• receptor
  • This pattern was not observed in mTALs from P2Y2 receptor knockout (KO) mice. (forskningsdatabasen.dk)
  • The inositol trisphosphate receptor Ca2+ release ion channel A focus of the lab is the molecular physiology of intracellular signaling by Ca2+, with a particular focus on unique approaches for studying the properties and regulation of intracellular Ca2+ release channels, especially inositol trisphosphate receptors (InsP3R), and their roles in normal and pathological cell physiological states. (upenn.edu)
  • Also, unlike vasopressin 1b receptor and oxytcoin knockout mice, Avpr1a KO mice have a normal Bruce effect (appropriate failure of pregnancy in presence of novel male). (wikipedia.org)
  • What is known for certain is that recombinant NmU receptors will increase the internal calcium concentration, signaling via the MAPK/ERK pathway Its role in cancer is not yet fully understood, though NmU and its receptor NMUR2 have been shown to be over-expressed in human pancreatic cancers compared to normal cells. (wikipedia.org)
  • agonists
  • We observed significant increases in drug-induced locomotor activity in G αq knockout mice from the dopaminergic agonists but not MK-801, indicating that basal ganglia locomotor circuitry is largely intact in the absence of G αq . (frontiersin.org)
  • Finally, when stimulated with cholinergic or cAMP agonists, cells from mice that lacked CFTR, as well as wild-type cells treated with a CFTR inhibitor, exhibited identical rates and magnitudes of shrinkage and Cl − efflux compared with control cells. (wiley.com)
  • behavior
  • However, in inflammatory pain models, IKKε-deficient mice exhibited a significantly reduced nociceptive behavior in comparison with wild type mice, indicating that IKKε contributed to the development of inflammatory hyperalgesia. (jimmunol.org)
  • Instead, the fragmented behavior of orexin KO mice may be best described as behavioral state instability, with apparently low thresholds to transition between states. (jneurosci.org)
  • We critically tested these hypotheses by examining the sleep-wake behavior of orexin KO mice under conditions that assess endogenous circadian rhythms, the integrity of fundamental arousal systems, and the homeostatic control of sleep. (jneurosci.org)
  • Biochemical and molecular tools are used within the context of physiological measurement, with the goal to understand how molecular behavior results in complex cell physiological processes in normal and disease states. (upenn.edu)
  • Male knockout mice in Avpr1a have reduced anxiety-like behavior and greatly impaired social recognition abilities, without any defects in spatial and nonsocial olfactory learning and memory tasks, as measured by the elevated plus maze, light/dark box, Morris water maze, forced swim, baseline acoustic startle and prepulse inhibition (PPI), and olfactory habituation tests. (wikipedia.org)
  • ICV injections of NmU in rats and mice induce behavior responses associated with activation of the nociceptive pathways, for example it will increase plasma levels of corticosterone, and stimulates the release of CRH from hypothalamic explants in vitro. (wikipedia.org)
  • increases
  • Over-expression of Egfl7 in tumour cells implanted in mice increases tumour growth and metastasis. (wikipedia.org)
  • Both NmUR2 expression and NmU-23 binding sites are highly localized to the outer layers of the spinal dorsal horn, and administration of NmU via intracerebroventricular (ICV) injections usually increases pain sensitivity in rats and mice. (wikipedia.org)
  • induces
  • Similarly, histone acetylation through histone deacetylase (HDAC) inhibitor Valproic Acid, an epilepsy therapeutic, in mouse embryonic stem cell (ESC) derived neural proginetors not only induces neuronal differentiation, but also selectively enriched the upper layer neuronal population. (wikipedia.org)
  • Central administration of NmU also induces expression of key genes in hypothalamic areas associated with stress, as well as stress-related behaviours that can be blocked by CRH antagonist (this is absent from CRH knockout mice). (wikipedia.org)
  • rats
  • Avpr1a transcripts are diurnally expressed 12 hours out of phase from vasopressin expression in vasopressin and vasoactive intestinal polypeptide neurons of the suprachiasmatic nucleus in both vasopressin-normal Sprague-Dawley rats, as well as vasopressin-deficient Brattleboro rats. (wikipedia.org)
  • gene
  • RNA was extracted from each sample, purified, and hybridized to Mouse Gene 1.0 ST arrays (Affymetrix). (pubmedcentralcanada.ca)
  • These signals participate in normal cell physiological processes, including mitosis, motility, secretion and gene transcription, and in pathological states, including epilepsy, Alzheimer's disease and programmed cell death (apoptosis). (upenn.edu)
  • The egfl7 gene is located on chromosomes 9 and 2 in human and mouse, respectively, and is structured in 11 exons and introns, including intron-1a and 1b which are alternatively transcribed from two different promoters. (wikipedia.org)
  • Although an initial gene inactivation report showed that mice which did not express egfl7 had various vascular defects, the observed phenotypes were later attributed to the concomitant inactivation of the miR-126 locus. (wikipedia.org)
  • Mutations in the human WISP3 gene are associated with progressive pseudorheumatoid dysplasia, a juvenile onset autosomal recessive skeletal disorder, indicating that the gene is essential for normal postnatal skeletal growth and cartilage homeostasis. (wikipedia.org)
  • The Thy-1 gene is located at human chromosome 11q22.3 (mouse chromosome 9qA5.1). (wikipedia.org)
  • Some believe that there may be a functional significance of both this gene and CD3 delta subunit (T3D) mapping to chromosome 11q in man and chromosome 9 in mouse, though there is no homology (in fact this speculation lead to its localization in chromosome 11q - the human chromosome region syntenic to mouse chromosome 9 which harbored T3D). (wikipedia.org)
  • homeostasis
  • Using orexin knock-out (KO) mice as a model of narcolepsy, we critically tested the three leading hypotheses: poor circadian control of sleep and wakefulness, inadequate activation of arousal regions, or abnormal sleep homeostasis. (jneurosci.org)
  • wild type
  • C) In the wild-type mice, the majority of the cells labeled at E15 migrate to the superficial parts of the CP, and the difference in BrdU + cell density between VZ and CP is clear at age E18. (rupress.org)
  • show
  • VU-36: Ki = 95 nM, EC50 = 10.6 nM VU-1545: Ki = 156 nM, EC50 = 9.6 nM CDPPB (3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide) DFB (1-(3-fluorophenyl)-N-((3-fluorophenyl)methylideneamino)methanimine) LY-344,545 Basimglurant Dipraglurant Fenobam GRN-529 MPEP MTEP: more potent than MPEP Raseglurant Mice with a knocked out mGluR5 show a lack of cocaine self-administration regardless of dose. (wikipedia.org)
  • SGK1 knockout mice show seemingly normal development. (wikipedia.org)
  • Function
  • Given the paramount role of NF-κB in inflammation, we investigated the regulation and function of IKKε in models of inflammatory hyperalgesia in mice. (jimmunol.org)
  • Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. (wikipedia.org)
  • Comparisons between mammalian ABCA4 to other ABCs, cellular localization of ABCA4, and analyses of ABCA4 knockout mice suggest that ABCA4 may function as an inward-directed retinoid flippase. (wikipedia.org)
  • cellular
  • The discovery of Thy-1 in mice and humans led to the subsequent discovery of many other T cell markers, which is very significant to the field of immunology since T cells (along with B cells) are the major cellular components of the adaptive immune response. (wikipedia.org)
  • occur
  • Furthermore, facilitated excitatory synaptic transmission in spinal dorsal horn neurons, a mechanism by which NmU stimulates pain, did not occur in NmUR2 KO mice. (wikipedia.org)
  • therapeutic
  • He showed that 'smart' mice suffered more pain, GluN2B and AC1 are novel therapeutic targets for treating chronic pain In 2003, he moved to the University of Toronto, and identified NB001 as a selective inhibitor for AC1. (wikipedia.org)
  • species
  • In addition to the main species of peripherin, 57 kDa, two other forms have been identified in mice: Per 61 and Per 56. (wikipedia.org)
  • cell
  • Briefly, anti-active Gα 13 mouse monoclonal antibody will be incubated with cell lysates containing Gα 13 -GTP. (neweastbio.com)
  • cells
  • In mice, inhibition of egfl7 in hepatocellular carcinoma cells decrease tumour growth and micro-vessel density. (wikipedia.org)
  • Thy-1 was discovered by Reif and Allen in 1964 during a search for heterologous antisera against mouse leukemia cells, and was demonstrated by them to be present on murine thymocytes, on T lymphocytes, and on neuronal cells. (wikipedia.org)
  • expression
  • Additionally, we observed normal phenotypes in both the elevated zero maze and the forced swim test indicating that anxiety and depression-related circuitry appears to be largely intact after loss of Gnaq expression. (frontiersin.org)
  • We have previously isolated the chicken and mouse orthologues of Mkp3 and studied their embryonic expression. (biologists.org)
  • body
  • It is released from the posterior pituitary in response to hypertonicity and causes the kidneys to reabsorb solute-free water and return it to the circulation from the tubules of the nephron, thus returning the tonicity of the body fluids toward normal. (wikipedia.org)
  • In contrast to NmU peptide-deficient mice, NmUR2 knockout (KO) mice appeared normal with regard to stress, anxiety, body weight regulation, and food consumption. (wikipedia.org)