• Tumor xenograft model and ocular pathological neovascularization model were constructed as well as Isolectin B4 (IsoB4) staining and immunofluorescence staining were used to assess the effects of AFAP1L1 on the progression of neoplasms and neovascular eye diseases in vivo. (biomedcentral.com)
  • The goal of this study was to examine the immunohistochemical localization and relative levels of VEGF receptor-2 (KDR) in canine retina during postnatal vasculogenesis and during angiogenesis in oxygen-induced retinopathy (OIR) and to investigate the effects of neutralizing KDR on these processes. (johnshopkins.edu)
  • Inhibiting neovascularization via antivascular endothelial growth factor (VEGF) drugs has been used for the effective treatment. (elsevierpure.com)
  • Our previous reports have indicated that HIF is associated with pathological retinal neovascularization in murine models of ROP and AMD, and HIF inhibition suppresses neovascularization by reducing an abnormal increase in VEGF expression. (elsevierpure.com)
  • Angiotensin II is now regarded as a tumor growth promoter via angiogenesis from activation of the VEGF pathway[ 4 - 6 ]. (jcancer.org)
  • This may be due to its role as a permissive factor for vascular endothelial growth factor (VEGF) function in normal and pathologic vascular development. (usp.br)
  • Topical treatments for corneal neovascularization include steroids and anti-VEGF agents are currently the mainstay initial treatment for corneal neovascularization. (aao.org)
  • Ranibizumab inhibits angiogenesis (the formation of new blood vessels) by inhibiting vascular endothelial growth factor alpha (VEGF-A). Ranibizumab can be used to treat macular degeneration by inhibiting VEGF, which is responsible for the excessive formation of blood vessels in the retina leading to progressive loss of vision. (gabionline.net)
  • Singerman LJ, Masonson H, Patel M, Adamis AP, Buggage R, Cunningham E. Pegaptanib sodium for neovascular age-related macular degeneration: third-year safety results of the VEGF Inhibition Study in Ocular Neovascularisation (VISION) trial. (medscape.com)
  • Targeted suppression of AFAP1L1 specifically in endothelial cells in vivo proves effective in inhibiting tumor formation and ocular pathological neovascularization. (biomedcentral.com)
  • KDR/Flk-1 was only weakly associated with normal developing primary retinal vessels but was strongly expressed by proliferating endothelial cells in reforming retinal vessels and intravitreal neovascularization after hyperoxic insult. (johnshopkins.edu)
  • Inhibits migration, proliferation and network formation by endothelial cells as well as angiogenesis. (novusbio.com)
  • Our observations point to a novel, previously unrecognized capacity of Drm/gremlin to interact directly with target endothelial cells and to modulate angiogenesis. (unibs.it)
  • Endothelial progenitor cells (EPC) are a subtype of stem cells with high proliferative potential that are capable of differentiating into mature endothelial cells, thus contributing to neovascularization in tumors. (nutriforce.cn)
  • The relationship between angiogenesis and the immune response in carcinogenesis and the progression of malignant disease. (ox.ac.uk)
  • Elucidation of this mechanism is essential for the therapeutic manipulation of these pathologies, and in the future, more than 500 million people worldwide may benefit from pro- or anti-angiogenesis treatment. (helsinki.fi)
  • [4] The main therapeutic aim of these treatments is to initiate anti-angiogenesis and inhibit the neoangiogenesis at early stages, whereas the other treatment modality aims to achieve angio-regression by inducing reversion of immature vessels. (aao.org)
  • Corneal neovascularization is a sight-threatening condition that introduces vascular pathology into the normally avascular cornea. (aao.org)
  • Corneal neovascularization (NV) is a pathologic condition of the cornea, characterized by the formation and extension of new vascular capillaries within and into the previously avascular corneal regions, extending from the limbus into the superficial or deep areas of the cornea. (aao.org)
  • The treatment of corneal neovascularization is challenging. (aao.org)
  • Treatments for corneal neovascularization are predominately off-lab with a multitude of complications as a result. (aao.org)
  • Cortisone, dexamethasone and prednisolone have all been shown to produce an antiangiogenic effect and hence inhibit corneal neovascularization. (aao.org)
  • More importantly, the results from tumor xenograft and experimental metastasis models showed that Bay11-7082 had significant antitumor effects on ESCC xenografts in nude mice by promoting apoptosis, and inhibiting proliferation and angiogenesis, as well as reduced the metastasis of ESCC cells to the lungs without significant toxic effects. (hku.hk)
  • In the mouse model of retinal vascular development, neonatal mice administrated with IL-37 displayed increased neovascularization. (johnshopkins.edu)
  • Angiogenesis is the intricate process of generating fresh blood vessels from pre-existing ones. (biomedcentral.com)
  • When there is an unusually high or fast rate of angiogenesis, there is an overgrowth of blood vessels called neovascularization. (wikipedia.org)
  • Solid tumours need a blood supply, and a large body of evidence has previously suggested that they can grow only if they induce the development of new blood vessels, a process known as tumour angiogenesis. (nature.com)
  • Angiogenesis research investigates the formation of new blood vessels in wound healing, tumour growth and embryonic development. (nutriforce.cn)
  • 20 Laboratory of Angiogenesis and Vascular Metabolism, Department of Oncology and Leuven Cancer Institute (LKI), KU Leuven, Leuven, Belgium. (nih.gov)
  • This review will describe several inhibitors of angiogenesis currently in clinical trial and their various targets. (ox.ac.uk)
  • Food ingredients were screened for prospective HIF inhibitors in ocular cell lines of 661W and ARPE‐19, and a murine AMD model was utilized for examining suppressive effects of the ingredients on retinal neovascularization. (elsevierpure.com)
  • Chae YK, Brown EN, Lei X, Melhem-Bertrandt A, Giordano SH, Litton JK, Hortobagyi GN, Gonzalez-Angulo AM, Chavez-MacGregor M. Use of ACE Inhibitors and Angiotensin Receptor Blockers and Primary Breast Cancer Outcomes. (jcancer.org)
  • Does not affect the proliferation of cancer cells in vitro, but inhibits tumor growth and tumor angiogenesis. (novusbio.com)
  • Angiogenesis plays a key role in various physiologic and pathologic conditions, including tumor growth. (unibs.it)
  • Erythropoietin accelerates tumor growth through increase of erythropoietin receptor (EpoR) as well as by the stimulation of angiogenesis in DLD-1 and Ht-29 xenografts. (edu.pl)
  • Blood vessel formation plays an essential role in many physiologic and pathologic processes, including normal tissue growth and healing, as well as tumor progression. (nutriforce.cn)
  • Causes of included multifocal choroiditis and panuveitis (N = 12), angioid streaks (N = 11), pathologic myopia (N = 10), and idiopathic or other causes (N = 6). (medscape.com)
  • Immunoreactivity was very strong in reforming retinal vessels and intravitreal neovascularization in oxygen-treated animals. (johnshopkins.edu)
  • Formation of new vessels in granulation tissue during wound healing has been assumed to occur solely through sprouting angiogenesis. (nature.com)
  • In contrast, we show here that neovascularization can be accomplished by nonangiogenic expansion of preexisting vessels. (nature.com)
  • Pathological neovascularization plays a pivotal role in the onset and progression of tumors and neovascular eye diseases. (biomedcentral.com)
  • We demonstrated further that IL-37 promoted pathological angiogenesis in the mouse model of oxygen-induced retinopathy. (johnshopkins.edu)
  • Proliferative retinopathy is the result of aberrant blood flow to the retina due to blood vessel overgrowth, or neovascularization. (wikipedia.org)
  • Angiogenesis and neovascularization tend to be a later manifestation of non-proliferative retinopathy. (wikipedia.org)
  • Pathological neovascularization in the eye is a leading cause of blindness in all age groups from retinopathy of prematurity (ROP) in children to age‐related macular degeneration (AMD) in the elderly. (elsevierpure.com)
  • Bone marrow-derived endothelial progenitor cells (EPCs) contribute to tumour angiogenesis. (nutriforce.cn)
  • Purpose: To test the efficacy of runt-related transcription factor 1 (RUNX1) inhibition with topical nanoemulsion containing Ro5-3335 (eNano-Ro5) in experimental ocular neovascularization. (bvsalud.org)
  • These data suggest that rice bran could have promising therapeutic values in the management of pathological ocular neovascularization. (elsevierpure.com)
  • In recent years, owing to the swift advancement of high-throughput sequencing technology, pan-cancer analysis and single-cell sequencing analysis have emerged as pivotal methodologies and focal areas within the domain of omics research, which is of great significance for us to find potential targets related to the regulation of pathological neovascularization. (biomedcentral.com)
  • Dual luciferase reporting, qRT-PCR and western blot were used to investigate the upstream and downstream mechanisms of pathological neovascularization mediated by AFAP1L1. (biomedcentral.com)
  • Moreover, fucoidan inhibited in vivo angiogenesis and micrometastasis in a transgenic zebrafish model. (tmu.edu.tw)
  • Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis. (nature.com)
  • Un rôle majeur des prostaglandines dans l'hématopoïèse, ainsi mis en évidence, a pu être étendu à la souris chez qui un traitement par la prostaglandine PGE2 provoque la multiplication des CSH in vivo et in vitro, un résultat qui génerera très probablement des applications cliniques. (hypotheses.org)
  • A novel in vivo model of puncture-induced iris neovascularization. (illumina.com)
  • Identifying key pathways involved in the regulation and promotion of angiogenesis has resulted in the development of numerous approaches targeting pro-angiogenic signalling pathways. (ox.ac.uk)
  • Bone marrow-derived endothelial progenitor cells are a major determinant of nascent tumor neovascularization. (nature.com)
  • Angiogenesis has emerged as a critical process for tumour progression. (ox.ac.uk)
  • Collectively these observations indicate that angiogenesis and suppressed CMI play a central role in the development and progression of malignant disease. (ox.ac.uk)
  • Our first study showed that VEGFR-2 could to sustain angiogenesis to some extent and that postnatal angiogenesis requires VEGFR-2 signaling also in the absence of VEGFR-3. (helsinki.fi)
  • Using neovascularization models based on the chick chorioallantoic membrane and the healing mouse cornea, we found that tissue tension generated by activated fibroblasts or myofibroblasts during wound contraction mediated and directed translocation of the vasculature. (nature.com)
  • Assessment of inflammatory infiltration and angiogenesis in the thrombus and the wall of abdominal aortic aneurysms on the basis of histological parameters and computed tomography angiography study. (edu.pl)
  • Folkman, J. Tumor angiogenesis: therapeutic implications. (nature.com)
  • Weis, S. M. & Cheresh, D. A. Tumor angiogenesis: molecular pathways and therapeutic targets. (nature.com)
  • The principal mechanism of angiogenesis inhibition entails the regulation of tip cell behavior through the YAP-DLL4-NOTCH axis. (biomedcentral.com)
  • Inhibiting AFAP1L1 results in the inhibition of angiogenesis by suppressing the germination of endothelial tip cells through the YAP-DLL4-NOTCH axis. (biomedcentral.com)
  • Anti-KDR antibody delivered by slow-release pellets had no effect on normal vasculogenesis, but it inhibited the formation of intravitreal neovascularization and retinal vessel development in OIR. (johnshopkins.edu)
  • Thirty-four eyes of 34 pathologic myopic patients with CNV were treated with intravitreal conbercept (IVC) 0.5 mg with a follow up of 12 months. (biomedcentral.com)
  • Angiogenesis is tightly controlled by growth factors and cytokines in pathophysiological settings. (johnshopkins.edu)
  • Normally, angiogenesis is a natural part of tissue growth and formation. (wikipedia.org)
  • Recent studies have demonstrated that angiogenesis and suppressed cell-mediated immunity (CMI) play a central role in the pathogenesis of malignant disease facilitating tumour growth, invasion and metastasis. (ox.ac.uk)
  • The study suggests that blocking KDR may be beneficial for treating pathologic angiogenesis in adult tissue. (johnshopkins.edu)
  • Bmp2 in osteoblasts also indirectly controls angiogenesis in the periosteum and bone marrow. (ox.ac.uk)
  • As perfluorocarbon nanoparticles have recently entered Phase I clinical study, this review provides a timely focus on the development of this platform technology and its application for angiogenesis-related pathologies. (nih.gov)
  • Interleukin 37 (IL-37) is a newly identified cytokine of the IL-1 family, some members of which are important in inflammation and angiogenesis. (johnshopkins.edu)
  • Figure 5: Neovascularization of the wounded mouse cornea by recruitment of functional microvascular loops from the limbal capillary network. (nature.com)
  • These results suggest that RSV may be and Ewa Piatkowska ˛ useful in the prevention or treatment of pathological angiogenesis in eye disorders. (deepdyve.com)