• The two monoclonal antibodies MAX.1 and MAX.11 recognize cell surface antigens that are almost undetectable on monocytes but highly expressed on differentiated macrophages. (uni-regensburg.de)
  • Cross-reactivity with bovine cells of monoclonal antibodies submitted to the 6th International Workshop on Human Leukocyte Differentiation Antigens. (ox.ac.uk)
  • Twelve subpanels of monoclonal antibodies (MAb) included within the 6th International Workshop on Human Leukocyte Differentiation Antigens (6th HLDA) were assayed for reactivity with bovine peripheral blood leukocytes. (ox.ac.uk)
  • The surface antigens of melanocytes from newborn and adult skin have been analyzed with monoclonal antibodies detecting cell surface antigens of malignant melanoma. (silverchair.com)
  • Immunophenotyping relies on detecting specific antigenic determinants on the surface of WBCs by antigen-specific monoclonal antibodies that have been labeled with a fluorescent dye or fluorochrome, such as phycoerythrin (PE) or fluorescein isothiocyanate (FITC). (cdc.gov)
  • Both the TRA-1-60 and TRA-1-81 monoclonal antibodies (MAB4381) recognize antigens that are associated with a pericellular matrix proteoglycan. (sigmaaldrich.com)
  • Thymus-dependent membrane antigens in man: inhibition of cell-mediated lympholysis by monoclonal antibodies to TH2 antigen. (bdbiosciences.com)
  • cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)
  • If the result is "reactive," this indicates possible presence of HIV-1 antibodies, HIV-2 antibodies and/or HIV-1 p24 antigen. (cdc.gov)
  • 1992) Cloning and expression of the human myeloid cell nuclear differentiation antigen: regulation by interferon alpha. (guidetopharmacology.org)
  • 2014) Purification, characterization and docking studies of the HIN domain of human myeloid nuclear differentiation antigen (MNDA). (guidetopharmacology.org)
  • Absent in melanoma (AIM)-like receptors (ALRs): myeloid cell nuclear differentiation antigen. (guidetopharmacology.org)
  • The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. (origene.com)
  • B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene. (wikipedia.org)
  • Serum B-cell maturation antigen (sBCMA) is the cleaved form of BCMA, found at low levels in the serum of normal patients and generally elevated in patients with multiple myeloma (MM). The protein encoded by this gene is a member of the TNF-receptor superfamily. (wikipedia.org)
  • We hypothesized that memory-like (ML) NK cell differentiation, tumor targeting with cetuximab, and engineering with an anti-EphA2 (Erythropoietin-producing hepatocellular receptor A2) chimeric antigen receptor (CAR) enhance NK cell responses against HNSCC. (figshare.com)
  • The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. (bdbiosciences.com)
  • Leukocyte differentiation antigens often represent important markers for the diagnosis, classification, prognosis, and therapeutic targeting of myeloid leukemia. (biomedcentral.com)
  • Herein, we report a potential leukocyte differentiation antigen gene VSTM1 ( V-set and transmembrane domain-containing 1 ) that was downregulated in bone marrow cells from leukemia patients and exhibited a higher degree of promoter methylation. (biomedcentral.com)
  • Therefore, VSTM1-v1 might represent an important myeloid leukocyte differentiation antigen and provide a potential target for the diagnosis and treatment of leukemia. (biomedcentral.com)
  • VSTM1 ( V-set and transmembrane domain-containing 1 ) encodes a potential leukocyte differentiation antigen that is highly expressed in myeloid cells, but silenced in multiple leukemia cell lines [ 1 ]. (biomedcentral.com)
  • Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1. (wikidata.org)
  • Antigen-initiated b lymphocyte differentiation. (jax.org)
  • MicroRNAs not only participate in determining DCs phenotype and then naive T lymphocyte differentiation, but also participate in the regulation of airway inflammation and airway remodeling in asthma. (cdc.gov)
  • Here, we determined the effect of Jiyuan oridonin A (JOA), an ent -kaurene diterpenoid compound, on the differentiation blockade in imatinib-sensitive, particularly, imatinib-resistant CML cells with BCR-ABL-T315I mutation by cell proliferation assay, apoptosis analysis, cell differentiation analysis, cell cycle analysis and colony formation assay. (jcancer.org)
  • We found that JOA at lower concentration significantly inhibited the proliferation of CML cells expressing mutant BCR-ABL (T315I mutation included) and wild-type BCR-ABL, which was due to that JOA induced the cell differentiation and the cell cycle arrest at G0/G1 phase. (jcancer.org)
  • BCR-ABL oncogene encodes a BCR-ABL tyrosine kinase (TK), which triggers different downstream targets including c-Myc, STAT5 and CrkL, which participated in the control of cell differentiation, proliferation, migration and other cellular behaviors [ 3 - 5 ]. (jcancer.org)
  • CD27 binds to CD70, and plays a role in costimulation of T cell activation and regulation of B cell differentiation and proliferation. (biolegend.com)
  • SRA1 augments cellular proliferation and differentiation and stimulates apoptosis in vivo. (prospecbio.com)
  • This L161 monoclonal antibody detects CD1c, a glycoprotein that is noncovalently linked to beta-2 microglobulin on thymocytes and antigen presenting cells such as dendritic and Langerhans cells. (fishersci.com)
  • They express several high molecular weight glycoprotein antigens that are down-regulated upon differentiation. (sigmaaldrich.com)
  • We purified the MAX.1/11 antigen by immunoaffinity chromatography using monoclonal antibody MAX.11. (uni-regensburg.de)
  • Identification with a monoclonal antibody of a predominantly B lymphocyte-specific determinant of the human leukocyte common antigen. (wikidata.org)
  • CBL-1, a murine monoclonal antibody, recognises an antigen on activated T cells, B cells, and natural killer cells. (nih.gov)
  • ImmunoCult™ Human Th1 Differentiation Supplement contains a combination of human cytokines and a blocking antibody formulated to promote the robust activation, expansion, and differentiation of peripheral blood-derived, naïve, CD4+ human T cells into Th1 cells. (stemcell.com)
  • One of these antigens, defined by monoclonal antibody TRA-1-60, can be detected in the serum of GCT patients and provides a useful complement to the established serum markers human chorionic gonadotropin and α-fetoprotein, especially in those patients without elevated serum human chorionic gonadotropin or α-fetoprotein. (sigmaaldrich.com)
  • This antibody reacts with TRA-1-60 antigen that is expressed upon the surface of human tetracarcinoma stem cells (EC), human embryonic germ cells (EG) and human embryonic stem cells (ES). (sigmaaldrich.com)
  • An EIA utilizing a monoclonal antibody was then developed that eliminated equivocal readings, creating better differentiation between results. (medscape.com)
  • HIV-1/2 antigen/antibody combination immunoassay (IA) which, if reactive, is followed by supplemental testing with an HIV-1/2 antibody differentiation assay. (cdc.gov)
  • Specimens negative or indeterminate by the HIV-1/2 antibody differentiation assay undergo an HIV-1 nucleic acid test (NAT). (cdc.gov)
  • If a 3rd generation IA is used in step 1, the remainder of the algorithm should be followed because the HIV-1/HIV-2 antibody differentiation assay and HIV-1 NAT assay, in combination, provide fewer false negative results than the Western blot for specimens collected early after infection. (cdc.gov)
  • Expression of carboxypeptidase M on mRNA level and enzymatic activity markedly increase during in vitro differentiation of monocytes, according to the described increase in MAX.1 and MAX.11 antigen expression. (uni-regensburg.de)
  • Antigen-driven differentiation of naive Ig-transgenic B cells in vitro. (ox.ac.uk)
  • Because all steps of differentiation occurred in vitro, they are easily accessible for study. (ox.ac.uk)
  • Chronic myeloid leukemia (CML) results from BCR-ABL oncogene, which blocks CML cells differentiation and protects these cells from apoptosis. (jcancer.org)
  • We propose that cell signalling initiated by extracellular GAS compromises the epithelial barrier by inducing premature keratinocyte differentiation and apoptosis, thereby facilitating GAS invasion of deeper tissues. (lu.se)
  • Markers of melanocyte differentiation and melanoma subsets. (silverchair.com)
  • Engagement of B cell surface Ig was not essential for primary B cell differentiation. (ox.ac.uk)
  • Surface antigens of melanocytes and melanomas. (silverchair.com)
  • A rudimentary surface antigen map of cells undergoing melanocyte differentiation and a new classification of melanomas based on the expression of melanocyte differentiation antigens are proposed. (silverchair.com)
  • Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
  • The stage-specific embryonic antigen 4 (SSEA4) is com- isolate the NSCs from neonatal mice and rats (Campos monly used as a cell surface marker to identify the pluri- et al. (lu.se)
  • ALLO-715 is a CAR-T therapy by Allogene Therapeutics that targets B-cell maturation antigen (BCMA). (wikipedia.org)
  • Differential changes in the pattern of cell antigens were revealed. (columbia.edu)
  • Vitamin D3-induced monocytic differentiation resulted in an increased carboxypeptidase M expression in all three cell lines. (uni-regensburg.de)
  • Differentiation of a cell line of myeloid leukemia. (wikidata.org)
  • CTL-associated antigen 4 (CTLA-4) can inhibit T-cell activation and helps maintain peripheral self-tolerance. (nih.gov)
  • In conclusion, PM enhances DC activation that primes naive T cell differentiation towards a Th17-like phenotype in an AhR-dependent manner. (cdc.gov)
  • Mechanistically, the cell differentiation mediated by JOA may be originated from the inhibition of BCR-ABL/c-MYC signaling in CML cells expressing wild-type BCR-ABL and BCR-ABL-T315I. (jcancer.org)
  • Leucocyte Typing IV: White Cell Differentiation Antigens. (bdbiosciences.com)
  • ECSA/DPPA2 is an embryo-cancer antigen that is coexpressed with cancer-testis antigens in non-small cell lung cancer. (nih.gov)
  • ImmunoCult™ Human Th1 Differentiation Supplement is intended for use with ImmunoCult™-XF T Cell Expansion Medium (Catalog #10981) and ImmunoCult™ Human CD3/CD28 T Cell Activator (Catalog #10971). (stemcell.com)
  • Activation of mTOR-dependent pathways regulates the specification and differentiation of CD4 + T effector cell subsets. (jci.org)
  • T cell memory is antigen-specific, and can provide durable host-wide protection. (frontiersin.org)
  • Distinct dynamics of antigen-specific induction and differentiation of different CD11c + Tbet + B-cell subsets. (bvsalud.org)
  • T cell differentiation. (cdc.gov)
  • In addition, tumor-associated antigens (TAAs) produced by irradiated tumor cells can be captured by antigen-presenting cells (APCs) in the TME and presented to T cells. (nature.com)
  • T RM responses against tumor/self-antigens can concurrently result in the development of pathogenic T RM responses to self, with a growing number of autoimmune diseases and inflammatory pathologies being attributed to T RM responses. (frontiersin.org)
  • While innate immune cells are important for early tumor immune surveillance, T cells are fundamentally recognized for their crucial role in the antigen-specific recognition and elimination of malignantly transformed cells ( 2 ). (frontiersin.org)
  • Serum fucosylated prostate-specific antigen (PSA) improves the differentiation of aggressive from non-aggressive prostate cancers. (nih.gov)
  • METHODS: Serum from 24 patients with IgG4-RD (14 treatment-naive, 10 treatment-experienced), 9 patients with primary sclerosing cholangitis and an elevated serum IgG4 (PSC-high IgG4), and 18 healthy controls were tested against egg white and yolk, milk, banana, cat, peanut, rice and wheat antigens by radioimmunoassay. (ox.ac.uk)
  • There was a strong correlation between serum IgG4 and antigen-specific responses. (ox.ac.uk)
  • Responses to antigens were higher in treatment-naive compared with treatment-experienced patients with IgG4-RD. Serum electrophoresis and immunofixation demonstrated polyclonality. (ox.ac.uk)
  • To assess the potential role of the AhR in PM-mediated activation of DCs, co-stimulation, and cytokine expression, bone marrow (BM)-derived macrophages and DCs from C57BL/6 wildtype or AhR knockout (AhR-/-) mice were treated with PM. Th17 differentiation was assessed via co-cultures of wildtype or AhR-/- BMDCs with autologous naive T cells. (cdc.gov)
  • Increased IgG4 responses to multiple food and animal antigens indicate a polyclonal expansion and differentiation of pre-existing B cells in IgG4-related disease. (ox.ac.uk)
  • Monocytes can also present fungal antigens to elicit adaptive immune responses. (frontiersin.org)
  • These were investigated further by two-colour immunofluorescence to compare the cellular expression of the antigen on cattle cells with that reported for the different CD antigens in humans. (ox.ac.uk)
  • Four of the MAb that belonged to CD23, CD39, CD47, and CDw149 stained bovine cells in a manner that indicated an almost identical cellular distribution of the antigen to that reported in humans. (ox.ac.uk)
  • CONCLUSIONS: This is the first study to show enhanced levels of polyclonal IgG4 to multiple antigens in IgG4-RD. This supports that elevated IgG4 levels reflect an aberrant immunological regulation of the overall IgG4 response, but does not exclude that causality of disease could be antigen-driven. (ox.ac.uk)
  • H pylori antigen testing has 3 distinct forms. (medscape.com)
  • Dr. Clarke's results on the distinct differentiation between the viruses of tick-borne encephalitis group in agar-gel precipitation test [5] , [6] had not been confirmed in our laboratory by N. Gorev by comparison of tick-borne and biphasic meningoencephalitis viruses. (cdc.gov)
  • Other cross-reacting MAb either recognized antigens already defined in cattle or antigens not yet clustered in humans. (ox.ac.uk)
  • Further studies are needed to elucidate the functional role of carboxypeptidase M during monocytic differentiation and activation. (uni-regensburg.de)
  • The aim of this study was to apply a combination of sequential multiplex PCRs targeting the O, H and Vi antigens to serotype a panel of 122 recently isolated human- and foodborne-Salmonella strains. (um.edu.my)
  • [10] It is less common in younger patients and in those with closer human leukocyte antigens (HLA) matches between donor and the patient. (wikipedia.org)
  • Bernard A, Boumsell L, Hill C. Joint report of the first international workshop on human leucocyte differentiation antigens by the investigators of the participating laboratories: T2 protocol. (bdbiosciences.com)
  • H pylori antigen is a protein constituent of the H pylori bacterium, which is shed in human stool. (medscape.com)
  • Prostate-specific antigen (PSA), tissue inhibitor of metallopeptidase 1 (TIMP1) and tissue plasminogen activator (tPA), and their fucosylated glycoforms were captured by Aleuria Aurantia Lectin (AAL), followed by the multiplex magnetic bead-based immunoassay. (nih.gov)
  • Tissue antigens 2004 Apr 63 (4): 293-325. (cdc.gov)
  • Tissue antigens 2006 Jan 67 (1): 30-7. (cdc.gov)
  • CD1c is involved in the presentation of lipid antigens such as microbial fatty acids to effector T cells during the adaptive immune response. (fishersci.com)
  • Antigenic markers that distinguish early, intermediate, and mature stages in melanocyte differentiation have been defined. (silverchair.com)
  • In the early 2000's, large and persistent populations of antigen (Ag)-specific CD8 T cells in peripheral tissues were initially classified as T EM cells in recirculation from the blood ( 8 , 11 ). (frontiersin.org)
  • Differentiation between African populations is evidenced by the diversity of alleles and haplotypes of HLA class I loci. (cdc.gov)
  • OBJECTIVES: To investigate if the IgG4 response in IgG4-RD represents a generalised polyclonal amplification by examining the response to common environmental antigens. (ox.ac.uk)
  • RESULTS: We demonstrated an elevated polyclonal IgG4 response to multiple antigens in patients with IgG4-RD and in PSC-high IgG4, compared with healthy controls. (ox.ac.uk)
  • VC 2006 Wiley-Liss, Inc. a glycolipid antigen with globo-series carbohydrate core structures (Kannagi et al. (lu.se)
  • Antigen composition of Absettarov virus is closely related, if not identical, to tick-borne encephalitis virus and louping ill virus in cross HI, NT and in cross-resistance tests in actively immunized mice. (cdc.gov)
  • The characteristics of the normal melanocyte precursor have been inferred from the features of melanomas that express early markers of melanocyte differentiation. (silverchair.com)