• neuronal
  • Our results do not reveal a migration disorder in the mouse model, adding to the body of evidence available for Dcdc2 and Dyx1c1 that, unlike in the rat in utero knockdown models, the dyslexia-susceptibility candidate mouse homolog genes do not play an evident role in neuronal migration. (uclan.ac.uk)
  • Genetic elimination of dopamine vesicular stocks in the nigrostriatal pathway replicates Parkinson's disease motor symptoms without neuronal degeneration in adult mice. (nih.gov)
  • The effects on neuronal health in vivo are not solely due to disruption of developmental processes, because inducing OGT knock-out in the sensory neurons of adult mice results in a similar decrease in nerve fiber endings and cell bodies. (jneurosci.org)
  • Similarly, histone acetylation through histone deacetylase (HDAC) inhibitor Valproic Acid, an epilepsy therapeutic, in mouse embryonic stem cell (ESC) derived neural proginetors not only induces neuronal differentiation, but also selectively enriched the upper layer neuronal population. (wikipedia.org)
  • Thy-1 was discovered by Reif and Allen in 1964 during a search for heterologous antisera against mouse leukemia cells, and was demonstrated by them to be present on murine thymocytes, on T lymphocytes, and on neuronal cells. (wikipedia.org)
  • rats
  • Neuromolecular basis of parental behavior in laboratory mice and rats: with special emphasis on technical issues of using mouse genetics. (semanticscholar.org)
  • Avpr1a transcripts are diurnally expressed 12 hours out of phase from vasopressin expression in vasopressin and vasoactive intestinal polypeptide neurons of the suprachiasmatic nucleus in both vasopressin-normal Sprague-Dawley rats, as well as vasopressin-deficient Brattleboro rats. (wikipedia.org)
  • Both NmUR2 expression and NmU-23 binding sites are highly localized to the outer layers of the spinal dorsal horn, and administration of NmU via intracerebroventricular (ICV) injections usually increases pain sensitivity in rats and mice. (wikipedia.org)
  • ICV injections of NmU in rats and mice induce behavior responses associated with activation of the nociceptive pathways, for example it will increase plasma levels of corticosterone, and stimulates the release of CRH from hypothalamic explants in vitro. (wikipedia.org)
  • behavior
  • However, in inflammatory pain models, IKKε-deficient mice exhibited a significantly reduced nociceptive behavior in comparison with wild type mice, indicating that IKKε contributed to the development of inflammatory hyperalgesia. (jimmunol.org)
  • Male knockout mice in Avpr1a have reduced anxiety-like behavior and greatly impaired social recognition abilities, without any defects in spatial and nonsocial olfactory learning and memory tasks, as measured by the elevated plus maze, light/dark box, Morris water maze, forced swim, baseline acoustic startle and prepulse inhibition (PPI), and olfactory habituation tests. (wikipedia.org)
  • gene
  • To investigate on the gene-relationship between NGF, BDNF, and Osteocalcin we compared by RT-PCR the transcript levels of Ngf, Bdnf and Osteocalcin as well as of their receptors p75NTR/NTRK1, NTRK2 , and Gprc6a in brain, bone, white/brown adipose tissue (WAT/BAT) and reproductive organs of 3 months old female and male mice. (frontiersin.org)
  • The egfl7 gene is located on chromosomes 9 and 2 in human and mouse, respectively, and is structured in 11 exons and introns, including intron-1a and 1b which are alternatively transcribed from two different promoters. (wikipedia.org)
  • Although an initial gene inactivation report showed that mice which did not express egfl7 had various vascular defects, the observed phenotypes were later attributed to the concomitant inactivation of the miR-126 locus. (wikipedia.org)
  • Mutations in the human WISP3 gene are associated with progressive pseudorheumatoid dysplasia, a juvenile onset autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. (wikipedia.org)
  • The Thy-1 gene is located at human chromosome 11q22.3 (mouse chromosome 9qA5.1). (wikipedia.org)
  • Some believe that there may be a functional significance of both this gene and CD3 delta subunit (T3D) mapping to chromosome 11q in man and chromosome 9 in mouse, though there is no homology (in fact this speculation lead to its localization in chromosome 11q - the human chromosome region syntenic to mouse chromosome 9 which harbored T3D). (wikipedia.org)
  • Inactivation of the Avpr1b gene in mice (knockout) produces mice with greatly reduced aggression and a reduced ability to recognize recently investigated mice. (wikipedia.org)
  • impairment
  • IRS-1 plays important biological function for both metabolic and mitogenic (growth promoting) pathways: mice deficient of IRS1 have only a mild diabetic phenotype, but a pronounced growth impairment, i.e. (wikipedia.org)
  • show
  • Here, we show that OGT is essential for sensory neuron survival and maintenance in mice. (jneurosci.org)
  • VU-36: Ki = 95 nM, EC50 = 10.6 nM VU-1545: Ki = 156 nM, EC50 = 9.6 nM CDPPB (3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide) DFB (1-(3-fluorophenyl)-N-((3-fluorophenyl)methylideneamino)methanimine) LY-344,545 Basimglurant Dipraglurant Fenobam GRN-529 MPEP MTEP: more potent than MPEP Raseglurant Mice with a knocked out mGluR5 show a lack of cocaine self-administration regardless of dose. (wikipedia.org)
  • SGK1 knockout mice show seemingly normal development. (wikipedia.org)
  • Function
  • Given the paramount role of NF-κB in inflammation, we investigated the regulation and function of IKKε in models of inflammatory hyperalgesia in mice. (jimmunol.org)
  • Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. (wikipedia.org)
  • Comparisons between mammalian ABCA4 to other ABCs, cellular localization of ABCA4, and analyses of ABCA4 knockout mice suggest that ABCA4 may function as an inward-directed retinoid flippase. (wikipedia.org)
  • cellular
  • The discovery of Thy-1 in mice and humans led to the subsequent discovery of many other T cell markers, which is very significant to the field of immunology since T cells (along with B cells) are the major cellular components of the adaptive immune response. (wikipedia.org)
  • cells
  • CD8+ T cells have been reported to play an important role in defense against B. abortus infection in mouse models. (hindawi.com)
  • In the present report, we use CD8 knockout mice to further elucidate the role of these cells in protection from B. melitensis infection. (hindawi.com)
  • In mice, inhibition of egfl7 in hepatocellular carcinoma cells decrease tumour growth and micro-vessel density. (wikipedia.org)
  • therapeutic
  • He showed that 'smart' mice suffered more pain, GluN2B and AC1 are novel therapeutic targets for treating chronic pain In 2003, he moved to the University of Toronto, and identified NB001 as a selective inhibitor for AC1. (wikipedia.org)
  • model
  • The production of IFN- γ is essential for protection, clearance, and survival in the face of virulent Brucella challenge in the mouse model [ 17 ]. (hindawi.com)
  • whereas
  • Per 57 and 56 are normally co-expressed, whereas Per 61 is not found in normal peripherin expression in adult motor neurons. (wikipedia.org)
  • Thy 1.2 is expressed by most strains of mice, whereas Thy1.1 is expressed by some like AKR/J and PL mouse strains. (wikipedia.org)
  • Expression
  • To understand the tissue distribution of FosB, we have studied its expression pattern by immunohistochemistry in newborn and late embryonic stage mice. (semanticscholar.org)
  • Additionally, we observed normal phenotypes in both the elevated zero maze and the forced swim test indicating that anxiety and depression-related circuitry appears to be largely intact after loss of Gnaq expression. (frontiersin.org)
  • Central administration of NmU also induces expression of key genes in hypothalamic areas associated with stress, as well as stress-related behaviours that can be blocked by CRH antagonist (this is absent from CRH knockout mice). (wikipedia.org)
  • cell
  • Briefly, anti-active Gα 13 mouse monoclonal antibody will be incubated with cell lysates containing Gα 13 -GTP. (neweastbio.com)
  • role
  • Our findings provide a foundation for understanding the role of OGT under normal physiological conditions in the peripheral nervous system. (jneurosci.org)
  • The increase after a reduction of brain water content from salt water loading indicated AVPR1B's role in the neuroendocrine feedback loop in maintaining normal central nervous system fluid balance. (wikipedia.org)