissue is regulated by an extensive alternative splicing of the primary transcript. (geneticsmr.com)
Programmed death 1 (PD-1) is an immunoreceptor of the CD28/CTLA-4 family whose expression is induced in activated T- and B-cells and in macrophages ( 1 , 2 ). (diabetesjournals.org)
To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)

It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. (wikipedia.org)
The cytokines of a possible significance in that range include interleukin 17 family (IL-17) containing the group of IL-17A-F ligands and IL-17RA-E receptors. (czytelniamedyczna.pl)
1 In RA, numerous cytokines play a fundamental role in inflammation and joint destruction and are thought to originate primarily from synoviocytes and leucocytes that massively infiltrate synovial tissue. (bmj.com)

While trials of IL-1 receptor antagonist in RA have been encouraging, it clearly is more difficult to target two molecules (IL-1 α and β) than one (TNF-α). (biomedcentral.com)
Upon activation, the IL-1 receptor antagonist (IL-1Ra)/IL-1β ratio was higher in AAT than in SM cultures. (bmj.com)
To determine whether HMGB-1 signaling is necessary for stress-induced sensitization of microglia, the HMGB-1 antagonist BoxA was injected into the cisterna magna before IS. (jneurosci.org)

In the mouse, a sec8 mutant has been identified, but these mice die shortly after gastrulation of the embryo, precluding a more detailed analysis of the role of the complex (Friedrich, 1997). (sdbonline.org)
However, GFAP-IL6/sgp130 mice had decreased pY 705 -STAT3 in the brain due to a reduction in the total number of pY 705 -STAT3-positive cells and a marked loss of pY 705 -STAT3 in specific cell types. (jneurosci.org)
This issue has been extensively debated and even in the best-defined models, such as collagen-induced arthritis in DBA/1 mice, the aggressive, acute nature of the disease makes it unlike human RA. (biomedcentral.com)
However, limitations apart, it is of interest that in these huTNF transgenic mice, a neutralizing monoclonal antibody to the murine type I IL-1 receptor completely prevented the development of arthritis, suggesting that IL-1 acts downstream of TNF in the pathogenesis of chronic arthritis [ 6 ]. (biomedcentral.com)
Aside from these two receptors, evidence exists supporting the presence of yet uncloned cannabinoid receptors, a hypothesis predominantly based on pharmacological activity of cannabinoid compounds in CB1 and CB2 receptor-deficient mice or following the administration of 'selective' CB1 and CB2 receptor antagonists (Jarai et al. (420magazine.com)
Suppressive Role of B Cells in Chronic Colitis of T Cell Receptor\u03b1 Mutant Mice [J].1997. (wanfangdata.com.cn)
Decreased production of interleukin-10 and transforming growth factor-β in Toll-like receptor-activated intestinal B cells in SAMP1/Yit mice [J].2010,131(4). (wanfangdata.com.cn)
Kleiman A and Tuckermann JP: Glucocorticoid receptor action in beneficial and side effects of steroid therapy: Lessons from conditional knockout mice. (spandidos-publications.com)

Within the epidermis, C albicans phospholipomannan triggers an inflammatory response through Toll-like receptor (TLR)-2. (medscape.com)
genetic and environmental factors seem to increase the susceptibility of some individuals in developing this severe inflammatory disease (1) ( Fig. 1 ). (bvsalud.org)

1. Hull, R. (2002) Matthews' Plant Virology , 4th ed. (springer.com)
The lutropin/choriogonadotropin receptor, a 2002 perspective. (geneticsmr.com)
The concept has developed that innate immune receptors discriminate between danger and non-danger rather than self and non-self ( Matzinger, 2002 ). (jneurosci.org)

Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. (sagepub.com)
5 , - , 9 This loose connective tissue is composed of extracellular matrix and various types of cells: fat cells-named adipocytes, and the non-fat cells of the stromal vascular fraction that contains preadipocytes, capillary endothelial cells, infiltrating leucocytes and multipotent stem cells. (bmj.com)
Production and characterization of monoclonal antibodies to the extracellular domain of P0. (2medicalcare.com)

Inhibition of experimental autoimmune encephalomyelitis by an antibody to the intercellular adhesion molecule ICAM-1. (2medicalcare.com)
Inhibition of experimental autoimmune neuritis by an antibody to the lymphocyte function-associated antigen-1. (2medicalcare.com)
Similarly, inhibition of the PI3K-mTOR pathway by addition of the PI3K inhibitor 2-[4-morpholinyl]-8-phenyl-4H-1-benzopyran-4-one (LY294002) or the mTOR inhibitor rapamycin, although reducing several parameters of transformation, also failed to block transformation. (embl.de)
PD-1 has two cytoplasmic tyrosine motifs: one an immunoreceptor tyrosine-based inhibition motif and the other an immunoreceptor tyrosine-based switch motif (ITSM). (diabetesjournals.org)

The protein encoded by this gene is a receptor for interleukin 10. (wikipedia.org)
IL-1β upregulated Nav1.7 mRNA and protein expressions in the TG explants, whereas NS398, PF-04418948, H89, or PKI-(6-22)-amide could all block this upregulation, and forskolin could also upregulate Nav1.7 mRNA and protein expressions. (biomedcentral.com)
1997). Degradation of Amyloid β-Protein by a Metalloprotease Secreted by Microglia and Other Neural and Non-neural Cells. (igem.org)
Two cannabinoid G protein-coupled receptors have been cloned thus far, CB1 receptors (Matsuda et al. (420magazine.com)
Human apelin was identified and isolated in 1998 as an endogenous ligand of the G-protein-coupled receptor APJ and was named the APJ endogenous ligand. (encyclopedia.pub)
Members of a subfamily of these enzymes share a specific domain that was first identified in the yeast Sac1 protein [1]. (embl.de)
Despite the detailed in vitro characterization of the enzymatic properties of yeast Sac1p, the exact cellular function of this protein has remained obscure. (embl.de)
Here, high mobility group box-1 (HMGB-1) protein was explored as a potential mediator of stress-induced microglial priming and whether HMGB-1 does so via the nucleotide-binding domain, leucine-rich repeat, pyrin domain containing protein 3 (NLRP3) inflammasome. (jneurosci.org)
Exposure to 100 inescapable tail shocks (ISs) increased HMGB-1 and NLRP3 protein in the hippocampus and led isolated microglia to release HMGB-1 ex vivo . (jneurosci.org)
High mobility group box-1 protein (HMGB-1) is perhaps the most studied alarmin. (jneurosci.org)
MCP-1 monocyte chemoattractant protein type 1 workplace. (cdc.gov)

Toll-like receptor 7/8 agonist R848 alters the immune tumor microenvironment and enhances SBRT-induced antitumor efficacy in murine models of pancreatic cancer. (rochester.edu)
76 patients were confirmed germinoma, 29 mixed germ cell tumor, 4 teratoma, 9 malignant teratoma, 6 endodermal sinus tumor, 20 choriocarcinoma and 1 embryonal carcinoma. (researchsquare.com)
Classification of central nervous system germ cell tumors according to the World Health Organization divides them into germinoma and non-germinoma germ cell tumors(NGGCTs), with 6 different types of the latter, which includes teratoma, embryonal carcinoma, endodermal sinus tumor (yolk sac tumor), chorionic epithelioma (also called choriocarcinoma) and mixed germ cell tumors(GCTs) 7 (including above components sometimes teratoma and germinoma as well). (researchsquare.com)

Our findings identify an endogenous receptor-mediated event that drives Tr1 differentiation and suggest that the complement system has a previously unappreciated role in T-cell-mediated immunity and tolerance. (nature.com)
Toll-like receptors (TLRs) play a crucial role in immunity and development. (biomedcentral.com)
Transgenic animals have identified a role for specific manufacturing, auto body painting and repair and immunity, including the involvement of T-helper type 1/2 plastics manufacturing. (cdc.gov)

Two important pathways were examined in the current study: (1) a basic pathway of exocytosis that brings new proteins to the cell surface and permits the cell to grow, and (2) synaptic transmission, a specialized form of exocytosis, regulated by Ca 2+ entry, in which vesicles already present at synapses fuse with the membrane and recycle locally (Murthy, 2003). (sdbonline.org)
1. DamaniaB (2004) Oncogenic gamma-herpesviruses: comparison of viral proteins involved in tumorigenesis. (prelekara.sk)

Th1 immunocytes produce interleukin 12 and RANTES/MIP-1alpha and granulomas. (medscape.com)

Here we found that the regulation of natural killer (NK) cell function by the glucocorticoid receptor (GR) was required for host survival after infection with mouse cytomegalovirus (MCMV). (nature.com)
Fig. 1: Organ-specific glucocorticoid regulation of the production of IFN-γ by NCR1 + ILCs in the spleen and liver after infection with MCMV. (nature.com)
Fig. 5: MCMV-induced IFN-γ production by spleen NK cells is regulated by a glucocorticoid-PD-1 axis. (nature.com)
Fig. 6: The glucocorticoid-PD-1 regulatory pathway is required for protection against infection with MCMV. (nature.com)

Immunol Rev. 2011;239(1):167-77. (smw.ch)

Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. (wikipedia.org)
Tyrosine 343 in the erythropoietin receptor positively regulates erythropoietin‐induced cell proliferation and Stat5 activation. (sagepub.com)

Combination of NKG2A and PD-1 Blockade Improves Radiotherapy Response in Radioresistant Tumors. (rochester.edu)

Stereotactic Body Radiation and Interleukin-12 Combination Therapy Eradicates Pancreatic Tumors by Repolarizing the Immune Microenvironment. (rochester.edu)

Note: Certain human cell lines or cell types (e.g., neutrophils, monocytes) can first be treated with reagents that block receptors for the Fc regions of immunoglobulin to avoid nonspecific immunofluorescent staining mediated by Fc receptors (for example see Browning et al). (bdbiosciences.com)
In contrast, on monocytes and, indeed, more-differentiated macrophages, TNF is a much more potent activator than IL-1. (biomedcentral.com)
Clearly, this difference reflects receptor distribution, as monocytes have very few IL-1 receptors [ 8 ] but relatively abundant p55 and p75 TNF receptors. (biomedcentral.com)

Clin Radiol 1996;51 Suppl 1:19-23. (2medicalcare.com)

2007). Monoclonal T-Cell Receptors: New Reagents for Cancer Therapy. (igem.org)

The potent chondrogenic effects of IL-1 are well recognised, and it is clear that IL-1 activates chondrocytes and fibroblasts more potently than TNF does, a difference that may reflect the relative abundance of IL-1 receptors on these cells. (biomedcentral.com)
Characterization and relative abundance of alternatively spliced luteinizing hormone receptor messenger ribonucleic acid in the ovine ovary. (geneticsmr.com)

The therapeutic effectiveness of a single dose of CPC-IGF-1 was compared with free IGF-1 in an IL-1α-challenged cartilage explant culture post-traumatic OA model. (biomedcentral.com)

1990), expressed primarily by neurons, and CB2 receptors (Munro et al. (420magazine.com)

Abstract：调节性B细胞(regulatoryB cells,Breg)作为B淋巴细胞中一种特殊的亚群,通过产生白介素( (wanfangdata.com.cn)

The human toll receptor TLR4 was the first TLR discovered in mammals [ 11 ]. (biomedcentral.com)

2009). Isolation and characterization of cancer stem like cells in human glioblastoma cell lines. (igem.org)
Isolation and characterization of an oligodendrocyte precursor-derived B-cell epitope in multiple sclerosis. (2medicalcare.com)

Epub 1997/01/01. (smw.ch)

Following the cloning of CB1 and CB2 receptors, two endocannabinoid ligands were identified and characterized: arachidonoylethanolamide (anandamide) (Devane et al. (420magazine.com)

Langerhans cells detect C albicans via Dectin-1 and initiate a Th17 response via interleukin (IL)-6. (medscape.com)
The role of Th17 cells in type I diabetes (TID) remains largely unknown. (rupress.org)

This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. (wikipedia.org)

Classic signaling involves IL-6 binding to a specific transmembrane receptor termed IL-6Rα. (jneurosci.org)
They contain leucine-rich repeat domains, one transmembrane domain, and one Toll/IL-1 receptor domain. (biomedcentral.com)

Suppression of experimental allergic neuritis by an antibody to the intracellular adhesion molecule ICAM-1. (2medicalcare.com)

However, the simple list of individual differentially expressed genes can only tell us which genes are altered by biological differences between different cell types and/or states. (hindawi.com)
Surface display of IgG Fc on baculovirus vectors enhances binding to antigen-presenting cells and cell lines expressing Fc receptors. (igem.org)
Many cell types involved in this process express components of the cannabinoid signaling system that can be endogenously or pharmacologically controlled. (420magazine.com)
The gene is located on chromosome 12q23 [ 26 ] and regulates transforming growth factor (TGF)-beta 1 activity as well as the cell cycle [ 27 ] . (encyclopedia.pub)
Treatment with a single dose of CPC-IGF-1 effectively suppressed IL-1α-induced GAG loss and nitrite release and rescued cell metabolism and viability throughout the 16-day culture period, while free IGF at the equivalent dose was not effective. (biomedcentral.com)
Programmed death 1 ligand 1 (PD-L1), the interacting ligand for PD-1, widely expressed in many cell types, acts as a tissue-specific negative regulator of pathogenic T-cell responses. (diabetesjournals.org)
The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)
Other types include squamous cell carcinoma (see the image below) and adenocarcinomas. (medscape.com)

Globally, respiratory infections in childhood are a lead- Hospital and Pamela Youde Nethersole Eastern Hospital, ing cause of disease, contributing to absenteeism and provide 90% of all acute pediatric hospital care (admission economic strain through use of healthcare resources (1). (cdc.gov)
This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
The present results suggest that the CNS innate immune system can respond to an acute stressor as if it were cellular damage, thereby releasing the danger signal HMGB-1 in the brain to prime microglia by acting on the NLRP3 inflammasome, in preparation for a later immune challenge. (jneurosci.org)
Rabbit vascular endothelial adhesion molecules: ELAM-1 is most elevated in acute inflammation, whereas VCAM-1 and ICAM-1 predominate in chronic inflammation. (cdc.gov)
1997. Biochemical alterations in rat lung lavage fluid following acute sulfur mustard inhalation. (cdc.gov)

The findings indicate that in the CNS: (1) sgp130 is able to block IL-6 trans-signaling, (2) trans-signaling is important for IL-6 cellular communication with selective cellular and molecular targets, and (3) blocking of trans-signaling alleviates many of the detrimental effects of IL-6. (jneurosci.org)
Therefore, it is critical to understand the relationship (e.g., interactions) between genes across different types of cancer in order to gain insights into the molecular mechanisms of cancer. (hindawi.com)
Here we propose an integrative method based on the bootstrapping Kolmogorov-Smirnov test and a large set of microarray data produced with various types of cancer to discover common molecular changes in cells from normal state to cancerous state. (hindawi.com)

OBJECTIVE -Coinhibitory signals mediated via programmed death 1 (PD-1) receptor play a critical role in downregulating immune responses and in maintaining peripheral tolerance. (diabetesjournals.org)
The demonstration of antibodies, mixed T-helper (Th) type 1/2 responses diisocyanate occupational asthma in a murine model after sub- and the involvement of CD8 T lymphocytes in chronic inhalation exposure at relevant exposure levels should diisocyanate OA. (cdc.gov)

Moreover, microinjection of fluorocitrate into the TGs completely blocked TMJ inflammation-induced activation of SGCs and the upregulation of IL-1β and COX-2 in the SGCs, and phospho-CREB and Nav1.7 in the neurons and alleviated inflammation-induced TMJ hypernociception. (biomedcentral.com)
These secondary neurons immediately cross over to the opposite anterolateral spinothalamic tract 3 to the thalamus and then to the somatosensory cortex of the postcentral gyrus 6 ( fig. 1 ). (asahq.org)

In the subsequent step, the planned plasmids, including the planned chimeric receptors will be created and consequently characterized. (igem.org)

2004). Fcγ receptor signaling in primary human microglia: differential roles of PI-3K and Ras/ERK MAPK pathways in phagocytosis and chemokine induction. (igem.org)
Pathogens remain a significant threat to biodiversity, livestock farming and human health [ 1 ]. (biomedcentral.com)
a partial map of receptors on human mast cells cultured in vitro. (spandidos-publications.com)
Launch Calpain 3 (CAPN3) belongs to a Rabbit polyclonal to CDH1 family group of Ca2+- turned on natural cysteine proteinases which have been discovered in a multitude of microorganisms as disparate as human beings and worms (1,2). (exposed-skin-care.net)
In human beings, calpains are encoded by 15 genes with examined associates from the grouped family members getting the ubiquitously portrayed associates, calpains 1 and 2, referred to as - and m-calpain also, respectively. (exposed-skin-care.net)

In a broader view, a 2013 review of pathologic mechanisms of C albicans cited (1) the secretion of hydrolases, (2) molecules that mediate adhesion with concomitant invasion into host cells, (3) the yeast-to-hypha transition, (4) biofilm formation, (5) contact sensing and thigmotropism, (6) phenotypic switching, and (7) a variety of fitness attributes. (medscape.com)
Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells. (nature.com)
Characterization of Regulatory B Cells in Graves' Disease and Hashimoto's Thyroiditis. (wanfangdata.com.cn)
The present study aimed to investigate the effects of Solanum nigrum Linne (SNL) in a model of 1‑chloro‑2,4‑dinitrobenzene (DNCB)‑induced atopic dermatitis (AD) and in TNF‑α/IFN‑γ‑stimulated HaCaT cells. (spandidos-publications.com)

Objectives (1) To compare spontaneous and stimuli-induced adipocytokine secretion by articular adipose tissue (AAT) and synovial membrane (SM) explants obtained from patients with rheumatoid arthritis (RA). (bmj.com)
The biological activity of tissue-conditioned media was evaluated by measuring production of selected factors (IL-6, IL-8, Dickkopf-1, osteoprotegerin) by fibroblast-like synoviocytes (FLS). (bmj.com)
CPC-IGF-1 remained bound within the tissue while unmodified IGF-1 cleared out. (biomedcentral.com)

The apelin gene located at chromosome Xq25-26.1, encodes a 77 amino acid preproprotein [ 1 ] [ 2 ] . (encyclopedia.pub)

Increased curiosity about CAPN3 was highly stimulated when it had been reported that mutations in its gene bring about limb-girdle muscular dystrophy (LGMD) type 2A, seen as a the continuous atrophy of hip and make muscle tissues (LGMD2A, or calpainopathy) (21). (exposed-skin-care.net)
It really is plausible which the subcellular localization of CAPN3 determines its particular mobile function, which mutations make a difference some of those features straight or indirectly (1). (exposed-skin-care.net)

Recent Advances in Autoimmune Pancreatitis [J].2015,149(1). (wanfangdata.com.cn)

Anatomy39

Organisms12

Diseases9

Chemicals and Drugs134

Analytical, Diagnostic and Therapeutic Techniques and Equipment22

Phenomena and Processes39

Disciplines and Occupations1

Information Science3

Health Care2

Cytokine12

Induces5

Interferon6

Subunit5

Expression12

Cytokines3

Antagonist3

Mice8

Inflammatory2

20023

Extracellular3

Inhibition4

Protein11

Tumor3

Immunity3

Proteins2

RANTES1

Glucocorticoid4

Immunol1

Tyrosine2

Blockade1

Tumors1

Monocytes3

19961

Reagents1

Relative abundance2

Therapeutic1

19901

Abstract1

TLR41

Isolation2

Epub1

Ligands1

Th172

Pathway1

Transmembrane2

Intracellular1

Cell8

Acute5

Molecular3

Responses2

Neurons2

Subsequent1

Human5

Cells4

Tissue3

Chromosome1

CAPN32

Advances1