Here, we present the enantioselective synthesis of small-molecule compounds based on the tetrahydro-beta-carboline core system with improved solubility, and the influence of the stereochemistry on the biological activity. (uni-regensburg.de)
Among Magi's beta-Carboline nootropics is my personal favorite minidose, Stard Deep Meditation Aid which has been shown by brain scans to help you achieve a deeper state of meditation. (thethirdwave.co)
Steve Beyer , author of Singing to the Plants: A Guide to Mestizo Shamanism in the Upper Amazon , questions the Western conventional wisdom that the sole function of the beta-carbolines in the ayahuasca drink is simply to allow DMT to become orally active, and explores the scientific and ethnographic literature for evidence of beta-carboline psychoactivity. (ayahuasca.com)
In addition to peaks 97, 100, and 200, ongoing investigation is directed at 1-methyl-1,2,3,4-tetrahydro-beta-carboline-3-carboxylic acid (MTCA) (Figure 1B) and bacitracin, detected in LT lots from the implicated manufacturer (6). (cdc.gov)
The protection afforded by levetiracetam on the threshold for methyl-6,7-dimethoxy-4-ethyl-beta-carboline-3-carboxylate (DMCM)-induced seizures persisted after chronic administration (17-170 mg/kg, i.p., twice daily/14 days) and levetiracetam did not lower the seizure threshold for the proconvulsant action of the inverse benzodiazepine receptor agonist, N-methyl-beta-carboline-3-carboxamide (FG 7142). (nih.gov)
10. Synthesis and antitumoral activity of novel 3-(2-substituted-1,3,4-oxadiazol-5-yl) and 3-(5-substituted-1,2,4-triazol-3-yl) beta-carboline derivatives. (nih.gov)
Active substances include the hallucinogen N-N-dimethyltryptamine and beta-carboline alkaloids such as harmine and harmaline. (cdc.gov)
Tetrahydro-beta-carbolines2
The family of the tetrahydro-beta-carbolines has been associated with both biologically helpful and harmful compounds. (medscape.com)
12. Discovery of tetrahydro-beta-carbolines as inhibitors of the mitotic kinesin KSP. (nih.gov)
however, the suspected decomposition products, the beta-carbolines, exhibit a variety of biologic properties (7). (cdc.gov)
Synthesis2
14. Synthesis and biological evaluation of novel 3,9-substituted β-carboline derivatives as anticancer agents. (nih.gov)
The Pictet-Spengler reaction is an important class of name reaction employed extensively for the synthesis of tetrahydro-β-carboline [1-9] . (beilstein-journals.org)
Inhibitors3
1. Discovery of 4-anilino α-carbolines as novel Brk inhibitors. (nih.gov)
4. Computational & experimental evaluation of the structure/activity relationship of β-carbolines as DYRK1A inhibitors. (nih.gov)
8. Discovery of 4-benzylamino-substituted α-carbolines as a novel class of receptor tyrosine kinase inhibitors. (nih.gov)
Derivatives2
γ-Carbolines and their hydrogenated derivatives. (wikipedia.org)
2. Novel 4-anilino-α-carboline derivatives induce cell death in nonadhesive breast cancer cells through inhibition of Brk activity. (nih.gov)
Substances1
They explain the unique neurobiological and subjective effects of beta-Carbolines, including when combined with tryptamine-containing substances such as in an Ayahuasca brew. (thethirdwave.co)
Team2
Even with the significant changes we made collectively as a team, Carboline saw an impressive 11-point increase in employee connectedness to the company," he added. (coatingspromag.com)
By applying advanced scientific tools in chemistry, neurophysiology and psychopharmacology to the study of the Iranian inebriating elixir of truth, Haoma, his team discovered neurological health properties in beta-carbolines and developed Magi ancestral nootropic supplements. (thethirdwave.co)