• Vaccines and Diagnostics
  • The companies receiving the contracts were: GlaxoSmithKline $274.8 million MedImmune Inc $169.5 million Novartis Vaccines and Diagnostics $220.5 million DynPort Vaccine Company, LLC $41 million Solvay Pharmaceuticals $298.6 million The US government purchased from Sanofi Pasteur and Chiron Corporation several million doses of vaccine meant to be used in case of an influenza pandemic due to H5N1 and is conducting clinical trials on them[when? (wikipedia.org)
  • Diagnostics
  • Novartis Vaccine and Diagnostics, among other companies, developed a synthetic approach that very rapidly generates vaccine viruses from sequence data in order to be able to administer vaccinations early in the pandemic outbreak. (wikipedia.org)
  • vitro
  • Its enabling technologies have multiple applications and will be particularly relevant to the control of cell differentiation and function in vitro. (smi-online.co.uk)
  • What are the options in terms of current technologies for the in vitro study of cell in 3 dimensions. (smi-online.co.uk)
  • His subsequent investigations showed that the early biochemical effect of the two epipodophyllotoxins on proliferating cells in vitro differed from that of the alkylating agents, antimetabolites and Vinca alkaloids. (wikipedia.org)
  • GPR84 is normally expressed at low levels in myeloid cells and can be induced in vitro by stimulating macrophage or microglial cells with LPS, TNFα, or PMA. (wikipedia.org)
  • imatinib
  • Tyrosine kinase inhibitors (such as imatinib and sunitinib) are important drugs against a variety of cancers including CML, renal cell carcinoma (RCC) and gastrointestinal stromal tumors (GISTs). (wikipedia.org)
  • 2017
  • SMi Group proudly presents the inaugural launch of 3D Cell Culture, an exciting new conference scheduled to take place on the 22nd and 23rd February 2017, London UK. (smi-online.co.uk)
  • 3D Cell Culture 2017 will bring together leading professionals and researchers in the industry to discuss the latest developments and future potential of this technique. (smi-online.co.uk)
  • 3D Cell Culture 2017 will present success stories 3D culture applications, identifying the newest and brightest technologies, and the translation of 3D models into successful clinical and industrial applications. (smi-online.co.uk)
  • Get your copy now to see why you need to be at Cell Culture World Congress USA 2017. (terrapinn.com)
  • In a Dec. 14, 2017 decision, the United States Court of Appeals for the Federal Circuit found in favor of Sandoz, the generic drug arm of Novartis, in an ongoing biosimilars patent dispute between the pharma major and Amgen. (biopharminternational.com)
  • regulatory
  • Schibler together with his research team in University of Geneva have developed a technique called "Synthetic Tandem Repeat PROMoter (STAR-PROM) screening" which can assist identify transcription factors and their functions in peripheral cells so that to figure out how circadian gene expression is governed rhythmically with regulatory mechanisms in cultured cells. (wikipedia.org)
  • microbial
  • Bioprocessing begins upstream, most often with culturing of animal or microbial cells in a range of vessel types (such as bags or stirred tanks) using different controlled feeding, aerating, and process strategies. (bioprocessintl.com)
  • In summary, the proposed glucose monitoring and control technique proved to be a reliable tool which can be applied with confidence at an industrial scale for either microbial or mammalian cell cultures. (bioprocessintl.com)
  • Stähelin was also instrumental in the discovery process of several microbial products inhibiting cell proliferation, including cytochalasin B, brefeldin A, verrucarin A, anguinine and chlamydocin, which have played an important role in basic cancer research. (wikipedia.org)
  • viral
  • The potential use of cell culture techniques in developing viral vaccines, especially for the Influenza virus, has been widely investigated in recent years as a complementary and alternative platform to the current egg-based strategies. (wikipedia.org)
  • stem cell
  • There will be emphasis on the success and future of 3D methods in organoid research, disease modeling and toxicology screening, stem cell research, and much more. (smi-online.co.uk)
  • Further provided are cultures of feeder cells for use in stem cell technology, as well as cultures, culture systems and methods for maintenance and propagating of stem cells in an undifferentiated state as well as for the development. (google.es)
  • He was formerly the Robert A. Stranahan Professor of Pediatrics at Harvard Medical School, Director of the Stem Cell Transplantation Program at Boston Children's Hospital, and an investigator of the Howard Hughes Medical Institute, Associate Director of Children's Stem Cell Program, a member of the Executive Committee of the Harvard Stem Cell Institute. (wikipedia.org)
  • He is a past president of the International Society for Stem Cell Research (2007-2008). (wikipedia.org)
  • Daley has been prominent in advocating for ethical oversight of human stem cell research. (wikipedia.org)
  • Dr. Daley has testified six times before committees of the United States Senate and United States House of Representatives to advocate for expanded governmental support for stem cell research. (wikipedia.org)
  • He has served on the scientific advisory board of the Massachusetts Life Sciences Center and on the editorial board of the journals Science, Cell, Cell Stem Cell, Stem Cells, and Blood. (wikipedia.org)
  • Treatments may include supportive care, drug therapy, and stem cell transplantation. (wikipedia.org)
  • mechanisms
  • Some mechanisms of drug resistance include: Cell wall: The cell wall of M. tuberculosis (TB) contains complex lipid molecules which act as a barrier to stop drugs from entering the cell. (wikipedia.org)
  • Insights
  • Our 3-day event, formed of two half day post-conference workshops and a two-day conference will provide useful insights into the latest developments within cell culture. (smi-online.co.uk)
  • fibroblasts
  • The study demonstrated that "immortalized rat fibroblasts", frozen in cell culture for 25 years, were still capable of expressing strong circadian rhythms. (wikipedia.org)
  • After an initial serum-shock, both rat-1 fibroblasts and H35 hepatoma cells demonstrated cyclic mRNA expression of clock genes rper1 and rper2, and Rev-Erbα, and the clock controlled genes Tef and Dbp, with a period of nearly 24 hours and a phase relationship closely mimicking those observed in rat liver cells in vivo. (wikipedia.org)
  • Single-cell recordings revealed how circadian gene expression in fibroblasts persists during cell division, and how cell division can phase shift the circadian cycle of the dividing cells. (wikipedia.org)
  • clinical
  • In 1996, he was recruited away from UCSF by Chiron, one of the early Bay Area biotechnology companies, where he served as Corporate VP responsible for the clinical development of both therapeutics and vaccines until its acquisition in 2006 by Novartis, where he remained for two years. (wikipedia.org)
  • tissue culture
  • After 6 months of training in the state-of-the art tissue-culture techniques in John F. Enders' laboratory in Boston, sponsored by Sandoz, Stähelin joined its pharmacology department in Basel to head the newly created laboratory, then a research group working on cancer and immunology (1955-1979). (wikipedia.org)
  • scheme
  • Here we describe the application of a closed-loop control scheme for the long-term cultivation of CHO cells in a high cell density (35 - 40 million cells/ml) perfusion process. (bioprocessintl.com)
  • It recommended the drug as an option for treating severe, persistent allergic asthma in adults, adolescents and children following additional analyses and submission of a patient access scheme (PAS) by Novartis, the manufacturer. (wikipedia.org)
  • Children and Adolescents
  • Within the context of trials, the potentially dangerous white blood cell decline seems to be more frequent in children and adolescents and in the elderly than in young adults or people of middle age. (wikipedia.org)
  • 2000
  • Since 2000, new cells under investigation for making flu shots include cells derived from retinas of aborted fetuses (PER.C6), cells from ovaries of Chinese hamsters, and even cells from insects. (huffingtonpost.com)
  • Induction
  • In microglial cells, the GPR84 induction with interleukin-1 (IL-1) and tumor necrosis factor α (TNFα) was also demonstrated. (wikipedia.org)
  • chromosome
  • The Philadelphia chromosome or Philadelphia translocation is a specific genetic abnormality in chromosome 22 of leukemia cancer cells (particularly chronic myeloid leukemia (CML) cells). (wikipedia.org)
  • This gene is the ABL1 gene of chromosome 9 juxtaposed onto the BCR gene of chromosome 22, coding for a hybrid protein: a tyrosine kinase signalling protein that is "always on", causing the cell to divide uncontrollably. (wikipedia.org)
  • antibiotics
  • The advantages of the cell culture vaccine include less need for preservatives or antibiotics to prevent contamination, and usefulness in patients with severe egg allergies. (mmm-online.com)
  • Supportive care may include blood transfusions, medications to increase the making of red blood cells, and antibiotics. (wikipedia.org)
  • Drug
  • The court decided that Sandoz cannot be compelled by any state to give a 180-day exclusivity notice to Amgen when it plans to launch a biosimilar version of Neupogen (filigrastim), Amgen's innovator biologic drug for treating neutropenia (low white blood cell count). (biopharminternational.com)
  • The original work found that an anti-malaria drug or the neurotransmitter GABA could increase the number of insulin-producing pancreatic cells in mice. (the-scientist.com)
  • Fingolimod (INN, trade name Gilenya, Novartis) is an immunomodulating drug, mostly used for treating multiple sclerosis (MS). It has reduced the rate of relapses in relapsing-remitting multiple sclerosis by approximately one-half over a two-year period. (wikipedia.org)
  • Novartis announced on March 10, 2011 that it had received a notice of compliance from Health Canada and that the drug would be available April 1, 2011 at pharmacies. (wikipedia.org)
  • Drug efflux systems: The TB cell contains molecular systems that actively pump drug molecules out of the cell. (wikipedia.org)
  • viruses
  • Vaccines will be brewed from animal cells mixed with viruses in six 1,320 gallon fermenters which are owned by the U.S. government and the Department of HHS, as identified by a bright yellow, plastic plaque on the sides of the giant vats. (huffingtonpost.com)
  • No matter how careful manufacturers try to be, animal cells, animal DNA and culture-contaminating viruses end up in the final vials. (huffingtonpost.com)
  • enzymes
  • Since ABL activates a number of cell cycle-controlling proteins and enzymes, the result of the BCR-Abl fusion is to speed up cell division. (wikipedia.org)
  • leukemia
  • EST clones corresponding to hgpr84 were from B cells (leukemia), neuroendocrine lung as well as in microglial cells and adipocytes. (wikipedia.org)
  • Department
  • The project is a collaborative effort between Novartis and the U.S. Department of Health and Human Services, which contributed $457M for the design, construction, and licensing of the facility. (huffingtonpost.com)
  • While at Boston, the biomedical talent of the 27-year-old Stähelin was spotted by the director of the pharmacology department of the Sandoz Corp. (now Novartis AG. (wikipedia.org)
  • high
  • Richard Kim from TTP Labtech explains how combination of TTP's acumen ® Cellista scanning laser cytometer with Corning's spheroid plates enables rapid, high throughput, 3D cell culture screening. (selectscience.net)
  • Among the variables that are appropriate for direct feedback control of the perfusion rate in mammalian cell cultures, high priority should be given to the glucose concentration. (bioprocessintl.com)
  • Unlike an ordinary anti-IgE antibody, it does not bind to IgE that is already bound by the high affinity IgE receptor (FcεRI) on the surface of mast cells, basophils, and antigen-presenting dendritic cells. (wikipedia.org)
  • Clozapine is associated with a relatively high risk of low white blood cells which may result in death. (wikipedia.org)
  • mice
  • There was also a GPR84 downregulation in dentritic cell derived from FcRgamma chain KO mice. (wikipedia.org)
  • Process
  • The performance of the perfusion culture was evaluated at four different glucose set points, providing essential information about process optimization. (bioprocessintl.com)
  • It has also been reported to stimulate the repair process of glial cells and precursor cells after injury. (wikipedia.org)
  • Phase
  • Teniposide and etoposide were found by Stähelin to have a new mechanism of action: they blocked the entry of cells into mitosis (with arrest in late S or G2 phase), in contrast to SP-G and SP-I, which were spindle poisons. (wikipedia.org)